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61.
62.
Radiation-Induced Colo-rectal Carcinoma -- A Report of Seven Cases --   总被引:1,自引:0,他引:1  
Seven cases of colo-rectal carcinoma which were considered tohave developed secondarily to radiation injuries are reported.The incidence in our series was 0.8% (seven out of 880 primarycolo-rectal carcinomas). Initial diseases, the targets of radiotherapy,were five carcinomas of the uterine cervix, one of the cecum,and one of the vulva. The latent period, the interval between the initiation of irradiationand the detection of colo-rectal carcinoma, varied from 16 to21 years with an average of 18 years. Late radiation injuries were confirmed histologically in thesegments of the resected bowel involved in all cases. Postoperativecomplications were highly related to the radiation injuriesof the urinary bladder, macrohematuria in two and vesical fistulain three. Among the seven patients, four died within five years and threemonths, two of postoperative complications and two of recurrenceof the disease; the other three are alive and well without evidenceof disease, for three years and seven months, three years andthree months, and 11 months, respectively.  相似文献   
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64.
Abstract A 3-year-old boy was admitted for yellowish discharge from a tiny opening in the midline prepubic area on the dorsal base of the penis. No other symptom related to the genitourinary tract was noted. Sinuousgraphy showed a non-communicating sinus tract with the urinary tract. At surgical exploration, through a diamond-shaped incision, a 4.5 cm-long sinus was found that ended blindly as a fibrous cord at the anterior surface of the pubic symphisis. Histologically, it was lined by stratified squamous epithelium and surrounded by bundles of smooth muscle and collagen. According to Stephens' classification, the sinus appears to be a variant of dorsal urethral duplication of Stephens type 3.  相似文献   
65.
We report a 16-year 8-month-old girl with neuroblastoma (stageIII) who received surgery for abdominal masses four times duringa 52-month period. She is now treated with oral administrationof cyclophosphamide (2 mg/kg) and is in good condition eventhough she has several metastatic lesions. In this paper, we consider why a 16-year-old girl with a tumorof estimated stage III has had a long survival period of 52months. There seem to be three interesting points related toher long survival. The first is that the tumor response to thetreatments was good, particularly to a large dose of cyclophosphamide.The second is the histological observation of the tumor specimensobtained at four different occasions from the same or differentportions. The immature tumor cells of the primary tumor changedto ganglioneuroma during the first 30-month period, but thenewly appearing metastatic lymphnodes were histologically neuroblastoma.The third is her immunological condition during treatment. Thefact that her nonspecific humoral and cellular immune competenceremained in good condition seems to be a factor favorable forher good prognosis.  相似文献   
66.
Abstract The c-K-ras 2 gene mutations were examined in colorectal tumours from patients with synchronous or metachronous tumours in order to investigate tumorigenesis. Sixty-seven colorectal carcinomas from patients with a single lesion, 50 from patients with synchronous lesions, and 12 from patients with metachronous lesions were analysed for the presence of point mutations in codons 12 and 13 of c-K-ras proto-oncogene. In the patients with metachronous or synchronous lesions, the finding of the mutation in one tumour was not associated with a greater frequency of the mutation in other carcinomas from the same patient. In the patients with tumours that each contained the mutation, the mutations were not always the same. In tumours from the patients with original and synchronous lesions, the mutation frequency was significantly lower in advanced carcinomas invading through the entire muscularis propria (10.5%) than in early carcinomas confined to the mucosa (47.8%), and the mutation frequency in carcinomas invading through the entire muscularis propria was significantly lower in patients with synchronous lesions (10.5%) than in patients with a single lesion (37.7%). These results suggest that the tumorigenesis of colorectal carcinomas from patients with synchronous lesions is different from that in patients with a single lesion.  相似文献   
67.
