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51.
Pavlak M Stojković R Radacić-Aumiler M Kasnar-Samprec J Jercić J Vlahović K Zinić B Radacić M 《Journal of cancer research and clinical oncology》2005,131(12):829-836
Purpose: The purpose of this study was to investigate in vivo antitumor activity of newly synthesized N-sulfonylpyrimidine derivatives 1-(p-toluenesulfonyl)cytosine (4H), 1-(p-toluenesulfonyl)cytosine hydrochloride (4H×HCl) and zinc(II) complex of 1-(p-toluenesulfonyl)cytosine (4K). Materials and methods: In order to do that we have used mouse anaplastic mammary carcinoma (AMCa). Tumor cells (106) in a volume of 0.02 ml were transplanted into the thigh of the right hind leg of CBA mice. All compounds were dissolved
in distilled water immediately before injecting to animals. Results: Antitumor effect of these compounds depends on drug doses and time interval between tumor transplantation and drug application.
Further the efficacy of these compounds depends on number of drug injections, i. e. whether drug was given in single or in
multiple doses. Multiple doses of 400 mg/kg of 1-(p-toluenesulfonyl)cytosine (4H) showed good antitumor effect when applied on day 1, 3, 5, 7 and 9 after tumor transplantation.
Still good but slightly lower antitumor effect was also achieved when that compound was given in a single dose (1,200 mg/kg)
on day 1 after tumor transplantation. The longest period of tumor growth time was obtained after application of 1-(p-toluenesulfonyl)cytosine hydrochloride (4H×HCl) given as a single dose (300 mg/kg) on day 1 or on day 6 after tumor implantation.
However, antitumor effect of zinc(II) complex of 1-(p-toluenesulfonyl)cytosine (4K) was very strong when 300 mg/kg was given on day 1 or day 6, while this effect was slightly
lower when drug (200 mg/kg/inj) was given on day 1, 3, 5, 7 and 9 or on day 6, 8, 10, 12 and 14. Conclusion: In this work it has been found that N-1-sulfonylcytosine derivatives have strong antitumor activity against mouse mammary carcinoma which is a good reason for
further research of these compounds both in experimental and preclinical studies. 相似文献
52.
Kadir Serafettin Tekgunduz Mustafa Kara Ibrahim Caner Yasar Demirelli 《Iranian journal of pediatrics.》2015,25(4)
Background:
Although it is well described among adults, intravenous colistin use and its associated toxicities in newborns are poorly understood.Objectives:
We present our experience of efficacy and safety of intravenous colistin in the treatment of sepsis in term and preterm neonates.Patients and Methods:
The records of neonates who received colistin between January 2013 and February 2014 were retrospectively reviewed. All neonates with culture proven nosocomial infections due to multidrug resistant organisms and treated continuously with colistin for more than 72 hours were included in the study.Results:
Patients were evaluated for clinical and microbiological response to the drug and its and side effects. Twelve newborn infants with mean 31.8 ± 3.5 weeks gestational age and median 1482 (810 - 3200) gram birth weight were included. 11/12 (91.7%) patients showed microbiological clearance with intravenous colistin. One patient who had recurrent cerebrospinal fluid positive culture was treated with intraventricular colistin. The major side effects observed was hyponatremia and hypokalemia in 2 (16.6%) patients, all infants required magnesium supplementation.Conclusions:
Intravenous colistin administration appears to be safe and efficacious for multidrug-resistant gram-negative infections in neonates, including preterm infants. However, we believe that large prospective controlled studies are needed to confirm its efficacy and safety in neonates. 相似文献53.
Serpil Türkleş Mualla Yılmaz Pınar Soylu 《Collegian (Royal College of Nursing, Australia)》2018,25(4):441-446
Background
It is of the utmost importance to determine the views of nurses about patients with suicidal behavior and who attempt suicide so that they can help such individuals.Aim
The aim of this study was to investigate the feelings, thoughts and experiences of nurses working in a mental health clinic regarding individuals with suicidal behaviors and suicide attempts.Methods
A qualitative study design was employed. Data in this research study were collected through individual in-depth interviews. The study population included 121 nurses working at a Mental Health and Diseases Hospital in Turkey. The study sample consisted of 33 nurses who had been working at the hospital for at least one year, had experience working with patients who attempted suicide, and agreed to participate in the study.Results
The nurses understood the patients; they experienced sadness, worry, anxiety, stress, unrest and fear; they were blamed by the hospital administration when a patient committed suicide; they blamed themselves and doctors for patient suicides; and they had developed proposals to prevent suicide among hospitalized or discharged patients. The nurses also stated that patients committed suicide in the evening or in the early hours of the morning by strangling or hanging themselves or by shocking and unforeseen methods, although the nurses performed the necessary emergency intervention procedures.Conclusion
It is recommended that planned group meetings for nurses be arranged and that follow-up guidelines/protocols for patients with suicidal tendencies who are residing in mental health clinics be prepared by a committee of healthcare professionals. 相似文献54.
