全文获取类型
收费全文 | 407225篇 |
免费 | 39135篇 |
国内免费 | 28160篇 |
专业分类
耳鼻咽喉 | 3675篇 |
儿科学 | 4938篇 |
妇产科学 | 5706篇 |
基础医学 | 46506篇 |
口腔科学 | 7137篇 |
临床医学 | 56976篇 |
内科学 | 58372篇 |
皮肤病学 | 3939篇 |
神经病学 | 20677篇 |
特种医学 | 14988篇 |
外国民族医学 | 235篇 |
外科学 | 38576篇 |
综合类 | 70450篇 |
现状与发展 | 97篇 |
一般理论 | 21篇 |
预防医学 | 28662篇 |
眼科学 | 11689篇 |
药学 | 43485篇 |
484篇 | |
中国医学 | 25395篇 |
肿瘤学 | 32512篇 |
出版年
2024年 | 1482篇 |
2023年 | 6322篇 |
2022年 | 16539篇 |
2021年 | 20627篇 |
2020年 | 15832篇 |
2019年 | 13257篇 |
2018年 | 13914篇 |
2017年 | 13045篇 |
2016年 | 11754篇 |
2015年 | 18407篇 |
2014年 | 22810篇 |
2013年 | 21041篇 |
2012年 | 30808篇 |
2011年 | 34287篇 |
2010年 | 22379篇 |
2009年 | 17663篇 |
2008年 | 22751篇 |
2007年 | 22390篇 |
2006年 | 21913篇 |
2005年 | 20484篇 |
2004年 | 13233篇 |
2003年 | 12141篇 |
2002年 | 10251篇 |
2001年 | 8939篇 |
2000年 | 9347篇 |
1999年 | 9730篇 |
1998年 | 5838篇 |
1997年 | 5839篇 |
1996年 | 4563篇 |
1995年 | 4145篇 |
1994年 | 3383篇 |
1993年 | 2173篇 |
1992年 | 2887篇 |
1991年 | 2474篇 |
1990年 | 2182篇 |
1989年 | 1899篇 |
1988年 | 1613篇 |
1987年 | 1384篇 |
1986年 | 1126篇 |
1985年 | 924篇 |
1984年 | 533篇 |
1983年 | 375篇 |
1982年 | 246篇 |
1981年 | 245篇 |
1980年 | 193篇 |
1979年 | 231篇 |
1978年 | 85篇 |
1977年 | 94篇 |
1974年 | 105篇 |
1973年 | 84篇 |
排序方式: 共有10000条查询结果,搜索用时 93 毫秒
41.
目的 利用频域光学相干断层扫描深度增强(enhanced depth imaging spectral domain optical coherence tomography,EDI SD-OCT)观察糖尿病黄斑水肿(diabetic macular edema,DME)患者脉络膜厚度(choroidal thickness,CT)的变化及结构特点,探讨DME病变程度与CT的关系。方法 纳入2型糖尿病患者共123例204眼,其中69眼诊断为DME(DME组),135眼无黄斑水肿为对照组。DME眼依据OCT形态学特点进一步分为视网膜弥漫性增厚(diffuse retinal thickness,DRT)型(34眼)、黄斑囊样水肿(cystoid macular edema,CME)型(19眼)和浆液性视网膜脱离(serous retinal detachment,SRD)型(16眼),利用EDI-OCT分别测量黄斑中心凹下CT和以黄斑为中心上、下、鼻、颞500 μm、1000 μm、1500 μm、2000 μm处CT。结果 DME组黄斑中心凹下CT为(326.72±90.15)μm,对照组为(320.17±106.46)μm,两组之间无统计学差异,但黄斑中心凹下CT与视网膜厚度间具有明显正相关关系(r=0.270,P=0.025)。DME亚型CT分别为:DRT型(303.94±81.47)μm、CME型(304.42±73.98)μm和SRD型(401.63±88.80)μm,SRD型CT明显高于其他亚型(P<0.05),此外,SRD型的周边CT同样呈现均匀一致的增厚;鼻侧CT从500 μm至2000 μm呈距离敏感性降低(P<0.05),但SRD型鼻侧CT降低幅度明显变缓(P=0.195)。结论 SRD型黄斑水肿患者CT在中心凹下及周边部均显著增厚,CT与DME病变程度之间有一定相关性。 相似文献
42.
当代社会,老年人口比例呈现不断上升的趋势,老龄化问题日益严峻。因此,如何有效地延缓衰老不仅成为了世界医学研究的热点,也成为了全球亟待解决的问题。中医药在延缓衰老方面经验丰富,而滋阴药在此类研究中效果显著。本文通过整理滋阴药抗衰老作用机制的若干文献,对滋阴复方六味地黄丸、二至丸、左归丸及其他滋阴中药延缓衰老的机制研究进展进行综述。 相似文献
43.
