全文获取类型
收费全文 | 85篇 |
免费 | 3篇 |
专业分类
儿科学 | 7篇 |
基础医学 | 2篇 |
临床医学 | 8篇 |
内科学 | 24篇 |
神经病学 | 2篇 |
外科学 | 8篇 |
药学 | 2篇 |
肿瘤学 | 35篇 |
出版年
2017年 | 1篇 |
2016年 | 2篇 |
2014年 | 2篇 |
2013年 | 2篇 |
2011年 | 1篇 |
2010年 | 4篇 |
2009年 | 1篇 |
2007年 | 2篇 |
2006年 | 2篇 |
2005年 | 2篇 |
2003年 | 4篇 |
2002年 | 2篇 |
2000年 | 2篇 |
1999年 | 3篇 |
1998年 | 4篇 |
1997年 | 4篇 |
1996年 | 2篇 |
1995年 | 3篇 |
1994年 | 1篇 |
1993年 | 2篇 |
1990年 | 1篇 |
1988年 | 2篇 |
1986年 | 6篇 |
1985年 | 5篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 5篇 |
1981年 | 1篇 |
1980年 | 5篇 |
1979年 | 6篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1975年 | 1篇 |
1970年 | 1篇 |
1955年 | 1篇 |
1954年 | 2篇 |
排序方式: 共有88条查询结果,搜索用时 0 毫秒
1.
2.
TOMOE KINOSHITA KEIICHI HANAKI JUN-ICHI NAGAISHI YUKI KAWASHIMA KAORI ADACHI EIJI NANBA SUSUMU KANZAKI 《Pediatrics international》2007,49(2):133-137
BACKGROUND: Decreased energy expenditure and increased food intake are principal causes for obesity. In the present study, genotypes of beta(3)-adrenergic receptor (beta(3)AR) and of melanocortin-4 receptor (MC4R), both of which are believed to have a close link to the cause of obesity, were analyzed and compared with phenotypes of childhood obesity. METHODS: Thirty-five obese children with moderate to severe obesity were enrolled. Direct sequencing of the MC4R coding region and pinpoint-polymerase chain reaction were used to detect genomic variation in the beta(3)AR gene using peripheral blood-derived DNA. RESULTS: Allele frequency of Trp64Arg variation in the beta(3)AR gene in the obese subjects was 0.16, which is comparable with that in the healthy general population in eastern Asia. Comparison of phenotypical characteristics did not show a significant difference between Trp/Trp and Trp/Arg subjects. It was notable that body height SD was significantly higher in the Trp/Trp than the Trp/Arg subjects (0.93 +/- 1.0 SD vs 0.07 +/- 1.3 SD, P= 0.03). Annual weight gains were far beyond a hypothetical fat gain in an Arg64 heterozygote with decreased energy consumption, suggesting increased food intake in childhood obesity. There was, however, no variation in the MC4R gene despite thorough sequencing of the entire coding region. CONCLUSIONS: The Trp64Arg variation in the beta(3)AR gene has no relationship to the degree or the incidence of childhood obesity. The majority of childhood obesity can be characterized as tall stature, more rapid weight gain than that expected by decreased energy expenditure. Further investigation is necessary in regard to the increased food intake as a major cause of childhood obesity. 相似文献
3.
TENGAN ISAMU; SUEMASU KEIICHI; EGUCHI KENJI; KODAMA TETSURO; SHIMOSATO YUKIO; KAJITA MASAFUMI; TSUCHIYA RYOSUKE 《Japanese journal of clinical oncology》1981,11(2):343-352
Forty-eight cases of surgically resected benign tumors and tumor-likelesions of the lung were analyzed, with the following results:1) Hamartoma and sclerosing hemangioma have well defined borders,compressing bronchi and blood vessels, and are loosely boundto the surrounding lung parenchyma. 2) Hamartomas, in 90% ofthe cases, showed "nodularity" on film tomograms. Histologically,nodularity at the edge was produced by lobules of cartilage.3) Fifty-three percent of the patients with sclerosing hemangiomawere middle-aged females and asymptomatic. Only two patientscomplained of hemosputum. Routine roentgenograms showed a roundshadow with homogeneous density. Cut surfaces were solid withvarious degrees of hasemorrhage. 4) Roentgenograms of benignmesothelioma showed large tumors more than 4 cm in diameter,in which extrapleural signs could be observed. 5) "Calcification"was seen on the roentgenograms of seven out of 27 hamartomasand one out of 15 sclerosing hemangiomas. Pleural retractioncould not be seen in our series. Xerotomography was superiorto film tomography in showing calcification. 6) One of the sclerosinghemangiomas was double, and the other 47 benign tumors and tumor-likelesions were solitary; the lesions were peripheral in 45 casesand central in three. All of the patients were free of localrecurrence and distant metastasis. 相似文献
4.
KEIICHI ISOYAMA MITSURU IMAI AKIRA ISHIKAWA KAZUHIRO FUJITA YUMIKO SUTO TAMIKO SHINOHARA 《Pediatrics international》1995,37(1):101-104
A female child with dicentric translocation between chromosome 9 and chromosome 18 presented non-specific minor anomalies with laryngomalacia. Chromosomal analyses were performed by the G-banding method and a fluorescence in situ hybridization (FISH) technique with a specific probe for the centromeric region of chromosome 18 and the painting probe for the chromosomes 9 and 18. Her full karyotype was confirmed as 45, XX, tdic (9;18)(p24;p11). This is the first case of dicentric translocation between chromosomes 9 and 18. The FISH technique is an important tool in chromosome diagnostics. 相似文献
5.
