全文获取类型
收费全文 | 6965篇 |
免费 | 328篇 |
国内免费 | 53篇 |
专业分类
耳鼻咽喉 | 35篇 |
儿科学 | 194篇 |
妇产科学 | 55篇 |
基础医学 | 915篇 |
口腔科学 | 206篇 |
临床医学 | 414篇 |
内科学 | 1483篇 |
皮肤病学 | 106篇 |
神经病学 | 687篇 |
特种医学 | 360篇 |
外科学 | 1536篇 |
综合类 | 20篇 |
预防医学 | 245篇 |
眼科学 | 99篇 |
药学 | 338篇 |
中国医学 | 16篇 |
肿瘤学 | 637篇 |
出版年
2023年 | 38篇 |
2022年 | 77篇 |
2021年 | 151篇 |
2020年 | 82篇 |
2019年 | 119篇 |
2018年 | 151篇 |
2017年 | 130篇 |
2016年 | 130篇 |
2015年 | 165篇 |
2014年 | 205篇 |
2013年 | 217篇 |
2012年 | 343篇 |
2011年 | 370篇 |
2010年 | 222篇 |
2009年 | 178篇 |
2008年 | 298篇 |
2007年 | 352篇 |
2006年 | 310篇 |
2005年 | 312篇 |
2004年 | 374篇 |
2003年 | 314篇 |
2002年 | 346篇 |
2001年 | 239篇 |
2000年 | 239篇 |
1999年 | 203篇 |
1998年 | 98篇 |
1997年 | 78篇 |
1996年 | 88篇 |
1995年 | 64篇 |
1994年 | 62篇 |
1993年 | 38篇 |
1992年 | 145篇 |
1991年 | 119篇 |
1990年 | 122篇 |
1989年 | 115篇 |
1988年 | 96篇 |
1987年 | 70篇 |
1986年 | 69篇 |
1985年 | 76篇 |
1984年 | 59篇 |
1983年 | 50篇 |
1981年 | 23篇 |
1979年 | 49篇 |
1977年 | 32篇 |
1974年 | 39篇 |
1973年 | 31篇 |
1972年 | 24篇 |
1971年 | 24篇 |
1968年 | 24篇 |
1967年 | 22篇 |
排序方式: 共有7346条查询结果,搜索用时 15 毫秒
71.
A case of acute-on-chronic renal failure in a 70-year-old woman with ischemic nephropathy and primary hypothyroidism is presented. Her renal function became progressively worse as the level of serum creatinine increased from 283 to 628 micromol/l (3.2-7.1 mg/dl) within 8 months. Her thyroid function had been normal before the exacerbation of renal failure, but it was markedly reduced with a marked elevation of serum thyroid-stimulating hormone. Thyroid hormone replacement therapy resulted in rapid improvement of the renal function to 159 micromol/l (1.8 mg/dl) of serum creatinine. The development of primary hypothyroidism seemed to worsen the already impaired renal function in this case. We suggest the assessment of thyroid function in patients with unexplained deterioration of renal failure. 相似文献
72.
Macrophage-derived transforming growth factor-beta1 induces hepatocellular injury via apoptosis in rat severe acute pancreatitis 总被引:9,自引:0,他引:9
BACKGROUND: The mechanism of acute pancreatitis-induced hepatocellular injury is unclear. We have observed hepatocyte apoptosis in rat acute necrotizing pancreatitis. These studies were designed to determine the mediator(s) responsible for hepatocyte apoptosis and to clarify the significance of macrophages as its source. METHODS: A rat sodium deoxycholate-induced pancreatitis model was used. Immunohistochemical studies for apoptosis-inducing mediators on hepatocytes were examined in the liver and on the peritoneal macrophages. The levels of transforming growth factor-beta1 (TGF-beta1) were also evaluated quantitatively with an enzyme-linked immunosorbent assay. Induction of apoptosis on the hepatocytes was evaluated by in situ nick-end labeling and tissue DNA fragmentation enzyme-linked immunosorbent assay. Finally, the effects of TGF-beta1 neutralization and macrophage depletion were examined. RESULTS: In the liver and the peritoneal macrophages, strong expression of TGF-beta1 was detected early in the course of pancreatitis. In sodium deoxycholate-induced pancreatitis, the levels of TGF-beta1 were also elevated in the plasma (9.2 +/- 0.8 ng/mL), in the pancreatitis-associated ascitic fluid (11.5 +/- 0.6 ng/mL), and in the liver homogenate (2.8 +/- 0.3 ng/g of liver tissue). Moreover, the amount of fragmented DNA of the liver with pancreatitis was 290% +/- 20% of that with a sham operation and serum alanine aminotransferase levels elevated to 248.2 +/- 67.0 IU/L. TGF-beta1 neutralization partly blocked the positive labeling on the nuclei of the hepatocytes, the elevation of the amounts of fragmented DNA (205% +/- 10% of sham operation), and the serum alanine aminotransferase level (144.2 +/- 14.9 IU/L). On the other hand, the macrophage depletion caused a marked decrease in the