全文获取类型
收费全文 | 1431篇 |
免费 | 101篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 22篇 |
儿科学 | 33篇 |
妇产科学 | 24篇 |
基础医学 | 132篇 |
口腔科学 | 25篇 |
临床医学 | 101篇 |
内科学 | 283篇 |
皮肤病学 | 52篇 |
神经病学 | 125篇 |
特种医学 | 55篇 |
外科学 | 292篇 |
综合类 | 37篇 |
一般理论 | 2篇 |
预防医学 | 77篇 |
眼科学 | 62篇 |
药学 | 122篇 |
中国医学 | 1篇 |
肿瘤学 | 96篇 |
出版年
2023年 | 11篇 |
2022年 | 22篇 |
2021年 | 47篇 |
2020年 | 26篇 |
2019年 | 48篇 |
2018年 | 42篇 |
2017年 | 35篇 |
2016年 | 33篇 |
2015年 | 49篇 |
2014年 | 64篇 |
2013年 | 91篇 |
2012年 | 123篇 |
2011年 | 107篇 |
2010年 | 63篇 |
2009年 | 49篇 |
2008年 | 80篇 |
2007年 | 73篇 |
2006年 | 65篇 |
2005年 | 72篇 |
2004年 | 77篇 |
2003年 | 61篇 |
2002年 | 48篇 |
2001年 | 31篇 |
2000年 | 32篇 |
1999年 | 19篇 |
1998年 | 7篇 |
1997年 | 6篇 |
1996年 | 9篇 |
1995年 | 4篇 |
1994年 | 2篇 |
1993年 | 4篇 |
1992年 | 27篇 |
1991年 | 18篇 |
1990年 | 14篇 |
1989年 | 13篇 |
1988年 | 9篇 |
1987年 | 10篇 |
1986年 | 4篇 |
1985年 | 2篇 |
1980年 | 3篇 |
1978年 | 2篇 |
1977年 | 8篇 |
1976年 | 3篇 |
1975年 | 4篇 |
1974年 | 4篇 |
1973年 | 4篇 |
1972年 | 5篇 |
1969年 | 2篇 |
1965年 | 1篇 |
1930年 | 1篇 |
排序方式: 共有1541条查询结果,搜索用时 15 毫秒
51.
Sheng-Yu Lee Shiou-Lan Chen Yun-Hsuan Chang Chun-Hsien Chu Shih-Heng Chen Po See Chen San-Yuan Huang Nian-Sheng Tzeng Liang-Jen Wang I Hui Lee Tzu-Yun Wang Kao Chin Chen Yen Kuang Yang Jau-Shyong Hong Ru-Band Lu 《The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)》2015,18(7)
Background:
Low-dose dextromethorphan (DM) might have anti-inflammatory and neurotrophic effects mechanistically remote from an NMDA receptor. In a randomized, double-blind, controlled 12 week study, we investigated whether add-on dextromethorphan reduced cytokine levels and benefitted opioid-dependent patients undergoing methadone maintenance therapy (MMT).Methods:
Patients were randomly assigned to a group: DM60 (60mg/day dextromethorphan; n = 65), DM120 (120mg/day dextromethorphan; n = 65), or placebo (n = 66). Primary outcomes were the methadone dose required, plasma morphine level, and retention in treatment. Plasma tumor necrosis factor (TNF)-α, C-reactive protein, interleukin (IL)-6, IL-8, transforming growth factor–β1, and brain-derived neurotrophic factor (BDNF) levels were examined during weeks 0, 1, 4, 8, and 12. Multiple linear regressions with generalized estimating equation methods were used to examine the therapeutic effect.Results:
After 12 weeks, the DM60 group had significantly longer treatment retention and lower plasma morphine levels than did the placebo group. Plasma TNF-α was significantly decreased in the DM60 group compared to the placebo group. However, changes in plasma cytokine levels, BDNF levels, and the methadone dose required in the three groups were not significantly different.Conclusions:
We provide evidence—decreased concomitant heroin use—of low-dose add-on DM’s efficacy for treating opioid-dependent patients undergoing MMT. 相似文献52.
Luyi Zhou Wei-Lun Sun Amy B. Young Kunhee Lee Jacqueline F. McGinty Ronald E. See 《The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)》2015,18(1)
Background:
Oxytocin, a neurohypophyseal neuropeptide, is a potential mediator and regulator of drug addiction. However, the cellular mechanisms of oxytocin in drug seeking remain unknown.Methods:
In the present study, we used a self-administration/reinstatement model to study the effects of oxytocin on cocaine seeking and its potential interaction with glutamate function at the receptor level.Results:
Systemic oxytocin dose-dependently reduced cocaine self-administration during various schedules of reinforcement, including fixed ratio 1, fixed ratio 5, and progressive ratio. Oxytocin also attenuated reinstatement to cocaine seeking induced by cocaine prime or conditioned cues. Western-blot analysis indicated that oxytocin increased phosphorylation of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunit at the Ser 845 site with or without accompanying increases in phosphorylation of extracellular signal-regulated kinase, in several brain regions, including the prefrontal cortex, bed nucleus of the stria terminalis, amygdala, and dorsal hippocampus. Immunoprecipitation of oxytocin receptor and GluA1 subunit receptors further demonstrated a physical interaction between these 2 receptors, although the interaction was not influenced by chronic cocaine or oxytocin treatment. Oxytocin also attenuated sucrose seeking in a GluA1- or extracellular-signal-regulated kinase-independent manner.Conclusions:
These findings suggest that oxytocin mediates cocaine seeking through interacting with glutamate receptor systems via second messenger cascades in mesocorticolimbic regions. 相似文献53.
