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Noncomparative contraceptive efficacy of cellulose sulfate gel 总被引:1,自引:0,他引:1
Mauck CK Freziers RG Walsh TL Peacock K Schwartz JL Callahan MM 《Obstetrics and gynecology》2008,111(3):739-746
OBJECTIVE: To estimate the 6-month cumulative probability of pregnancy, short-term adverse effects, and acceptability of cellulose sulfate vaginal contraceptive gel. METHODS: Two hundred fertile heterosexual couples were enrolled in this single-center, phase II, 6-month noncomparative study conducted at the California Family Health Council in Los Angeles, California. Couples did not desire pregnancy, were at low risk for sexually transmitted diseases, and agreed to use 3.5 mL of cellulose sulfate gel intravaginally before each coital act as their primary means of contraception. Scheduled follow-up visits took place after one menstrual cycle and at study completion, which occurred after 6 months and six menstrual cycles had elapsed. In addition, participants were instructed to call the site at the onset of each menses to review their diary cards. RESULTS: The cumulative probabilities of pregnancy during 6 months and six cycles of typical use were 13.4% (95% confidence interval [CI] 7.5-19.4%) and 13.9% (95% CI 7.7-20.2%), respectively, and during 6 cycles of correct and consistent ("perfect") use: 3.9% (95% CI 0.0-9.2%). Slightly over one fourth of the women and one man reported experiencing gel-related adverse events, two thirds of which were mild and only possibly related to the gel. Three quarters of women and men reported that they would buy cellulose sulfate gel for contraception. CONCLUSION: Cellulose sulfate vaginal gel yields pregnancy rates comparable to nonoxynol-9 and few adverse events among couples at low risk for sexually transmitted diseases. 相似文献
74.
Cheyne H Dowding D Hundley V Aucott L Styles M Mollison J Greer I Niven C 《Midwifery》2008,24(2):199-213
OBJECTIVES: to describe the development and testing of an algorithm for diagnosis of active labour in primiparous women. DESIGN: qualitative and quantitative methods were used. A literature review was first conducted to identify the key cues for inclusion in the algorithm. Focus groups of midwives were then conducted to assess content validity, finally a vignette study assessed the inter-rater reliability of the algorithm. SETTING: midwives from two study sites were invited to participate. Data were collected during 2002 and 2003. PARTICIPANTS: midwives from the first site took part in the focus groups (n=13), completed vignettes (n=19), or both. Midwives from the second site then completed vignettes (n=17). FINDINGS: an algorithm, developed from the key informational cues reported in the literature, was validated in relation to content validity by the findings from the focus groups. Inter-rater reliability was tested using vignettes of admission case histories and was found to be moderate in the first test (K=0.45). However, after modifying the algorithm the kappa score was 0.86, indicating a high level of agreement. KEY CONCLUSIONS: diagnosis of labour may be straightforward on paper but is frequently problematic in practice. This may be because the diagnosis of labour is made in a high pressured environment where conflicting pressures of workload, limited resources and emotional pressures add to the complexity of the judgement. IMPLICATIONS FOR PRACTICE: we offer a valid and reliable decision-support tool as an aid for diagnosis of labour. The evaluation of the implementation of this tool is under way and will determine whether it is effective in reducing unnecessary admissions and improving clinical outcomes for women. 相似文献
75.
Cilliers D Alanay Y Boduroglu K Utine E Tunçbilek E Clayton-Smith J 《Clinical dysmorphology》2007,16(2):121-125
We report a further two patients with cerebro-facio-thoracic dysplasia, a rare autosomal recessive condition with thoracic costovertebral dysplasia, developmental delay and characteristic facial features. One of our patients has the additional features of large, bilateral colobomas of the optic nerve, ptosis, small conical teeth and severe left-sided talipes. He also has hypermobile joints, especially in his hands and anterior subluxation of the shoulders. The second patient has hypodensity of the grey matter on magnetic resonance imaging, which is the second report of this finding in cerebro-facio-thoracic dysplasia. In addition, he has hypoplasia of the corpus callosum. These cases illustrate the expanding phenotype of this condition, and support the hypothesis that this is an autosomal recessive condition. 相似文献
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van Karnebeek Clara D. Blydt-Hansen Ingrid Matthews Allison M. Avramovic Vladimir Price Magda Drogemoller Britt Shyr Casper Lee Jessica Mwenifumbo Jill Ghani Aisha Stockler Sylvia Friedman Jan M. Lehman Anna Ross Colin J. Wasserman Wyeth W. Tarailo-Graovac Maja Horvath Gabriella A. 《Neurogenetics》2021,22(4):251-262
neurogenetics - Monoamine neurotransmitter disorders present predominantly with neurologic features, including dystonic or dyskinetic cerebral palsy and movement disorders. Genetic conditions that... 相似文献
79.
Olivia Bonardi Yutong Wang Kexin Li Xiaowen Jiang Ankur Krishnan Chen He Ying Sun Yin Wu Jill T. Boruff Sarah Markham Danielle B. Rice Ian Thombs-Vite Amina Tasleem Tiffany Dal Santo Anneke Yao Marleine Azar Branka Agic Christine Fahim Michael S. Martin Sanjeev Sockalingam Gustavo Turecki Andrea Benedetti Brett D. Thombs 《Revue canadienne de psychiatrie》2022,67(5):336