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排序方式: 共有533条查询结果,搜索用时 15 毫秒
501.
502.
Platelet-activating factor and arachidonic acid metabolites in psoriatic inflammation 总被引:2,自引:0,他引:2
S. IZAKI T. YAMAMOTO Y. GOTO S. ISHIMARU F. YUDATE K. KITAMURA M. MATSUZAKI 《The British journal of dermatology》1996,134(6):1060-1064
Platelet-activating factor (PAF). as wel as PAF acetylhydrolase (PAF-AH) activity in the peripheral blood plasma of patients with psoriasis and palmoplantar pustolosis, was measured with a radio-immunoassay technique, and compared with leukotriene (LT) B4. LTC4. LTD4, and E4, (LTD4/E4). thromboxane (TX) B2 and prostaglandin (PG) E2 levels. In a normal healthy group (n= 1 2) PAF level was 25.9 ± 6.5 pg/0.1 ml plasma (mean ± standard error of the mean: SEM). and this was elevated in patients with psoriasis (68.1 ± 11.8, n= 25. P<0.01), without a change in the PAF-AH level. LTB4 showed a similar increase (115.0 ± 21.6 pg/ml vs. 68.2 ± 11.8 pg/ml. P < 0.05), while TXB2, and PGE2 showed insignificant (P > 0.05) changes. LTC4 and LTE4/E4 were around the level of the limit of detection. Patients with palmoplantar pustulosis (n= 33) demonstrated similar, but milder and statistically insignificant, increases in PAF. LTB4. TXB2 and PGF2 levels. Modulation of the mediator levels before and after treatment was compared in 16 patients with psoriasis and 11 with palmoplantar pustulosis. PAF in psoriasis significantly decreased after treatment (70.9 ± 17.1 to 25.1 ± 5.5, P < 0.05) and this was moderately correlated (r= 0.298) with clinical improvement as indicated by the psoriasis area and severity index (38.5 ± 7.5 to 10.9 ± 4.2. P < 0.01). TXB2. (180.2 + 100.4 to 34.1 ± 13.5). PGF2 (3.7 ± 0.7 to 2.9 ± 0.5) and LTB4 (120.1 + 31.1 to 84.2 + 8.2). in psoriasis, mildly decreased without statistical significance. Patients with palmoplantar pustulosis demonstrated a similar decrease in all mediators without statistical significance. The results obtained suggest a role of PAF in psoriasis. As the priming effects of PAF have been shown, for leucocytes and endothelial cells, to enhance their inflammatory response, we assume that PAF has roles in the acute phase of osoriatic and leucotactic inflammation. 相似文献
503.
S. TSUDA Y. MAEYAMA N. YAMAMOTO Y. SASAI K. YOSHIDA 《Clinical and experimental dermatology》1996,21(2):141-144
We report a patient with secondary systemic amyloidosis complicating arthropathic psoriasis, At autopsy amyloidosis was observed in the spleen, kidneys, liver, gastrointestinal tract, lung, heart, pancreas, adrenal glands, thyroid and gall-bladder in addition to the skin by historical, histochemical and ultrastructural studies. The amyloid deposits in these organs were of amyloid A protein type. 相似文献
504.
