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排序方式: 共有635条查询结果,搜索用时 15 毫秒
31.
Anastasia Mala Kalliopi Foteinogiannopoulou Ioannis E Koutroubakis 《World journal of gastrointestinal oncology》2021,13(12):1956-1980
Malignancies constitute the second cause of death in patients with inflammatory bowel diseases (IBD), after cardiovascular diseases. Although it has been postulated that IBD patients are at greater risk of colorectal cancer compared to the general population, lately there has been evidence supporting that this risk is diminishing over time as a result of better surveillance, while the incidence of extraintestinal cancers (EICs) is increasing. This could be attributed either to systemic inflammation caused by IBD or to long-lasting immunosuppression due to IBD treatments. It seems that the overall risk of EICs is higher for Crohn’s disease patients and it is mainly driven by skin cancers, and liver-biliary cancers in patients with IBD and primary sclerosing cholangitis. The aims of this review were first to evaluate the prevalence, characteristics, and risk factors of EICs in patients with IBD and second to raise awareness regarding a proper surveillance program resulting in early diagnosis, better prognosis and survival, especially in the era of new IBD treatments that are on the way. 相似文献
32.
Hidradenitis suppurativa treated with tetracycline in combination with colchicine: a prospective series of 20 patients 下载免费PDF全文
33.
▪ Abstract: After clinical staging, the single most important prognostic factor for patients with newly diagnosed primary breast cancer is the presence or absence of detectable metastases to axillary lymph nodes when examined by conventional light microscopy. More sensitive methods of determination of lymph node status, such as evaluation of serial sections, immunohistochemical staining, and use of molecular biological assays increase the rate of detection of micrometastases. Although the feasibility of enhanced detection of occult axillary metastatic disease is well established, the prognostic significance of such detection is only recently starting to emerge. Furthermore, the enormous recent interest in the application of sentinel lymph node biopsy as an alternative to the evaluation of the entire axilla in patients with breast cancer makes the first-time detailed evaluation for micrometastases practically feasible. In this review the different methods of detecting micrometastatic disease in the axilla and the significance of such findings are discussed. ▪ 相似文献
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35.
Kalliopi Keramida MD PhD Dimitrios Farmakis MD PhD Teresa López Fernández MD Patrizio Lancellotti MD PhD 《Echocardiography (Mount Kisco, N.Y.)》2020,37(8):1149-1158
Transthoracic echocardiography (TTE) is the cornerstone of imaging in patients with a malignancy in all stages of their treatment—before, during, and after the completion of it—to identify most of the cardiotoxic complications. However, the restricted time and resources of cardio-oncology services and the high volume of oncological patients and survivors on the other hand limit the access of this population to this modality. Focused Echo in Cardio-Oncology (FECO) in proportion to other focused cardiac protocols is proposed as a valuable tool after the initial standard complete TTE to: (a) identify the potential toxicity expected by the specific cancer therapy applied; (b) assess sequentially the pre-existing abnormality, if any, in relation to therapy; (c) assess the effect of any cardio-protective intervention; (d) identify any cardiac origin of patient complaints during or after therapy; (e) assess cardiac function in asymptomatic patients who develop significant changes in cardiac biomarkers during cancer therapy. Four different protocols of FECO are proposed according to the type of cardiotoxicity anticipated: FECOm (in patients on chemotherapeutics that cause myocardial dysfunction), FECOv (in patients at risk of valvular heart disease), FECOpd (in patients at risk of pericardial disease), and FECOph (in patients at risk of pulmonary hypertension). The application of FECO protocols is aimed to ensure accuracy, reliability, and effectiveness in the early identification of cardiovascular complications, improving quality of life, and being at the same time cost-effective. 相似文献
36.
Ovidiu Chioncel John Parissis Alexandre Mebazaa Holger Thiele Steffen Desch Johann Bauersachs Veli‐Pekka Harjola Elena‐Laura Antohi Mattia Arrigo Tuvia B. Gal Jelena Celutkiene Sean P. Collins Daniel DeBacker Vlad A. Iliescu Ewa Jankowska Tiny Jaarsma Kalliopi Keramida Mitja Lainscak Lars H Lund Alexander R. Lyon Josep Masip Marco Metra Oscar Miro Andrea Mortara Christian Mueller Wilfried Mullens Maria Nikolaou Massimo Piepoli Susana Price Giuseppe Rosano Antoine Vieillard‐Baron Jean M. Weinstein Stefan D. Anker Gerasimos Filippatos Frank Ruschitzka Andrew J.S. Coats Petar Seferovic 《European journal of heart failure》2020,22(8):1315-1341
Cardiogenic shock (CS) is a complex multifactorial clinical syndrome with extremely high mortality, developing as a continuum, and progressing from the initial insult (underlying cause) to the subsequent occurrence of organ failure and death. There is a large spectrum of CS presentations resulting from the interaction between an acute cardiac insult and a patient's underlying cardiac and overall medical condition. Phenotyping patients with CS may have clinical impact on management because classification would support initiation of appropriate therapies. CS management should consider appropriate organization of the health care services, and therapies must be given to the appropriately selected patients, in a timely manner, whilst avoiding iatrogenic harm. Although several consensus‐driven algorithms have been proposed, CS management remains challenging and substantial investments in research and development have not yielded proof of efficacy and safety for most of the therapies tested, and outcome in this condition remains poor. Future studies should consider the identification of the new pathophysiological targets, and high‐quality translational research should facilitate incorporation of more targeted interventions in clinical research protocols, aimed to improve individual patient outcomes. Designing outcome clinical trials in CS remains particularly challenging in this critical and very costly scenario in cardiology, but information from these trials is imperiously needed to better inform the guidelines and clinical practice. The goal of this review is to summarize the current knowledge concerning the definition, epidemiology, underlying causes, pathophysiology and management of CS based on important lessons from clinical trials and registries, with a focus on improving in‐hospital management. 相似文献
37.
