全文获取类型
收费全文 | 2306篇 |
免费 | 95篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 27篇 |
儿科学 | 28篇 |
妇产科学 | 23篇 |
基础医学 | 316篇 |
口腔科学 | 8篇 |
临床医学 | 230篇 |
内科学 | 512篇 |
皮肤病学 | 53篇 |
神经病学 | 239篇 |
特种医学 | 77篇 |
外科学 | 389篇 |
综合类 | 8篇 |
一般理论 | 2篇 |
预防医学 | 119篇 |
眼科学 | 15篇 |
药学 | 163篇 |
中国医学 | 1篇 |
肿瘤学 | 197篇 |
出版年
2023年 | 14篇 |
2022年 | 26篇 |
2021年 | 67篇 |
2020年 | 21篇 |
2019年 | 42篇 |
2018年 | 56篇 |
2017年 | 27篇 |
2016年 | 34篇 |
2015年 | 50篇 |
2014年 | 70篇 |
2013年 | 99篇 |
2012年 | 209篇 |
2011年 | 219篇 |
2010年 | 104篇 |
2009年 | 100篇 |
2008年 | 182篇 |
2007年 | 149篇 |
2006年 | 164篇 |
2005年 | 158篇 |
2004年 | 120篇 |
2003年 | 123篇 |
2002年 | 107篇 |
2001年 | 18篇 |
2000年 | 17篇 |
1999年 | 19篇 |
1998年 | 20篇 |
1997年 | 13篇 |
1996年 | 13篇 |
1995年 | 9篇 |
1994年 | 8篇 |
1993年 | 15篇 |
1992年 | 16篇 |
1991年 | 10篇 |
1990年 | 11篇 |
1989年 | 8篇 |
1988年 | 7篇 |
1987年 | 6篇 |
1986年 | 10篇 |
1985年 | 8篇 |
1984年 | 5篇 |
1983年 | 3篇 |
1982年 | 6篇 |
1981年 | 3篇 |
1980年 | 5篇 |
1979年 | 7篇 |
1977年 | 6篇 |
1975年 | 3篇 |
1973年 | 3篇 |
1972年 | 3篇 |
1970年 | 3篇 |
排序方式: 共有2407条查询结果,搜索用时 0 毫秒
71.
Solitary fibrous tumors of the pleura: clinical characteristics, surgical treatment and outcome 总被引:6,自引:0,他引:6
Pierre Magdeleinat Marco Alifano Antonio Petino Jean-Philippe Le Rochais Elisabeth Dulmet Franoise Galateau Philippe Icard Jean-Franois Regnard 《European journal of cardio-thoracic surgery》2002,21(6):1087-1093
Objective: The aim of this paper is to study clinical characteristics, surgical treatment and outcome of patients with solitary fibrous tumor of the pleura operated in our institutions in a 20-year period. Methods: Clinical records of all patients operated for solitary fibrous tumors of the pleura between 1981 and 2000 were reviewed retrospectively. Tumors were classified as malignant in the presence of at least one of the following criteria: (1) high mitotic activity; (2) high cellularity with crowding and overlapping of nuclei; (3) presence of necrosis; (4) pleomorphism; otherwise they were considered as benign. Results: Sixty patients (mean age 55 years) were operated in this period. None had asbestos exposure. Symptoms were present in 31 cases. Surgical approaches included thoracotomy (n=53), video-assisted thoracoscopy (n=6), and median sternotomy (n=1). Tumors originated from visceral pleura in 48 cases, from parietal, mediastinal or diaphragmatic pleura in seven, two and three cases, respectively; their mean diameter was 8.5 cm. Tumors could be resected with their implantation basis in 49 patients. In the remaining 11, extended resections were performed, including lung parenchyma (lobectomy, n=4, pneumonectomy, n=2), osteomuscular chest wall structures (n=2), diaphragm (n=2), and pericardium (n=1). Two postoperative deaths (due to myocardial infarction and pulmonary embolism, respectively) occurred. Tumors were pathologically benign in 38 cases and malignant in 22 cases. Mean follow-up was 88 months. Resection was complete in all the patients with benign tumors and no recurrence occurred. Resection was considered as complete in 21/22 malignant tumors. Local recurrence was observed in two cases. Both could be successfully managed by iterative exeresis (no extended resection had been initially performed). Metastatic disease (responsible for patient's death) was observed following the only incomplete resection. Actuarial 5- and 10-year survival rates were 97% for benign tumors and 89% for malignant ones. Conclusions: Surgical resection provided cure in all the patients with benign tumors. As insufficiency of exeresis is associated with all recurrences in malignant tumors, completeness of resection is in our experience the best prognostic factor in these forms. 相似文献
72.
