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991.
Patricia A. Smiley Lindsey C. Partington Caroline R. Cochran Jessica L. Borelli 《Developmental psychobiology》2020,62(8):1134-1149
Parental socialization that infringes on children's autonomy may have consequences for physiological regulation, trait anxiety, and state distress. One such practice is the use of positive conditional regard (CR)—the provision of extra attention/affection when children meet parents’ expectations. Self-determination theory proposes that CR thwarts satisfaction of children's basic needs for relatedness and autonomy by placing these needs in conflict. We evaluate associations among children's (N = 106, 51% male, Mage = 10.27 years, SD = 1.09) reports of their mothers’ use of positive CR to suppress anger expression (PCR-anger), their physiological regulation (resting respiratory sinus arrhythmia, RSA), and their trait anxiety and state distress, in light of perceived relationship closeness. After controlling demographics, mothers’ reports of positive and negative CR-anger, children's reports of mothers’ negative CR-anger and depressive symptoms, greater child-reported positive CR-anger was significantly associated with greater child anxiety and with lower resting RSA. Resting RSA mediated associations of child-reported positive CR-anger with greater child anxiety and post-failure distress. These indirect effects were significant for children low or moderate in closeness to mother. We conclude that autonomy-restrictive socialization is a concurrent correlate of children's physiological regulation, anxiety, and state distress, with these associations dependent on relational distance. 相似文献
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995.
Flavia Savassi-Ribas Jessica G. Pereira Marco A. P. Horta Tereza C. S. Wagner Tereza A. Matuck Deise B. Monteiro de Carvalho Francisco C. A. Mello Rafael B. Varella Caroline C. Soares 《Journal of medical virology》2020,92(12):2961-2968
Kidney transplantation is the treatment of choice for patients with end-stage renal disease. In the posttransplant period, the induced immunosuppression leads to an increased risk of developing infectious diseases, a leading cause of death after kidney transplantation. Human pegivirus-1 (HPgV-1) is considered a nonpathogenic human virus and is highly frequent in individuals parenterally exposed, however, its impact on kidney transplantation outcome is poorly understood. Given the scarcity of epidemiological data for this infection on organ recipients in Brazil, we conducted a study in a single center for kidney transplantation in Rio de Janeiro, aiming to determine HPgV-1 prevalence and genotypic distribution. Serum samples from 61 renal recipients, followed up for the first year after transplantation, were evaluated for viral RNA and genotypes were determined by sequencing of the 5′-untranslated region. HPgV-1 RNA was detected in 36.1% (22/61) of patients. Genotype 2 was the most commonly found (80.9%), followed by genotypes 3 (9.5%), 1, and 5, in 4.8% each. Statistical comparisons did not reveal any significant impact of HPgV-1 in patient outcome. Further epidemiologic studies are needed to understand if immunosuppression may interfere in HPgV-1 persistence rates and if viremia might impact graft dysfunction rates in kidney recipients. 相似文献
996.
