全文获取类型
收费全文 | 2984篇 |
免费 | 191篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 16篇 |
儿科学 | 70篇 |
妇产科学 | 65篇 |
基础医学 | 496篇 |
口腔科学 | 51篇 |
临床医学 | 275篇 |
内科学 | 559篇 |
皮肤病学 | 46篇 |
神经病学 | 359篇 |
特种医学 | 103篇 |
外科学 | 366篇 |
综合类 | 10篇 |
预防医学 | 231篇 |
眼科学 | 40篇 |
药学 | 206篇 |
中国医学 | 6篇 |
肿瘤学 | 281篇 |
出版年
2023年 | 27篇 |
2022年 | 53篇 |
2021年 | 70篇 |
2020年 | 36篇 |
2019年 | 86篇 |
2018年 | 90篇 |
2017年 | 51篇 |
2016年 | 60篇 |
2015年 | 107篇 |
2014年 | 113篇 |
2013年 | 165篇 |
2012年 | 211篇 |
2011年 | 234篇 |
2010年 | 128篇 |
2009年 | 138篇 |
2008年 | 190篇 |
2007年 | 195篇 |
2006年 | 174篇 |
2005年 | 181篇 |
2004年 | 149篇 |
2003年 | 123篇 |
2002年 | 91篇 |
2001年 | 21篇 |
2000年 | 19篇 |
1999年 | 33篇 |
1998年 | 23篇 |
1997年 | 14篇 |
1996年 | 11篇 |
1995年 | 14篇 |
1994年 | 10篇 |
1992年 | 31篇 |
1991年 | 25篇 |
1990年 | 32篇 |
1989年 | 23篇 |
1988年 | 18篇 |
1987年 | 20篇 |
1986年 | 14篇 |
1985年 | 15篇 |
1984年 | 10篇 |
1983年 | 11篇 |
1982年 | 8篇 |
1981年 | 8篇 |
1979年 | 12篇 |
1978年 | 7篇 |
1976年 | 8篇 |
1974年 | 12篇 |
1973年 | 13篇 |
1972年 | 8篇 |
1968年 | 9篇 |
1967年 | 7篇 |
排序方式: 共有3180条查询结果,搜索用时 15 毫秒
41.
Katia Falasca Jacopo Vecchiet Claudio Ucciferri Marta Di Nicola Chiara D’Angelo Marcella Reale 《Nutrients》2015,7(10):8335-8347
Inflammation persists in patients infected with HIV. Reduction of inflammatory cytokines and microbial translocation might be one way that this could be managed. Purpose: The anti-inflammatory properties of certain probiotic strains prompted us to investigate whether a probiotic could reduce the inflammatory index of HIV-infected patients. Methods: The study involved 30 HIV+ males on antiretroviral therapy, who were given one bottle of fermented milk Yakult Light® containing Lactobacillus casei Shirota (LcS) twice a day for four weeks. Results: The probiotic LcS was associated with an increase of T lymphocytes and a significant increase of CD56+ cells (p = 0.04). There was also a significant decrease of mRNA levels of TGFβ, IL-10 and IL-12 (p < 0.001) and IL-1β expression (p < 0.001) and an increase of serum IL-23 (p = 0.03). In addition, decreased inflammation and cardiovascular risk were observed, as shown by a reduction of cystatin C (p < 0.001). Conclusions: These data provide preliminary evidence that probiotic supplementation may modulate certain immunological parameters and some of the cytokines that were analyzed. Thus, we propose that LcS may be an inexpensive and practical strategy to support the immune function of HIV+ patients. 相似文献
42.
Claudio Ucciferri Jacopo Vecchiet Katia Falasca 《World Journal of Clinical Cases》2020,8(19):4280-4285
Currently clinicians all around the world are experiencing a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical presentation of this pathology includes fever, dry cough, fatigue and acute respiratory distress syndrome that can lead to death infected patients. Current studies on coronavirus disease 2019 (COVID-19) continue to highlight the urgent need for an effective therapy. Numerous therapeutic strategies have been used until now but, to date, there is no specific effective treatment for SARS-CoV-2 infection. Elevated inflammatory cytokines have been reported in patients with COVID-19. Evidence suggests that elevated cytokine levels, reflecting a hyperinflammatory response secondary to SARS-CoV-2 infection, are responsible for multi-organ damage in patients with COVID-19. For these reason, numerous randomized clinical trials are currently underway to explore the effectiveness of biopharmaceutical drugs, such as, interleukin-1 blockers, interleukin-6 inhibitors, Janus kinase inhibitors, in COVID-19. The aim of the present paper is to briefly summarize the pathogenetic rationale and the state of the art of therapeutic strategy blocking hyperinflammation. 相似文献
43.
Alison T. Stopeck Karim Fizazi Jean-Jacques Body Janet E. Brown Michael Carducci Ingo Diel Yasuhiro Fujiwara Miguel Martín Alexander Paterson Katia Tonkin Neal Shore Paul Sieber Frank Kueppers Lawrence Karsh Denise Yardley Huei Wang Tapan Maniar Jorge Arellano Ada Braun 《Supportive care in cancer》2016,24(1):447-455
44.
