全文获取类型
收费全文 | 44179篇 |
免费 | 1973篇 |
国内免费 | 196篇 |
专业分类
耳鼻咽喉 | 378篇 |
儿科学 | 719篇 |
妇产科学 | 491篇 |
基础医学 | 5824篇 |
口腔科学 | 1266篇 |
临床医学 | 2822篇 |
内科学 | 10938篇 |
皮肤病学 | 831篇 |
神经病学 | 3396篇 |
特种医学 | 1670篇 |
外科学 | 7301篇 |
综合类 | 209篇 |
一般理论 | 1篇 |
预防医学 | 1492篇 |
眼科学 | 1029篇 |
药学 | 3160篇 |
中国医学 | 134篇 |
肿瘤学 | 4687篇 |
出版年
2022年 | 294篇 |
2021年 | 710篇 |
2020年 | 356篇 |
2019年 | 483篇 |
2018年 | 666篇 |
2017年 | 530篇 |
2016年 | 671篇 |
2015年 | 680篇 |
2014年 | 921篇 |
2013年 | 1208篇 |
2012年 | 1939篇 |
2011年 | 2209篇 |
2010年 | 1168篇 |
2009年 | 1073篇 |
2008年 | 1990篇 |
2007年 | 2225篇 |
2006年 | 2302篇 |
2005年 | 2329篇 |
2004年 | 2242篇 |
2003年 | 2303篇 |
2002年 | 2405篇 |
2001年 | 1573篇 |
2000年 | 1544篇 |
1999年 | 1392篇 |
1998年 | 680篇 |
1997年 | 529篇 |
1996年 | 469篇 |
1995年 | 404篇 |
1994年 | 382篇 |
1993年 | 355篇 |
1992年 | 1002篇 |
1991年 | 900篇 |
1990年 | 814篇 |
1989年 | 807篇 |
1988年 | 735篇 |
1987年 | 745篇 |
1986年 | 652篇 |
1985年 | 622篇 |
1984年 | 428篇 |
1983年 | 354篇 |
1982年 | 214篇 |
1981年 | 190篇 |
1980年 | 181篇 |
1979年 | 273篇 |
1978年 | 218篇 |
1977年 | 180篇 |
1975年 | 175篇 |
1974年 | 171篇 |
1973年 | 184篇 |
1967年 | 169篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
Naoya Emoto Eiji Ohmura Osamu Isozaki Toshio Tsushima Kazuo Shizume Hiroshi Demure 《Clinical endocrinology》1991,34(5):377-382
In order to study the mechanism of GH secretion from somatotroph adenoma cells, we have compared the effect of 12–O-tetradecanoyl phorboi-13-acetate (TPA) with that of growth hormone releasing factor (GRF) on GH secretion from human somatotroph adenoma cells cultured in monolayer. Pituitary adenoma cells were obtained from 13 patients with acromegaly undergoing surgery. On the 7th day of culture, the cells were exposed for 2 h to secretagogues. All 13 adenoma cell cultures (100%) responded to TPA (1·6–16·0 nmol/I) with a two- to six-fold increase in GH release (240·37% Increase of control: mean±SE). The response was detectable within 10 min, and was maximal at 2 h. Phosphollpase C (7·7 mmol/I) also stimulated a two-to ten-fold Increase In GH release in all four adenomas examined (100%). GH release was stimulated by GRF (2·0 nmol/I) in eight out of 12 adenoma cells (67%), but the magnitude of the responses to GRF (60·18% Increase of control: mean ± SE) were much smaller than that of TPA. Five out of 13 adenomas secreted detectable amount of PRL Into the medium and these five adenomas (100%) responded to TPA (16·0 nmol/I) with a two- to six-fold Increase. These observations indicate that the activation of protein kinase C is the consistent stimulator in GH and PRL secretion In human somatotroph adenoma cells. However, It is not determined whether the protein kinase C 相似文献
102.
H Sato H Matsuda T Hatakeyama M Okada K Nakamura 《The Journal of cardiovascular surgery》1992,33(2):202-203
Primary pulmonary artery sarcoma is a rare tumor. We present a case report in which the presumptive diagnosis was made preoperatively with magnetic resonance imaging, Doppler color flow methods, and computer tomography. Surgical treatment was successful. 相似文献
103.
