全文获取类型
收费全文 | 7581篇 |
免费 | 408篇 |
国内免费 | 80篇 |
专业分类
耳鼻咽喉 | 62篇 |
儿科学 | 134篇 |
妇产科学 | 93篇 |
基础医学 | 961篇 |
口腔科学 | 157篇 |
临床医学 | 454篇 |
内科学 | 2227篇 |
皮肤病学 | 140篇 |
神经病学 | 542篇 |
特种医学 | 200篇 |
外科学 | 1021篇 |
综合类 | 53篇 |
预防医学 | 280篇 |
眼科学 | 139篇 |
药学 | 540篇 |
中国医学 | 11篇 |
肿瘤学 | 1055篇 |
出版年
2023年 | 30篇 |
2022年 | 73篇 |
2021年 | 172篇 |
2020年 | 110篇 |
2019年 | 138篇 |
2018年 | 211篇 |
2017年 | 166篇 |
2016年 | 171篇 |
2015年 | 198篇 |
2014年 | 265篇 |
2013年 | 331篇 |
2012年 | 525篇 |
2011年 | 594篇 |
2010年 | 318篇 |
2009年 | 249篇 |
2008年 | 474篇 |
2007年 | 536篇 |
2006年 | 500篇 |
2005年 | 456篇 |
2004年 | 484篇 |
2003年 | 464篇 |
2002年 | 505篇 |
2001年 | 75篇 |
2000年 | 53篇 |
1999年 | 89篇 |
1998年 | 106篇 |
1997年 | 79篇 |
1996年 | 88篇 |
1995年 | 86篇 |
1994年 | 67篇 |
1993年 | 64篇 |
1992年 | 53篇 |
1991年 | 34篇 |
1990年 | 30篇 |
1989年 | 36篇 |
1988年 | 29篇 |
1987年 | 28篇 |
1986年 | 20篇 |
1985年 | 19篇 |
1984年 | 20篇 |
1983年 | 14篇 |
1982年 | 13篇 |
1981年 | 15篇 |
1980年 | 17篇 |
1979年 | 10篇 |
1978年 | 9篇 |
1977年 | 5篇 |
1976年 | 9篇 |
1975年 | 7篇 |
1965年 | 4篇 |
排序方式: 共有8069条查询结果,搜索用时 234 毫秒
111.
112.
Kazumichi Kawakubo Hiroyuki Isayama Yousuke Nakai Naoki Sasahira Hirofumi Kogure Takashi Sasaki Kenji Hirano Minoru Tada Kazuhiko Koike 《Gut and liver》2012,6(3):399-402
Patients with pancreatic cancer frequently suffer from both biliary and duodenal obstruction. For such patients, both biliary and duodenal self-expandable metal stent placement is necessary to palliate their symptoms, but it was difficult to cross two metal stents. Recently, endoscopic ultrasonography-guided choledochoduodenostomy (EUS-CDS) was reported to be effective for patients with an inaccessible papilla. We report two cases of pancreatic cancer with both biliary and duodenal obstructions treated successfully with simultaneous duodenal metal stent placement and EUS-CDS. The first case was a 74-year-old man with pancreatic cancer. Duodenoscopy revealed that papilla had been invaded with tumor and duodenography showed severe stenosis in the horizontal portion. After a duodenal uncovered metal stent was placed across the duodenal stricture, EUS-CDS was performed. The second case was a 63-year-old man who previously had a covered metal stent placed for malignant biliary obstruction. After removing the previously placed metal stent, EUS-CDS was performed. Then, a duodenal covered metal stent was placed across the duodenal stenosis. Both patients could tolerate a regular diet and did not suffer from stent occlusion. EUS-CDS combined with duodenal metal stent placement may be an ideal treatment strategy in patients with pancreatic cancer with both duodenal and biliary malignant obstruction. 相似文献
113.
