全文获取类型
收费全文 | 60500篇 |
免费 | 3592篇 |
国内免费 | 654篇 |
专业分类
耳鼻咽喉 | 1099篇 |
儿科学 | 681篇 |
妇产科学 | 847篇 |
基础医学 | 10446篇 |
口腔科学 | 1412篇 |
临床医学 | 5185篇 |
内科学 | 11325篇 |
皮肤病学 | 2036篇 |
神经病学 | 4317篇 |
特种医学 | 3572篇 |
外科学 | 8153篇 |
综合类 | 227篇 |
现状与发展 | 1篇 |
一般理论 | 18篇 |
预防医学 | 2797篇 |
眼科学 | 1395篇 |
药学 | 5447篇 |
中国医学 | 680篇 |
肿瘤学 | 5108篇 |
出版年
2023年 | 318篇 |
2022年 | 1389篇 |
2021年 | 2217篇 |
2020年 | 1083篇 |
2019年 | 1428篇 |
2018年 | 1809篇 |
2017年 | 1363篇 |
2016年 | 1951篇 |
2015年 | 2816篇 |
2014年 | 3337篇 |
2013年 | 3810篇 |
2012年 | 5763篇 |
2011年 | 5233篇 |
2010年 | 3071篇 |
2009年 | 2589篇 |
2008年 | 3703篇 |
2007年 | 3424篇 |
2006年 | 2934篇 |
2005年 | 2593篇 |
2004年 | 2207篇 |
2003年 | 1854篇 |
2002年 | 1575篇 |
2001年 | 1392篇 |
2000年 | 1287篇 |
1999年 | 931篇 |
1998年 | 388篇 |
1997年 | 273篇 |
1996年 | 223篇 |
1995年 | 184篇 |
1994年 | 159篇 |
1993年 | 140篇 |
1992年 | 341篇 |
1991年 | 325篇 |
1990年 | 287篇 |
1989年 | 265篇 |
1988年 | 249篇 |
1987年 | 251篇 |
1986年 | 181篇 |
1985年 | 169篇 |
1984年 | 124篇 |
1983年 | 115篇 |
1982年 | 55篇 |
1981年 | 60篇 |
1979年 | 82篇 |
1978年 | 69篇 |
1975年 | 50篇 |
1974年 | 60篇 |
1973年 | 51篇 |
1972年 | 50篇 |
1970年 | 49篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
992.
Mi-Young Song Ui-Jin Bae Bong-Hee Lee Kang-Beom Kwon Eun-A Seo Sung-Joo Park Min-Sun Kim Ho-Joon Song Keun-Sang Kwon Jin-Woo Park Do-Gon Ryu Byung-Hyun Park 《World journal of gastroenterology : WJG》2010,(26)
AIM: To investigate the anti-diabetogenic mechanism of Nardostachys jatamansi extract (NJE). METHODS: Mice were injected with streptozotocin viaa tail vein to induce diabetes. Rat insulinoma RINm5F cells and isolated rat islets were treated with interleukin1β and interferon-γ to induce cytotoxicity. RESULTS: Treatment of mice with streptozotocin resulted in hyperglycemia and hypoinsulinemia, which was conf irmed by immunohistochemical staining of the islets. The diabetogenic effects of streptozotocin were c... 相似文献
993.
994.
995.
996.
June-Bum Kim Ji-Hyun Choi Ji-Hye Kim Hyang-Joon Park Jae-Seung Lee Ok-Ja Joh Kye Yong Song 《ANNALS OF DERMATOLOGY》2010,22(4):472-477
Primary cutaneous mucinous carcinoma is a rare malignant tumor that originates from the deepest portion of the eccrine sweat duct. Common sites of involvement are the face and scalp. Biopsy shows dermal epithelial cell islands embedded in mucin pools separated by fibrous septae. It is difficult to differentiate this tumor histologically from metastatic adenocarcinoma. Recurrence after excision is common but metastases are rare. We report a primary cutaneous mucinous carcinoma with neuroendocrine differentiation on the right cheek of a 63-year-old man. 相似文献
997.
998.
999.