Ioana Agache Jessica Beltran Cezmi Akdis Mubeccel Akdis Carlos Canelo-Aybar Giorgio Walter Canonica Thomas Casale Tomas Chivato Jonathan Corren Stefano Del Giacco Thomas Eiwegger Davide Firinu James E. Gern Eckard Hamelmann Nicola Hanania Mika Mäkelä Irene Hernández-Martín Parameswaran Nair Liam O'Mahony Nikolaos G. Papadopoulos Alberto Papi Hae-Sim Park Luis Pérez de Llano Margarita Posso Claudio Rocha Santiago Quirce Joaquin Sastre Mohamed Shamji Yang Song Corinna Steiner Jurgen Schwarze Pablo Alonso-Coello Oscar Palomares Marek Jutel 《Allergy》2020,75(5):1023-1042
Five biologicals have been approved for severe eosinophilic asthma, a well-recognized phenotype. Systematic reviews (SR) evaluated the efficacy and safety of benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab (alphabetical order) compared to standard of care for severe eosinophilic asthma. PubMed, Embase and Cochrane Library were searched to identify RCTs and health economic evaluations, published in English. Critical and important asthma-related outcomes were evaluated for each of the biologicals. The risk of bias and the certainty of the evidence were assessed using GRADE. 19 RCTs (three RCTs for benralizumab, three RCTs for dupilumab, three RCTs for mepolizumab, five RCTs for omalizumab and five RCTs for reslizumab), including subjects 12 to 75 years old (except for omalizumab including also subjects 6-11 years old), ranging from 12 to 56 weeks were evaluated. All biologicals reduce exacerbation rates with high certainty of evidence: benralizumab incidence rate ratio (IRR) 0.53 (95% CI 0.39 to 0.72), dupilumab (IRR) 0.43 (95% CI 0.32 to 0.59), mepolizumab IRR 0.49 (95% CI 0.38 to 0.66), omalizumab (IRR) 0.56 (95% CI 0.40 to 0.77) and reslizumab (IRR) 0.46 (95% CI 0.37 to 0.58). Benralizumab, dupilumab and mepolizumab reduce the daily dose of oral corticosteroids (OCS) with high certainty of evidence. All evaluated biologicals probably improve asthma control, QoL and FEV1, without reaching the minimal important difference (moderate certainty). Benralizumab, mepolizumab and reslizumab slightly increase drug-related adverse events (AE) and drug-related serious AE (low to very low certainty of evidence). The incremental cost-effectiveness ratio per quality-adjusted life year value is above the willingness to pay threshold for all biologicals (moderate certainty). Potential savings are driven by decrease in hospitalizations, emergency and primary care visits. There is high certainty that all approved biologicals reduce the rate of severe asthma exacerbations and for benralizumab, dupilumab and mepolizumab for reducing OCS. There is moderate certainty for improving asthma control, QoL, FEV1. More data on long-term safety are needed together with more efficacy data in the paediatric population. 相似文献
997.
998.
Julieann C. Lee Javier E. Villanueva‐Meyer Sean P. Ferris Elaine M. Cham Jacob Zucker Tabitha Cooney Ahmed Gilani Bette K. Kleinschmidt‐DeMasters Dimitri Trembath Manuela Mafra Jason Chiang David W. Ellison Soo‐Jin Cho Andrew E. Horvai Jessica Van Ziffle Courtney Onodera Patrick Devine James P. Grenert Carmen M.A. de Voijs W.T. Marja van Blokland Wendy W.J. de Leng Marieke J. Ploegmakers Uta Flucke Melike Pekmezci Andrew W. Bollen Tarik Tihan Christian Koelsche Andreas von Deimling Pieter Wesseling David A. Solomon Arie Perry 《Brain pathology (Zurich, Switzerland)》2020,30(2):213-225
Desmoplastic small round cell tumors (DSRCTs) are highly aggressive sarcomas that most commonly occur intra‐abdominally, and are defined by EWSR1‐WT1 gene fusion. Intracranial DSRCTs are exceptionally rare with only seven previously reported fusion‐positive cases. Herein, we evaluate the clinical, morphologic, immunohistochemical and molecular features of five additional examples. All patients were male (age range 6–25 years; median 11 years), with four tumors located supratentorially and one within the posterior fossa. The histologic features were highly variable including small cell, embryonal, clear cell, rhabdoid, anaplastic and glioma‐like appearances. A prominent desmoplastic stroma was seen in only two cases. The mitotic index ranged from <1 to 12/10 HPF (median 5). While all tumors showed strong desmin positivity, epithelial markers such as EMA, CAM 5.2 and other keratins were strongly positive in only one, focally positive in two and negative in two cases. EWSR1‐WT1 gene fusion was present in all cases, with accompanying mutations in the TERT promoter or STAG2 gene in individual cases. Given the significant histologic diversity, in the absence of genetic evaluation these cases could easily be misinterpreted as other entities. Desmin immunostaining is a useful initial screening method for consideration of a DSRCT diagnosis, prompting confirmatory molecular testing. Demonstrating the presence of an EWSR1‐WT1 fusion provides a definitive diagnosis of DSRCT. Genome‐wide methylation profiles of intracranial DSRCTs matched those of extracranial DSRCTs. Thus, despite the occasionally unusual histologic features and immunoprofile, intracranial DSRCTs likely represent a similar, if not the same, entity as their soft tissue counterpart based on the shared fusion and methylation profiles. 相似文献
999.