Niels?Egholm?PedersenEmail author Lars?Simon?Rasmussen John?Asger?Petersen Thomas?Alexander?Gerds Doris??stergaard Anne?Lippert 《Journal of clinical monitoring and computing》2018,32(1):109-116
The national early warning score (NEWS) is recommended to detect deterioration in hospitalised patients. In 2013, a NEWS-based system was introduced in a hospital service with over 250,000 annual admissions, generating large amounts of NEWS data. The quality of such data has not been described. We critically assessed NEWS data recorded over 12 months. This observational study included NEWS records from adult inpatients hospitalized in the Capital Region of Denmark during 2014. Physiological variables and the use of supplementary oxygen (NEWS variables) were recorded. We identified implausible records and assessed the distributions of NEWS variable values. Of 2,835,331 NEWS records, 271,103 (10%) were incomplete with one or more variable missing and 0.2% of records containing implausible values. Digit preferences were identified for respiratory rate, supplementation oxygen flow, pulse rate, and systolic blood pressure. There was an accumulation of pulse rate records below 91 beats per minute. Among complete NEWS records, 64% had NEWS?≥?1; 29% had NEWS?≥?3; and 8% had NEWS?≥?6. In a large set of NEWS data, 10% of the records were incomplete. In a system where data were manually entered into an electronic medical record, digit preferences and the accumulation of pulse rate records below 91 beats per minute, which is the limit for NEWS point generation, showed that staff practice influenced the recorded values. This indicates a potential limitation of transferability of research results obtained in such systems to fully automated systems. 相似文献
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58.
Rohde Sofie Muslem Rahatullah Kaya Emrah Dalinghaus Michel van Waning Jaap I. Majoor-Krakauer Danielle Towbin Jeffery Caliskan Kadir 《Heart failure reviews》2022,27(1):15-28
Heart Failure Reviews - Noncompaction cardiomyopathy (NCCM) is a disease characterized by hypertrabeculation, commonly hypothesized due to an arrest in compaction during fetal development. In 2006,... 相似文献
59.
Cevdet?Erd?lEmail author ?ükrü??elik Merih?Baykan 《The International journal of angiology》2003,12(4):213-218
Stenting is a safe and efficient method for treatment of ischaemic heart disease. Nevertheless, it gives rise to some additional problems, especially in-stent restenosis. Several techniques including balloon angioplasty, restenting, rotaablation, excimer laser angioplasty, directional coronary atherectomy, cutting balloon angioplasty, brachitherapy and radioactive stents have been performed to treat in-stent restenosis. Balloon angioplasty is preferred in focal lesions (<10 mm). Restenting can be used only in selective cases. The clinical results of debulking techniques associated with balloon angioplasty in patients with long lesions are better especially in diabetic patients. In addition to these procedures, coronary bypass surgery in patients in-stent restenosis with multivessel disease seems to yield to best outcomes. On the other hand, current smoking, diabetes mellitus, unstable angina pectoris, and time to reintervention and in-stent restenosis in saphenous vein lesions are important negative predictors for re-restenosis. The main goal of the treatment of in-stent restenosis is the prevention of the restenosis. Unless this problem is solved the newer techniques will develop, and they will also carry on the newer problems. 相似文献
60.
Sung-Ho Huh Katja N?rhi P?ivi H. Lindfors Otso H??r? Lu Yang David M. Ornitz Marja L. Mikkola 《Genes & development》2013,27(4):450-458
In hair follicle development, a placode-derived signal is believed to induce formation of the dermal condensation, an essential component of ectodermal organs. However, the identity of this signal is unknown. Furthermore, although induction and patterning of hair follicles are intimately linked, it is not known whether the mesenchymal condensation is necessary for inducing the initial epithelial pattern. Here, we show that fibroblast growth factor 20 (Fgf20) is expressed in hair placodes and is induced by and functions downstream from epithelial ectodysplasin (Eda)/Edar and Wnt/β-Catenin signaling to initiate formation of the underlying dermal condensation. Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles and subsequent formation of guard, awl, and auchene hairs. Although primary dermal condensations are absent in Fgf20 mutant mice, a regular array of hair placodes is formed, demonstrating that the epithelial patterning process is independent of known histological and molecular markers of underlying mesenchymal patterns during the initial stages of hair follicle development. 相似文献