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991.
Devastating massive knee defect reconstruction using the cornucopian chimera flap from the subscapular axis: two case reports 总被引:1,自引:0,他引:1
Sano K Hallock GG Ozeki S Suzuki H Mawatari R Yoshino K Hamazaki M 《Journal of reconstructive microsurgery》2006,22(1):25-32
Two cases of successful reconstruction of massive defects around the knee with multiple-island combined flaps based on the subscapular axis are reported. Both defects resulted from aggressive debridement for acute osteomyelitis after open fixation of high-energy fractures around the knee. In Case 1, a four-island combined flap consisting of the scapular flap, the lattissimus dorsi muscle flap, the serratus anterior muscle flap, and the scapular osseous flap, based on the same subscapular axis, was used. Partial bone transport using the Ilizarov apparatus was added as reinforcement of arthrodesis. In Case 2, a five-island combined flap, consisting of the scapular, parascapular flap, the lattissimus dorsi muscle flap, the serratus anterior fascial flap, and the scapular osseous flap, was used. Consequent ankylosis of the knee joint afforded the patient painless full weight bearing without secondary arthrodesis. Multiple-island combined flaps based on the subscapular axis can provide three-dimensional reconstruction of destructive knee defects. 相似文献
992.
Nakashima A Ogata S Doi S Yamahira M Naraki S Takasugi N Ohmoto T Ito T Masaki T Yorioka N 《Clinical and experimental nephrology》2006,10(3):210-215
Background It is important to observe the flow pattern of dialysate when evaluating dialyzer function and developing the most appropriate
design. We investigated dialysate flow through two polysulfone membrane dialyzers (TS-UL [Toray Medical] and APS-S [Asahi
Medical]) by computed tomography (CT), with barium sulfate as the contrast medium. We also performed a clinical comparison
of these two dialyzers.
Methods For the in vitro experiment, after confirming the steady-state flow of mock blood (xanthan gum solution; 200 ml/min) and dialysate
(500 ml/min), fresh dialysate, containing 5% (w/v) barium sulfate was perfused, and longitudinal CT scans of the dialyzer
were obtained. Then the concentration of barium sulfate was measured (in Hounsfield units) in three fixed regions of interest.
For the in vivo experiment, 12 patients on stable hemodialysis who had been using the APS-S for more than 1 month were switched
to the TS-UL for 1 month and changes in various parameters were assessed.
Results The distribution of dialysate was homogeneous on CT scans of the TS-UL, but not on scans of the APS-S. The dialysate concentration
curves for the three regions of interest were similar with the TS-UL, but not with the APS-S. Clearance of urea nitrogen and
albumin loss were both significantly higher with the TS-UL than with the APS-S. The decrease in alpha 1-microglobulin was
larger with the TS-UL than with the APS-S, but not significantly.
Conclusions Clearance of substances over a wide range of molecular weights was higher with the TS-UL than with the APS-S, and differences
in the design of the dialysate compartment may have been involved in this feature. 相似文献
993.
Imaizumi M Usa T Tominaga T Neriishi K Akahoshi M Nakashima E Ashizawa K Hida A Soda M Fujiwara S Yamada M Ejima E Yokoyama N Okubo M Sugino K Suzuki G Maeda R Nagataki S Eguchi K 《JAMA》2006,295(9):1011-1022
Context Effects of irradiation on thyroid diseases such as thyroid nodules and autoimmune thyroid diseases have not been evaluated among people exposed to radiation more than 50 years in the past. Objective To evaluate the prevalence of thyroid diseases and their radiation-dose responses in atomic bomb survivors. Design, Setting, and Participants Survey study comprising 4091 cohort members (mean age, 70 [SD, 9] years; 1352 men and 2739 women) who participated in the thyroid study at the Radiation Effects Research Foundation. Thyroid examinations were conducted between March 2000 and February 2003. Main Outcome Measures Prevalence of thyroid diseases, including thyroid nodules (malignant and benign) and autoimmune thyroid diseases, and the dose-response relationship of atomic bomb radiation in each thyroid disease. Results Thyroid diseases were identified in 1833 (44.8%) of the total participants (436 men [32.2% of men] and 1397 women [51.0% of women]) (P<.001). In 3185 participants, excluding persons exposed in utero, not in the city at the time of the atomic bombings, or with unknown radiation dose, the prevalence of all solid nodules, malignant tumors, benign nodules, and cysts was 14.6%, 2.2%, 4.9%, and 7.7%, respectively. The prevalence of positive thyroid antibodies, antithyroid antibodypositive hypothyroidism, and Graves disease was 28.2%, 3.2%, and 1.2%, respectively. A significant linear dose-response relationship was observed for the prevalence of all solid nodules, malignant tumors, benign nodules, and cysts (P<.001). We estimate that about 28% of all solid nodules, 37% of malignant tumors, 31% of benign nodules, and 25% of cysts are associated with radiation exposure at a mean and median thyroid radiation dose of 0.449 Sv and 0.087 Sv, respectively. No significant dose-response relationship was observed for positive antithyroid antibodies (P = .20), antithyroid antibodypositive hypothyroidism (P = .92), or Graves disease (P = .10). Conclusions A significant linear radiation dose response for thyroid nodules, including malignant tumors and benign nodules, exists in atomic bomb survivors. However, there is no significant dose response for autoimmune thyroid diseases. 相似文献
994.