Abdulkarim AS Burgart LJ See J Murray JA 《The American journal of gastroenterology》2002,97(8):2016-2021
OBJECTIVES: Nonresponse or relapse of symptoms is common in patients with celiac disease treated with gluten free diet. Refractory sprue (RS) is defined as initial or subsequent failure of a strict gluten-free diet to restore normal intestinal architecture and function in patients who have celiac-like enteropathy. The aims of this study were: 1) to identify causes of persistent symptoms in patients referred with presumed diagnosis of nonresponsive celiac disease (NCD); and 2) to characterize patients with true RS. METHODS: Patients were identified who had been systematically evaluated for NCD between January 1997, and May 2001. Patient records and small bowel biopsy results were reviewed. RESULTS: A total of 55 patients were referred with a presumed diagnosis of NCD. Six did not have celiac disease and had other diseases responsible for their symptoms. Diarrhea, abdominal pain, and weight loss were the most common reasons for evaluation in cases of NCD, whereas weight loss, steatorrhea, and diarrhea were the most common presenting features of RS (nine patients). Of the 49 patients with celiac disease, 25 were identified as having gluten contamination. Additional diagnoses accounting for persistent symptoms included: pancreatic insufficiency, irritable bowel syndrome, bacterial overgrowth, lymphocytic colitis, collagenous colitis, ulcerative jejunitis, T-cell lymphoma, pancreatic cancer, fructose intolerance, protein losing enteropathy, cavitating lymphadenopathy syndrome, and tropical sprue. CONCLUSIONS: Based on this study, we conclude the following: 1) gluten contamination is the leading reason for NCD; 2) of NCD cases, 18% are due to RS; and 3) alternative diseases or those coexistent with celiac disease and gluten contamination should be ruled out before a diagnosis of RS is made. 相似文献
54.
Prevalence of malnutrition,obesity and nutritional risk of Australian paediatric inpatients: A national one‐day snapshot
下载免费PDF全文
![点击此处可从《Journal of paediatrics and child health》网站下载免费的PDF全文](/ch/ext_images/free.gif)
55.
Left atrial thrombus two years after placement of a left atrial appendage closure device: Unexplored area of the Watchman
下载免费PDF全文
![点击此处可从《Pacing and clinical electrophysiology : PACE》网站下载免费的PDF全文](/ch/ext_images/free.gif)
David H Yoo MD Brian Clark MD Daniel Nguyen MD Timm‐Michael Dickfeld MD PhD Andrew S Zohlman MD Libin Wang MD Vincent Y See MD 《Pacing and clinical electrophysiology : PACE》2018,41(7):870-871
A 72‐year‐old man who underwent a left atrial appendage (LAA) closure device 2 years ago presented with atrial flutter with rapid ventricular rate and was referred for cardioversion. Precardioversion transesophageal echocardiogram showed left atrial thrombus and therefore the procedure was aborted. Currently, there is no guideline on imaging surveillance or anticoagulation in patients with LAA closure device who develop intracardiac thrombus after the initial 6‐month surveillance period. 相似文献
56.
57.
58.
Brian Miller MD Rama Vunnam MD Olurotimi Mesubi MD Mark F. Smith PhD Wengen Chen MD Jagat Bandhu Mahat MD Soren M. Bentzen D.M.Sc PhD Vincent See MD Alejandro Restrepo MD Stephen Shorofsky MD PhD Vasken Dilsizian MD Timm-Michael L. Dickfeld MD PhD 《Journal of cardiovascular electrophysiology》2021,32(8):2238-2245
59.
Dietary factors associated with hyperuricemia in adults 总被引:1,自引:0,他引:1
OBJECTIVES: Although diet has long been assumed to be associated with hyperuricemia, the association between diet and hyperuricemia remains to be verified. METHODS: The Nutrition and Health Survey in Taiwan (NAHSIT) implemented between 1993 and 1996 was a nationwide survey using a stratified multistage sampling design. A food frequency questionnaire (FFQ), 24-hour diet recall, and blood samples were utilized. Hyperuricemia was defined as serum urate >7.7 mg/dL for men and >6.6 mg/dL for women. RESULTS: In total, 2176 adults, 987 (45%) men and 1189 (55%) women, were recruited. Mean serum urate was 6.81 +/- 1.66 mg/dL (range, 2.5-16.8 mg/dL) and 5.47 +/- 1.55 mg/dL (range, 1.4-11.5 mg/dL) for men and women, respectively. Multiple logistic regression analysis indicated that beer consumption in both the FFQ and the 24-hour diet recall were significantly associated with hyperuricemia in men after adjusting for age, total caloric intake, body mass index, and geographic area. In FFQ, the adjusted odds ratio was 1.49 for men who imbibed 0.1 to 11.6 g ethanol (<1 standard drink) daily and 1.56 for men who imbibed > or =11.7 g ethanol (> or =1 standard drink) daily, when compared with that for men who did not drink beer (P = 0.035). In the 24-hour diet recall, the adjusted odds ratio for men who drank <5 cans of beer daily was 1.13, and for men who drank > or =5 cans daily was 1.28 when compared with that for men who did not drink beer (P = 0.003). CONCLUSIONS: This cross-sectional survey demonstrated that beer intake is independently associated with increased risk of hyperuricemia in men. Restricted beer intake may help prevent hyperuricemia in the population. The finding of elevated mean serum urate levels over recent decades warrants further study. 相似文献
60.
Hui Hua Chang Mei Hung Chi I Hui Lee Hsin Chun Tsai Po Wu Gean Yen Kuang Yang Ru-Band Lu Po See Chen 《Journal of affective disorders》2013