A protocol was drawn up and a prospective randomized study wascarried out to test the effectiveness of BCG on lung cancer.BCG obtained from the Japan BCG Institute was used. A dose of5.4 mg or 2–4 x 108 viable organisms was administeredinto the arm by the tine technique. Administration of BCG wascarried out once before surgery and four times after surgery.Surgery consisted basically of radical lobectomy or pneumonectomywith complete mediastinal lymphadenectomy. The survival rate in the BCG administered group was significantly(P < 0.05) more than in the control group. Further, whenonly the cases that were treated strictly in accordance withthe protocol were taken into consideration, the effectivenessof BCG was even more significant (P < 0.02). The period ofobservation of these cases was from a minimum of 10 months toa maximum of 28 months. On the basis of these results, it can be said that BCG is beneficialin the treatment of lung cancer.  相似文献   
68.
Polypectomy was conducted under rectoscopic observation fora patient with a small rectal polypoid cancer (mucosal cancer)on an outpatient treatment basis. The serum carcinoembryonicantigen (CEA) level, which had been high before the polypectomy,was reduced and complete cure seemed to have been attained.However, the postoperative serum CEA level at the patient'speriodical check-up proved to be abnormally high, and a closerexamination revealed a small pulmonary metastasis. Eight monthsafter the polypectomy, the metastatic focus in the lung wasresected curatively and the serum CEA level returned to normal.It was verified by immunofluorescence that the tissues in themetastatic focus were CEA-productive. As the pulmonary metastasis, which is extremely rare in thecases of early cancers, could be detected at its early stageby the periodical check of the serum CEA level, and as the serumCEA level could be returned to normal by resection of the metastaticfocus, it was thought that the resection was curative.  相似文献   
69.
BACKGROUND: The purpose of the present study was to establish the normal values of flow propagation velocity (FPV) in healthy children and examine the variables that affect FPV in clinical situations. METHODS: Two hundred and thirty- five healthy children and adolescents were assessed (aged 0-22.6 years, mean age 7.4 +/- 5.4 years; male, n = 142; female, n = 93). FPV was obtained from an apical four-chamber view and determined as the slope of aliasing velocity of early diastolic transmitral flow on the color M-mode using Aloka SSD-5500 with 5.0 MHz transducer. Aliasing velocity was set at 50-70% of the peak transmitral flow velocity. Peak transmitral flow velocities in early diastole (E) and during atrial contraction (A), and the ratio of early to late peak velocity (E/A) were obtained. Tei index was also measured for analysis of general left ventricular performance. Left ventricular mass index (LVMI) was obtained from conventional echo measurement. E, E/A, Tei index and LVMI were compared with FPV in healthy subjects. RESULTS: FPV obtained from all subjects ranged from 23.7 to 96.0 cm/s (61.3 +/- 13.6 cm/s). Normal value of FPV was less dependent on age, body size, heart rate and left ventricular dimension. In contrast, although there was no significant correlation between FPV and ejection fraction, statistically significant correlation was found between FPV, LVMI (P = 0.0008) and Tei index (P = 0.025). CONCLUSIONS: FPV is independent of age, body size and heart rate and is useful to assess left ventricular relaxation in children.  相似文献   
70.
Up to now sigmoid colostomy has been a widely accepted and conventionaltreatment for the radiation-injured rectum, but patients withoutresidual malignancy strongly desire to live without a colostomy.We have tried to remove the involved rectal segments by sphincter-savingprocedures. Four patients underwent these procedures, pull-throughprocedure in three and low anterior resection in one. Amongsphincter-saving procedures, the pull-through procedure wasthe most adequate. Provided the following five conditions are fulfilled, the pull-throughprocedure should be considered for the severely radiation-injuredrectum.
  1. No recurrence of the initial malignancy in the pelvis.
  2. Preferably,a more than 2 cm intact rectal segment above thedentate linepreserved.
  3. No radiation-injured segment in the upper sigmoid.
  4. No severe radiation damage in the small intestine.
  5. Normalanal function.
  相似文献   
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