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排序方式: 共有231条查询结果,搜索用时 15 毫秒
71.
72.
Jérôme Harambat Marjolein Bonthuis Jaap W. Groothoff Franz Schaefer E. Jane Tizard Enrico Verrina Karlijn J. van Stralen Kitty J. Jager 《Pediatric nephrology (Berlin, Germany)》2016,31(11):2055-2064
End-stage renal disease (ESRD) in children is a medically challenging condition. Due to its rarity and special features, methodologically sound collaborative studies are required. In 2007, a new European registry of pediatric renal replacement therapy (RRT), the ESPN/ERA–EDTA Registry, was launched. In recent years, the Registry has provided comprehensive data on incidence, prevalence, patient characteristics, RRT modalities, and mortality in pediatric ESRD, along with relevant insights into cardiovascular risk, anemia, nutrition and growth, transplantation outcomes, and rare diseases. In this review, we describe the study design and structure underlying the ESPN/ERA–EDTA Registry, summarize the major research findings from more than 20 publications, and discuss current limitations and the future challenges to overcome. 相似文献
73.
van Stralen KJ Doggen CJ Lumley T Cushman M Folsom AR Psaty BM Siscovick D Rosendaal FR Heckbert SR 《Journal of the American Geriatrics Society》2008,56(3):517-522
OBJECTIVES: To study whether exercise is associated with the risk of venous thrombosis in elderly people.
DESIGN: Observational study with a median follow-up of 11.6 years.
SETTING: The Cardiovascular Health Study in four U.S. communities.
PARTICIPANTS: People aged 65 and older without prior venous thrombosis (deep venous thrombosis or pulmonary embolism).
MEASUREMENTS: Self-reported exercise was measured two or three times during follow-up and was defined as expending more than 500 kcal/wk on exercise, including walking for exercise. Venous thrombosis cases were verified using medical record review.
RESULTS: Of 5,534 participants, 171 developed a first venous thrombosis. Self-reported exercise at baseline was not related to the risk of venous thrombosis after adjustment for sex, age, race, self-reported health, and body mass index (adjusted hazard ratio (HRadj )=1.16, 95% confidence interval (CI)=0.84–1.61), although with exercise modeled as a time-varying exposure, overall results were in the direction of greater risk of venous thrombosis (HRadj =1.38, 95% CI=0.99–1.91). For mild-intensity exercise, such as walking, there was a nonsignificant finding in the direction of benefit (HRadj =0.75, 95% CI=0.49–1.16), but strenuous exercise, such as jogging, was associated with greater risk of venous thrombosis (HRadj =1.75, 95% CI=1.08–2.83) than no exercise at all.
CONCLUSION: In elderly people, strenuous exercise was associated with a higher risk of venous thrombosis than no exercise at all. Future studies are needed to explain this unexpected higher risk. 相似文献
DESIGN: Observational study with a median follow-up of 11.6 years.
SETTING: The Cardiovascular Health Study in four U.S. communities.
PARTICIPANTS: People aged 65 and older without prior venous thrombosis (deep venous thrombosis or pulmonary embolism).
MEASUREMENTS: Self-reported exercise was measured two or three times during follow-up and was defined as expending more than 500 kcal/wk on exercise, including walking for exercise. Venous thrombosis cases were verified using medical record review.
RESULTS: Of 5,534 participants, 171 developed a first venous thrombosis. Self-reported exercise at baseline was not related to the risk of venous thrombosis after adjustment for sex, age, race, self-reported health, and body mass index (adjusted hazard ratio (HR
CONCLUSION: In elderly people, strenuous exercise was associated with a higher risk of venous thrombosis than no exercise at all. Future studies are needed to explain this unexpected higher risk. 相似文献
74.
Harambat J van Stralen KJ Kim JJ Tizard EJ 《Pediatric nephrology (Berlin, Germany)》2012,27(3):363-373
In the past 30 years there have been major improvements in the care of children with chronic kidney disease (CKD). However,
most of the available epidemiological data stem from end-stage renal disease (ESRD) registries and information on the earlier
stages of pediatric CKD is still limited. The median reported incidence of renal replacement therapy (RRT) in children aged
0–19 years across the world in 2008 was 9 per million of the age-related population (4–18 years). The prevalence of RRT in
2008 ranged from 18 to 100 per million of the age-related population. Congenital disorders, including congenital anomalies
of the kidney and urinary tract (CAKUT) and hereditary nephropathies, are responsible for about two thirds of all cases of
CKD in developed countries, while acquired causes predominate in developing countries. Children with congenital disorders
experience a slower progression of CKD than those with glomerulonephritis, resulting in a lower proportion of CAKUT in the
ESRD population compared with less advanced stages of CKD. Most children with ESRD start on dialysis and then receive a transplant.
While the survival rate of children with ERSD has improved, it remains about 30 times lower than that of healthy peers. Children
now mainly die of cardiovascular causes and infection rather than from renal failure. 相似文献
75.
