全文获取类型
收费全文 | 2037篇 |
免费 | 155篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 112篇 |
妇产科学 | 33篇 |
基础医学 | 296篇 |
口腔科学 | 58篇 |
临床医学 | 175篇 |
内科学 | 381篇 |
皮肤病学 | 35篇 |
神经病学 | 131篇 |
特种医学 | 279篇 |
外科学 | 215篇 |
综合类 | 51篇 |
预防医学 | 119篇 |
眼科学 | 64篇 |
药学 | 65篇 |
1篇 | |
肿瘤学 | 194篇 |
出版年
2021年 | 24篇 |
2019年 | 20篇 |
2018年 | 23篇 |
2017年 | 16篇 |
2016年 | 34篇 |
2015年 | 28篇 |
2014年 | 38篇 |
2013年 | 41篇 |
2012年 | 68篇 |
2011年 | 58篇 |
2010年 | 50篇 |
2009年 | 47篇 |
2008年 | 62篇 |
2007年 | 67篇 |
2006年 | 69篇 |
2005年 | 58篇 |
2004年 | 62篇 |
2003年 | 52篇 |
2002年 | 30篇 |
2001年 | 47篇 |
2000年 | 47篇 |
1999年 | 48篇 |
1998年 | 52篇 |
1997年 | 55篇 |
1996年 | 50篇 |
1995年 | 48篇 |
1994年 | 36篇 |
1993年 | 42篇 |
1992年 | 60篇 |
1991年 | 60篇 |
1990年 | 46篇 |
1989年 | 53篇 |
1988年 | 65篇 |
1987年 | 84篇 |
1986年 | 62篇 |
1985年 | 42篇 |
1984年 | 44篇 |
1983年 | 46篇 |
1982年 | 37篇 |
1981年 | 42篇 |
1980年 | 48篇 |
1979年 | 21篇 |
1978年 | 19篇 |
1977年 | 16篇 |
1976年 | 31篇 |
1975年 | 16篇 |
1974年 | 11篇 |
1973年 | 13篇 |
1971年 | 16篇 |
1969年 | 11篇 |
排序方式: 共有2215条查询结果,搜索用时 14 毫秒
71.
Aimee L. Smith Deborah R. Karp Vivian C. Aguilar G. Willy Davila 《International urogynecology journal》2013,24(6):963-968
Introduction and hypothesis
Our goal was to compare outcomes of repeat vs. primary synthetic slings in patients with stress urinary incontinence (SUI) with intrinsic sphincter deficiency (ISD).Materials and methods
We reviewed patients who underwent a sling for SUI with ISD from 2003 to 2010. The patients were divided into two groups according to whether they underwent primary or repeat sling. Surgical success was defined as no incontinence and no reintervention (i.e., urethral bulking) during follow-up. Statistical analysis included the unpaired t test, Wilcoxon rank sums test, chi-squared/Fisher’s exact tests, and logistic regression to identify risk factors associated with failure.Results
Six hundred and thirty-seven patients with ISD underwent a sling procedure at our institution; 557 (87 %) a primary sling and 80 (13 %) a repeat sling. Patient demographics were similar. Preoperatively, patients with recurrent SUI reported more subjective bother. Mean follow-up was 66.5 weeks (24–374). Success was achieved in 81 % of primary compared with 55 % of repeat slings (p?<?0.0001). Repeat patients were 3.4 times more likely to fail surgery [odds ratio (OR)?=?3.43, 95 % confidence interval (CI) 2.1–5.6]. Additionally 30 % of the repeat group underwent urethral bulking postoperatively compared with 8.6 % in the primary group (OR?=?4.4, 95 % CI 2.5–7.7). Prior incontinence procedures, a positive supine stress test, and transobturator sling were independent risk factors for failure. Among the types of slings placed (transobturator, retropubic, tensioned pubovaginal), pubovaginal slings were most successful (OR?=?2.7, 95 % CI 1.4–5.2).Conclusion
In women with ISD, repeat slings are associated with lower success rates compared with primary slings. Pubovaginal slings resulted in the highest success rate compared with both transobturator and retropubic slings. 相似文献72.
73.
