全文获取类型
收费全文 | 9814篇 |
免费 | 431篇 |
国内免费 | 132篇 |
专业分类
耳鼻咽喉 | 76篇 |
儿科学 | 156篇 |
妇产科学 | 63篇 |
基础医学 | 1063篇 |
口腔科学 | 269篇 |
临床医学 | 611篇 |
内科学 | 2690篇 |
皮肤病学 | 144篇 |
神经病学 | 658篇 |
特种医学 | 407篇 |
外科学 | 2094篇 |
综合类 | 39篇 |
预防医学 | 206篇 |
眼科学 | 115篇 |
药学 | 544篇 |
中国医学 | 15篇 |
肿瘤学 | 1227篇 |
出版年
2024年 | 7篇 |
2023年 | 80篇 |
2022年 | 145篇 |
2021年 | 277篇 |
2020年 | 161篇 |
2019年 | 176篇 |
2018年 | 229篇 |
2017年 | 184篇 |
2016年 | 239篇 |
2015年 | 247篇 |
2014年 | 358篇 |
2013年 | 433篇 |
2012年 | 656篇 |
2011年 | 703篇 |
2010年 | 387篇 |
2009年 | 338篇 |
2008年 | 610篇 |
2007年 | 639篇 |
2006年 | 639篇 |
2005年 | 699篇 |
2004年 | 678篇 |
2003年 | 626篇 |
2002年 | 612篇 |
2001年 | 106篇 |
2000年 | 73篇 |
1999年 | 118篇 |
1998年 | 165篇 |
1997年 | 119篇 |
1996年 | 116篇 |
1995年 | 79篇 |
1994年 | 73篇 |
1993年 | 74篇 |
1992年 | 45篇 |
1991年 | 43篇 |
1990年 | 33篇 |
1989年 | 38篇 |
1988年 | 27篇 |
1987年 | 18篇 |
1986年 | 19篇 |
1985年 | 15篇 |
1984年 | 16篇 |
1983年 | 15篇 |
1982年 | 7篇 |
1981年 | 11篇 |
1980年 | 7篇 |
1979年 | 7篇 |
1978年 | 8篇 |
1977年 | 4篇 |
1975年 | 6篇 |
1973年 | 3篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
102.
BackgroundShoulder 36 (Sh-36) is an original quality of life measure for shoulder lesions with high reliability and validity; however, in some cases, especially in those with a Bankart lesion, we observed no improvement in Sh-36 during the postoperative follow-up. Sh-36 may be less effective for a certain shoulder lesion. This study aimed to compare the reliability, validity, and responsiveness of Sh-36 among different representative diagnoses of shoulder lesions.MethodsSh-36 and the Disability of the Arm, Shoulder and Hand (DASH) were measured in 192 patients with a Bankart lesion (Bankart group), rotator cuff tear (Cuff group), and SLAP lesion (SLAP group) who underwent arthroscopic surgery. Both measures were evaluated before surgery, and at 3, 6, 9, 12, 18, and 24 months postoperatively, and reliability, validity, and responsiveness of Sh-36 and the DASH were compared among the three groups.ResultsSignificant postoperative improvement was observed in the three groups (p < 0.0001) within 9 months. No marked improvement was observed after 9 months in the Bankart and SLAP groups due to the ceiling effect; however, most domains of Sh-36 increased continuously in the Cuff group during the whole follow-up period. Reliability and construct validity were sufficient in all the groups. The longitudinal validity was sufficient in most domains for the three groups; however, the standardized response mean in the Bankart group was lower than that in other two groups, indicating low responsiveness in this group because of the ceiling effect.ConclusionsSh-36 was a valid and reliable instrument in patients who have undergone arthroscopic shoulder surgery, especially for patient with a rotator cuff tear with high responsiveness. However, Sh-36 had lower standard response mean representing lower responsiveness in the Bankart group due to the ceiling effect and may not be ideal for longitudinal follow-up in patients with a Bankart lesion. 相似文献
103.
Wada Takehiko Ishimoto Takuji Nakaya Izaya Kawaguchi Takehiko Sofue Tadashi Shimizu Sayaka Kurita Noriaki Sasaki Sho Nishiwaki Hiroki Koizumi Masahiro Saito Shoji Nishibori Nobuhiro Oe Yuji Yoshida Mai Miyaoka Yoshitaka Akiyama Shin’ichi Itano Yuya Okazaki Masaki Ozeki Takaya Ichikawa Daisuke Oguchi Hideyo Kohsaka Satoshi Kosaka Shiho Kataoka Yuki Shima Hideaki Shirai Sayuri Sugiyama Kazuhiro Suzuki Tomo Son Daisuke Tanaka Tomomi Nango Eishu Niihata Kakuya Nishijima Yoko Nozu Kandai Hasegawa Midori Miyata Rei Yazawa Masahiko Yamamoto Yoshihiro Yamamoto Ryohei Shibagaki Yugo Furuichi Kengo Okada Hirokazu Narita Ichiei 《Clinical and experimental nephrology》2021,25(12):1277-1285
Clinical and Experimental Nephrology - 相似文献
104.
