False positive detection of serum cryptococcal antigens due to insufficient sample dilution: A case series

At present, with the development of technology, the detection of cryptococcal antigen (CRAG) plays an increasingly important role in the diagnosis of cryptococcosis. However, the three major CRAG detection technologies, latex agglutination test (LA), lateral flow assay (LFA) and Enzyme-linked Immunosorbent Assay, have certain limitations. Although these techniques do not often lead to false-positive results, once this result occurs in a particular group of patients (such as human immunodeficiency virus patients), it might lead to severe consequences.     

心痛泰对动脉粥样硬化兔血脂及主动脉ox-LDL、IL-1β的影响

目的观察心痛泰对动脉粥样硬化兔血脂、载脂蛋白A、B及主动脉氧化型低密度脂蛋白(ox-LDL)和白细胞介素1β(IL-1β)的影响。方法 120只清洁级日本大耳白兔随机分为六组:空白组、模型组、心痛泰高剂量、中剂量和低剂量组、瑞舒伐他汀组,采用高脂喂养加免疫损伤造模,造模同时予以相应药物灌胃。60天后,采血测定血脂与载脂蛋白。取胸主动脉用免疫组织化学法测定ox-LDL、IL-1β。结果与模型组相比,心痛泰中剂量、高剂量组和瑞舒伐他汀组总胆固醇、甘油三酯、低密度脂蛋白、载脂蛋白B明显降低(P0.01或P0.05),载脂蛋白A和高密度脂蛋白明显升高(P0.01或P0.05),主动脉ox-LDL、IL-1β明显降低(P0.01)。结论心痛泰能减轻动脉粥样硬化炎症反应,其作用机制可能是通过降低血脂、减少ox-LDL、IL-1β的表达减轻血管炎症,以达到抗动脉粥样硬化的目的。