Tadashi SATO Masayuki A. FUJINO Masahiro IKEDA Masazumi TAKEKAWA Toshiya NAKAMURA Hirokuni TACHIKAWA Tadashi KINOSE Takao AINOTA Yoshiki MIYAZAKI Yasuyuki YAMAMOTO Yoshihiro AKAHANE Hiroshi SUZUKI Katsuhiko SUGAHARA Akira KAWAOI 《Digestive endoscopy》1990,2(2):195-200
Abstract: A 63-year-old female with von Recklinghausen's disease was referred to us because of intermittent periumbilical pain and vomiting. Abdominal ultrasonography showed a segment of the bowel with intussusception in the left ripper quadrant. After intestinal decompression, small-intestinal endoscopy was performed. Endoscopy revealed multiple protruding lesions in the esophagus, stomach, and jejunum, the largest one markedly stenosing the proximal jejunum. We were able to identify a tumor as the lead point preoperatively. Segmental jejunectomy was performed for the resection of the tumor. Pathological studies revealed that the tumor was leiomyosarcoma. Gastrointestinal involvement is well documented in von Recklinghausen 's disease. Thus attention should be paid to gastrointestinal involvement in the management of these patients. The present case had intussusception, a rare complication of von Recklinghausen 's disease. Svnall-intestinal Endoscopy played an essential vole in the diagnosis of gastrointestinal involvement in our patient. 相似文献
505.
KIMIHIDE NAKAMURA MASASHI YONEDA ATSUSHI KIMURA KEISUKE TAMORI SHIRO YOKOHAMA YOICHI SATO TAKAFUMI KATO TAKENAO HASEGAWA HIDEAKI SAITO MASARU AOSHIMA MASANORI FUJITA ISAO MAKINO 《Journal of gastroenterology and hepatology》1996,11(4):385-390
The present study was undertaken in order to investigate the influence of ursodeoxycholic acid (UDCA) on the composition of sulfate-conjugated bile acids in the serum and urine of patients with chronic active hepatitis and compensated liver cirrhosis. After a 12 week UDCA treatment (600 mg/day), total serum bile acid concentration increased two-fold in patients with compensated liver cirrhosis and increased slightly in patients with chronic active hepatitis. The percentage of sulfated bile acids significantly increased in patients with both compensated liver cirrhosis and chronic active hepatitis. UDCA made up 63% of the total serum bile acids in compensated liver cirrhosis and 61% in chronic active hepatitis after UDCA treatment. Of the serum bile acids after UDCA treatment, 35.2 and 53.9% of UDCA was sulfate conjugated in compensated liver cirrhosis and chronic active hepatitis, respectively. Urinary excretion of total bile acid and UDCA after UDCA treatment in compensated liver cirrhosis were higher than in chronic active hepatitis. UDCA made up 68% of the total urinary bile acids in compensated liver cirrhosis and 64% in chronic active hepatitis after UDCA treatment. Of the urinary bile acids after UDCA treatment, 51.8 and 54.8% of UDCA was sulfate conjugated in compensated liver cirrhosis and chronic active hepatitis, respectively. UDCA treatment for compensated liver cirrhosis was less effective than for chronic active hepatitis. We found that sulfate conjugation is one of the major metabolic pathways for UDCA after UDCA treatment in chronic liver diseases. 相似文献
506.
YASUKI HABU HIDETO INOKUCHI KEISUKE KIYOTA KYOHEI HAYASHI YOSHIYUKI WATANABE KEIICHI KAWAI NILS-OLOV STLHAMMAR 《Journal of gastroenterology and hepatology》1998,13(3):280-287
To evaluate the socio-economic effects of Helicobacter pylori eradication in the treatment of duodenal ulcer disease in Japan, a clinical decision analysis was performed to assess H. pylori eradication therapy compared with the conventional strategy of maintenance with histamine-2 receptor antagonists. A decision tree-based state transition model (Markov chain approach) implemented to simulate a 5 year period of follow up was constructed. The H. pylori eradication strategy was found to be superior to the conventional maintenance strategy with regard to clinical effectiveness and other dimensions of a patient’s outcome. Furthermore, in a long-term perspective, the eradication strategy was less costly than the maintenance strategy. Helicobacter pylori eradication should be recommended as the ?rst choice treatment of H. pylori-positive duodenal ulcer patients. The clinical implication of H. pylori eradication entails an improvement in clinical effectiveness and other dimensions of a patient’s outcome and a signi?cant reduction in the costs of duodenal ulcer treatment. The long-term total costs do not depend on the initial drug cost of an eradication regimen. Pursuing a high eradication rate of H. pylori is essential in improving the patient’s outcome and the cost-effectiveness of treatment. 相似文献
507.