Calixto‐Hope G. Lucas Javier E. Villanueva‐Meyer Nicholas Whipple Nancy Ann Oberheim Bush Tabitha Cooney Susan Chang Michael McDermott Mitchel Berger Elaine Cham Peter P. Sun Angelica Putnam Hong Zhou Robert Bollo Samuel Cheshier Matthew M. Poppe Kar‐Ming Fung Sarah Sung Chad Glenn Xuemo Fan Serguei Bannykh Jethro Hu Moise Danielpour Rong Li Elizabeth Alva James Johnston Jessica Van Ziffle Courtney Onodera Patrick Devine James P. Grenert Julieann C. Lee Melike Pekmezci Tarik Tihan Andrew W. Bollen Arie Perry David A. Solomon 《Brain pathology (Zurich, Switzerland)》2020,30(3):479-494
“Myxoid glioneuronal tumor, PDGFRA p.K385‐mutant” is a recently described tumor entity of the central nervous system with a predilection for origin in the septum pellucidum and a defining dinucleotide mutation at codon 385 of the PDGFRA oncogene replacing lysine with either leucine or isoleucine (p.K385L/I). Clinical outcomes and optimal treatment for this new tumor entity have yet to be defined. Here, we report a comprehensive clinical, radiologic, and histopathologic assessment of eight cases. In addition to its stereotypic location in the septum pellucidum, we identify that this tumor can also occur in the corpus callosum and periventricular white matter of the lateral ventricle. Tumors centered in the septum pellucidum uniformly were associated with obstructive hydrocephalus, whereas tumors centered in the corpus callosum and periventricular white matter did not demonstrate hydrocephalus. While multiple patients were found to have ventricular dissemination or local recurrence/progression, all patients in this series remain alive at last clinical follow‐up despite only biopsy or subtotal resection without adjuvant therapy in most cases. Our study further supports “myxoid glioneuronal tumor, PDGFRA p.K385‐mutant” as a distinct CNS tumor entity and expands the spectrum of clinicopathologic and radiologic features of this neoplasm. 相似文献
1000.
Jessica A. Hudson Jonathan Broad Natalie G. Martin Manish Sadarangani Ushma Galal Dominic F. Kelly Andrew J. Pollard Seilesh Kadambari 《Reviews in medical virology》2020,30(2)
Viruses are the commonest cause of childhood meningitis, but outcomes beyond hospital discharge are poorly described. We undertook a systematic literature review of long‐term outcomes following paediatric viral meningitis. A search was carried out using MEDLINE, Embase, and Cochrane Review for studies from 1 January 1990 to 31 December 2018. Studies were included where specific outcome measures were available beyond hospital discharge for children <16 years old with viral meningitis. In total, 3588 papers were identified of which 14 were eligible for inclusion. Four studies reported outcomes in children with nonenterovirus 71 meningitis. A US study of 16 cases demonstrated subtle language difficulties at 3‐year follow‐up in infants in contrast to an Australian study, which revealed no impairment in language. A Fijian study showed that two out of eight cases had sensorineural hearing loss compared with none in a UK cohort of 668 infants. Three studies evaluated outcomes of enterovirus 71 meningitis in China and Taiwan, two showed cases recovered without sequelae, while one demonstrated an increased risk of attention deficit hyperactivity disorder. Two studies including 141 cases of human parechovirus revealed no evidence of neurodevelopmental sequelae. Conversely, an Australian study demonstrated neurodevelopmental sequelae in 11 out of 77 infants with parechovirus meningitis. Most studies identified in this review demonstrated a high proportion of good clinical outcomes following viral meningitis. However, the data are limited, so robustly conducted neurodevelopmental studies are warranted to inform the evidence‐based management of viral meningitis beyond hospital discharge. 相似文献