105.
106.
Estrogen receptors and their downstream targets in cancer 总被引:6,自引:0,他引:6
107.
Shimpei Ariki Sotaro Ozaka Nozomi Sachi Thanyakorn Chalalai Yasuhiro Soga Chiaki Fukuda Yomei Kagoshima Supanuch Ekronarongchai Kazuhiro Mizukami Naganori Kamiyama Kazunari Murakami Takashi Kobayashi 《Genes to cells : devoted to molecular & cellular mechanisms》2023,28(4):267-276
Although excessive immune responses by Th17 cells, a helper T cell subset, are implicated in the pathogenesis of inflammatory bowel disease (IBD), the mechanism by which its localization in an inflamed colon is regulated remains unclear. Chemokines and their receptors are involved in the pathogenesis of IBD, however, the relative significance of each receptor on Th17 cells remains unknown. We generated C–C motif chemokine receptor 2 (CCR2) knockout (KO) and CCR6 KO mice in the syngeneic background using the CRISPR/Cas9 system and found that the phenotypes of experimental colitis worsened in both mutant mice. Surprisingly, the phenotype of colitis in CCR2/CCR6-double knockout (CCR2/6 DKO) mice was opposite to that of the single-deficient mice, with significantly milder experimental colitis (p < .05). The same was true for the symptoms in CCR6 KO mice, but not in wild type mice treated with a CCR2 inhibitor, propagermanium. Colonic CCR2+CCR6+ Th17 cells produced a potentially pathogenic cytokine GM-CSF whose levels in the gut were significantly reduced in CCR2/6 DKO mice (p < .05). These results suggest that GM-CSF-producing CCR2+CCR6+ Th17 cells are pathogenic and are attracted to the inflamed colon by either CCR2 or CCR6 gradient, which subsequently exacerbates experimental colitis in mice. 相似文献
108.
109.
Shuto T Hirohashi K Ikebe T Mikami S Yamamoto T Kubo S Wakasa K Kinoshita H 《World journal of surgery》2000,24(12):1566-1569
The presence of small additional hepatocellular carcinomas (HCCs) undetectable before hepatic resection is a crucial topic
for hepatic surgeons. We assessed the incidence of pathologically diagnosed multiple HCCs in 267 patients who underwent hepatic
resection for HCC. Ninety-five additional HCC nodules were detected in 72 of the patients (27%). The survival rate of these
72 patients was significant worse than for the 195 with single nodular HCC (p= 0.0013). Twenty-one (22%) were detected before surgery, 29 (31%) during surgery, and 45 (47%) on pathologic examination
after surgery. The mean nodule diameters for each group were 2.1, 1.0, and 0.9 cm, respectively (p < 0.0001). None of the 21 nodules detected before surgery was well differentiated, whereas 30 of the 74 nodules in the other
two groups were well-differentiated. Although the mean nodule diameter of the well-differentiated HCC group was the smallest,
there was no significant difference among the three groups assigned according to tumor differentiation (p= 0.2355). Altogether, 9 of 16 patients with additional nodules detected before surgery (56%) and 49 of 59 with additional
nodules detected during or after surgery (88%) had cirrhosis of the liver. The odds ratio for detecting a new HCC nodule during
or after surgery in the presence of cirrhosis was 5.444 (p= 0.0087). Improvement in the detection of small additional HCC nodules before and during surgery and meticulous follow-up
after surgery are necessary for patients with cirrhosis. For patients without cirrhosis, surgical treatment may be performed
according to the results of preoperative imaging studies. 相似文献
110.
Kouichirou Nishiyama Hajime Hirose Yoshiaki Iguchi Kazuhiro Yamamoto Takashi Masaki Takahiro Kamijo Takeshi Ino Jun Yamanaka Kazuo Yao Makito Okamoto 《Nihon Jibiinkoka Gakkai kaiho》2003,106(3):220-225
To improve low-pitched voices in cases with polypoid vocal cords, YAG laser irradiation combined with a mucosal suturing technique was attempted in 9 female cases with severe polypoid changes in their vocal cords. A YAG laser beam (5 to 10 W) was used to irradiate the upper surface of the polypoid vocal cord. The polypoid content of the cord was gradually coagulated, and the free edge of the cord appeared to slide up toward the burned area. The polypoid content was then removed and squeezed through an open wound made in the burned area using a conventional method. Bleeding was successfully controlled using the laser. After the excessive mucosal margin was trimmed and the contour of the vocal cord was adjusted, the wound was closed by 7-0 monofilament absorbable suture. Suturing was relatively easy because the mucosal edge was also coagulated. Postoperative evaluations of voice quality revealed an improvement in the GRBAS scale of voice quality as well as an elevation in voice pitch and an upwards shift in the voice range in all cases. 相似文献