Joshua L Gowin Katia M Harlé Jennifer L Stewart Marc Wittmann Susan F Tapert Martin P Paulus 《Neuropsychopharmacology》2014,39(6):1379-1387
There is some evidence that neuroimaging can be used to predict relapse among abstinent methamphetamine-dependent (MD) individuals. However, it remains unclear what cognitive and neural processes contribute to relapse. This investigation examined whether insula activation during risk-taking decisions—a process shown to be disrupted in MD—is able to predict susceptibility for relapse. Sixty-eight MD enrolled in a treatment program during early abstinence completed a risk-taking task during functional magnetic resonance imaging. Sixty-three of the sixty-eight individuals were followed up 1 year after the study. Of these, 18 MD reported relapse. The 45 abstinent MD showed patterns of insula activation during risky decisions that resembled those found in prior studies of healthy controls, consisting of lower insula activation during safe decisions paired with higher activation during risky decisions. In contrast, the 18 relapsed MD showed similar insula activation during safe and risky decisions. An increase in one standard deviation in the difference in insula activation between risky and safe choices was associated with a 0.34 odds ratio for relapse at any given time. A median split of insula activation (difference between risky and safe) showed that individuals in the bottom half were two times more likely to relapse. In addition, a model that included several other brain regions increased prediction accuracy compared with insula-based model alone. These results suggest that failure to differentially activate the insula as a function of risk is a part of an altered risk-processing network associated with an increased susceptibility to relapse. 相似文献
45.
46.
Katia E. Ferrar Tim S. Olds Carol A. Maher Sjaan R. Gomersall 《Australian and New Zealand journal of public health》2012,36(4):378-384
Objective: Young people's socioeconomic position and time use behaviours – including physical activity, sedentary behaviours, social engagement, sleep and cognitive activities – have been associated with health outcomes. This study aimed to describe how time use varies with household income in a representative sample of 9–16 year old Australians. Methods: A random sample of 2,071 9–16 year old Australian children provided household income data and four days’ use‐of‐time data. Average daily minutes spent in various types of activities were calculated. Kruskal‐Wallis and Mann Whitney U tests were used to compare time use across the income bands. Results: Higher income participants spent significantly more time playing sport (p<0.0001), including team sports (p=0.0005), and in cognitively demanding behaviours such as school routine (p<0.0001), doing homework (p<0.0001) and playing music (p=0.001) than their low‐income counterparts. Conversely, low‐income participants spent significantly more time watching television (p<0.001) and playing videogames (p<0.0002). There were no differences in sleep or social interaction. Screen time and school‐related activities were the major locations of differences. Conclusions: Time use differences in the areas of sport, school‐related and screen activities may be associated with various health and wellbeing outcomes, and thus be a source of health inequalities. Implications : Socioeconomic‐related time use behaviour differences could be used to develop specific interventions to address health inequalities via interventions addressing time use or income inequalities. 相似文献
47.
Prime K Sethi G Navaratne L Dean G Fox E Sabin C Taylor C de Ruiter A Taylor G Edwards S 《AIDS (London, England)》2003,17(2):260-262
Our findings show a high rate of loss to follow-up in HIV-positive teenagers compared with adults. Of concern is the fact that this group also have high rates of sexually transmitted infections, unprotected sex and pregnancy. There is an urgent need to examine the reasons for this and adopt strategies to minimize risk-taking behaviour and to improve access to appropriate healthcare. 相似文献
48.
Yi Yangtian Sossenheimer Philip H. Erondu Amarachi I. Skowron Kinga B. Rai Victoria Singer Jorie M. El Jurdi Katia Hyman Neil H. Rubin David T. 《Digestive diseases and sciences》2022,67(3):844-853
Digestive Diseases and Sciences - It remains unknown whether ambulation or sleep predicts postoperative length of stay for patients with IBD. We aim to identify the utility of wearable biosensors... 相似文献
49.
50.
Valentina Pinna Valentina Lanari Paola Daniele Federica Consoli Emanuele Agolini Katia Margiotti Irene Bottillo Isabella Torrente Alessandro Bruselles Caterina Fusilli Anna Ficcadenti Sara Bargiacchi Eva Trevisson Monica Forzan Sandra Giustini Chiara Leoni Giuseppe Zampino Maria Cristina Digilio Bruno Dallapiccola Maurizio Clementi Marco Tartaglia Alessandro De Luca 《European journal of human genetics : EJHG》2015,23(8):1068-1071
Analysis of 786 NF1 mutation-positive subjects with clinical diagnosis of neurofibromatosis type 1 (NF1) allowed to identify the heterozygous c.5425C>T missense variant (p.Arg1809Cys) in six (0.7%) unrelated probands (three familial and three sporadic cases), all exhibiting a mild form of disease. Detailed clinical characterization of these subjects and other eight affected relatives showed that all individuals had multiple cafè-au-lait spots, frequently associated with skinfold freckling, but absence of discrete cutaneous or plexiform neurofibromas, Lisch nodules, typical NF1 osseous lesions or symptomatic optic gliomas. Facial features in half of the individuals were suggestive of Noonan syndrome. Our finding and revision of the literature consistently indicate that the c.5425C>T change is associated with a distinctive, mild form of NF1, providing new data with direct impact on genetic counseling and patient management. 相似文献