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991.
Monica Fung Iris Otani Michele Pham Jennifer Babik 《Annals of allergy, asthma & immunology》2021,126(4):321-337
ObjectiveTo review the virology, immunology, epidemiology, clinical manifestations, and treatment of the following 3 major zoonotic coronavirus epidemics: severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and coronavirus disease 2019 (COVID-19).Data SourcesPublished literature obtained through PubMed database searches and reports from national and international public health agencies.Study SelectionsStudies relevant to the basic science, epidemiology, clinical characteristics, and treatment of SARS, MERS, and COVID-19, with a focus on patients with asthma, allergy, and primary immunodeficiency.ResultsAlthough SARS and MERS each caused less than a thousand deaths, COVID-19 has caused a worldwide pandemic with nearly 1 million deaths. Diagnosing COVID-19 relies on nucleic acid amplification tests, and infection has broad clinical manifestations that can affect almost every organ system. Asthma and atopy do not seem to predispose patients to COVID-19 infection, but their effects on COVID-19 clinical outcomes remain mixed and inconclusive. It is recommended that effective therapies, including inhaled corticosteroids and biologic therapy, be continued to maintain disease control. There are no reports of COVID-19 among patients with primary innate and T-cell deficiencies. The presentation of COVID-19 among patients with primary antibody deficiencies is variable, with some experiencing mild clinical courses, whereas others experiencing a fatal disease. The landscape of treatment for COVID-19 is rapidly evolving, with both antivirals and immunomodulators demonstrating efficacy.ConclusionFurther data are needed to better understand the role of asthma, allergy, and primary immunodeficiency on COVID-19 infection and outcomes. 相似文献
992.
993.
994.
Dawn Peck Amy White Gisele Pino April Studinski Meghan Strenk Randi Gadea Jennifer Gannon Bryce Heese Esperanza Font-Montgomery Tracy Klug Jennifer Burton George Hoganson Devin Oglesbee Dimitar Gavrilov Dietrich Matern Kimiyo Raymond Piero Rinaldo Silvia Tortorelli 《Molecular genetics and metabolism》2021
995.
Carroll Melissa A. Blandino Jennifer Flynn Alex Laughran Ryan Pennella Shannon 《Anatomical science international / Japanese Association of Anatomists》2021,96(1):161-167
Anatomical Science International - Variants of the axillary artery and brachial plexus were found bilaterally in the axilla of an 86-year-old Asian female. On the left, the cadaver donor had a high... 相似文献
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997.
Jennifer L. Heyward Benjamin D. Reynolds Melanie L. Foster Kate E. Archibald Michael K. Stoskopf Freya M. Mowat 《Anatomical record (Hoboken, N.J. : 2007)》2021,304(3):662-672
The distribution of cone photoreceptor subtypes (important for color vision and vision quality) varies widely in different carnivore species, but there have been limited studies on bear (ursid) cone distribution. A previous behavioral study suggests that American black bears (Ursus americanus) are dichromatic, indicating that they possess two cone subtypes, although the retinal distribution of cones is unknown. The purpose of this study was to examine the subtype and topography of cones in American black bear retinas to further predict the nature of their color vision and image resolution. We studied 10 eyes from seven individual legally hunted black bears in northeastern North Carolina. Cryosections and retinal wholemounts were labeled using antibodies targeting two cone opsin subtypes: long/medium (L/M) wavelength sensitive and short (S) wavelength sensitive. Cones in fluorescent microscopy images were counted and density maps were created for retinal wholemounts. The black bear retina contains both cone subtypes and L/M cones outnumber S cones by at least 3:1, a finding confirmed in retinal frozen sections. There are higher concentrations of S cones present than typically seen in other carnivores with some evidence for co-expression of L/M and S cones. A cone-dense area centralis is present dorsotemporal to the optic nerve, similar to other carnivores. These results confirm that American black bears are predicted to have a dichromatic vision with high acuity indicated by the presence of a dorsotemporally located area centralis. 相似文献
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999.
Young Jennifer M. Power D. Kanokwongnuwut P. Linacre A. 《International journal of legal medicine》2021,135(1):81-89
International Journal of Legal Medicine - Direct PCR can be used to successfully generate full STR profiles from DNA present on the surface of objects. STR profiles are only of use in cases where a... 相似文献
1000.
Holland Charity A. McElhoe Jennifer A. Gaston-Sanchez Sidney Holland Mitchell M. 《International journal of legal medicine》2021,135(1):91-106
International Journal of Legal Medicine - Massively parallel sequencing (MPS) of mitochondrial (mt) DNA allows practitioners the ability to fully resolve heteroplasmic sites. In forensic DNA... 相似文献