Motoyasu Kobayashi Kazuhiko Ishihara 《Journal of biomaterials science. Polymer edition》2014,25(14-15):1673-1686
The swollen brush structures of polycation and zwitterionic polymer brushes, such as poly(2-methacryloyloxyethyltrimethylammonium chloride) (PMTAC), poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), and poly[3-(N-2-methacryloyloxyethyl-N,N-dimethyl)ammonatopropanesulfonate] (PMAPS), in aqueous solutions of various ionic strengths were characterized by neutron reflectivity (NR) measurements. A series of the polyelectrolyte brushes were prepared by surface-initiated controlled radical polymerization on silicon substrates. A high-graft-density PMTAC brush in salt-free water (D2O) adopted a two-region step-like structure consisting of a shrunk region near the Si substrate surface and a diffuse brush region with a relatively stretched chain structure at the solution interface. The diffuse region of PMTAC was reduced with increase in salt (NaCl) concentration. The PMAPS brush in D2O formed a collapsed structure due to the strong molecular interaction between betaine groups, while significant increase in the swollen thickness was observed in salt aqueous solution. In contrast, no change was observed in the depth profile of the swollen PMPC brush in D2O with various salt concentrations. The unique solution behaviors of zwitterionic polymer brushes were described. 相似文献
114.
115.
Aki Masuzawa Chikako Kiyotani Tomoo Osumi Yoko Shioda Kazutoshi Iijima Osamu Tomita Kazuhiko Nakabayashi Keisuke Oboki Kazuki Yasuda Hiromi Sakamoto Hitoshi Ichikawa Kenichiro Hata Teruhiko Yoshida Kenji Matsumoto Nobutaka Kiyokawa Tetsuya Mori 《European journal of haematology》2014,92(3):263-267
In addition to BCR, various rare fusion partners for the ABL1 gene have been reported in leukemia. We have identified the fusion gene SNX2‐ABL1 in a pediatric case of acute lymphoblastic leukemia (ALL), which has only once previously been reported in an adult patient. Cytogenetic analysis detected this fusion gene arising from a t(5;9)(q22;q34) translocation. ALL cells carrying a SNX2‐ABL1 fusion exhibited a BCR‐ABL1+ ALL‐like gene expression profile. The patient poorly responded to dasatinib but partially responded to imatinib. Treatment using tyrosine kinase inhibitors requires further investigation to optimize the genotype‐based treatment stratification for patients with SNX2‐ABL1 fusion. 相似文献
116.
117.
Impact of the Charlson comorbidity index and prognostic nutritional index on prognosis in patients with early gastric cancer after endoscopic submucosal dissection
下载免费PDF全文
![点击此处可从《Digestive endoscopy》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Naoto Iwai Osamu Dohi Yuji Naito Yutaka Inada Akifumi Fukui Shun Takayama Kazuyuki Ogita Kei Terasaki Takahiro Nakano Tomohiro Ueda Tetsuya Okayama Naohisa Yoshida Kazuhiro Katada Kazuhiro Kamada Kazuhiko Uchiyama Takeshi Ishikawa Osamu Handa Tomohisa Takagi Hideyuki Konishi Nobuaki Yagi Yoshito Itoh 《Digestive endoscopy》2018,30(5):616-623
118.
119.
120.
Kayoko Nagayama Kazuhiko Nakano Yuka Yamaguchi Kazuyo Fujita Yukiko Takashima Atsuko Takada Takashi Ooshima 《Pediatric Dental Journal》2012,22(1):78-83
We used the Isolite system for treatment of dental caries identified in a submerged mandibular right primary second molar. A 5-year-6-month-old girl was referred to our clinic for close examination of an impacted mandibular right second primary molar. An intraoral examination showed a slight pit extending inside the gingiva and on the occlusal surface of the tooth. X-ray photographic examination revealed that the affected tooth was severely submerged and had a radiolucent area on the occlusal surface, which extended close to the pulp cavity. Most of the periodontal ligament space could not be clearly identified except for the distal side of the distal root. We considered that the area of the tooth was partially ankylosed and consulted with oral surgeons, who decided to postpone extraction, due to the presence of the permanent successor close to the affected tooth. Thus, we treated the dental caries, which appeared to be technically difficult because of the deep location of the tooth. The Isolite system was utilized in this case, as we considered that adjacent soft tissue and saliva could be excluded with its use. Under infiltration anesthesia, gingival tissue covering the occlusal surface was removed with an electric knife, and the carious lesion was removed, which resulted in pulp exposure. Severe inflammation of the pulp was revealed and pulpectomy was performed. There were no signs and symptoms after the treatment. At 1 year after treatment, the occlusal surface remained exposed and no inflammatory findings were observed in adjacent gingival tissue. 相似文献