44.
Caroline E. Sloan Judy Zhong Dinushika Mohottige Rasheeda Hall Clarissa J. Diamantidis Leight E. Boulware Virginia Wang 《Seminars in dialysis》2020,33(6):440-448
Caring for patients with end-stage kidney disease (ESKD) in the United States is challenging, due in part to the complex epidemiology of the disease's progression as well as the ways in which care is delivered. As CKD progresses toward ESKD, the number of comorbidities increases and care involves multiple healthcare providers from multiple subspecialties. This occurs in the context of a fragmented US healthcare delivery system that is traditionally siloed by provider specialty, organization, as well as systems of payment and administration. This article describes the role of care fragmentation in the delivery of optimal ESKD care and identifies research gaps in the evidence across the continuum of care. We then consider the impact of care fragmentation on ESKD care from the patient and health system perspectives and explore opportunities for system-level interventions aimed at improving care for patients with ESKD. 相似文献
45.
Jinju Wang Shuzhen Chen Wenfeng Zhang Yanfang Chen Ji C. Bihl 《CNS Neuroscience & Therapeutics》2020,26(12):1255
AimsWe previously showed that the protective effects of endothelial progenitor cells (EPCs)‐released exosomes (EPC‐EXs) on endothelium in diabetes. However, whether EPC‐EXs are protective in diabetic ischemic stroke is unknown. Here, we investigated the effects of EPC‐EXs on diabetic stroke mice and tested whether miR‐126 enriched EPC‐EXs (EPC‐EXsmiR126) have enhanced efficacy.MethodsThe db/db mice subjected to ischemic stroke were intravenously administrated with EPC‐EXs 2 hours after ischemic stroke. The infarct volume, cerebral microvascular density (MVD), cerebral blood flow (CBF), neurological function, angiogenesis and neurogenesis, and levels of cleaved caspase‐3, miR‐126, and VEGFR2 were measured on day 2 and 14.ResultsWe found that (a) injected EPC‐EXs merged with brain endothelial cells, neurons, astrocytes, and microglia in the peri‐infarct area; (b) EPC‐EXsmiR126 were more effective than EPC‐EXs in decreasing infarct size and increasing CBF and MVD, and in promoting angiogenesis and neurogenesis as well as neurological functional recovery; (c) These effects were accompanied with downregulated cleaved caspase‐3 on day 2 and vascular endothelial growth factor receptor 2 (VEGFR2) upregulation till day 14.ConclusionOur results indicate that enrichment of miR126 enhanced the therapeutic efficacy of EPC‐EXs on diabetic ischemic stroke by attenuating acute injury and promoting neurological function recovery. 相似文献
46.
47.
48.
49.
The objective of this study was to investigate short segment decompression of degenerative lumbar scoliosis (DLS) and the efficiency of fusion treatment.After DLS surgery, the patients were retrospectively reviewed using the VAS (visual analog scale) and ODI (Oswestry Disability Index) to assess clinical outcomes. All patients underwent posterior lumbar decompressive laminectomy, pedicle screw internal fixation, and posterolateral bone graft fusion surgery. Radiographic measurements included the scoliotic Cobb angle, the fused Cobb angle, the anterior intervertebral angle (AIA), the sagittal intervertebral angle (SIA), and lumbar lordosis angle. The relationships between these parameters were examined by bivariate Pearson analysis and linear regression analysis.Preoperatively, the Cobb angle at the scoliotic segment was 15.4°, which decreased to 10.2° immediately following surgery (P < 0.05). The AIA significantly increased by the last follow-up (4.4 ± 3.4) compared with pre- and postoperative values (2.5 ± 2.8 and 2.2 ± 2.4, respectively; P < 0.05). However, the scoliotic Cobb angle and the AIA did not correlate with the VAS or ODI scores. At the final follow-up, no patients had pseudoarthrosis or internal instrumentation-related complications.Short fusion surgical treatment results in limited DLS correction, with correction loss over time. The AIA between the upper adjacent segment and proximal fused vertebra continues to increase postoperatively, which does not exacerbate clinical symptoms, as reflected by the low reoperation rates for repairing degeneration at adjacent levels. 相似文献
50.
Sophocarpine attenuates toll‐like receptor 4 in steatotic hepatocytes to suppress pro‐inflammatory cytokines synthesis
下载免费PDF全文
![点击此处可从《Journal of gastroenterology and hepatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)