Ara A. Salibian Jonathan M. Bekisz Jordan D. Frey Brooke Miller Mihye Choi Nolan S. Karp 《The breast journal》2020,26(5):971-975
Bilateral prophylactic mastectomies (BPM) in young previvors with high‐risk mutations are rising; however, little data on management, therapy timing, and outcomes exist. BRCA+ patients under 30 undergoing BPM from 2006 to 2018 were reviewed. Twenty‐two patients aged 23‐29 underwent mastectomy 4.2 years after genetic diagnosis. Twelve patients completed surveys, most often citing personal decisions (50%) for undergoing mastectomy and plastic surgeons’ recommendations (83.3%) for reconstruction. About 73% of patients completely understood risks/benefits of mastectomy and 63.6% of reconstruction. Patients reported high BREAST‐Q Satisfaction and Well‐Being scores. Continued educational resource development will optimize shared decision‐making in the reconstructive process. 相似文献
74.
Svingen PA Karp JE Krajewski S Mesner PW Gore SD Burke PJ Reed JC Lazebnik YA Kaufmann SH 《Blood》2000,96(12):3922-3931
Recent studies have suggested that variations in levels of caspases, a family of intracellular cysteine proteases, can profoundly affect the ability of cells to undergo apoptosis. In this study, immunoblotting was used to examine levels of apoptotic protease activating factor-1 (Apaf-1) and procaspases-2, -3, -7, -8, and -9 in bone marrow samples (at least 80% leukemia) harvested before chemotherapy from adults with newly diagnosed acute myelogenous leukemia (AML, 42 patients) and acute lymphocytic leukemia (ALL, 18 patients). Levels of each of these polypeptides varied over a more than 10-fold range between specimens. In AML samples, expression of procaspase-2 correlated with levels of Apaf-1 (R(s) = 0.52, P <.02), procaspase-3 (R(s) = 0.56, P <.006) and procaspase-8 (R(s) = 0.64, P <.002). In ALL samples, expression of procaspases-7 and -9 was highly correlated (R(s) = 0.90, P <.003). Levels of these polypeptides did not correlate with prognostic factors or response to induction chemotherapy. In further studies, 16 paired samples (13 AML, 3 ALL), the first harvested before induction therapy and the second harvested at the time of leukemia regrowth, were also examined. There were no systematic alterations in levels of Apaf-1 or procaspases at relapse compared with diagnosis. These results indicate that levels of initiator caspases vary widely among different leukemia specimens but cast doubt on the hypothesis that this variation is a major determinant of drug sensitivity for acute leukemia in the clinical setting. (Blood. 2000;96:3922-3931) 相似文献
75.
76.
Sorafenib is tolerable and improves clinical outcomes in patients with FLT3‐ITD acute myeloid leukemia prior to stem cell transplant and after relapse post‐transplant
下载免费PDF全文
![点击此处可从《American journal of hematology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
77.
78.
由于采用血浆置换(PE)治疗血栓性血小板减少性紫癜溶血性尿毒综合征(TTP HUS)频率的增加,PE引起的并发症也成为制定治疗方案时需要考虑的因素。由于TTP HUS的诊断常常是不确定的,掌握PE治疗利弊之间的平衡已成为制定适当治疗方案的焦点。之前,我们于1996年~2002年间曾两次报道 相似文献
79.
This study examined the factor structure of the Apperceptive Personality Test (APT), a recently developed picture-story technique with both projective and objective features. University undergraduates (513 males, 664 females) were administered the APT in individual group sessions. A principal components analysis (Varimax rotation) was performed with 18 of the standard APT variables and resulted in three similar factors for both male and female samples. The first and largest factor was a positive evaluation factor, the second a negative evaluation factor, and the third an "intensity" factor. The usefulness and meaning of the factor analysis are discussed briefly. 相似文献
80.
Robert W. Holmstrom Stephen A. Karp David E. Silber 《Journal of clinical psychology》1994,50(2):234-237
This study examined the relationship between depression and the Apperceptive Personality Test (APT), a picture-story assessment device with an objective scoring system. Subjects were 206 undergraduate volunteer females who completed the APT and the Beck Depression Inventory (BDI). Multiple regression analysis showed significant APT predictors for the BDI. Results are discussed and directions for future research are proposed. 相似文献