OISHI SEIICHI; UMEDA TERUHISA; SAGARA KATSURO; SATO TATSUO; SOEJIMA HIDEHISA; KEIICHI IKEGAMI 《Japanese journal of clinical oncology》1978,8(1):55-61
A patient with urinary bladder pheochromocytoma and anotherpheo-chromocytoma in the para-aortic region is presented. Also,nine cases which have already been reported in Japan are reviewed. The following conclusions are made: bladder pheochromocytomacan appear at any age in either sex. The clinical triad consistingof hypertension, gross intermittent or transient painless hematuriaand micturitional attacks typical of pheochromocytoma are seenin most cases. Attention is called to such urinary bladder 相似文献
6.
HIROSHI INOUE KIYOSHI INOUE HIROSHI MATSUO KEIICHI KUWAKI TETSURO SHIRAI SATORU MURAO 《Pacing and clinical electrophysiology : PACE》1984,7(1):3-9
In two cases with recurrent sustained ventricular tachycardia (VT) due to re-entry, the response pattern to extrastimuli during the tachycardia was studied. In each case, right ventricular extrastimuli with longer coupling intervals during VT were followed by fully compensatory pauses and with shorter coupling intervals reset the tachycardia cycle. In one case, a plateau was produced by a single extrastimulus, resembling that seen in the response curve of sinus node automaticity as well as ectopic atrial tachycardia. Two successive stimuli produced three definite zones, i.e., fully compensatory, reset producing a plateau, and progressive prolongation zones with shortening of the coupling intervals between the two stimuli, and terminated the tachycardia with further shortening of the coupling intervals. In conclusion, resetting phenomenon was confirmed on two cases with re-entrant VT. This phenomenon cannot be used as a criterion to determine the mechanism responsible for VT. 相似文献
7.
Jaundice and Renal Failure Following Radical Surgery for Cancer: An Analysis of Five Autopsied Cases
HATTORI NOBU; NAKAMOTO YASUSHI; KOBAYASHI KENICHI; IIZUKA TOSHIFUMI; MATSUMOTO KEIICHI 《Japanese journal of clinical oncology》1980,10(1):21-29
An analysis of postoperative jaundice and renal failure in fiveautopsied cases is presented. Two patients had total resectionof esophageal cancer, one had a subtotal gastrectomy, and theother two had radical operations for urinary bladder carcinoma.Halothane was used for anesthesia for three patients, and allfive required blood transfusions. Postoperatively, jaundiceand azotemia developed between the 1st and 7th days, with deathsix to 10 days after surgery. Total bilirubin ranged from 1.5to 13.4mg/dl despite the normal or modest rise in hepatic enzymes.BUN varied from 46 to 288 mg/dl. Pre- and postoperative ECGrevealed a prolongation of QTc in all cases. At autopsy, theliver, kidneys and heart showed a definite increase in weight.The salient hepatic pathology included diffusely dilated spaceof Disse, centrilobular bile stasis and steatosis. This, alongwith acute tubular necrosis confirmed at autopsy, was thoughtto be due to ischemia. Although the significance of prolongedQTc remains uncertain, it is worthy of attention as one of thepreoperative checks. 相似文献
8.
KAKIZOE TADAO; OHTANI MIKINOBU; TOBISU KENICHI; MATSUMOTO KEIICHI; TESHIMA SHINICHI; KISHI KIYOZO 《Japanese journal of clinical oncology》1986,16(1):59-63
A primary neoplasm arising in a vesical diverticulum was cystectomizedand analyzed by step-sectioning of the whole bladder in an attemptto determine the carcinogenic process. Serial sections of thecystectomy specimen revealed a small area of mild dysplasiain the mucosa of the bladder and the diverticulum without atumor. Most of the mucosal cells in the tumor-bearing diverticulumwere desquamated, but a small area of dysplasia in the remainingcells was also observed. 相似文献
9.
SAKURAI MASANORI; SAIJO NAGAHIRO; SHINKAI TETSU; EGUCHI KENJI; SASAKI YASUTSUNA; TAMURA TOMOHIDE; SANO TETSURO; SUEMASU KEIICHI; JETT JAMES R. 《Japanese journal of clinical oncology》1986,16(2):153-156
High-dose ifosfamide (one or two courses of 6 g/m2) with orwithout mesna was administered to 13 patients with advancednon-small cell lung cancer. The protective effect of 2-mercapto-ethanesulfonate (mesna) against the urotoxic side effects inducedby ifosfamide was examined by a randomized crossover trial.A significant reduction in the incidence of hematuria was observedin the patients receiving mesna. Macroscopic hematuria was observedin only one patient who received treatment with mesna versusseven patients treated with ifosfamide alone. Other symptoms,such as frequency and dysuria, tended to be diminished in thepatients receiving mesna, although the difference was not statisticallysignificant. Our results suggest that mesna is effective inpreventing or diminishing ifosfamide-induced hemorrhagic cystitis.Concomitant use of mesna should allow the administration ofa high dose of ifosfamide although more extensive studies areneeded to define the optimal dose and schedule of administrationof mesna to prevent or attenuate the hemorrhagic cystitis. 相似文献
10.
TERUO INOUE M.D. KAZUHIRO HOSHI M.D. KEIICHI MIZOGUCHI M.D. MINORU SHIMIZU M.D. YOSHIHIKO SAKAI M.D. SHIGENORI MOROOKA M.D. 《Journal of interventional cardiology》1997,10(2):121-124
We successfully performed cutting balloon angioplasty for a restenotic lesion involving the distal saphenous vein graft (SVG) anastomosis that had developed within 1 month after conventional balloon angioplasty. We considered that cutting balloon angioplasty, which has been considered to produce less vascular injury, could be a viable choice for the treatment of a lesion at the distal anastomosis of an SVG. 相似文献