自主研制新型肩胛颈部解剖锁定钢板的生物力学对比

目的 将自主研制新型肩胛颈部解剖锁定钢板与 Watson 重建接骨板进行生物力学对比分析,观察其生物力学方面的特点及优势。 方法 选取 12 具防腐、湿润的成人肩胛骨尸体标本(男 7 具,女 5 具),造模成肩胛颈骨折(Miller 分型 II B 型)标本,根据取标本的先后顺序及性别随机分为实验组和对照组:实验组采用新型肩胛颈部解剖锁定钢板内固定,对照组采用 Watson 重建接骨板内固定。 将标本安置钢板后在生物力学实验机上分别进行肩胛颈部抗拉伸实验、钢板螺钉抗拔出实验、动态疲劳实验。 通过与实验终端相连接的计算机采集实验数据,并绘制力-位移曲线以及周期-位移曲线。 结果 在肩胛颈部抗拉伸实验中,实验组平均抗拉伸力[(356. 50±32. 19) N]优于对照组[(193. 83±29. 39) N] (P<0. 05)。 在肩胛颈部钢板螺钉抗拔出实验中,实验组平均抗拔出力[( 263. 83±22. 85) N]优于对照组[(135. 50±15. 40) N)](P<0. 05)。 在动态疲劳实验中,300 个周期内实验组平均位移小于对照组(P<0. 05),且均未出现钢板、螺钉断裂松动现象。 结论 自主研制的新型肩胛颈部解剖锁定钢板在抗拉伸、抗拔出、动态疲劳生物力学性能优于重建接骨板,可为临床上治疗肩胛骨颈部骨折提供一种较为理想的内固定系统。     

Emodin inhibiting epithelial-mesenchymal transition in pulmonary fibrosis through the c-MYC/miR-182-5p/ZEB2 axis

Emodin is a natural anthraquinone compound, which is the main component found in the traditional Chinese herb Polygonum cuspidatum. The anti-fibrosis effects of Emodin have been reported. This study aimed to explore the specific mechanism of Emodin in the epithelial-mesenchymal transition (EMT) of pulmonary fibrosis. The pulmonary fibrosis mice models were constructed with bleomycin, the EMT models of alveolar epithelial cells were stimulated by TGF-β1, and Emodin was used for intervention. c-MYC and miR-182-5p were overexpressed or silenced by cell transfection. Our results demonstrated that Emodin attenuated pulmonary fibrosis induced by bleomycin in mice, and inhibited EMT, meanwhile downregulated c-MYC, upregulated miR-182-5p, and downregulated ZEB2 in vitro and vivo. Next, overexpression of c-MYC promoted EMT, while silencing c-MYC and overexpressing miR-182-5p inhibited EMT. Then, c-MYC negatively regulated the expression of miR-182-5p with a direct binding relationship. And miR-182-5p inhibited ZEB2 expression in a targeted manner. Finally, Emodin inhibited EMT that had been promoted by overexpression of c-MYC. In conclusion, Emodin could attenuate pulmonary fibrosis and EMT by regulating the c-MYC/miR-182-5p/ZEB2 axis, which might provide evidence for the application of Emodin in the treatment of pulmonary fibrosis.     

补中益气丸干预气虚质的临床观察

目的 通过补中益气丸干预气虚质人群，改善其症状及健康状况。方法 招募健康气虚体质，随机分为干预组和对照组，应用补中益气丸干预1个月后进行临床疗效观察。结果 用药1个月后，干预组气虚质转化分与对照组相比有明显改善，中医体质量表中其他体质分数有所变化。其中，干预组在干预前后无明显差异，而对照组阳虚质、阴虚质、血瘀质分数较干预前有明显改变，有显著差异。结论 补中益气丸干预气虚体质有明显作用，而气虚体质可以通过中药进行改善和调理。