Jin-Woo Park Hye-Kyoung Kim Youn-Jeong Kim Chang-Hyeon An Takao Hanawa 《Clinical oral implants research》2009,20(7):684-690
Objectives: This study evaluated the osseointegration in rabbit cancellous bone of titanium (Ti) implants with a micro-topographically complex surface structure produced by grit-blasting/acid-etching with or without the addition of surface calcium ion (Ca) chemistry.
Material and methods: Micro-structured Ti implants (XiVE S CELLplus™ screw implant, Dentsply Friadent GmbH) were hydrothermally treated in an alkaline Ca-containing solution to produce a nano-structured Ca-incorporated oxide surface layer. The surface characteristics were evaluated by scanning electron microscopy and stylus profilometry before and after Ca surface treatment. Twenty implants (10 control and 10 experimental) were placed in the femoral condyles of 10 New Zealand White rabbits. Histomorphometric analysis was performed 6 weeks after implantation.
Results: Ca-incorporated and untreated control implants showed similar surface morphologies and surface roughness values at the micron scale. Untreated micro-structured Ti implants achieved a high degree of bone-to-implant contact (BIC), and Ca incorporation further increased BIC% ( P <0.05). Active new bone apposition was found on surfaces of Ca-incorporated implants in areas of loose trabeculae.
Conclusion: The nano-structured Ca-incorporated oxide surface significantly enhanced osteoconductivity of micro-structured Ti implants in rabbit cancellous bone. Results indicate that this surface produced by simple hydrothermal treatment may be effective in improving the osseointegration of implants with micro-topographically complex surface structures in areas of loose cancellous bone. 相似文献
Material and methods: Micro-structured Ti implants (XiVE S CELLplus
Results: Ca-incorporated and untreated control implants showed similar surface morphologies and surface roughness values at the micron scale. Untreated micro-structured Ti implants achieved a high degree of bone-to-implant contact (BIC), and Ca incorporation further increased BIC% ( P <0.05). Active new bone apposition was found on surfaces of Ca-incorporated implants in areas of loose trabeculae.
Conclusion: The nano-structured Ca-incorporated oxide surface significantly enhanced osteoconductivity of micro-structured Ti implants in rabbit cancellous bone. Results indicate that this surface produced by simple hydrothermal treatment may be effective in improving the osseointegration of implants with micro-topographically complex surface structures in areas of loose cancellous bone. 相似文献
1000.
Jeong-Im Sin Jung-Min Kim Sung Hwa Bae In Hee Lee Jong Sup Park Hun Mo Ryoo 《Molecular therapy》2009,17(5):906-913
Adoptive cytotoxic T lymphocyte (CTL) therapy has an important implication in treating cancer patients. Here, we investigate whether adoptive transfer of human papillomavirus (HPV) E7-specific CTL can enhance tumor chemoresponse using an established cervical cancer animal model. Cisplatin-based chemotherapy plus CTL therapy showed an improved therapeutic effectiveness, along with antitumor protective responses to a parental tumor cell rechallenge. Cisplatin treatment dose-dependently increased the expression of Fas, intercellular adhesion molecule (ICAM)-1, and major histocompatibility complex (MHC) class I antigens (Ags) on tumor cells in vitro. However, CTL-expressing FasL failed to improve antitumor activity in vitro and in animals, resulting from nonfunctional Fas expressed on tumor cells. In contrast, ethylene glycol tetraacetic acid (EGTA) treatment blocked increased sensitivity of cisplatin-treated tumor cells to CTL-mediated killing in vitro, suggesting an important role of the perforin/granzyme-mediated pathway for improved therapeutic effectiveness. This notion was further confirmed by perforin knockout animal studies. Thus, this study shows that (i) modulation of Ag (Fas, ICAM-1) expression by tumor cells has little effect on their increased sensitivity to CTL-mediated killing, (ii) improved therapeutic effectiveness is mediated mainly through the perforin/granzyme-mediated tumor killing pathway, and (iii) a combination of chemotherapy and adoptive E7-specific CTL transfer augments antitumor therapeutic activity in vivo. This finding may have important implications for treating HPV-associated cervical cancer. 相似文献