全文获取类型
收费全文 | 1130篇 |
免费 | 41篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 29篇 |
妇产科学 | 11篇 |
基础医学 | 137篇 |
口腔科学 | 24篇 |
临床医学 | 68篇 |
内科学 | 165篇 |
皮肤病学 | 24篇 |
神经病学 | 30篇 |
特种医学 | 26篇 |
外科学 | 315篇 |
综合类 | 20篇 |
预防医学 | 221篇 |
眼科学 | 12篇 |
药学 | 56篇 |
肿瘤学 | 34篇 |
出版年
2023年 | 8篇 |
2022年 | 18篇 |
2021年 | 32篇 |
2020年 | 23篇 |
2019年 | 24篇 |
2018年 | 32篇 |
2017年 | 26篇 |
2016年 | 19篇 |
2015年 | 20篇 |
2014年 | 31篇 |
2013年 | 55篇 |
2012年 | 72篇 |
2011年 | 81篇 |
2010年 | 51篇 |
2009年 | 47篇 |
2008年 | 48篇 |
2007年 | 76篇 |
2006年 | 92篇 |
2005年 | 67篇 |
2004年 | 46篇 |
2003年 | 59篇 |
2002年 | 50篇 |
2001年 | 23篇 |
2000年 | 19篇 |
1999年 | 20篇 |
1998年 | 7篇 |
1996年 | 4篇 |
1995年 | 3篇 |
1994年 | 5篇 |
1992年 | 3篇 |
1990年 | 9篇 |
1989年 | 11篇 |
1988年 | 10篇 |
1987年 | 10篇 |
1986年 | 10篇 |
1985年 | 10篇 |
1984年 | 4篇 |
1983年 | 5篇 |
1979年 | 5篇 |
1977年 | 3篇 |
1976年 | 2篇 |
1975年 | 2篇 |
1974年 | 5篇 |
1973年 | 5篇 |
1972年 | 5篇 |
1971年 | 3篇 |
1970年 | 3篇 |
1969年 | 2篇 |
1968年 | 2篇 |
1965年 | 2篇 |
排序方式: 共有1178条查询结果,搜索用时 31 毫秒
991.
992.
993.
Achraf Khedhaier Elham Hassen Noureddine Bouaouina Sallouha Gabbouj Slim Ben Ahmed Lotfi Chouchane 《BMC cancer》2008,8(1):109
Background
Xenobiotic Metabolizing Enzymes (XMEs) contribute to the detoxification of numerous cancer therapy-induced products. This study investigated the susceptibility and prognostic implications of the CYP2E1, CYP2C19, CYP2D6, mEH and NAT2 gene polymorphisms in breast carcinoma patients. 相似文献994.
Rafaella S. Ferraz Caio S. Silva Giovanna C. Cavalcante Natrcia N. M. de Queiroz Karem M. Felício Joo S. Felício ndrea Ribeiro-dos-Santos 《Nutrients》2022,14(5)
Vitamin D has been considered a strong contributing factor to type 1 diabetes mellitus (T1DM). Many studies have investigated polymorphisms in the VDR gene in association with T1DM in different populations, but there are still conflicting findings. This study aimed to evaluate the association of four variants in the VDR gene (rs7975232, rs1544410, rs731236, and rs2228570) with T1DM risk and vitamin D levels within a population from North Region, Brazil, as well as the influence of genomic ancestry on T1DM. A total of 65 T1DM patients and 83 non-T1DM patients were enrolled in this study. VDR gene polymorphisms were assessed using Sanger sequencing analysis. Genomic ancestry was analyzed using a set of 61 ancestry-informative markers. T1DM patients showed higher European genomic contribution and lower Native American genomic contribution when compared to non-T1DM patients. T1DM patients with AA genotype in rs1544410 or CC genotype in rs731236 had significantly lower 25(OH)D levels compared to the other two genotypes (p = 0.013 and p = 0.02, respectively), while T1DM with TT genotype in rs2228570 had higher 25(OH)D levels compared to CC + TC in the same polymorphism (p = 0.011). Our findings suggest that the association between 25(OH)D and T1DM may be modified by VDR variants, possibly influencing the development of this autoimmune disease. 相似文献
995.
Wissal Abdelli Asmahen Souissi Fatima Alaoui Wiem Sassi Ines Chelly Slim Haouat Mourad Mokni 《Clinical Case Reports》2022,10(3)
Rapp–Hodgkin syndrome (RHS) is a rare condition that is characterized by ectodermal dysplasia and palatal abnormalities. Palmoplantar keratoderma (PPK) is an unusual manifestation of hidrotic ED. Ulcerations on the palms are also not common in RHS. We describe a 15‐year‐old boy who has RHS associated with PPK. 相似文献
996.
