全文获取类型
收费全文 | 87718篇 |
免费 | 7407篇 |
国内免费 | 4694篇 |
专业分类
耳鼻咽喉 | 1091篇 |
儿科学 | 1018篇 |
妇产科学 | 925篇 |
基础医学 | 11271篇 |
口腔科学 | 1552篇 |
临床医学 | 9487篇 |
内科学 | 13212篇 |
皮肤病学 | 1707篇 |
神经病学 | 4746篇 |
特种医学 | 4411篇 |
外国民族医学 | 21篇 |
外科学 | 9218篇 |
综合类 | 12071篇 |
现状与发展 | 28篇 |
一般理论 | 9篇 |
预防医学 | 5629篇 |
眼科学 | 2487篇 |
药学 | 9344篇 |
67篇 | |
中国医学 | 4063篇 |
肿瘤学 | 7462篇 |
出版年
2024年 | 188篇 |
2023年 | 1053篇 |
2022年 | 2733篇 |
2021年 | 3817篇 |
2020年 | 2663篇 |
2019年 | 2484篇 |
2018年 | 2718篇 |
2017年 | 2538篇 |
2016年 | 2813篇 |
2015年 | 4219篇 |
2014年 | 5185篇 |
2013年 | 5169篇 |
2012年 | 7566篇 |
2011年 | 7977篇 |
2010年 | 5169篇 |
2009年 | 4449篇 |
2008年 | 5569篇 |
2007年 | 5223篇 |
2006年 | 4818篇 |
2005年 | 4230篇 |
2004年 | 3180篇 |
2003年 | 3142篇 |
2002年 | 2639篇 |
2001年 | 1763篇 |
2000年 | 1475篇 |
1999年 | 1301篇 |
1998年 | 828篇 |
1997年 | 715篇 |
1996年 | 611篇 |
1995年 | 555篇 |
1994年 | 528篇 |
1993年 | 352篇 |
1992年 | 387篇 |
1991年 | 346篇 |
1990年 | 289篇 |
1989年 | 263篇 |
1988年 | 175篇 |
1987年 | 191篇 |
1986年 | 143篇 |
1985年 | 98篇 |
1984年 | 56篇 |
1983年 | 39篇 |
1982年 | 38篇 |
1981年 | 27篇 |
1980年 | 27篇 |
1979年 | 16篇 |
1978年 | 6篇 |
1975年 | 7篇 |
1973年 | 10篇 |
1972年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
21.
22.
23.
Recent studies have reported an association between gastroesophageal reflux disease (GERD) and atrial fibrillation (AF). The objective of the present study was to evaluate whether AF is one of the risk factors for GERD occurrence.In this hospital-based, retrospective, case–control study, the patients were classified into 2 groups. The patients diagnosed with new AF were assigned to the AF group (n = 1612); those diagnosed without AF and GERD were assigned to the control group (n = 1612). The subjects in the control group were selected from outpatients of total healthcare center without a history of AF or GERD, and matched for age and gender. We evaluated the incidence of GERD and risk factors for GERD occurrence between the 2 groups.The number of patients experiencing occurrence of GERD during the follow-up period was significantly higher in the AF group than those in the control group, respectively (129 patients vs 98 subjects, P = 0.037). The incidence of GERD was significantly higher in the AF group than in the control group by Kaplan–Meier analysis with log-rank test (P = 0.008). The AF group''s adjusted hazard ratio of GERD occurrence against that of the control group was 1.37 (95% confidence interval [CI]: 1.16–1.57; P = 0.009) according to Cox''s proportional hazard model.The presence of AF appears to increase the incidence of GERD and may be considered a risk factor for the development of GERD. Further, large prospective and cohort studies will be required to better establish the correlation of GERD with AF. 相似文献
24.
25.
AbstractThe autoimmune condition Hashimoto’s thyroiditis (HT) is a disease wherein lymphocytes mediate the autoimmune damage and destruction of the thyroid gland. There are currently no effective means of treating HT, with the primary strategies of thyroid hormone therapy, surgery, or immunomodulatory therapy being associated with serious risks and side effects. There is thus a clear and urgent need to identify novel treatments for HT. In this study, we utilize female SD rats induced HT to evaluated the ability of transplanted MSCs to regulate Th17/Treg interactions in a rat Hashimoto’s thyroiditis (HT) model system. The results showed that Rats in the HT model group exhibited increased thyroid autoantibody levels consistent with successful model development, whereas these levels were lower in rats treated with MSCs. There were also fewer thyroid lesions and less lymphoid infiltration of the thyroid in MSC-treated rats relative to HT model rats, as well as fewer Th17 cells and more Treg cells – an observation consistent with the cytokine analyses. All of these showed that MSCs can regulate Th17/Treg interactions in a rat Hashimoto’s thyroiditis (HT) model system. It suggested that transplanted MSCs could be a potential immunotherapy strategy for the treatment of Hashimoto’s thyroiditis. 相似文献
26.
