全文获取类型
收费全文 | 2400838篇 |
免费 | 171470篇 |
国内免费 | 4652篇 |
专业分类
耳鼻咽喉 | 33205篇 |
儿科学 | 78986篇 |
妇产科学 | 67044篇 |
基础医学 | 340436篇 |
口腔科学 | 66539篇 |
临床医学 | 212993篇 |
内科学 | 465893篇 |
皮肤病学 | 56249篇 |
神经病学 | 193259篇 |
特种医学 | 94370篇 |
外国民族医学 | 688篇 |
外科学 | 361994篇 |
综合类 | 50656篇 |
现状与发展 | 3篇 |
一般理论 | 738篇 |
预防医学 | 177336篇 |
眼科学 | 55121篇 |
药学 | 178452篇 |
8篇 | |
中国医学 | 5723篇 |
肿瘤学 | 137267篇 |
出版年
2021年 | 17686篇 |
2019年 | 18527篇 |
2018年 | 27185篇 |
2017年 | 21088篇 |
2016年 | 24302篇 |
2015年 | 27132篇 |
2014年 | 36975篇 |
2013年 | 54788篇 |
2012年 | 75062篇 |
2011年 | 78924篇 |
2010年 | 46584篇 |
2009年 | 43634篇 |
2008年 | 73404篇 |
2007年 | 78384篇 |
2006年 | 79398篇 |
2005年 | 76941篇 |
2004年 | 73505篇 |
2003年 | 70741篇 |
2002年 | 68279篇 |
2001年 | 121282篇 |
2000年 | 124344篇 |
1999年 | 103806篇 |
1998年 | 27917篇 |
1997年 | 24912篇 |
1996年 | 24789篇 |
1995年 | 23335篇 |
1994年 | 21287篇 |
1993年 | 20014篇 |
1992年 | 77361篇 |
1991年 | 74113篇 |
1990年 | 71981篇 |
1989年 | 68855篇 |
1988年 | 62878篇 |
1987年 | 61266篇 |
1986年 | 57507篇 |
1985年 | 54443篇 |
1984年 | 40657篇 |
1983年 | 34269篇 |
1982年 | 20058篇 |
1979年 | 36142篇 |
1978年 | 25046篇 |
1977年 | 21502篇 |
1976年 | 19535篇 |
1975年 | 21140篇 |
1974年 | 24982篇 |
1973年 | 24088篇 |
1972年 | 22889篇 |
1971年 | 21115篇 |
1970年 | 19756篇 |
1969年 | 18697篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
71.
JM Martín† L Calduch† C Monteagudo‡ I Molina† D Ramón† V Alonso† E Jordᆠ《Journal of the European Academy of Dermatology and Venereology》2006,20(4):428-431
Cutaneous plasmacytosis is a rare disorder characterized by a benign proliferation of mature plasma cells that appears as multiple dark-brown to purplish skin lesions, often associated with polyclonal hypergammaglobulinaemia. We present the case of a 55-year-old Caucasian man who suffered from a cutaneous plasmacytosis associated with two different carcinomas. Cutaneous plasmacytosis seems to be a reactive process because most cases reported are not associated with any apparent underlying disease. Nevertheless, because few reported cases were associated with malignancies, screening of additional neoplasms would be justified. 相似文献
72.
73.
The absence of the temporary incisors could be to a genetic illness or to some multiple premature extractions. These extractions are the aftermaths of the carious lesions or some traumatisms underwent by the temporary incisors. Beyond measure the loss of the space, the premature loss some temporary incisors very often assign the relational development of the child and disturb its psychological development and the aesthetic function. Across some cases clinics, the authors show that the replacement of the temporary incisors is the therapeutic ideal solution. Indeed, the child prosthesis, replacing the temporary absent incisors, solves the psychological, aesthetic and relational problems of the child. 相似文献
74.
75.
