全文获取类型
收费全文 | 44179篇 |
免费 | 1973篇 |
国内免费 | 196篇 |
专业分类
耳鼻咽喉 | 378篇 |
儿科学 | 719篇 |
妇产科学 | 491篇 |
基础医学 | 5824篇 |
口腔科学 | 1266篇 |
临床医学 | 2822篇 |
内科学 | 10938篇 |
皮肤病学 | 831篇 |
神经病学 | 3396篇 |
特种医学 | 1670篇 |
外科学 | 7301篇 |
综合类 | 209篇 |
一般理论 | 1篇 |
预防医学 | 1492篇 |
眼科学 | 1029篇 |
药学 | 3160篇 |
中国医学 | 134篇 |
肿瘤学 | 4687篇 |
出版年
2022年 | 294篇 |
2021年 | 710篇 |
2020年 | 356篇 |
2019年 | 483篇 |
2018年 | 666篇 |
2017年 | 530篇 |
2016年 | 671篇 |
2015年 | 680篇 |
2014年 | 921篇 |
2013年 | 1208篇 |
2012年 | 1939篇 |
2011年 | 2209篇 |
2010年 | 1168篇 |
2009年 | 1073篇 |
2008年 | 1990篇 |
2007年 | 2225篇 |
2006年 | 2302篇 |
2005年 | 2329篇 |
2004年 | 2242篇 |
2003年 | 2303篇 |
2002年 | 2405篇 |
2001年 | 1573篇 |
2000年 | 1544篇 |
1999年 | 1392篇 |
1998年 | 680篇 |
1997年 | 529篇 |
1996年 | 469篇 |
1995年 | 404篇 |
1994年 | 382篇 |
1993年 | 355篇 |
1992年 | 1002篇 |
1991年 | 900篇 |
1990年 | 814篇 |
1989年 | 807篇 |
1988年 | 735篇 |
1987年 | 745篇 |
1986年 | 652篇 |
1985年 | 622篇 |
1984年 | 428篇 |
1983年 | 354篇 |
1982年 | 214篇 |
1981年 | 190篇 |
1980年 | 181篇 |
1979年 | 273篇 |
1978年 | 218篇 |
1977年 | 180篇 |
1975年 | 175篇 |
1974年 | 171篇 |
1973年 | 184篇 |
1967年 | 169篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Naomi Sekizuka-Kagami Keiko Shimada Noriko Tabuchi Hiroyuki Nakamura 《Environmental health and preventive medicine》2015,20(2):90-96
Objectives
The purpose of this study is to determine whether the score of the sense of coherence 13-item version (SOC-13) scale in the second trimester of pregnancy is associated with threatened premature birth.Methods
All the subjects gave their informed written consent before their participation in the study. A self-reported questionnaire survey was conducted on the pregnant women at approximately 18 weeks of pregnancy. The questionnaire consisted of items on demographic characteristics, perinatal abnormalities, stress perception scale (SPS), and SOC-13 scale. Approximately 30 weeks of pregnancy after the first survey, we surveyed whether any treatment had been provided for threatened premature birth during the course of the current pregnancy. The study period was from December 2007 to February 2010. One hundred and seventy-seven pregnant women participated in the study, but only the data from 151 pregnant women were analyzed.Results
Forty-three (28.5 %) pregnant women had threatened premature birth and received some treatment. Logistic regression analysis was carried out with threatened premature birth as the dependent variable and age, childbirth history, smoking habit, history of miscarriage or premature birth in previous pregnancies, SPS score, and SOC-13 scale score as the independent variables. It was shown that SOC-13 scale score affected threatened premature birth (p < 0.001) and that a low SOC-13 scale score was associated with threatened premature birth.Conclusions
This study suggests that the SOC-13 scale score in the second trimester of pregnancy could be of great value in clinical health care of pregnant women with a risk of threatened premature birth in the subsequent course of pregnancy. 相似文献992.