TGF-beta1 protein level in the plasma (4.8 +/- 1.2 ng/mL) or in the pancreatitis-associated ascitic fluid (8.0 +/- 1.0 ng/mL). Moreover, the macrophage depletion completely inhibited the elevation of the TGF-beta1 protein level in the liver homogenate (1.5 +/- 0.4 ng/g of liver tissue), and thereafter decreased the amounts of the positive labeling on the nuclei of the hepatocytes and decreased the amount of fragmented DNA (120% +/- 18% of sham operation) and the serum alanine aminotransferase elevation (119.2 +/- 24.2 IU/L). CONCLUSIONS: In a model of sodium deoxycholate-induced pancreatitis, macrophages are responsible for pancreatitis-induced hepatocellular injury by means of apoptosis, and macrophage-derived TGF-beta1 is one of the major factors inducing the hepatocyte apoptosis. 相似文献
73.
74.
75.
Kunio Yano Masahide Kobayashi Kazunari Iijima Kazunori Kawane Sumiko Hamanaka 《International journal of clinical oncology / Japan Society of Clinical Oncology》1997,2(1):55-57
The case of an 80-year-old man with plasma cell leukemia characterized by basophilic cytoplasm, and extensive lobulated nuclei
is described. In spite of the peculiar morphologic nuclei, the diagnosis was based on the presence of M protein and Bence
Jones protein in the serum and urine, immunophenotypic characteristics, immunoglobulin gene rearrangement, and findings of
transmission electron microscopy. 相似文献
76.
Kuroda S Itoh H Yamagami T Kizu O Murata H Kusuzaki K Yamano T Maeda T 《Skeletal radiology》2000,29(5):293-297
A 41-year-old man presented with an asymptomatic mass in the right medial thigh. Magnetic resonance imaging (MRI) revealed
a well-demarcated, 10-cm mass in the right adductor muscles. The margins of the mass exhibited high signal intensity and the
rest showed low or iso signal intensity on T1-weighted MR images. However, the high signal intensity was decreased on T2-weighted
images with fat suppression. The central part of the tumor was of inhomogeneous high signal intensity on T2-weighted images;
after Gd-DTPA injection it enhanced inhomogeneously on T1-weighted images with fat suppression. On dynamic computed tomography
(CT) in the arterial phase, there were strongly enhancing spotty areas in the tumor. At surgery, a yellow-whitish tumor was
resected and a pathological diagnosis of angiomyolipoma (AML) in the thigh was made.
Received: 21 June 1999 Revision requested: 28 July 1999 Revision received: 13 December 1999 Accepted: 15 December 1999 相似文献
77.
Ichiba T Takemoto N Nanba T Ishiguro S Ikebuchi M Kuroda H Ohgi S 《Kyobu geka. The Japanese journal of thoracic surgery》2000,53(2):110-112
A 78-year-old male who had a bronchial asthma underwent coronary artery bypass grafting (CABG) using the left internal thoracic artery and the radial artery. The patient could not be weaned from the cardiopulmonary bypass because the radial artery which anastomosed to the obtuse marginal artery (OM) had a spasm after CABG. An additional bypass using a long saphenous vein to OM was carried out immediately. It brought a weaning from cardiopulmonary bypass. If the cardiac function after CABG is insufficient in patients with bronchial asthma, CABG must be re-done immediately, considering that they cause the arterial spasm more than patients without bronchial asthma. 相似文献
78.
Kamata S Kitayama Y Usui N Kuroda S Nose K Sawai T Okada A 《Journal of pediatric surgery》2000,35(4):655-657
A case of patent ductus venosus (PDV) presenting intrapulmonary shunting is described. Although retrograde venography of ductus venosus showed few intrahepatic branches, banding of PDV resulted in increased intrahepatic portal branches and disappearance of symptoms 10 months after the operation. Banding of the ductus venosus may be effective in PDV even with hypoplastic intrahepatic portal system. 相似文献
79.
80.