全文获取类型
收费全文 | 13020篇 |
免费 | 529篇 |
国内免费 | 67篇 |
专业分类
耳鼻咽喉 | 86篇 |
儿科学 | 188篇 |
妇产科学 | 167篇 |
基础医学 | 1514篇 |
口腔科学 | 465篇 |
临床医学 | 763篇 |
内科学 | 3027篇 |
皮肤病学 | 278篇 |
神经病学 | 837篇 |
特种医学 | 690篇 |
外科学 | 2372篇 |
综合类 | 50篇 |
预防医学 | 506篇 |
眼科学 | 170篇 |
药学 | 899篇 |
中国医学 | 18篇 |
肿瘤学 | 1586篇 |
出版年
2023年 | 73篇 |
2022年 | 124篇 |
2021年 | 219篇 |
2020年 | 113篇 |
2019年 | 158篇 |
2018年 | 231篇 |
2017年 | 187篇 |
2016年 | 228篇 |
2015年 | 196篇 |
2014年 | 315篇 |
2013年 | 383篇 |
2012年 | 586篇 |
2011年 | 654篇 |
2010年 | 377篇 |
2009年 | 332篇 |
2008年 | 568篇 |
2007年 | 598篇 |
2006年 | 619篇 |
2005年 | 618篇 |
2004年 | 613篇 |
2003年 | 540篇 |
2002年 | 561篇 |
2001年 | 444篇 |
2000年 | 500篇 |
1999年 | 468篇 |
1998年 | 182篇 |
1997年 | 145篇 |
1996年 | 117篇 |
1995年 | 103篇 |
1994年 | 103篇 |
1993年 | 80篇 |
1992年 | 242篇 |
1991年 | 243篇 |
1990年 | 251篇 |
1989年 | 253篇 |
1988年 | 212篇 |
1987年 | 237篇 |
1986年 | 231篇 |
1985年 | 215篇 |
1984年 | 154篇 |
1983年 | 107篇 |
1979年 | 112篇 |
1978年 | 87篇 |
1977年 | 82篇 |
1975年 | 56篇 |
1974年 | 62篇 |
1973年 | 67篇 |
1972年 | 57篇 |
1969年 | 63篇 |
1968年 | 53篇 |
排序方式: 共有10000条查询结果,搜索用时 9 毫秒
31.
Y Hotta T Shiono M Hayakawa T Hashimoto A Kanai A Nakajima M Noro T Sakuma M Tamai K Fujiki 《Nippon Ganka Gakkai zasshi》1992,96(2):237-242
The author analyzed codon 347 of the rhodopsin gene using PCR (polymerase chain reaction) amplification and restriction enzymes in 19 unrelated Japanese families including 28 patients with autosomal dominant retinitis pigmentosa (ADRP). An allele of codon 347 mutation was found in a family (father and daughter). Sequence analysis shows that the mutation is from CCG to CTG. This mutation appears to be the cause of one form of ADRP, since it was also found in Japanese cases of ADRP which have a different racial background from families reported by Dryja et al. 相似文献
32.
Masahiko Kawaguchi Masakazu Kuro Hisatoshi Ohsumi Toshito Nakajima Yoshihiro Kuriyama Jun Karasawa 《Journal of anesthesia》1994,8(1):60-63
We assessed the local cerebral blood flow (LCBF) in 40 patients under fentanyl-diazepam anesthesia. The measurement of LCBF
was made using 50%–70% stable xenon with 20 min of inhalation interval and a shuttle method for computed tomography imaging.
All patients were anesthetized with 5.95±1.76 μg·kg−1 fentanyl and 0.22±0.07 mg·kg−1 diazepam under mechanical ventilation during CBF measurement. The values and distribution of LCBF on non-affected hemisphere
appeared to be unaltered by fentanyldiazepam anesthesia. We also assessed the cerebral carbon dioxide reactivity in 6 patients.
The cerebral carbon dioxide reactivity, expressed as percentage change in LCBF per unit change in arterial carbon dioxide
partial pressure, was 5.39±1.07, and there were no significant differences of reactivity among regions studied. In conclusion,
we showed reference values of LCBF and carbon dioxide reactivity, measured by stable xenon-enhanced computed tomography, in
patients under fentanyl-diazepam anesthesia. Carbon dioxide reactivity was preserved in all regions including gray matter,
white matter, and basal ganglia. 相似文献
33.
Yu Kojima Hisao Fujii Renta Katsui Yoshiyuki Nakajima Miyako Takaki 《Journal of Smooth Muscle Research》2006,42(5):139-147
The defecation reflex is composed of rectal distension-evoked rectal (R-R) reflex contractions and synchronous internal anal sphincter (R-IAS) reflex relaxations in guinea pigs. These R-R and R-IAS reflexes are controlled via extrinsic sacral excitatory nerve pathway (pelvic nerves), lumbar inhibitory nerve pathways (colonic nerves) and by intrinsic cholinergic excitatory and nitrergic inhibitory nerve pathways. The effect of mosapride (a prokinetic benzamide) on the intrinsic reflexes, mediated via enteric 5-HT(4) receptors, was evaluated by measuring the mechanical activity of the rectum and IAS in anesthetized guinea pigs using an intrinsic R-R and R-IAS reflex model resulting from chronic (two to nine days) lumbosacral denervation (PITH). In this model, the myenteric plexus remains undamaged and the distribution of myenteric and intramuscular interstitial cells of Cajal is unchanged. Although R-R and R-IAS reflex patterns markedly changed, the reflex indices (reflex pressure or force curve-time integral) of both the R-R contractions and the synchronous R-IAS relaxations were unchanged. The frequency of the spontaneous R and IAS motility was also unchanged. Mosapride (0.1-1.0 mg/kg) dose-dependently increased both intrinsic R-R (maximum: 1.82) and R-IAS reflex indices (maximum: 2.76) from that of the control (1.0) 6-9 days following chronic PITH. The dose-response curve was similar to that in the intact guinea pig, and had shifted to the left from that in the guinea pig after acute PITH. A specific 5-HT(4) receptor antagonist, GR 113808 (1.0 mg/kg), decreased both reflex indices by approximately 50% and antagonized the effect of mosapride 1.0 mg/kg. This was quite different from the result in the intact guinea pig where GR 113808 (1.0 mg/kg) did not affect either of the reflex indices. The present results indicate that mosapride enhanced the intrinsic R-R and R-IAS reflexes and functionally compensated for the deprivation of extrinsic innervation. The actions of mosapride were mediated through endogenously active, intrinsic 5-HT(4) receptors which may be post-synaptically located in the myenteric plexus of the anorectum. 相似文献
34.
