大鼠不同程度的急性颅脑损伤后血糖浓度的变化及其预后

目的 :探讨大鼠不同程度的急性颅脑损伤后血糖浓度的变化及其与预后的关系。方法 :Wistar雄性大鼠 2 0只 ,随机分为 2组 ,A组 :将 5 0 0 g砝码由 35 cm高度自由下落打击大鼠头部 ;B组 :将 5 0 0 g砝码由 2 0 cm高度自由下落打击大鼠头部 ;设自身对照 ,分别测定不同伤情的两组动物伤前及伤后血糖浓度的变化及观察 2 4h内两组动物死亡情况。结果 :A、B组伤后测得的血糖值均显著高于正常值 (P <0 .0 5 ) ;且 A组伤后测得的血糖值又显著高于 B组 (P <0 .0 5 ) ;A组动物死亡 8只 ,B组死亡 1只。结论 :急性颅脑损伤后均有不同程度的血糖升高 ,而且颅脑损伤程度越重 ,血糖值越高 ,死亡率越高。     

醒脑静在重症一氧化碳中毒抢救中的临床应用

目的　探讨醒脑静对急性重症一氧化碳 (CO)中毒的催醒作用。方法　在急性重症CO中毒常规综合抢救中加入醒脑静并与常规方法进行对比研究。结果　醒脑静治疗组较常规治疗组清醒时间明显缩短 (P <0 .0 1)。结论　醒脑静可作为急性重症CO中毒病人综合抢救中常规用药。     

乳腺髓样癌的超声检查与组织病理的相关性分析

目的:探讨超声检查在诊断乳腺典型髓样癌中的临床意义。方法:按严格的病理诊断学标准将病例重新分类为乳腺典型髓样癌和非典型髓样癌,比较两者间声像学特征的异同。结果:32例中有13侧重新诊断为乳腺典型髓样癌;另外19例为非典型髓样癌。13例典型髓样癌患者中的10例边界整齐光滑;全部19例非典型髓样癌病人没有一例边界光滑,或者边界呈锯齿状(16例),或者边界光滑伴局部不规则(3例)。非典型与典型髓样癌间肿瘤边界的规则性有明显的差异。结论:如果超声检查提示肿瘤边界呈锯齿状或肿瘤边界光滑伴局部不规则,应行整个肿瘤的病理评估防止典型髓样癌的过诊断。     

电磁辐射对小鼠神经系统超微结构影向的分析

目的探讨移动电话的电磁辐射对生物体的影响.方法用大众常用移动电话作为辐射源,工作频率为900MHz,功率密度为1190μW/cm2,在一定范围对小鼠辐射2h/d,30d后把小鼠断颈处死,取出大脑皮层、海马和小脑进行电镜观察分析.结果电镜所见,处理组与对照组小鼠的神经系统的细胞超微结构未见明显异常.结论一定时间内,移动电话的电磁辐射,对小鼠神经系统的细胞超微结构并没有明显影响.     

中药复方发明专利创造性审查的影响因素分析

目的 寻找中药复方发明专利创造性审查的关键影响因素并分析原因,为完善相关审查标准提供参考。方法 筛选驳回依据为创造性的中药复方发明专利复审决定,建立数据库,通过分类和单因素逻辑（Logistic）回归等方法分析影响因素。结果 中药复方专利创造性的审查标准受年度变化的影响明显。按要求补充实验数据、区别技术特征数量、复方的发明类型、审查员所引用的对比文件及公知常识情况均能提高专利复审的撤驳率。结论 我国尚未建立合理、统一、清晰的中药复方发明专利创造性审查标准,仍有待从多个方面进一步完善。     

Dark Tea: A popular beverage with possible medicinal application

Tea is a famous beverage that is produced from leaves of Camellia sinensis. Amongst the six major tea categories in China, dark tea is the only one that involves microbial fermentation in the manufacturing process, which contributes unique flavors and functions for the tea. In the recent decade, the reports about the biofunctions of dark teas have increased rapidly. Therefore it may be the proper time to consider dark tea as one potential homology of medicine and food. In this viewpoint, our current understanding of the chemical constituents, biological activities and possible health beneficial effects of dark teas were introduced. Some future directions and challenges to the development perspectives of dark teas were also discussed.     

Neuroprotective effects of Longxue Tongluo Capsule on ischemic stroke rats revealed by LC-MS/MS-based metabolomics approach

Objective: The present study aimed to evaluate the therapeutic effect and explore the underlying mechanisms of Longxue Tongluo Capsule (LTC) on ischemic stroke rats. Methods: Twenty-six rats were randomly divided into four groups, including sham group, sham + LTC group, MCAO group, and MCAO + LTC group. Ischemic stroke rats were simulated by middle cerebral artery occlusion (MCAO), and LTC treatment group were orally administrated with 300 mg/kg of LTC once daily for seven consecutive days. LTC therapy was validated in terms of neurobehavioral abnormality evaluation, cerebral infarct area, and histological assessments. The plasma metabolome comparisons amongst different groups were conducted by UHPLC-Q Exactive MS in combination with subsequent multivariate statistical analysis, aiming to finding the molecules in respond to the surgery or LTC treatment. Results: Intragastric administration of LTC significantly decreased not only the neurobehavioral abnormality scores but also the cerebral infarct area of MCAO rats. The interstitial edema, atrophy, and pyknosis of glial and neuronal cells occurred in the infarcted area, core area, and marginal area of cerebral cortex were improved after LTC treatment. A total of 13 potential biomarkers were observed, and Youden index of 11 biomarkers such as LysoPC, SM, and PE were more than 0.7, which were involved in neuroprotective process. The correlation and pathway analysis showed that LTC was beneficial to ischemic stroke rats via regulating glycerophospholipid and sphingolipid metabolism, together with nicotinate and nicotinamide metabolism. Heatmap and ternary analysis indicated the synergistic effect of carbohydrates and lipids may be induced by flavonoid intake from LTC. Conclusion: The present study could provide evidence that metabolomics, as systematic approach, revealed its capacity to evaluate the holistic efficacy of TCM, and investigate the molecular mechanism underlying the clinical treatment of LTC on ischemic stroke.     

李彦民治疗类风湿关节炎经验

类风湿关节炎(RA)在中医学中属于“痹病”范畴,是临床中常见的难治性疾病,且呈年轻化趋势,迁延难愈。目前现代医学对RA的发病病因及机制尚不完全清楚。《素问·痹论》提出风寒湿三邪致痹,还有学者提出痰瘀致痹、肝肾亏虚等观点。李彦民主任医师根据多年临床经验提出RA的病机关键是络脉痹阻,其病机特点是虚实夹杂,临床辨证分为寒湿阻络型、湿热蕴结型、痰瘀互结型、气血两虚型、肝肾亏虚型等五型。分别采用祛邪通络和补虚通络等不同治则,辨证施法。李老师善用川乌、鸡血藤以及乌梢蛇等药以通络止痛,并主张辨证用药,内外兼治,多取良效。临床采用经验方仙龙汤,配合外用舒筋活络洗剂,且取得理想疗效。     

Recent Developments in the Determination of PM2.5 Chemical Composition

Bulletin of Environmental Contamination and Toxicology - Fine particulate matter (named PM2.5) has become a prominent and dangerous form of air pollution. The chemical composition of PM2.5 mainly...