Chukwuka C Okafor Hana Haleem-Smith Patrice Laqueriere Paul A Manner Rocky S Tuan 《Journal of orthopaedic research》2006,24(3):461-473
Continual loading and articulation cycles undergone by metallic (e.g., titanium) alloy arthroplasty prostheses lead to liberation of a large number of metallic debris particulates, which have long been implicated as a primary cause of periprosthetic osteolysis and postarthroplasty aseptic implant loosening. Long-term stability of total joint replacement prostheses relies on proper integration between implant biomaterial and osseous tissue, and factors that interfere with this integration are likely to cause osteolysis. Because multipotent mesenchymal stem cells (MSCs) located adjacent to the implant have an osteoprogenitor function and are critical contributors to osseous tissue integrity, when their functions or activities are compromised, osteolysis will most likely occur. To date, it is not certain or sufficiently confirmed whether MSCs endocytose titanium particles, and if so, whether particulate endocytosis has any effect on cellular responses to wear debris. This study seeks to clarify the phenomenon of titanium endocytosis by human MSCs (hMSCs), and investigates the influence of endocytosis on their activities. hMSCs incubated with commercially pure titanium particles exhibited internalized particles, as observed by scanning electron microscopy and confocal laser scanning microscopy, with time-dependent reduction in the number of extracellular particles. Particulate endocytosis was associated with reduced rates of cellular proliferation and cell-substrate adhesion, suppressed osteogenic differentiation, and increased rate of apoptosis. These cellular effects of exposure to titanium particles were reduced when endocytosis was inhibited by treatment with cytochalasin D, and no significant effect was seen when hMSCs were treated only with conditioned medium obtained from particulate-treated cells. These findings strongly suggest that the biological responses of hMSCs to wear debris are triggered primarily by the direct endocytosis of titanium particulates, and not mediated by secreted soluble factors. In this manner, therapeutical approaches that suppress particle endocytosis could reduce the bioreactivity of hMSCs to particulates, and enhance long-term orthopedic implant prognosis by minimizing wear-debris periprosthethic osteolysis. 相似文献
76.
77.
78.
Zusammenfassung Viele gastrointestinale Tumoren werden im Rahmen multimodaler Therapiekonzepte behandelt. Für den Chirurgen ist die neoadjuvante, präoperative Behandlung von besonderem Interesse, da sie durch therapiebedingte Nebenwirkungen und Komplikationen zu einer Beeinflussung des postoperativen Verlaufs führen kann. Die neoadjuvante Radiochemotherapie ist fester Bestandteil der Therapie beim primären T4-Rektumkarzinom, beim Rektumkarzinomrezidiv und bei tief sitzenden primären Rektumkarzinomen. Durch Erhöhung der R0-Resektionsrate können die lokale Tumorkontrolle verbessert und die Überlebenszeit verlängert werden. Die postoperative Komplikationsrate ist dabei nicht wesentlich erhöht. In der Behandlung des primär resektablen Ösophaguskarzinoms deutet sich ein Vorteil der neoadjuvanten Radiochemotherapie im Vergleich zur alleinigen Chirurgie an. Beim lokal fortgeschrittenen Ösophaguskarzinom bietet die präoperative Radiochemotherapie häufig die einzige Chance zur Resektion, jedoch mit einer deutlich erhöhten postoperativen Morbidität und Mortalität. Die Wirksamkeit und Sicherheit einer neoadjuvanten Chemo- oder kombinierten Radiochemotherapie beim fortgeschrittenen Magenkarzinom wird derzeit im Rahmen von Studienprotokollen untersucht. 相似文献
79.
Ohne Zusammenfassung 相似文献
80.
Lisa A. Lang DDS MS David C. Holmes DDS MS Craig Passon DDS MS Robert M. Trombly DDS JD Jeffrey D. Astroth DDS MSPH Arnold F. Tavel DMD 《Journal of prosthodontics》2003,12(3):206-210
Using complete denture treatment as an introduction to clinical patient care for dental students, the purposes of the Complete Denture Prosthodontics Transition Clinic at the University of Colorado School of Dentistry are to reduce the time lapse between the preclinical complete denture prosthodontics course and the first denture patient experience, and to encourage development of student self-confidence and skills. In the 2002 spring semester, faculty at the University of Colorado School of Dentistry initiated the Complete Denture Prosthodontics Transition Clinic for DS-II (second-year) dental students, as an introduction to clinical patient care. Each patient was assigned to a team of two dental students. Three Division of Prosthodontics faculty members staffed each clinic session, providing a student-to-faculty ratio of approximately 6.6:1 and a patient-to-faculty ratio of approximately 3.3:1. All DS-II students in the Class of 2004 delivered their first complete dentures no later than 8 months (average, 184 days) after the last day of the preclinical complete denture prosthodontics course. The time from the diagnostic appointment through the denture placement appointment averaged 39 days for patients treated in this program, compared with an average of 98 days or more for previous classes. The program was successful in achieving the goal of reducing the time lapse between the preclinical complete denture prosthodontics course and the first denture patient experience. 相似文献