S Maeshima H Nakamura M Nishikawa T Murakami T Mitani T Marukawa S Hori T Kozuka M Irimoto 《Clinical imaging》1992,16(2):121-124
Tumors in the area of the adrenal were detected by chance in two patients who underwent a regular physical check-up. On arteriography the tumors were found to be fed by the adrenal artery. The diagnosis was retroperitoneal schwannoma, but in both patients it was difficult to differentiate the schwannoma from an adrenal tumor preoperatively. 相似文献
104.
H Nakamura H Masutani Y Tagaya A Yamauchi T Inamoto Y Nanbu S Fujii K Ozawa J Yodoi 《Cancer》1992,69(8):2091-2097
Adult T-cell leukemia-derived factor (ADF), originally defined as an interleukin-2 receptor inducer, is a human thioredoxin homologue. ADF is detected in many malignant tissues and has a growth-promoting effect on transformed cells. In this study, ADF expression was examined immunohistochemically in human liver cell lines and liver tissues, and its growth-promoting effect was tested on human hepatoma cells. On three liver cell line--PLC/PRF/5, HepG2, and Chang liver cells--ADF stained positively and also was detected by immunoblotting. ADF had strong staining in the fetal liver (n = 8), although it was faint in the normal adult liver (n = 6). In hepatocellular carcinoma (n = 25), ADF expression generally was enhanced and was very strong in 52% (13 of 25) of the cases, although it was moderate in cases of chronic hepatitis or cirrhosis. ADF augmented the growth of PLC/PRF/5 cells and showed an additive effect with epidermal growth factor. These results indicate possible involvement of ADF in cell activation and growth of hepatocytes, as is the case with lymphocytes. 相似文献
105.
A 52-year-old woman who developed acute transverse myelopathy following systemic lupus erythematosus (SLE) was reported. At the age of 46, she was diagnosed as having atypical psychosis. Neurological examination revealed mild depressive state, paraparesis, diffuse hyperreflexia, hypesthesia below the breasts, and urinary disturbance. Gait was slightly ataxic and Romberg sign was positive. Laboratory study disclosed lymphocytopenia, positive antinuclear antigen, false positive Venereal Disease Research Laboratories flocculation test and prolonged activated partial thromboplastin time. IgG anticardiolipin antibody (aCLA) was positive, whereas IgM aCLA was negative. Cerebrospinal fluid was normal except the elevation of %IgG. Nerve conduction studies were normal and no abnormality was detected in the brain and spinal cord by MRI and CT. We treated her by two series of steroid pulse therapy, which resulted in marked improvement of symptoms and disappearance of aCLA. Before and after the pulse therapy, symptoms were fluctuated in parallel with the levels of aCLA. These findings suggest the relation of aCLA to the transverse myelopathy in SLE. This is the first case report of a good prognosis of myelopathy in a SLE patient who was treated by steroid pulse therapy with the aim of disappearance of aCLA. 相似文献
106.
107.
Tsuyoshi Murase Kazuo Hiroshima 《Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi》2003,37(3):188-191
Flexor tendon rupture as a complication of Colles' fracture is rare. We describe a case of attrition rupture of flexor tendons to the ring and little fingers after a malunited Colles' fracture, and we review the 17 previously reported cases. 相似文献
108.