38.
Zois E. Christos Savvas P. Tokmakidis Konstantinos A. Volaklis Kalliopi Kotsa Anna-Maria Touvra Eleni Douda Ioannis G. Yovos 《European journal of applied physiology》2009,106(6):901-907
We studied the effects on blood lipids and physical fitness after a training program that combined strength and aerobic exercise
in postmenopausal women with type 2 diabetes. Ten patients (55.0 ± 5.2 years) followed four exercise sessions per week, two
strength and two aerobic, and ten (59.4 ± 3.2 years) served as a control group. Lipid profile, glycated hemoglobin (HbA1c), HOMA2 index, exercise stress and muscular testing were assessed at the beginning and after 16 weeks of training program.
Exercise training increased significantly HDL-C (17.2%; P < 0.001) and decreased triglycerides (18.9%), HbA1c (15.0%), fasting plasma glucose (5.4%), insulin resistance (HOMA2 25.2%) and resting blood pressure (P < 0.01). After 16 weeks of training, exercise time (17.8%) and muscular strength increased significantly (P < 0.001). The results indicated that a combined strength and aerobic training program could induce positive adaptations on
lipid profile, glycemic control, insulin resistance, cardiovascular function, and physical fitness in post-menopausal women
with type 2 diabetes.
An erratum to this article can be found at 相似文献
39.
Kalliopi N. Manola 《European journal of haematology》2009,83(5):391-405
Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease accounting for 15–20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. This article focuses on the significance of cytogenetic analysis in pediatric AML supporting the importance of cytogenetic analysis in the pathogenesis, diagnosis, prognosis, follow‐up and treatment selection in childhood AML. It reviews in detail the types and frequencies of most common chromosomal aberrations, their molecular background, their correlation with French American British (FAB) subtypes and age distribution and their prognostic relevance. It also summarizes some less frequent or rare chromosome aberrations in which the prognostic classification has not been determined yet owning to the small number of patients and the variable treatment modalities used in different study groups. Furthermore, it discusses the association of specific chromosome rearrangements with prenatal exposure to carcinogenic agents or therapeutic agents and highlights the ongoing and future research on pediatric AML in the evolving field of Cytogenetics. 相似文献
40.
Leptidis G Papanicolaou S Athanassiadi K Zogby H Iordanidou O Katsaris G 《World journal of surgery》2002,26(10):1214-1216
Tracheostomy is frequently required for
the treatment of critically ill patients to prevent the complications
with prolonged translaryngeal intubation. It may facilitate airway
suctioning and improve patient comfort during the process of weaning.
The purpose of the study was to introduce a new modified technique for
percutaneous dilational tracheostomy (MPDT) and assess its advantages.
From November 1997 through December 2000, a series of 600 patients (350
men, 250 women; mean age 44.5 years) underwent MPDT in our department.
The technique we used is a combination of the Seldinger and Schachner
techniques with an incision of 2 to 3 cm between the cricoid cartilage
and the notch. Using a small automatic retractor, the thyroid muscles
were dissected with the help of a curved mosquito clamp. This gave us
the opportunity to control the isthmus and offered the possibility of
ligation when the thyroid was large, providing a good operative field
directly on the trachea. Hence we avoided traumatizing the isthmus,
which is the main source of hemorrhage during this procedure. The mean
operating time was 4.5 minutes. The morbidity rate was 0.04%. One
patient developed a subcutaneous emphysema and in three cases we had to
ligate the external jugular vein. The surgical incision was completely
healed within 3 to 4 days after removing the tracheostoma. No tracheal
stenoses were observed during the follow-up. MPDT is a safe, applicable
technique that can be performed quickly even by a nonsurgeon in the
intensive care unit and emergency department, with a low risk of
complications because there is a direct view of the trachea and minimal
trauma. 相似文献