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101.
VanWijk MJ Boer K Berckmans RJ Meijers JC van der Post JA Sturk A VanBavel E Nieuwland R 《Thrombosis and haemostasis》2002,87(3):415-420
In the Second Northwick Park Heart Study, the activation peptides of factor IX (FIXpep) and factor X (FXpep) were measured in 1261 middle-aged men by double-antibody radioimmunoassay. During follow-up 147 men who had a first coronary heart disease (CHD) event were found to have had an increased FIXpep (p = 0.003) and a reduced FXpep (p = 0.05) at baseline compared with those remaining CHD-free (controls). Plasma FIXpep and FXpep were positively associated, but the rate of rise in FIXpep with increasing FXpep was higher in cases than controls (p for interaction = 0.01). In a sample of 87 controls, FIXpep was positively and independently related to the concentrations of a polymorphonuclear-specific fibrinogen degradation product (p = 0.036) and FXpep (p = 0.004), but in larger samples no statistically significant associations were found either with C-reactive protein or with fibrinogen concentration. The findings suggested that the increased FIXpep in men at high CHD-risk may have been partly due to the generation of factor IX inactivation peptides by inflammatory proteolysis and their recognition together with true FIXpep in the radioimmunoassay. Direct evidence for this hypothesis requires development of assays for human elastase-specific factor IX inactivation peptides. 相似文献
102.
Laurent S Detry O Detroz B DeRoover A Joris J Honoré P Louis E Belaïche J Jacquet N 《Acta chirurgica Belgica》2002,102(4):253-255
Strictureplasty for obstructive Crohn's disease is still controversial because lesions are left in place and the suture is performed on a diseased bowel. Many surgeons prefer to perform bowel resection, hoping for fewer complications and a lower recurrence rate. In this paper, the authors reports their strictureplasty experience. They performed a systematic retrospective review of the patients suffering from Crohn's disease who underwent strictureplasties during a 10-year period in the abdominal surgery department of the University Hospital of Liège Sart Tilman, and studied the short- and long-term clinical results of 68 strictureplasties performed in 18 patients. Median follow-up was 63 months (range 12 to 144). Mortality was 0% and septic morbidity was 11% (one wound abscess and one leakage). Among the 16 patients available for the latest follow-up, symptomatic stenotic recurrence had to be medically treated in hospital for 4 patients (25%) with a recurrence delay range of 19 to 49 months. Stenosis recurrence needed re-intervention in one patient 48 months after surgery: stenosis occurred at a distance from the corrected site. These results confirmed that strictureplasty is a safe and efficient procedure in selected patients undergoing surgery for obstructive Crohn's disease. 相似文献
103.
Bellis van den Berg Peter G. van der Velden C. Joris Yzermans Rebecca K. Stellato Linda Grievink 《Quality of life research》2006,15(10):1571-1576
Studies have shown that the chronically ill are at higher risk for reduced health-related quality of life (HRQL) and for mental
health problems. A combination with traumatic events might increase this risk. This longitudinal study among 1216 survivors
of a disaster examines whether chronically ill survivors had a different course of HRQL and mental health problems compared
to survivors without chronic diseases. HRQL and mental health problems were measured 3 weeks, 18 months and 4 years post-disaster.
Data on pre-disaster chronic diseases was obtained from the electronic medical records of general practitioners. Random coefficient
analyses showed significant interaction effects for social functioning, bodily pain and emotional role limitations at T2 only.
Chronically ill survivors did not consistently have a different course of general health, physical role limitations, and mental
health problems. In conclusion, chronic diseases were not an important risk factor for impaired HRQL and mental health problems
among survivors. 相似文献
104.