D’Onofrio Valentino Van Steenkiste Eveline Meersman Agnes Waumans Luc Cartuyvels Reinoud Van Halem Karlijn Messiaen Peter Gyssens Inge C. 《European journal of clinical microbiology & infectious diseases》2021,40(5):987-995
European Journal of Clinical Microbiology & Infectious Diseases - There is a need for a quick assessment of severely ill patients presenting to the hospital. The objectives of this study were... 相似文献
76.
Dieuwertje L. Kreb Taco J. Blokhuis Karlijn J. P. van Wessem Mike Bemelman Koen W. W. Lansink Luke P. H. Leenen 《Archives of orthopaedic and trauma surgery》2013,133(8):1109-1113
Background
Intramedullary fixation is the treatment of choice for diaphyseal fractures of the femur and tibia. Locking the implant can sometimes be cumbersome and time consuming. In our institution, fractures with axial and rotational stability are treated with intramedullary nailing without interlocking.Methods
All consecutive patients presented in the University Medical Center Utrecht from October 2003 to August 2009 with acute traumatic diaphyseal fractures of the tibia or femur that were considered axial and rotational stable were included. They underwent internal fixation using intramedullary nails without interlocking. Patient records were evaluated for duration of surgery, perioperative complications, consolidation time and re-operations.Results
Twenty-nine long bone fractures were treated in 27 patients: 20 men and 7 women, with an average age of 28.9 years (range 15.6–54.4). There were 12 femoral fractures and 17 tibial fractures. Sixteen fractures were closed and 13 were open (10 Gustilo 1, 3 Gustilo 2). The mean operating time was 43 min (range 18–68 min) for tibial fractures and 55 min (range 47–150 min) for femoral fractures. Postoperative complications occurred in six patients. Two patients (three fractures) were lost to follow-up. Healing occurred in 25 of the 26 remaining fractures (96 %) without additional interventions. One tibia was secondarily converted to a standard locked nail because of axial and rotational instability. All patients returned to their pre-injury level of activity.Conclusion
The use of intramedullary nailing without interlocking is associated with minimal complications in selected fractures. The advantages include a short operating time and the simplicity of its application. 相似文献77.
78.
Gijzen K Tacken PJ Zimmerman A Joosten B de Vries IJ Figdor CG Torensma R 《Journal of leukocyte biology》2007,81(3):729-740
The role of dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) in DC-T cell communication was assessed by analyzing the effect of DC-SIGN-blocking mAb in MLR. The results show that the degree of inhibition by DC-SIGN and LFA-1 mAb depends on the magnitude of the MLR and the maturation status of the DC. Addition of DC-SIGN mAb at several time-points during MLR showed that DC-SIGN is involved early on in DC-T cell contacts. This initial role is masked by strong adhesive and costimulatory mechanisms, indicating a short-lived effect of DC-SIGN in DC-T cell interactions. To examine this concept in more detail, the percentage of PBL capable of binding DC-SIGN was determined. Analysis of several donors revealed that 1-20% PBL bind to beads coated with recombinant DC-SIGN, and the DC-SIGN-binding cells comprised all major cell subsets found in blood. PBL isolated from a donor with high DC-SIGN-binding capacity were more prone to blocking by DC-SIGN mAb in MLR than PBL from a donor with low DC-SIGN-binding capacity. This study indicates an initial and transient role for DC-SIGN in T cell proliferation, which becomes apparent when T cell proliferation is low and when the percentage of DC-SIGN binding PBL is high. 相似文献
79.
Jérôme Harambat Karlijn J. van Stralen Enrico Verrina Jaap W. Groothoff Franz Schaefer Kitty J. Jager 《Pediatric nephrology (Berlin, Germany)》2014,29(3):453-459
Background
Registry data can be used to assess associations between medical and health-policy factors and the likelihood of children on renal replacement therapy (RRT) to live with a functioning kidney transplant in Europe.Methods
A survey questionnaire was distributed among renal registry representatives in 38 European countries, and additional data was obtained from the European Society for Pediatric Nephrology/European Renal Association–European Dialysis and Transplant Association (ESPN/ERA-EDTA) registry.Results
Thirty-two countries with a pediatric RRT program responded. The median percentage of children by country on RRT with a functioning transplant was 62 % (interquartile range 39–77). One per million population increase in donation rate from deceased donors was associated with a 5 % increase in the percentage of functioning transplants; the existence of an intermediate and high pediatric priority policy doubled and tripled this percentage, respectively, compared with no priority, whereas an increase in living donor pediatric kidney transplant rate of one per million children was associated with a 14 % higher percentage of functioning transplants. The percentage of functioning transplants was also strongly associated with the gross domestic product (GDP).Conclusion
Considerable variations exist in the percentages of prevalent pediatric RRT populations with functioning renal transplants across Europe. A macroeconomic indicator such as GDP is the most important determinant of these international differences. Efforts should be made for living donation programs and pediatric allocation priority to increase access to kidney transplantation for children. 相似文献80.
Mirjam P Fransen Gillian Rowlands Karlijn EF Leenaars Marie-Louise Essink-Bot 《Archives of Public Health》2014,72(1):14