全文获取类型
收费全文 | 63417篇 |
免费 | 5099篇 |
国内免费 | 186篇 |
专业分类
耳鼻咽喉 | 861篇 |
儿科学 | 1971篇 |
妇产科学 | 1154篇 |
基础医学 | 7995篇 |
口腔科学 | 1195篇 |
临床医学 | 7209篇 |
内科学 | 13388篇 |
皮肤病学 | 1109篇 |
神经病学 | 5683篇 |
特种医学 | 2442篇 |
外国民族医学 | 2篇 |
外科学 | 10283篇 |
综合类 | 715篇 |
一般理论 | 94篇 |
预防医学 | 5247篇 |
眼科学 | 1565篇 |
药学 | 3674篇 |
3篇 | |
中国医学 | 98篇 |
肿瘤学 | 4014篇 |
出版年
2023年 | 465篇 |
2022年 | 807篇 |
2021年 | 1811篇 |
2020年 | 960篇 |
2019年 | 1555篇 |
2018年 | 1891篇 |
2017年 | 1316篇 |
2016年 | 1452篇 |
2015年 | 1593篇 |
2014年 | 2253篇 |
2013年 | 2779篇 |
2012年 | 4490篇 |
2011年 | 4576篇 |
2010年 | 2502篇 |
2009年 | 2184篇 |
2008年 | 3719篇 |
2007年 | 3668篇 |
2006年 | 3622篇 |
2005年 | 3401篇 |
2004年 | 3445篇 |
2003年 | 2999篇 |
2002年 | 2706篇 |
2001年 | 1004篇 |
2000年 | 867篇 |
1999年 | 911篇 |
1998年 | 633篇 |
1997年 | 527篇 |
1996年 | 437篇 |
1995年 | 423篇 |
1994年 | 350篇 |
1993年 | 350篇 |
1992年 | 634篇 |
1991年 | 624篇 |
1990年 | 526篇 |
1989年 | 577篇 |
1988年 | 526篇 |
1987年 | 526篇 |
1986年 | 502篇 |
1985年 | 529篇 |
1984年 | 388篇 |
1983年 | 365篇 |
1982年 | 297篇 |
1981年 | 250篇 |
1980年 | 177篇 |
1979年 | 283篇 |
1978年 | 228篇 |
1977年 | 195篇 |
1976年 | 198篇 |
1974年 | 205篇 |
1973年 | 222篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
62.
63.
64.
Canadian Journal of Anesthesia/Journal canadien d'anesthésie - 相似文献
65.
66.
Fady K. Balaa T. Clark Gamblin Allan Tsung J. Wallis Marsh David A. Geller 《Journal of gastrointestinal surgery》2008,12(2):338-343
Background Application of linear stapling devices for extrahepatic vascular control in liver surgery has been well-established. However,
the technique for use of stapling devices in hepatic parenchymal transection is not well defined.
Purpose To describe the safety and efficacy of our technique for use of vascular stapling devices in hepatic parenchymal transection
during open right hepatic lobectomy is the purpose of this study.
Methodology We reviewed our experience with 101 consecutive open right hepatic lobectomies performed by a single surgeon between January
2003 and July 2006, in which vascular staplers were utilized for the parenchymal transection phase.
Results Of the 101 patients who underwent resection, 53 (52%) were female. The mean age was 58 years. Malignant disease was the indication
for resection in the majority of patients (88%). Of those with cancer, 78% (69 of 89) had metastatic colorectal cancer, 6%
(5 of 89) had metastatic neuroendocrine tumor, 4% (4 of 89) had hepatocellular carcinoma, 4% (4 of 89) had cholangiocarcinoma,
and the remaining 8% were other metastatic cancers. Twelve patients (12%) underwent resection for hepatic adenoma or symptomatic
benign disease (FNH or hemangioma). Forty-eight patients (48%) underwent a major ancillary procedure at the time of hepatic
resection. Thirty-nine patients (39%) had a nonanatomic wedge resection of a left lobe lesion, 27 patients (27%) had one or
more lesions treated with radiofrequency ablation (RFA), and 6 patients (6%) were treated with a synchronous bowel resection.