Toshihiro Miyamoto Masaki Iino Yasuji Komorizono Toru Kiguchi Nobufusa Furukawa Maki Otsuka Shohei Sawada Yutaka Okamoto Kenji Yamauchi Toshitaka Muto Tomoaki Fujisaki Hisashi Tsurumi Kimitoshi Nakamura 《Internal medicine (Tokyo, Japan)》2021,60(5):699
Objective For patients with Gaucher disease (GD), a rare, inherited lysosomal storage disease, obtaining a definitive diagnosis is currently time-consuming and costly. A simplified screening method to measure the glucocerebrosidase (GBA) activity using dried blood spots (DBS) on filter paper has recently been developed. Using this newly developed screening method, we evaluated real-world GD screening in patients suspected of having GD. Methods This multicenter, cross-sectional, observational study with a diagnostic intervention component evaluated real-world screening in patients suspected of having GD based on their clinical symptoms and a platelet count <120,000/μL. The endpoint was the number of patients with low GBA activity determined using DBS. Results In 994 patients who underwent initial DBS screening, 77 had low GBA activity. The assay was not repeated in 1 patient who was diagnosed as having a high possibility of GD due to clinical symptoms, and a further 21 patients completed the study without undergoing the second assay. Of the remaining 55 patients who had 2 DBS assays performed, 11 had a low GBA activity in both assays. Overall, DBS screening identified 12 (1.2%) patients with a low GBA activity, a proportion consistent with prior screening studies. Conclusion These results suggest that the simplified DBS method was less burdensome to patients, was easily utilized by many physicians, and could be a useful first-tier screening assay for GD prior to initiating burdensome genetic testing. 相似文献
993.
Yuki Nakamura Tomohiro Uemura Yuka Kawata Bungo Hirose Rika Yamauchi Shun Shimohama 《Internal medicine (Tokyo, Japan)》2021,60(5):789
An 81-year-old man with a history of gingival bleeding presented with a fever, headache, and drowsiness. His mouth and full dentures were unsanitary. Laboratory tests revealed Streptococcus oralis meningitis caused by odontogenic bacteremia. We reviewed eight reported cases, including the present case, because S. oralis meningitis is rare. Our review indicated that S. oralis meningitis needs to be considered when encountering cases of a fever, disturbance of consciousness, and headache with episodes of possible odontogenic bacteremia. 相似文献
994.
Ryutaro Nakamura Akihiro Kitamura Takahito Tsukamoto Ryota Tamura Nobuhiro Ogawa Isamu Yamakawa Hyoh Kim Michihiro Kawai Mitsuru Sanada Makoto Urushitani 《Internal medicine (Tokyo, Japan)》2021,60(8):1287
We herein report a 65-year-old man with progressive multifocal leukoencephalopathy (PML) after 2-year remission from acute myeloid leukemia who developed recurrent episodes of left hemiparesis with gadolinium enhancement on magnetic resonance imaging. Steroid pulse therapy for each exacerbation induced clinical and radiological improvement, suggesting that exacerbations are an excessive immune response to the JC virus and distinct from immune reconstitution inflammatory syndrome (IRIS). Although glucocorticoids are recommended only for IRIS, steroid pulse therapy should be considered as a therapeutic option in cases of exacerbation of hematologic malignancy-associated PML. Importantly, neuroimaging is not sufficient to differentiate excessive inflammation from a controlled inflammatory response, for which steroids are not recommended. 相似文献
995.
Yusuke Hanioka Katsushu Shimizu Keiko Yamagami Shuhei Yao Ryota Nakamura Tomoyuki Nakamura Hitoshi Goto 《Internal medicine (Tokyo, Japan)》2021,60(10):1615
Tocilizumab (TCZ), a biologic that blocks the signal transduction of interleukin-6, has been used for the treatment of various autoimmune diseases. Many of these cases are sometimes complicated by ulcerative colitis (UC). However, the effect of TCZ on UC is unclear. We experienced two cases with concomitant UC that were treated with TCZ, one for Takayasu arteritis (TAK) and the other for relapsing polychondritis (RP). TCZ did not improve UC in either of these cases. TCZ might have adverse effects on the intestinal tract, since interleukin-6 signaling plays an important role in intestinal epithelium maintenance. Treatment with TCZ should therefore be carefully provided in patients complicated with UC. 相似文献
996.
