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51.
52.
MITSUKO MAKINO TETSUFUMI KOGA KEIICHI ITO HARUMI KAWADA KEIICHI TABATA 《The Journal of pharmacy and pharmacology》1998,50(8):943-948
It has been suggested that there is a close relationship between Helicobacter pylori and the onset or recurrence of gastroduodenal disease. The aim of this study was to examine the effect of H. pylori on the healing of chronic gastric ulcers induced in mice. H. pylori administered to nude mice delayed the healing of experimental acetic acid-induced gastric ulcers. Histological examination showed the occurrence of high densities of H. pylori on the surface of epithelial cells and in the ulcerated area. Repeated administration of amoxicillin (10 mg kg ?1 daily for 5 days) eradicated H. pylori and increased the rate of healing of gastric ulcers in H. pylori-infected mice, but metronidazole, which also eradicated the organisms, did not significantly affect the rate of healing. In conclusion, H. pylori-infection delayed the healing of gastric ulcers induced by the serosal application of acetic acid in mice, possibly by aggravation or prolongation of the mucosal inflammation. Amoxicillin eradicated H. pylori and promoted gastric ulcer healing in mice infected with H. pylori. 相似文献
53.
TAKESHI AZUMA YASUSHI MAGAMI YASUKI HABU KEIICHI KAWAI R. THOMAS TAGGART JOHN H. WALSH 《Journal of gastroenterology and hepatology》1990,5(5):525-529
Recently, carboxyl terminal glycine extended progastrin (gastrin-G), the immediate biosynthetic precursor of amidated gastrin, was found in human gastric antral mucosa. To investigate in pathophysiological conditions, we examined gastrin and gastrin-G levels and their molecular forms in gastric antral mucosa of healthy controls and patients with gastric or duodenal ulcer and in gastrinomas. There were no significant differences between controls and gastric or duodenal ulcer patients in antral gastrin and gastrin-G levels, the ratio of gastrin-G to gastrin and the pattern of their molecular forms. In contrast, gastrin and gastrin-G levels and the ratio of gastrin-G to gastrin in gastrinomas were much higher than those in antral mucosa of controls or ulcer patients. The predominant molecular form of gastrin-G was different between two Zollinger-Ellison syndrome (ZES) cases. These results suggest that there are no significant differences between healthy controls and patients with gastric or duodenal ulcer in the nature of gastrin amidation, and that the nature of gastrin amination in gastrinomas is different from that in normal gastrointestinal tissues. 相似文献
54.
KEIICHI KAWAI M.D. F.A.C.G. YOSHIHIRO KOHLI M.D. † 《The American journal of gastroenterology》1975,63(1):20-28
Among 192 cases of duodenal ulcers and ulcer scars, which were endoscopically observed in the last three years, complete healing was observed in 109 cases. Study of the data in these cases by computer indicates that the healing tendency of duodenal ulcer is poorer with advancing age. It is less in a linear ulcer than in a round or irregularly shaped one and worse in an ulcer without marginal swelling than in one with it. Shape, number, distribution of lesions and degree of radiological deformity of duodenal cap are of no use in prognosis. Ulcer scars with redness or converged folds, however, are apt to relapse. 相似文献
55.
MASAHIRO IWABUCHI NOBUO HIWATASHI TATSUHIKO SUZUKI SHIN TESHIMA TOSHIHIRO SAITO HIROYOSHI SUZUKI YOSHIMASA MORI JUNICHI ISHIBASHI NOBUYUKI CHIDA KEIICHI TADOKORO 《Digestive endoscopy》2002,14(2):73-77
We present a rare case of multiple colonic metastases from advanced gastric cancer presenting colon depressed‐type multiple early cancer (IIc)‐like configuration. The case was a 74‐year‐old man who presented with a symptom of abdominal fullness. Colonoscopy and barium enema study revealed multiple IIc‐like lesions, which were shown histologically to be metastatic deposits of signet ring cell carcinoma. He had synchronous gastric cancer, which histologically demonstrated moderate to poorly differentiated adenocarcinoma with signet ring cell differentiation. In addition, he had concomitant multiple small bowel metastatic lesions. This appears to be the first published report of multiple IIc‐like colonic metastatic lesions from a gastric cancer. 相似文献
56.
