全文获取类型
收费全文 | 368篇 |
免费 | 20篇 |
国内免费 | 14篇 |
专业分类
儿科学 | 40篇 |
妇产科学 | 3篇 |
基础医学 | 19篇 |
口腔科学 | 10篇 |
临床医学 | 41篇 |
内科学 | 81篇 |
皮肤病学 | 5篇 |
神经病学 | 9篇 |
特种医学 | 70篇 |
外科学 | 40篇 |
综合类 | 16篇 |
预防医学 | 12篇 |
药学 | 36篇 |
肿瘤学 | 20篇 |
出版年
2023年 | 1篇 |
2022年 | 1篇 |
2020年 | 3篇 |
2019年 | 5篇 |
2018年 | 8篇 |
2017年 | 9篇 |
2016年 | 2篇 |
2015年 | 6篇 |
2014年 | 10篇 |
2013年 | 16篇 |
2012年 | 12篇 |
2011年 | 4篇 |
2010年 | 21篇 |
2009年 | 16篇 |
2008年 | 4篇 |
2007年 | 7篇 |
2006年 | 12篇 |
2005年 | 8篇 |
2004年 | 5篇 |
2003年 | 12篇 |
2002年 | 3篇 |
2001年 | 7篇 |
2000年 | 11篇 |
1999年 | 16篇 |
1998年 | 29篇 |
1997年 | 20篇 |
1996年 | 25篇 |
1995年 | 18篇 |
1994年 | 17篇 |
1993年 | 13篇 |
1992年 | 6篇 |
1991年 | 2篇 |
1990年 | 6篇 |
1989年 | 8篇 |
1988年 | 8篇 |
1987年 | 9篇 |
1986年 | 9篇 |
1985年 | 5篇 |
1984年 | 4篇 |
1983年 | 5篇 |
1982年 | 3篇 |
1981年 | 4篇 |
1980年 | 1篇 |
1979年 | 3篇 |
1977年 | 3篇 |
1976年 | 2篇 |
1975年 | 1篇 |
1972年 | 1篇 |
1950年 | 1篇 |
排序方式: 共有402条查询结果,搜索用时 0 毫秒
81.
82.
Yanjun Zhang Wei Huang Jiahuang Jiang Jing Xie Chunmin Xu Chunli Wang Lin Yin Li Yang Kevin Zhou Peter Chen KL Paul Sung 《Knee surgery, sports traumatology, arthroscopy》2014,22(9):1997-2006
Purpose
It was reported that not only ACL but also the synovium may be the major regulator of matrix metalloproteinases (MMPs) in synovial fluids after ACL injury. In order to further confirm whether synovium is capable of regulating the microenvironment in the process of ACL injury, the complicated microenvironment of joint cavity after ACL injury was mimicked and the combined effects of mechanical injury and inflammatory factor [tumour necrosis factor-α (TNF-α)] on expressions of lysyl oxidases (LOXs) and MMPs in synovial fibroblasts derived from normal human synovium were studied.Methods
Human normal knee joint synovial fibroblasts were stimulated for 1–6 h with mechanical stretch and inflammatory factor (TNF-α). Total RNA was harvested, reverse transcribed and assessed by real-time polymerase chain reaction for the expression of LOXs and MMP-1, 2, 3 messenger RNAs. MMP-2 activity was assayed from the collected culture media samples using zymography.Results
Compared to control group, our results showed that 6 % physiological stretch increased MMP-2 and LOXs (except LOXL-3), decreased MMP-1 and MMP-3; injurious stretch (12 %) decreased LOXs (except LOXL-2)and increased MMP-1, 2 and 3; the combination of injurious stretch and TNF-α decreased LOXs and increased MMP-1, 2 and 3 in synovial fibroblasts in a synergistical manner.Conclusion
This study demonstrated that combination of mechanical injury and inflammatory factors up-regulated the expressions of MMPs and down-regulated the expressions of LOXs in synovial fibroblasts, eventually alter the balance of tissue healing. Thus, synovium may be involved in regulating the microenvironment of joint cavity. Based on the mechanism, early interventions to inhibit the production of MMPs or promote the production of LOXs in the synovial fibroblasts should be performed to facilitate the healing of tissue. 相似文献83.
84.
PC Ng TF Fok CH Lee KL Cheung CK Li KW So W Wong PMP Yuen 《Acta paediatrica (Oslo, Norway : 1992)》1998,87(11):1197-1199
Two cases of homozygous α-thalassaemia who received active treatment in accordance with parental wishes are reported. One infant survived and the other, although successfully weaned off mechanical respiratory support, unexpectedly developed portal vein thrombosis and died. Homozygous a-thalassaemia, a condition previously considered to be universally fatal, and an indication for therapeutic abortion, is now potentially curable with advances in diagnostic technology and treatment. However, active management of these cases raises serious ethical questions and has major financial implications on the health-care system. Invasive prenatal and intensive postnatal interventions should remain experimental and cannot be recommended as routine clinical practice until the questions of long-term neurodevelopmental outcome, and the morbidity and mortality associated with bone-marrow transplantation have been fully addressed. As a result of advances in information technology, more and more parents of affected foetuses are likely to request active treatment. 相似文献
85.
86.
Paget disease of the nipple: radiologic-pathologic correlation 总被引:1,自引:0,他引:1
87.
Benzimra RE; Antao AJ; Donovan KL; Williams AJ 《QJM : monthly journal of the Association of Physicians》1998,91(6):417-422
Haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopenic purpura
(TTP) are conditions in which thrombocytopenia and microangiopathic
haemolytic anaemia are associated with organ damage due to thrombotic
microangiopathy (TMA). The prognosis for adults with HUS is variable, with
some patients presenting with an acute illness from which a full recovery
is made, whilst others develop irreversible renal failure. Evidence of
retinal ischaemia was noted on presentation in a normotensive patient with
irreversible renal failure due to HUS. This study examined prospectively
the optic fundi of all patients who subsequently presented to a single
adult renal unit (catchment population approximately 700,000) with HUS.
Eleven patients presented with HUS over 12 years (1985-1997). Six patients
with irreversible renal failure had retinal abnormalities either at the
time or within a few days of initial presentation. The other five patients
whose renal function recovered did not develop retinal changes during the
course of their illness. Retinal ischaemia associated with TMA is a poor
prognostic sign in adults with HUS.
相似文献
88.
89.
90.
U Poddar BR Thapa K Vaiphei KL Rao SK Mitra K Singh 《Archives of disease in childhood》1998,78(3):264-266
The clinical profile, malignant potential, and management of 17 children with juvenile polyposis (more than five juvenile polyps) were evaluated clinically and endoscopically. Colonoscopy and polypectomy were done three weekly until colonic clearance was achieved, and thereafter two yearly. All polyps were subjected to histological examination. Mean age was 7.7 years, with a male preponderance (3:1). Presentation was with rectal bleeding (94%), pallor (65%), stunted growth (53%), and oedema (47%), and the mean (SD) duration of symptoms was 33 (27) months. None had a positive family history or any congenital anomaly. Two children had six polyps up to the transverse colon; the rest had numerous polyps all over the colon. All children had juvenile polyps on histology and 10 (59%) had adenomatous changes (dysplasia). Total colectomy was done in six for intractable symptoms. Colon clearance was achieved in eight after an average 3.4 polypectomy sessions, and three were still on the polypectomy programme. In conclusion, juvenile polyposis is commonly associated with low grade dysplasia. Serial colonoscopic polypectomy is effective but colectomy is required for intractable symptoms and when clearance of the colon is not possible. 相似文献