W. Rebhandl Slim Saadi Andreas M. Herneth Elisabeth Presterl Paya Kurosh Klara Wandl-Vergesslich Ernst Horcher 《Pediatric nephrology (Berlin, Germany)》1999,13(8):688-692
Partial fungal obstruction of the renal collecting system is an unusual finding among infants that poses specific management
problems. We report a patient with sepsis and fungal infection of the kidneys post surgery who presented with bilateral fungus
balls and was successfully managed by conservative measures. Sonography is the imaging technique of choice in the diagnosis
and follow-up of such patients. The need for prompt diagnosis in high-risk patients and the role of sonography are discussed.
Received: 24 September 1998 / Revised: 15 March 1999 / Accepted: 16 March 1999 相似文献
997.
BALB/c mice were inoculated with Bartonella henselae by both systemic and mucosal routes. Culture analysis of tissues from mice infected intraperitoneally with a high dose of B. henselae yielded positive results 24 hr after infection. However, culture analysis of blood taken between 6 hr and 7 days after infection from groups receiving live B. henselae were negative. Following intraperitoneal infection, B. henselae was detected by polymerase chain reaction in liver and mesenteric lymph nodes by 6 hr and up to 7 days after infection in liver, kidney and spleen tissue. Enzyme-linked immunosorbent assay (ELISA) of serum samples collected as early as 13 days after infection indicated humoral immune responses to B. henselae. Specific humoral responses remained through week 6. Analysis of faecal samples revealed induction of B. henselae-specific immunoglobulin A by day 28 after infection. In addition, B. henselae-specific cellular responses were indicated by a positive delayed-type hypersensitivity and a T helper 1 (Th1) (CD4+ T cell)-type cytokine response following in vitro stimulation of splenocytes. The significance and implications of these data in relation to B. henselae infections are discussed. 相似文献
998.
André Mégarbané Rima Slim Gudrun Nürnberg Inga Ebermann Peter Nürnberg Hanno J?rn Bolz 《European journal of human genetics : EJHG》2009,17(8):1076-1079
We have earlier described a syndrome characterized by microcephaly, cutis verticis gyrata, retinitis pigmentosa, cataracts, hearing loss and mental retardation (Mendelian inheritance in man (MIM) no: 605685) in two brothers from a non-consanguineous Lebanese family. In view of the rarity of the disorder and the high rate of inbreeding in the Lebanese population, we assumed an autosomal recessive trait inherited from a common ancestor. A genomewide scan was performed. The single locus on the long arm of chromosome 8 that showed homozygosity by descent comprised the gene responsible for Cohen syndrome (CS), VPS13B. We then sequenced VPS13B in the patients and found a homozygous splice site mutation. Several possible explanations for the overlap between CS and the clinical features observed in our patients are discussed. Our data highlight the potential of high-resolution homozygosity mapping in small populations with a high rate of inbreeding. 相似文献
999.
Hepatocellular carcinoma: comparison between liver transplantation, resective surgery, ethanol injection, and chemoembolization 总被引:5,自引:0,他引:5
G. Colella R. Bottelli L. De Carlis C. V. Sansalone G. F. Rondinara A. Alberti L.S. Belli F. Gelosa G. M. Iamoni A. Rampoldi A. De Gasperi A. Corti E. Mazza P. Aseni A. Meroni A. O. Slim M. Finzi F. Di Benedetto F. Manochehri M. L. Follini G. Ideo D. Forti 《Transplant international》1998,11(S1):S193-S196
Abstract Between January 1989 and June 1997, 533 patients (423 male, 110 female, mean age 61 years, range 22–89 years) with hepatocellular carcinoma (HCC) were observed at our center. We report on 419 patients retrospectively compared for different treatments: liver transplantation (LT; 55 patients), resective surgery (RS; 41 patients), transarterial chemoembolization (TACE; 171 patients) and percutaneous ethanol injection (PEI; 152 patients). The 3- and 5-year actuarial survival rates were, respectively, 72% and 68% for LT, 64 and 44% for RS, 54 and 36% for PEI, and 32 and 22% for TACE. Survival curves were compared for sex, age, tumor characteristics, alphafetoprotein level, Child class, and etiology of cirrhosis. All patient-related characteristics examined (sex, age) are not significantly related to patient survival. Tumor-related variables and associated liver disease variables significantly conditioned survival in relation to different treatments. LT seems to be the treatment of choice for monofocal HCC less then 5 cm in diameter and in selected cases of plurifocal HCC. 相似文献
1000.
Immune adherence hemadsorption: specific method for rapid identification of adenovirus antigens.
下载免费PDF全文
![点击此处可从《Journal of clinical microbiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
An immune adherence hemadsorption test for the rapid group-specific identification of adenoviruses is described. The test was performed directly on the cell culture isolate in less than 1 h, by the sequential addition of the antiserum of any adenovirus serotype, complement, and then C3b receptor-rich human erythrocytes. Microscopic examination revealed the presence of erythrocytes adhering firmly to the infected cell sheet. The immune adherence hemadsorption test proved a specific and rapid diagnostic procedure for the detection of adenovirus group antigen in tissue cultures and was more simple than conventional tests. 相似文献