Everaert K Hoebeke P Delanghe J 《Clinica chimica acta; international journal of clinical chemistry》2000,297(1-2):183-189
INYRODUCTION: No review articles on outflow disease of the upper urinary tract discuss urinary protein excretion. DISCUSSION: Following acute partial and/or complete ureteral obstruction (UO) or chronic partial UO, alpha-1-microglobulin excretion is significantly higher than in the reference population or patients with proven renal dilatation without obstruction, but is not found to be diagnostic for these conditions as such. Chronic partial UO is followed first by a destructive and then by a steady-state phase in renal damage. The observed increase in tubular proteinuria during the destructive phase correlates with the decrease in absolute dimercaptosuccinic acid (DMSA) uptake. If the destructive phase is not followed by a stable phase, a mixed tubular and glomerular proteinuria is seen. Urinary alpha-1-microglobulin excretion is found to be diagnostically useful in vesico-ureteral reflux (VUR) patients, increases with higher intravesical-intrapyelic pressure, correlates with the decrease in absolute DMSA uptake or with urinary epidermal growth factor excretion (both markers of the number of functioning nephrons) and predicts the outcome after treatment. CONCLUSION: alpha-1-Microglobulin is useful in the detection of renal tubular damage in patients with outflow disease of the upper tract, is diagnostic for VUR but is not so for ureteral obstruction. 相似文献
105.
Catharine A. Hellingman Joris L.E. Logher Quinten Kammeijer Jerome J. Waterval Fenna A. Ebbens Erik van Spronsen 《Acta oto-laryngologica》2019,139(5):415-420
Background: Little is known about the growth rate of cholesteatoma in patients.Objective: Investigate the growth of residual cholesteatoma in subtotal petrosectomy based on volume measured in MRI scans.Materials and methods: Retrospective case series in a Tertiary Medical Centre. Thirteen residual cholesteatomas were identified in 10 patients after subtotal petrosectomy for which a wait-and-scan policy was adopted. Volume of the residual cholesteatoma was calculated by manual segmentation as well as the ‘box method’.Results: Mean growth rate was 27.9 mm3/month (SD 22.8), with a large individual variation ranging from 2.2 to 69.8 mm3/month. No complications were reported in 10 patients with a wait-and-scan policy for residual cholesteatoma in subtotal petrosectomy. The box method overestimates growth rate compared to the reference method manual segmentation and a linear increase of this systematic error was seen with increasing size of the cholesteatoma.Conclusions: Residual cholesteatoma growth rate shows a large individual variation. A wait-and-scan policy could be considered in case of a (small) residual in subtotal petrosectomy with ample room to grow before destroying any remaining structures. Furthermore, the clinically more applicable and less time-consuming box method can be used to accurately measure volumes of small cholesteatomasup to a volume of 500?mm3. 相似文献
106.
Marcoen F. Scholten Andrew S. Thornton Joris M. Mekel Luc J. Jordaens 《Journal of interventional cardiac electrophysiology》2006,15(1):27-33
Atrial fibrillation (AF), an important public health problem is a complex and multifactorial arrhythmia. Non-pharmacological
treatment for symptomatic patients is of increasing importance. The different catheter ablation techniques in AF treatment
developed during recent years, all based on different pathophysiological insights, are discussed. The non-standardized use
of different follow-up methods after ablation make interpretation and comparison of results difficult. 相似文献
107.
Avoiding blood products during liver transplantation 总被引:2,自引:0,他引:2
Detry O Deroover A Delwaide J Delbouille MH Kaba A Joris J Damas P Lamy M Honoré P Meurisse M 《Transplantation proceedings》2005,37(6):2869-2870
Liver transplantation is a major surgical procedure usually requiring large amount of blood products (red cells, platelets, fresh-frozen plasma). We developed a multidisciplinary transfusion-free protocol for liver transplantation in Jehovah's witnesses who refuse the use of blood products but accept organ transplantation. Between September 1998 and November 2004, 9 of 29 Jehovah's witnesses evaluated for liver transplantation were transplanted after medical preparation. None of these patients received any blood product during the surgical procedure. This experience may be beneficial for the entire liver transplantation population, as excessive transfusion has been linked to increased morbidity and mortality in liver transplantation. 相似文献
108.