Ryohei Sumitani Taiki Hori Jumpei Murai Shiyori Kawata Masahiro Oura Kimiko Sogabe Mamiko Takahashi Takeshi Harada Shiro Fujii Hirokazu Miki Kumiko Kagawa Masahiro Abe Shingen Nakamura 《Internal medicine (Tokyo, Japan)》2021,60(11):1753
A 33-year-old man was admitted to our hospital for fever and abdominal pain. A blood analysis revealed pancytopenia and increased serum pancreatic enzymes with disseminated intravascular coagulation. A detailed examination revealed acute pancreatitis, with diffuse swelling of the pancreas and diffuse beaded dilatation of the main pancreatic duct, which mimicked autoimmune pancreatitis complicated by acute myeloid leukemia. Systemic cytotoxic chemotherapy led to the remission of leukemia and pancreatitis. We hypothesized that the etiology of acute pancreatitis was invasion of leukemia cells. Acute pancreatitis is rare as a symptom of leukemia; however, we should consider the possibility of leukemia during the differential diagnosis of acute pancreatitis. 相似文献
997.
Shinzaki Shinichiro Matsuoka Katsuyoshi Tanaka Hiroki Takeshima Fuminao Kato Shingo Torisu Takehiro Ohta Yuki Watanabe Kenji Nakamura Shiro Yoshimura Naoki Kobayashi Taku Shiotani Akiko Hirai Fumihito Hiraoka Sakiko Watanabe Mamoru Matsuura Minoru Nishimoto Shohei Mizuno Shinta Iijima Hideki Takehara Tetsuo Naka Tetsuji Kanai Takanori Matsumoto Takayuki 《Journal of gastroenterology》2021,56(6):560-569
Journal of Gastroenterology - This multicenter prospective study (UMIN000019958) aimed to evaluate the usefulness of serum leucin-rich alpha-2 glycoprotein (LRG) levels in monitoring disease... 相似文献
998.
Toshihiro Nakamura MD Kunihiko Kiuchi MD FHRS Koji Fukuzawa MD Mitsuru Takami MD Yoshiaki Watanabe MD Yu Izawa MD Hideya Suehiro MD Tomomi Akita MD Makoto Takemoto MD Jun Sakai MD Atsusuke Yatomi MD Yusuke Sonoda MD Hiroyuki Takahara MD Kazutaka Nakasone MD Kyoko Yamamoto MD Noriyuki Negi RT Atsushi Kono MD Takashi Ashihara MD PhD Ken-ichi Hirata MD PhD 《Journal of cardiovascular electrophysiology》2021,32(4):1005-1013
999.
Yasuharu Matsunaga-Lee MD Yasuyuki Egami MD Kohei Ukita MD Akito Kawamura MD Hitoshi Nakamura MD Yutaka Matsuhiro MD Koji Yasumoto MD Masaki Tsuda MD Akihiro Tanaka MD Naotaka Okamoto MD Masamichi Yano MD PhD Ryu Shutta MD Yasushi Sakata MD PhD FACC FESC Masami Nishino MD PhD FACC FESC Jun Tanouchi MD PhD 《Journal of cardiovascular electrophysiology》2021,32(1):58-66
1000.
Kohki Nakamura MD PhD Takehito Sasaki MD Yutaka Take MD PhD Kentaro Minami MD Mitsuho Inoue MD Chisa Asahina MD Wataru Sasaki MD Shohei Kishi MD Shingo Yoshimura MD Yoshinori Okazaki MD Hiroyuki Motoda MD PhD Katsura Niijima MD PhD Yuko Miki MD PhD Koji Goto MD PhD Kenichi Kaseno MD PhD Eiji Yamashita MD PhD Keiko Koyama MD PhD Nobusada Funabashi MD PhD Shigeto Naito MD PhD 《Journal of cardiovascular electrophysiology》2021,32(1):16-26