Yoichi Kikuchi Taku Sakurada Masato Suzuki Tomoyasu Hirano Katsuyuki Kusajima 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2004,52(8):375-378
Off-pump coronary artery bypass grafting has become an attractive surgical alternative for myocar-dial revascularization because
of the advantage of myocardial protection and other benefits of patients. However, it is still regarded as a controversial
treatment for the coronary artery disease accompanied by atrial fibrillation (AF). A significant number of patients in need
of coronary revascularization have chronic AF. Although the Cox-Maze III procedure is the gold standard for the surgical treatment
of AF, few of these patients undergo AF operations at the time of their coronary bypass grafting. We report herein a case
of the pulmonary vein isolation to eliminate the AF by means of epicardial radiofrequency ablation combined with 2 vessels
coronary artery bypass grafting on the beating heart with the aid of cardiopulmonary bypass. 相似文献
35.
Masato Nakajima Koji Tsuchiya Yoshihiro Honda Hiroshi Koshiyama Tatsuho Kobayashi 《General thoracic and cardiovascular surgery》2009,57(12):654-656
Although the causes of stroke are diverse, thromboembolism due to a mobile aortic thrombus is rare. We describe a surgical
case of acute massive pulmonary embolism after critical cerebral infarction associated with a mobile ascending aortic thrombus
in a 52-year-old woman. Concomitant surgical removal of the aortic thrombus and pulmonary embolectomy was performed successfully,
and the patient has been stable without recurrent thromboembolic complications after 18 months of follow-up. 相似文献
36.
A prototype electronic radial scan ultrasound endoscope has been developed by Olympus (Tokyo, Japan) for endoscopic ultrasound (EUS) study. The ultrasound view‐angle of this model is 360° vertical to the scope. Though the diameter of the scanner and the shaft of the scope is bigger than those of the present mechanical radial scan model, clinical manipulation of the new scope is the same as that of the present model. Image quality of the ultrasound picture demonstrated by the electronic radial model was as clear as those provided by the mechanical radial scan model. Ultrasound penetration was better and satisfactory because of less echoic reduction compared to the mechanical radial model. The newly developed electronic radial model can be evaluated as an ultrasound endoscope for the next generation. The advantage of this system is to facilitate the clinical use of color Doppler function and tissue harmonic imaging, and this system can be operated by the same monitor unit as a convex model of ultrasound endoscope. 相似文献
37.
A case of small cell carcinoma of the prostate without a primary lesion in the lung was reported. The cancer was diagnosed after the patient complained of lumbago caused by bone metastasis. The tumor was 5.9 times 5.0 times 4.6cm. The patient was treated with 4 courses of chemotherapy using cisplatin and etoposide. The tumor diminished to 4.0 times 4.0 times 3.5 cm after completion of the 4 courses of treatment. Prostatic antigen levels were less than 1.0ng/mL during the therapy. Neuron-specific enolase levels were 35.9ng/mL at the beginning of therapy, and decreased to 7.4 ng/mL after completion of 4 courses of treatment. The patient died 3 months after the completion of treatment. This regimen had some value for inhibiting the growth of small cell carcinoma. 相似文献
38.
Type A aortic dissection: evaluation with ultrafast CT 总被引:3,自引:0,他引:3
39.
40.
Y Hayashi O Uchida O Takaki Y Ohnishi T Nakajima H Kataoka M Kuro 《Anesthesia and analgesia》1992,74(5):688-693
Central venous catheterization for pressure monitoring and drug administration is often important in the anesthetic management of infants undergoing cardiovascular surgery. We examined the effects of patient age, weight, and central venous pressure and the experience of the anesthesiologist on the rate of successful catheterization and catheterization time of the internal jugular vein (IJV) in a prospective study. We studied 106 infants undergoing IJV catheterization for cardiovascular surgery over a 7-mo period at our institution. We catheterized the IJV by the high approach. The direct venipuncture or the Seldinger method was used according to the patient's weight. Overall successful catheterization rate was 97.2%, and the average catheterization time was 353 +/- 21 s (mean +/- SEM). Complications included arterial puncture in 12 cases (11.3%), hematoma formation in four cases (3.8%), and catheter malposition in two cases (1.9%), but pneumothorax was not observed. When a patient was younger than 3 mo or weighed less than 4.0 kg, successful catheterization rate decreased significantly to 81.3% and 78.6%, respectively. Catheterization time was inversely correlated with both age and weight, whereas central venous pressure did not affect either successful catheterization rate or catheterization time. We were unable to demonstrate that the experience of the anesthesiologist plays a significant role in the success or complication of the catheterization procedure. Our results indicate that IJV catheterization by the high approach is a reliable and useful technique in infants, and that the weight and age of the patient significantly influence the rate of successful catheterization. 相似文献