目的: 应用文献计量学方法,分析国内外医用粘胶相关性皮肤损伤(Medical adhesive-related skin injuries,MARSI)文献的研究主题和热点。方法: 检索Cochrane Library、PubMed、EMbase、Web of science、sinoMed、CNKI、Wanfang、VIP等数据库MARSI相关文献,检索时限为建库至2019年5月。采用SPSS 22.0 软件进行文献计量分析,利用gCLUTO统计对国内外高频主题词进行聚类分析。结果: 共纳入论文103篇,其中外文文献占总文献量的27.18%,中文文献占总文献量的72.82%。聚类分析将国内外高频主题词聚为4大类,依次为皮肤损伤及损伤类型、相关危险因素、风险评估及风险管理、护理干预措施。结论: MARSI仍是国内外研究的热点,其发病机制研究仍处于探索阶段,目前尚缺乏有效的预防策略,研究领域较局限。在今后的研究中,应加强MARSI预防的研究、注重多学科合作。 相似文献
27.
28.
OBJECTIVES: To assess the effectiveness and safety of additional bedtime H2‐receptor antagonists (H2RAs) in suppressing nocturnal gastric acid breakthrough (NAB) via a systematic review. METHODS: Eligible trials were identified by searching the Cochrane Central Register of Controlled Trials (CENTRAL) (Cochrane Library Issue 2, 2004), MEDLINE (January 1966–June 2004), EMBASE (January 1980–June 2004) and CINAHL (January 1982–June 2004). Additional hand‐searching was conducted on the proceedings of correlated conferences, eight important Chinese journals and references of all included trials. All randomized controlled trials evaluating H2RAs for the control of NAB were eligible for inclusion. The systematic review was conducted using methods recommended by The Cochrane Collaboration. RESULTS: Only two randomized crossover studies, comprising 32 participants, met the inclusion criteria. Because the design, dosage and duration of the treatments were different between the studies, it was not possible to conduct meta‐analysis. There were no consistent conclusions found between the two included studies in evaluating H2RAs for the control of NAB. CONCLUSIONS: No implications for practice at this stage can be concluded. Appropriately designed large‐scale randomized controlled trials with long‐term follow up are needed to determine the effects of additional bedtime H2RAs in suppressing NAB. 相似文献
29.
Kei Kamide Yoshihiro Kokubo Hironori Hanada Junko Nagura Jin Yang Shin Takiuchi Chihiro Tanaka Mariko Banno Yoshikazu Miwa Masayoshi Yoshii Tetsutaro Matayoshi Hisayo Yasuda Takeshi Horio Akira Okayama Hitonobu Tomoike Yuhei Kawano Toshiyuki Miyata 《Hypertension research》2006,29(4):243-252
Mutations in the gene encoding 11beta-hydroxysteroid dehydrogenase type 2, HSD11B2, cause a rare monogenic juvenile hypertensive syndrome called apparent mineralocorticoid excess (AME). In AME, defective HSD11B2 enzyme activity results in overstimulation of the mineralocorticoid receptor (MR) by cortisol, causing sodium retention, hypokalemia, and salt-dependent hypertension. Here, we have studied whether genetic variations in HDS11B2 are implicated in essential hypertension in Japanese hypertensives and the general population. By sequencing the entire coding region and the promoter region of HDS11B2 in 953 Japanese hypertensives, we identified five missense mutations in 11 patients (L14F, n = 5; R74H, n = 1; R147H, n = 3; T156I, n = 1; R335H, n = 1) and one novel frameshift mutation (4884Gdel, n = 1) in a heterozygous state, in addition to 19 genetic variations. All genetic variations identified were rare, with minor allele frequencies less than 0.005. Four of 12 patients with the missense/frameshift mutations showed renal failure. Four missense mutations, L14F, R74H, R147H, and R335H, were successfully genotyped in the general population, with a sample size of 3,655 individuals (2,175 normotensives and 1,480 hypertensives). Mutations L14F, R74H, R147H, and R335H were identified in hypertensives (n = 6, 8, 3, and 0, respectively) and normotensives (n = 8, 12, 5, and 0, respectively) with a similar frequency, suggesting that these missense mutations may not strongly affect the etiology of essential hypertension. Since the allele frequency of all of the genetic variations identified in this study was rare, an association study was not conducted. Taken together, our results indicate that missense mutations in HSD11B2 do not substantially contribute to essential hypertension in Japanese. 相似文献
30.
目的了解我院门诊就诊者对子宫颈病变相关知识的认识。方法自制问卷调查表,采用无记名,当面问卷调查方式。结果从调查100例就诊者中,未做过健康体检、妇科盆腔检查和宫颈刮片检查分别为34例、24例和52例。对宫颈癌的认识不知道者53例。结论建议相关部门加强对妇女的健康教育,提高其健康意识,强化临床医生的防癌意识和对子宫病变的规范化诊治。 相似文献