The median total operative time was 336 min (range 155–620 min). A Pringle maneuver for temporary vascular inflow occlusion
was utilized in all cases, with a median time of 9 min (range 4–17 min). Ten patients (10%) required blood transfusion during
surgery or in the postoperative period. The maximum transfusion was 2 U of packed red blood cells (PRBC) in seven patients
and 1 U of PRBC in three patients. The mean nadir postoperative hematocrit was 28.2. All patients with malignant disease had
tumor-free margins at the completion of the procedure. The average hospital length of stay was 6.0 days. One patient (1%)
developed a clinically significant bile leak requiring a postoperative endoscopic retrograde cholangiography (ERCP). No patient
required reoperation. The 30 and 60-day postoperative survival was 100%.
Conclusion These findings indicate that application of vascular stapling devices for parenchymal transection in major hepatic resection
is a safe technique, with low transfusion requirements and minimal postoperative bile leak. The technique allows for rapid
transection of the entire right hepatic lobe in under 10 min. Short video clips of the technique will be demonstrated.
Presented at the 2007 American Hepato–Pancreato–Biliary Association, Las Vegas, Nevada, April 19–22, 2007 (oral presentation/video
presentation). 相似文献
67.
Assessment of quality of life in children with peanut allergy 总被引:5,自引:0,他引:5
Natalie J. Avery Rosemary M. King Susan Knight Jonathan O'B. Hourihane 《Pediatric allergy and immunology》2003,14(5):378-382
Children with a peanut allergy (PA) are faced with food and social restrictions due to the potentially life-threatening nature of their disease, for which there is no cure or treatment. This inevitably impacts upon their quality of life (QoL). QoL of 20 children with PA and 20 children with insulin-dependent diabetes mellitus (IDDM) was measured using two disease-specific QoL questionnaires (higher scores correspond to a poorer QoL). One questionnaire was designed by us and the other was adapted from the Vespid Allergy QoL questionnaire. We gave subjects cameras to record how their QoL is affected over a 24-h period. Response rates for both questionnaires were 100%. Mean ages were 9.0 and 10.4 years for PA and IDDM subjects, respectively. Children with a PA reported a poorer quality of life than children with IDDM: mean scores were 54.85 for PA subjects and 46.40 for diabetics (p = 0.004) in questionnaire 1 and 54.30 and 34.50 (p≤0.001) in questionnaire 2. PA children reported more fear of an adverse event and more anxiety about eating, especially when eating away from home. Photographs fell into seven common categories: food, management, environment, away from home, physical activities, restaurant and people. Most photographs related to food and management issues and revealed difficulties for both groups regarding food restrictions. PA subjects felt more threatened by potential hazards within their environment, felt more restricted by their PA regarding physical activities, and worried more about being away from home. However, they felt safe when carrying epinephrine kits and were positive about eating at familiar restaurants. The QoL in children with PA is more impaired than in children with IDDM. Their anxiety may be considered useful in some situations, promoting better adherence to allergen avoidance advice and rescue plans. 相似文献
68.
Sensory neurons in the pleural ganglion ofAplysia mediate the afferent portion of the tail withdrawal reflex. Previous work has shown that in these neurons and in the siphon sensory neurons ofAplysia, serotonin modulates a steady-state non-inactivating potassium current called the S current. Using the technique of patch clamping, we have examined the kinetics of single potassium channels and found that they share the properties of the S potassium channel of the siphon sensory neurons. This channel has an elementary slope conductance of73 ± 9.98pS(x±S.E.M.) and shows Goldman rectification. It is active at the resting potential and does not inactivate with maintained depolarization. Bath application of serotonin in a majority of experiments decreased the functional number of channels in the patch. 相似文献
69.
Fetal beta-endorphin release has been associated with fetal hypoxia. The purpose of this study was to assess the degree of uterine blood flow reduction needed to elicit fetal beta-endorphin release in the sheep since there is a large reserve of oxygen supply to the fetus. Uterine blood flow was reduced by 26 +/- 2, 46 +/- 3 and 66 +/- 2%, producing fetal oxygen content concentrations of 5.7 +/- 0.6, 4.4 +/- 0.7 and 2.6 +/- 0.3 ml/dl, respectively. Although fetal oxygen concentrations were significantly decreased in the groups with a reduction in uterine blood flow of 46 and 66%, beta-endorphin was elevated only in the latter group. It is speculated that fetal beta-endorphin is released at a level of hypoxia which leads to a decrease in fetal oxygen consumption. A reduction in uterine blood flow of 66% appears to produce a stressful environment for the fetus as measured by fetal plasma beta-endorphin levels. 相似文献
70.