YAMASAKI SUSUMU; HASEGAWA HIROSHI; MAKUUCHI MASATOSHI; KOYAMA YASUO; HOJO KEIICHI; MORIYA NOBUHIRO 《Japanese journal of clinical oncology》1985,15(1):121-131
Hepatectomy for liver metastasis front the colo-rectum and otherorgans was performed in 77 cases at the National Cancer CenterHospital. The operative procedures included every variety ofhepatectomy from extended resection as trisegmenlectomy to smallresection as partial resection. The operative mortality ratewas 3.9% (3/77). The overall cumulative 5-year survival ratewas 26.7 ± 13.9% (survival rate ± Greenwood's5% standard error). The long-term survival of the patients withunilobular metastasis (H1) was better than that of bilobular(H2) and disseminated (H4 metastasis). When H1 was divided intosolitary unilobular metastasis (H1 solitary) and multiple unilobularmetastasis (H1 multiple), the prognosis for the former was betterthan for the latter after hepatectomy. The long-term survivalof patients with H1 multiple was the same as that of patientswith H2 and H3 that means that one of the factors affectingprognosis after hepatectomy is whether the tumor is solitaryor multiple. 相似文献
57.
58.
TETSURO TOEDA SHYUJI SUETAKE KEIICHI TSUCHIDA KAZUYOSHI TAKAHASHI TSUTOMU MIIDA HIROTAKA ODA NORIO HIGUMA 《Pacing and clinical electrophysiology : PACE》2000,23(4):527-529
A 54-year-old man with normal atrioventricuiar (AV) conduction at rest gave a 4-year history of presyncope during exercise. Treadmill testing showed exercise induced AV block. Electrophysiological study demonstrated rate dependent infranodal AV block and abnormal refractory period of the His-Purkinje system. The gap phenomenon in AV conduction occurred during the programmed stimulation. Supernormal conduction could be considered as the mechanism of the gap phenomenon in this patient. 相似文献
59.
60.
IKUO HASHIMOTO KEI-ICHIRO UESE SAYAKA WATANABE KAZUHIRO WATANABE KEIICHI HIRONO FUKIKO ICHIDA TOSHIO MIYAWAKI 《Pediatrics international》2007,49(3):305-309
BACKGROUND: The purpose of the present study was to establish the normal values of flow propagation velocity (FPV) in healthy children and examine the variables that affect FPV in clinical situations. METHODS: Two hundred and thirty- five healthy children and adolescents were assessed (aged 0-22.6 years, mean age 7.4 +/- 5.4 years; male, n = 142; female, n = 93). FPV was obtained from an apical four-chamber view and determined as the slope of aliasing velocity of early diastolic transmitral flow on the color M-mode using Aloka SSD-5500 with 5.0 MHz transducer. Aliasing velocity was set at 50-70% of the peak transmitral flow velocity. Peak transmitral flow velocities in early diastole (E) and during atrial contraction (A), and the ratio of early to late peak velocity (E/A) were obtained. Tei index was also measured for analysis of general left ventricular performance. Left ventricular mass index (LVMI) was obtained from conventional echo measurement. E, E/A, Tei index and LVMI were compared with FPV in healthy subjects. RESULTS: FPV obtained from all subjects ranged from 23.7 to 96.0 cm/s (61.3 +/- 13.6 cm/s). Normal value of FPV was less dependent on age, body size, heart rate and left ventricular dimension. In contrast, although there was no significant correlation between FPV and ejection fraction, statistically significant correlation was found between FPV, LVMI (P = 0.0008) and Tei index (P = 0.025). CONCLUSIONS: FPV is independent of age, body size and heart rate and is useful to assess left ventricular relaxation in children. 相似文献