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Infection and immunoregulation of T lymphocytes by parainfluenza virus type 3. 总被引:5,自引:0,他引:5 下载免费PDF全文
S Sieg C Muro-Cacho S Robertson Y Huang D Kaplan 《Proceedings of the National Academy of Sciences of the United States of America》1994,91(14):6293-6297
Human parainfluenza virus type 3 (HPIV3) is a major cause of disease in newborns and infants. It also has a striking potential to reinfect individuals throughout their lives, suggesting that HPIV3 does not induce lifelong immunity; however, the operative mechanism for the failure to prevent reinfection is not known. We have assessed the potential of the virus to infect nontransformed human T lymphocytes and have found that T cells are readily infected by the virus. Productive infection requires activation of the T cells and results in a marked inhibition of proliferation. Furthermore, our results indicate that exposure to the virus, even without overt expression of viral proteins as detected by immunohistology, profoundly alters the functional capacity of the T cells. The capacity of the virus to regulate T-lymphocyte function may play an important role in the failure of the virus to induce lifelong immunity. 相似文献
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Hagit Cohen Joseph Zohar Michael A Matar Zeev Kaplan Amir B Geva 《Neuropsychopharmacology》2005,58(8):640-650
BACKGROUND: Unsupervised fuzzy clustering (UFC) analysis is a mathematical technique that groups together objects in the multidimensional feature space according to a specified similarity measurement, thereby yielding clusters of similar data points that can be represented by a set of prototypes or centroids. METHODS: Since clinical studies of mental disorders distinguish between affected and unaffected individuals, we designed an inclusion/exclusion criteria (cutoff behavioral criteria [CBC]) approach for animal behavioral studies. The effect of classifying the study population into clearly affected versus clearly unaffected individuals according to behaviors on two behavioral paradigms was statistically significant. RESULTS: Here the raw data from previous studies were subjected to UFC algorithms as a means of objectively testing the validity of the concept of the CBC for our experimental model. The first UFC algorithm yielded two clearly discrete clusters, found to consist almost exclusively of the exposed animals in the one and unexposed animals in the other. The second algorithm yielded three clusters corresponding to animals designated as clearly affected, partially affected, and clearly unaffected. The algorithm for physiological data in addition to behavioral data failed to elicit discrete clusters. CONCLUSIONS: The UFC analysis yielded data that support the conceptual contention of the CBC and lends additional validity to our previous behavioral studies. 相似文献
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A. Ben-Arie S. Perlman† Y. Hazan† L. A. Solomon C. Edwards & A. L. Kaplan 《International journal of gynecological cancer》2004,14(5):927-930
OBJECTIVE: The aim of this study was to evaluate a different prevalence and clinical pattern of high-risk endometrial cancer in an indigent population of young women. METHODS: Charts of 71 consecutive patients, treated for endometrial adenocarcinoma during a 6-year period, were reviewed. The patients were divided into two groups contingent upon age--(i) those who were below 40 years and (ii) those who were over 40. Based on histological type, grade, and stage, both groups were subdivided into a low, intermediate, or high-risk cancer category. RESULTS: Of the 13 (18.3%) patients in the younger age group, five patients (38.4%) had high-risk endometrial cancer, compared to only eight patients (13.8%) in the older age group. CONCLUSION: In contradiction to previous reports, our results show that a higher proportion of young indigent women diagnosed with endometrial cancer have a high-risk cancer. Delay in diagnosis can explain only some of the discrepancies in the special clinical pattern of endometrial cancer among this population. Other possible explanations include nutritional differences, genetic susceptibility, immunological status, and high-risk behavior. More epidemiological studies are needed for complete understanding of the unfavorable outcome of endometrial cancer in these young women. 相似文献
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M Kaplan HJ Vreman C Hammerman C Leiter B Rudensky MG MacDonald DK Stevenson 《Acta paediatrica (Oslo, Norway : 1992)》1998,87(4):455-457
The incidence (%) of hyperbilirubinemia (serum bilirubin ≥257 μmol/l) was similar in neonates with a combination of ABO incompatibility and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency (45%), with ABO incompatibility (54%) or G-6-PD deficiency (37%), alone (ns). Carboxyhemoglobin values, corrected for inspired CO, were similarly elevated in all three groups (0.87 ± 0.32%, 0.82 ± 0.29%, 0.76 ± 0.18%, respectively, ns), but correlated with bilirubin only in those with ABO incompatibility alone. ABO-incompatible/G-6-PD-deficient neonates, compared with those with either condition alone, are not at increased risk for hemolysis or hyperbilirubinemia. 相似文献
40.
M Kaplan 《Cancer nursing》1989,12(3):177-182
A retrospective study was conducted investigating the relationships between age and length of survival, and between age and the prognostic factors of disease stage, tumor size, histologic grade, and hematocrit. The subjects consisted of all of the women with early-stage invasive squamous cell cancer of the cervix, treated with radiation therapy alone in the Department of Radiation Oncology at the State University of New York-Health Science Center at Brooklyn between January 1, 1980, and December 31, 1986. The 105 eligible subjects were divided into two groups: those 39 and younger (n = 22) and those older than 39 (n = 83). Length of survival was significantly shorter for the younger group (p = 0.0009). Of this group, 50% had died from disease compared with 23% of the older group. Tumor size was also significantly greater in the younger group (p = 0.038). Further study is needed to determine the contributing risk factors for cancer of the cervix in young women and to develop a comprehensive gynecologic nursing assessment tool for identifying those at increased risk for this disease. In terms of developmental psychology, the young women fit into the stage of early adulthood. Knowledge of the tasks of this stage would facilitate the development of primary cancer prevention programs for this group. 相似文献