Seishiro Hirano Takako Asami Naomi Kodama Kazuo T. Suzuki 《Archives of toxicology》1994,68(7):444-449
In a preceding study, we reported that the numbers of macrophages and polymorphonuclear leukocytes (PMN) were increased in
bronchoalveolar lavage fluid (BALF) following the intratracheal instillation of nickel sulfate (NiSO4) in rats. In the present study, BALF chemotactic activities for both macrophages and PMN were measured to investigate if
the increases of these inflammatory cells in BALF depend on increases in chemotactic activities in epithelial lining fluid
(ELF) of the lung. Both the number of PMN and the PMN chemotactic activity peaked at 2 days post-instillation and they were
significantly correlated. However, the PMN chemotactic activity was inversely correlated with concentration of leukotriene
B4 (LTB4), a well-known chemotaxin. Although PMN were not observed in control BALF, LTB4 concentration in the control ELF (ca. 5×10–7 M) was estimated to have a potential to attract PMN chemotactically through a membrane in in vitro migration assay. These
results suggest that the presence of LTB4 in ELF itself does not trigger transpulmonary PMN infiltration. The rat BALF were fractionated by high performance liquid
chromatography (HPLC), and PMN chemotactic activity of each fraction was measured. The elution profiles of PMN chemotactic
activity showed that there were at least two different chemotaxins in BALF obtained from the NiSO4-exposed rats. Macrophage chemotactic activity in BALF also peaked at 2 days post-instillation. However, the number of macrophages
was not significantly correlated with the chemotactic activity for macrophage in BALF. The HPLC study showed that the macrophage
chemotactic substance in the BALF obtained from NiSO4-exposed rats was different from complement fragment (C5a) and its MW was estimated to be 10 – 12 kD.
Received: 1 December 1993/Accepted: 16 March 1994 相似文献
109.
Koichi Murata Yasuaki Nakagawa Takashi Suzuki Masahiko Kobayashi Seiya Kotani Takashi Nakamura 《Knee surgery, sports traumatology, arthroscopy》2007,15(10):1261-1263
Intraosseous ganglia of the glenoid are rare, and their etiology is unknown. This report describes a case of an intraosseous
ganglion about to cause fracture of the glenoid. The patient was a 61-year-old woman with a painful left shoulder with a limited
range of motion. Her symptoms did not improve after non-operative treatment. Arthroscopic examination showed a cartilage defect
and erosion in the posteroinferior portion of the glenoid, behind which computed tomography (CT) showed a cystic lesion of
the glenoid. There was no communication between the cyst and the joint space. The patient was treated by curettage and an
autogenous cancellous bone graft from the iliac crest. Two years after the operation, the patient was almost free from pain,
and CT showed good integration of the bone graft. 相似文献
110.
Aortic arch replacement with proximal first technique. 总被引:2,自引:0,他引:2
Yuji Miyamoto Kenji Onishi Masataka Mitsuno Koichi Toda Masao Yoshitatsu Kazuo Abe 《Annals of thoracic and cardiovascular surgery》2003,9(6):389-393
BACKGROUND: Deep hypothermic circulatory arrest (DHCA) without retrograde cerebral perfusion (RCP) has a strict time limit. We modified a surgical technique for anastomosis to shorten the period of DHCA and unilateral cerebral perfusion (UCP). METHODS: Between March 1993 and August 2001, retrospective analysis was done on 23 consecutive patients, who underwent aortic arch replacement with branches. The patients were divided into two groups: DHCA group and UCP group. The DHCA group, in which DHCA alone and without additional cerebral perfusion was performed, comprised of nine patients. Proximal aortic anastomosis was performed first during systemic cooling; then both the brachiocephalic artery and left carotid artery were reconstructed with the branches of the artificial graft during circulatory arrest; thereafter, cerebral and coronary perfusions were resumed. The UCP group, in which DHCA was not used but right hemisphere perfusion during deep hypothermia was performed when the origin of brachiocephalic artery was safely clamped, consisted of 14 patients. RESULTS: Mean time of DHCA was 18.8+/-4.2 minutes and that of right hemisphere perfusion time was 11.0+/-3.8 minutes, respectively. Twenty-one patients survived the surgery (91.3%), and two (8.7%) died during hospitalization. Transient cerebral complication occurred in four patients in the DHCA group and all recovered. Logistic regression analysis revealed that DHCA was the only parameter to significantly influence temporary neurological dysfunction. There was no other significant difference between the two groups. CONCLUSION: With our modified and simple surgical technique for aortic arch repair, we were able to successfully shorten the DHCA time and right hemisphere perfusion time. However, because DHCA was the only parameter to significantly influence temporary neurological dysfunction, some form of continuous cerebral perfusion at deep hypothermia may be a safer method to preserve cerebral function. 相似文献