Tatsumi Y Nakashima M Kitao T Kan K Tomita T Hashimoto Y Ema Y Kitagawa T Oguri K Yokota S 《Masui. The Japanese journal of anesthesiology》2006,55(10):1228-1230
This report describes a patient with mitochondrial encephalomyopathy who underwent tracheostomy under total intravenous anesthesia. This 15-year-old girl had been suffering from aspiration pneumonia repeatedly. Anesthesia was induced with propofol (30 mg) and fentanyl (50 microg), and the trachea was intubated without a muscle relaxant. The patient was mechanically ventilated also without a relaxant, and anesthesia was maintained with a continuous infusion of propofol 4-10 mg x kg(-1) x hr(-1) and a bolus injection of fentanyl 25 microg. Bispectral index (BIS) was monitored and maintained at 15-65. The patient showed smooth recovery from anesthesia, and the BIS value returned to the pre-anesthetic level 15 minutes after completion of the anesthesia. Her postoperative course was uneventful. We conclude that total intravenous anesthesia by propofol and fentanyl is a preferable method for the management of the patient with mitochondrial encephalomyopathy. 相似文献
995.
Effects of basic fibroblast growth factor on experimental diabetic neuropathy in rats 总被引:4,自引:0,他引:4
Nakae M Kamiya H Naruse K Horio N Ito Y Mizubayashi R Hamada Y Nakashima E Akiyama N Kobayashi Y Watarai A Kimura N Horiguchi M Tabata Y Oiso Y Nakamura J 《Diabetes》2006,55(5):1470-1477
Basic fibroblast growth factor (bFGF) stimulates angiogenesis and induces neural cell regeneration. We investigated the effects of bFGF on diabetic neuropathy in streptozotocin-induced diabetic rats. Diabetic rats were treated with human recombinant bFGF as follows: 1) intravenous administration, 2) intramuscular injection into thigh and soleus muscles with cross-linked gelatin hydrogel (CGH), and 3) intramuscular injection with saline. Ten or 30 days later, the motor nerve conduction velocity (MNCV) of the sciatic-tibial and caudal nerves, sensitivity to mechanical stimuli, sciatic nerve blood flow (SNBF), and retinal blood flow (RBF) were measured. Delayed MNCV in the sciatic-tibial and caudal nerves, hypoalgesia, and reduced SNBF in diabetic rats were all ameliorated by intravenous administration of bFGF after 10, but not 30, days. Intramuscular injection of bFGF with CGH also improved sciatic-tibial MNCV, hypoalgesia, and SNBF after 10 and 30 days, but caudal MNCV was not improved. However, intramuscular injection of bFGF with saline had no significant effects. bFGF did not significantly alter RBF in either normal or diabetic rats. These observations suggest that bFGF could have therapeutic value for diabetic neuropathy and that CGH could play important roles as a carrier of bFGF. 相似文献
996.
997.
Two cases of minute hepatocellular carcinoma (HCC) found in a liver infested with Clonorchis sinensis are described. One had mild infestation with hepatic changes suggestive of posthepatitic cirrhosis, and the other heavy infestation exhibiting secondary biliary cirrhosis with dilated intrahepatic bile ducts and periductal fibrosis. None had evidence of hepatitis B infection. The tumor nodule was solitary, measuring 5 X 7 mm and 10 X 11 mm, respectively, and the cells were differentiated to be classified as Grade I of Edmondson-Steiner's scale of anaplasia. It is not clear whether or not clonorchiasis was etiologically related to HCC, but it was of interest that in both cases the tumor nodule was very small representing the primary lesion without metastasis. 相似文献
998.
A Tsuji T Terasaki I Tamai E Nakashima K Takanosu 《The Journal of pharmacy and pharmacology》1985,37(1):55-57
The transport mechanism of benzylpenicillin was studied in freshly prepared rat hepatocytes. The initial uptake rate followed both saturable and unsaturable transport processes. The Arrhenius plot of the initial uptake rate gave an activation energy of 16.8 kcal mol-1 (69 kJ mol-1). The benzylpenicillin uptake by hepatocytes was significantly inhibited by antimycin A, sodium cyanide, rotenone, 2,4-dinitrophenol, phenoxymethylpenicillin, probenecid and taurocholic acid. No significant inhibition was observed by acetylaminohippuric acid and several kinds of amino acids and dipeptides. The present study provides the first evidence for the existence of a carrier-mediated and energy-dependent transport system of benzylpenicillin in the liver. 相似文献
999.
1000.
Kazufumi Akiyama M.D Takuo Nagao M.D Mitsutoshi Yamamoto M.D Akira Fujimoto M.D Takashi Ebara M.D Mitsumoto Sato M.D. Saburo Otsuki M.D. 《Psychiatry and clinical neurosciences》1983,37(2):129-136
Abstract: Cerebrospinal fluid (CSF) HVA, MHPG, 5-HIAA, cAMP and cGMP concentrations were measured in schizophrenic patients with tardive dyskinesia before and after a three-week administration of oxypertine (n = 4), hydroxyzine pamoate (n = 4) or placebo (n = 4). The oxypertine administration resulted in a reduction of the CSF HVA concentration and an elevation of the MHPG and cAMP concentrations, associated with a clinical improvement in tardive dyskinesia. The hydroxyzine administration reduced the CSF 5-HIAA concentration in all the patients and the CSF HVA concentration in two of four patients with a clinical improvement. A reduction in the CSF HVA concentration associated with possible therapeutic effects of oxypertine or hydroxyzine may suggest the normalization of a hyperdopaminergic state. Discussions were held that functional disorders of not only the dopaminergic system but the norepinephrinergic and serotoninergic systems may relate to the pathogenesis of tardive dyskinesia. 相似文献