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排序方式: 共有10000条查询结果,搜索用时 15 毫秒
191.
Umut Aypar Stephanie A. Smoley Beth A. Pitel Kathryn E. Pearce Roman M. Zenka George Vasmatzis Sarah H. Johnson James B. Smadbeck Jess F. Peterson Katherine B. Geiersbach Daniel L. Van Dyke Erik C. Thorland Robert B. Jenkins Rhett P. Ketterling Patricia T. Greipp Hutton M. Kearney Nicole L. Hoppman Linda B. Baughn 《European journal of haematology》2019,102(1):i-i
192.
Kathryn H. Bowles Sarah J. Ratcliffe John H. Holmes Sue Keim Sheryl Potashnik Emilia Flores Diane Humbrecht Christina R. Whitehouse Mary D. Naylor 《Journal of the American Medical Directors Association》2019,20(4):408-413
Objectives
Although hospital clinicians strive to effectively refer patients who require post-acute care (PAC), their discharge planning processes often vary greatly, and typically are not evidence-based.Design
Quasi-experimental study employing pre-/postdesign. Aimed at improving patient-centered discharge processes, we examined the effects of the Discharge Referral Expert System for Care Transitions (DIRECT) algorithm that provides clinical decision support (CDS) regarding which patients to refer to PAC and to what level of care (home care or facility).Setting and participants
Conducted in 2 hospitals, DIRECT data elements were collected in the pre-period (control) but discharging clinicians were blinded to the advice and provided usual discharge care. During the postperiod (intervention), referral advice was provided within 24 hours of admission to clinicians, and updated twice daily. Propensity modeling was used to account for differences between the pre-/post patient cohorts.Measures
Outcomes compared between the control and the intervention periods included PAC referral rates, patient characteristics, and same-, 7-, 14-, and 30-day readmissions or emergency department visits.Results
Although 24%–25% more patients were recommended for PAC referral by DIRECT algorithm advice, the proportion of patients receiving referrals for PAC did not significantly differ between the control (3302) and intervention (5006) periods. However, the characteristics of patients referred for PAC services differed significantly and inpatient readmission rates decreased significantly across all time intervals when clinicians had DIRECT CDS compared with without. There were no differences observed in return emergency department visits. Largest effects were observed when clinicians agreed with the algorithm to refer (yes/yes).Conclusions/Implications
Our findings suggest the value of timely, automated, discharge CDS for clinicians to optimize PAC referral for those most likely to benefit. Although overall referral rates did not change with CDS, the algorithm may have identified those patients most in need, resulting in significantly lower inpatient readmission rates. 相似文献193.
194.
Clifford L. Cua MD Pace Johnston MD Jill Harmon RDCS Kathryn Shelton RDCS Patrick I. McConnell MD 《Echocardiography (Mount Kisco, N.Y.)》2017,34(12):1956-1958
Mitral valve construction using extracellular matrix (ECM) is a relatively new procedure. In this case, a 15‐month‐old boy with a history of severe mitral valve regurgitation secondary to endocarditis underwent mitral valve surgery. Mitral valve repair was not possible, and thus, a 17 mm extracellular matrix cylinder valve (ECM‐CV) was constructed for valve replacement. The ECM‐CV is clearly imaged using echocardiography, especially three‐dimensional imaging, that helped define valve function. As the use of ECM for valve construction increases, echocardiography will play an essential role in evaluating the function and mechanics of these novel valves. 相似文献
195.
PPAR‐gamma agonist pioglitazone modifies craving intensity and brain white matter integrity in patients with primary cocaine use disorder: a double‐blind randomized controlled pilot trial
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196.
197.
Kathryn Simmons Raithel 《The Physician and sportsmedicine》2013,41(3):203-209
In the past, patients with chronic pain were told to limit their activity and shield themselves from pain. But that has changed: Physicians now prescribe both aerobic and resistance exercise to treat chronic pain. 相似文献
198.
199.
Xiaojie Wang Joan K. Brieland Joong H. Kim Ying‐Jr Chen Janet O'Neal Tsang‐Wei Tu Kathryn Trinkaus Sheng‐Kwei Song 《NMR in biomedicine》2013,26(12):1742-1750
Fingolimod (FTY720) is an orally available sphingosine‐1‐phosphate (S1P) receptor modulator reducing relapse frequency in patients with relapsing–remitting multiple sclerosis (RRMS). In addition to immunosuppression, neuronal protection by FTY720 has also been suggested, but remains controversial. Axial and radial diffusivities derived from in vivo diffusion tensor imaging (DTI) were employed as noninvasive biomarkers of axonal injury and demyelination to assess axonal protection by FTY720 in experimental autoimmune encephalomyelitis (EAE) mice. EAE was induced through active immunization of C57BL/6 mice using myelin oligodendrocyte glycoprotein peptide 35–55 (MOG35–55). We evaluated both the prophylactic and therapeutic treatment effect of FTY720 at doses of 3 and 10 mg/kg on EAE mice by daily clinical scoring and end‐point in vivo DTI. Prophylactic administration of FTY720 suppressed the disease onset and prevented axon and myelin damage when compared with EAE mice without treatment. Therapeutic treatment by FTY720 did not prevent EAE onset, but reduced disease severity, improving axial and radial diffusivity towards the control values without statistical significance. Consistent with previous findings, in vivo DTI‐derived axial and radial diffusivity correlated with clinical scores in EAE mice. The results support the use of in vivo DTI as an effective outcome measure for preclinical drug development. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
200.