BACKGROUND AND OBJECTIVES: Regional analgesic techniques allow better postoperative rehabilitation and shorter hospital stay after major knee surgery. The authors tested the hypothesis that similar results could be obtained after total-hip arthroplasty. METHODS: Forty-five patients scheduled for THA under general anesthesia were randomly divided into 3 groups. Postoperative analgesia was provided during the first 48 hours, with intravenous patient-controlled analgesia (IV PCA) induced by morphine (dose, 1.5 mg; lockout interval, 8 min) in group IV, continuous femoral nerve sheath block in group FNB, and continuous epidural analgesia in group EPI. The day after surgery, the 3 groups started identical physical therapy regimens. Pain scores at rest and on movement, supplemental analgesia, side effects, daily degree of maximal hip flexion and abduction, day of first walk, and duration of hospital stay were recorded. RESULTS: Population data, quality of pain relief, postoperative hip rehabilitation, and duration of hospital stay were comparable in the 3 groups. When compared with the two other techniques, continuous FNB was associated with a lower incidence of side effects (no nausea/vomiting, urinary retention, arterial hypotension, or catheter problem during the first 48 hours in 20%, 60%, and 13% of patients in groups IV, FNB, and EPI, respectively). CONCLUSIONS: This study suggests that IV PCA with morphine, continuous FNB, and continuous epidural analgesia provide similar pain relief and allow comparable hip rehabilitation and duration of hospital stay after total-hip arthroplasty (THA). As continuous FNB is associated with less side effects, it appears to offer the best option of the three. 相似文献
109.
Hanneke?SchuurmansEmail author Nardi?Steverink Nynke?Frieswijk Bram?P.?Buunk Joris?P.?J.?Slaets Siegwart?Lindenberg 《Quality of life research》2005,14(10):2215-2228
This paper presents the results of two studies carried out in order to design and test a self-report instrument to measure
Self-Management Ability (the SMAS-30) in aging individuals. SMA refers to the core behavioral and cognitive abilities which
presumably contribute to sustainable well-being in later life. Robust findings of the studies (n=275 and n=1338) showed that
SMA could be measured reliably as a composite concept of abilities systematically linked to dimensions of well-being in adults
aged 65 and over, with the different sub-scales revealing a profile of inter-related abilities. A sub-sample of participants
in Study 2 (n=86) showed that the SMAS-30 had high reproducibility over a period of 16 weeks. The validity of the SMAS-30
was supported by meaningful associations with other constructs in both studies. As expected, the older and frailer the people,
and the poorer their perceived health, the lower their SMA. Moreover, SMA was positively related to several dimensions of
subjective well-being and the related concepts of general self-efficacy and mastery. 相似文献
110.
Rouschop KM Roelofs JJ Claessen N da Costa Martins P Zwaginga JJ Pals ST Weening JJ Florquin S 《Journal of the American Society of Nephrology : JASN》2005,16(7):2034-2043
Inflammation contributes to renal ischemia reperfusion (I/R) injury, potentially causing renal dysfunction. The inflammatory infiltrate mainly consists of neutrophils, which are deleterious for the renal tissue. Because CD44 is expressed by neutrophils and is rapidly upregulated by capillary endothelial cells after I/R injury, it was hypothesized that CD44 might play an important role in the development of I/R injury. This study showed that rapid CD44 upregulation on renal capillary endothelial cells mediates neutrophil recruitment to the postischemic tissue. Hence, CD44 deficiency led to decreased influx of neutrophils regardless of comparable levels in chemotactic factors expressed in the kidney. The reduced influx of neutrophils was associated with preserved renal function and morphology. Adoptive transfer experiments of labeled neutrophils revealed that endothelial CD44 rather than neutrophil CD44 mediates neutrophil migration. Activation of neutrophils increased cell-surface expression of hyaluronic acid (HA). Altogether, a novel mechanism in the recruitment of neutrophils that involves interaction of endothelial CD44 and neutrophil HA was found. Either blocking endothelial CD44 or removal of neutrophil HA decreased rolling and adhesion of neutrophils. Administration of anti-CD44 to mice reduced the influx of neutrophils into the postischemic tissue, associated with renal function preservation. Therefore, anti-CD44-based therapies may contribute to prevent or reduce renal I/R injury. 相似文献