Nonfluoroscopic Guidance for Catheter Placement into the Coronary Sinus under Direct Vision Using a Balloon-Tipped Cardioscope 总被引:1,自引:0,他引:1
NAOHITO YAMAMOTO KENZO HIRAO NOBUO TOSHIDA HIROKO NAWATA FUMIO SUZUKI NOBUYUKI MIYASAKA KAZUMASA HIEJIMA† 《Pacing and clinical electrophysiology : PACE》1998,21(9):1724-1729
The right atrial posterior septum, including the coronary sinus (CS) ostium, is an important landmark in radio frequency catheter ablation therapy for supraventricular tachycardia or atrial flutter. The anatomical findings around the CS ostium would be useful to determine a target site or line during catheter ablation. The aim of the study was to test the ability of the imaging catheter to identify structures in the posterior septal area of the right atrium and to evaluate the feasibility of guidance for catheter placement in the CS using a cardiosccpe that we recently developed. In 12 anesthetized dogs, the Cardioscope, consisting of a deflectable 7 Fr fiberoptic endoscope with an inflatable and transparent balloon, was introduced into the right atrium via the femoral vein. The cardioscope was manipulated to observe the right atrial posterior septum. A deflectable electrode catheter was inserted via the jugular vein and positioned in the CS under cardioscopic guidance. In 10 of 12 dogs, the right atrial posterior septum, including the CS ostium, and the tendon of Todaro could be anatomically identified by cardioscopy. It was possible to position an electrode catheter in the CS in all 10 dogs under direct vision without fluoroscopy. But the CS ostium could not be detected in the remaining two dogs, although the cardioscope was placed at as many sites as possible. No complication occurred. The balloon-tipped cardioscope appears to be useful in observing the right atrial posterior septum and in guiding an electrode catheter into the CS. 相似文献
508.
H. SUZUKI H. FRANZ† T. YAMAMOTO Y. IWASAKI H. KONNO 《Neuropathology and applied neurobiology》1988,14(3):221-227
Mistletoe lectin-1 (ML-1) and Ricinus communis agglutinin-120 (RCA-1) both possess D-galactose-specific surface-binding sites. They were used to selectively identify microglial populations in aldehyde-fixed normal brain tissue by lectin immunohistochemistry on paraffin and frozen sections. Mistletoe lectin-1 was superior to RCA-1 in labelling microglia in the rat brain, whereas RCA-1 labelled human microglia better than ML-1. Thus, RCA-1 and ML-1 supplement each other for identifying microglial in human and rodent central nervous system tissues. The high reproducibility of the results and the applicability of the technique to routine histology, using formalin-fixed tissue, should facilitate study of the histogenesis and role of microglia in the CNS. 相似文献
509.
510.
A. ISHIKAWA K. FUKAO E. TANAKA K. TSUJI A. OSADA Y. YAMAMOTO T. KIYOSAWA Y. IWASAKI 《Journal of gastroenterology and hepatology》1991,6(4):363-367
The quantitative estimation of the hepatic functional volume in rats was attempted using the serum dimethadione (DMO)/trimethadione (TMO) ratio in a single blood sampling after oral administration of TMO, which we call the TMO tolerance test, in order to develop a means of pre-operatively assessing hepatic resectability. Serum DMO/TMO ratios correlated well with the total amount of the hepatic microsomal TMO-N-demethylase activity (enzyme activity) and with the remnant liver weight after 37% and 68% partial hepatectomy. These ratios increased after partial hepatectomy in parallel with the changes in the enzyme activity and the remnant liver weight. The results suggest that the quantitative functional changes of the remnant liver after hepatectomy in both CCl4-treated and untreated rats can be estimated pre-operatively by the TMO tolerance test. 相似文献