The aim of this study was to determine the threshold for detecting knee effusion by ultrasound (US). Five knee specimens from embalmed cadavers were studied. Intra-articular injection of saline, blood and synovial fluid was performed under ultrasound control and methylene blue dye instillation. The smallest amount of fluid detectable by US in the knee was 7.4 ml for synovial fluid, 10.1 and 10.4 ml for saline solution and 9.7 for blood. The threshold for detecting knee joint effusion by US in cadaver specimens was 10 ml for saline and blood and 7 ml for synovial fluid.Abbreviations US
Ultrasound 相似文献
73.
Marco Valgimigli Héctor Bueno Robert A. Byrne Jean-Philippe Collet Francesco Costa Anders Jeppsson Peter Jüni Adnan Kastrati Philippe Kolh Laura Mauri Gilles Montalescot Franz-Josef Neumann Mate Petricevic Marco Roffi Philippe Gabriel Steg Stephan Windecker José Luis Zamorano 《Revista espa?ola de cardiología》2018,71(1):42
74.
Accuracy and Precision of an Ultrasound-Based Device to Measure the Pelvic Tilt in Several Positions
75.
Thomas Desmidt Frédéric Andersson Bruno Brizard Paul-Armand Dujardin Jean-Philippe Cottier Frédéric Patat Jean-Pierre Réméniéras Valérie Gissot Wissam El-Hage Vincent Camus 《Ultrasound in medicine & biology》2018,44(11):2307-2313
Increasing evidence suggests that brain pulsatility is involved in the pathophysiology of various neurological and psychiatric disorders. However, it remains unclear whether high brain pulsatility is damaging to or protective of the brain in normal conditions, and this could depend on the age of the individual and the methods used to measure brain pulsatility. The goal of our study was to investigate associations between subcortical volumes and brain pulsatility as assessed with ultrasound in healthy young adults using both a conventional method (transcranial Doppler pulsatility index [TCD-PI]) and the innovative method of tissue pulsatility imaging (TPI), which allows a high level of detection of small brain movements (micrometers). Twenty-five females aged 18–55 with no history of significant medical disorder underwent magnetic resonance imaging and ultrasound assessment. The volumes of six subcortical regions known to be particularly sensitive to change in cerebral blood flow were measured and compared with brain pulsatility as assessed with TCD-PI and TPI. TCD-PI and TPI measures positively correlated with all subcortical regions, with the caudate nucleus having the strongest association. Linear regressions found that TCD-PI and TPI measures of brain pulsatility explained 16% to 67% of the variance of the subcortical volumes. Our results suggest that a greater pulsatility as assessed with ultrasound in healthy young adults may constitute a protective factor for brain structure. Ultrasound measures of brain pulsatility may be appropriate to provide costless, non-invasive, portable and highly sensitive markers of cerebral blood flow pulsatility related to brain structure. 相似文献
76.
Roger PM Perbost I Ticchioni M Fuzibet JG Breittmayer JP Durant J Pesce A Bernard A Dellamonica P;Groupe d'Etudes Niçois Polyvalent en Infectiologie 《The Journal of infection》2004,49(3):216-221
OBJECTIVE: Because the absence of immune restoration in HIV-infected patients efficiently treated by highly active antiretroviral therapy (HAART) may be due to excessive immune activation, we prospectively studied the effect of hydrocortisone on T-cell apoptosis in a cohort of patients with satisfactory virologic response. METHODS: Apoptosis of T-cell subsets including na?ve CD45RA(+)CD4+ T-cells was determined at baseline and at months 1 and 3 after initiation of HAART. A satisfactory immune response was defined as an increase >100/microL CD4+ T-cells at month 3 compared to baseline. RESULTS: Twenty out of 63 patients showed undetectable viral load at month 3, among whom eight exhibited a satisfactory immune response. Down-regulation spontaneous CD4+T-cell apoptosis was significant in the group of patients with a satisfactory immune response compared to the other patients. However, hydrocortisone up-regulated apoptosis of na?ve CD4+ CD45RA+ T-cells, specifically in group of patients with poor immune response, whatever the time point considered: percentage of apoptotic CD4 T-cells was 16+/-16% without hydrocortisone and 22+/-22% with hydrocortisone at month 1, and respectively, 10+/-9 and 17+/-15% at month 3 (P < 0.05) Hydrocortisone had no impact on CD8+ T-cell apoptosis, whatever the considered group. CONCLUSION: Our results suggest to not use steroid therapy as adjuvant immunotherapy in patients with less than optimal immunologic response to HAART. 相似文献
77.
Galanaud D Nicoli F Le Fur Y Roche P Confort-Gouny S Dufour H Ranjeva JP Peragut JC Viout P Cozzone PJ 《Annales de médecine interne》2002,153(8):491-498
Magnetic resonance spectroscopy (MRS) is a method enabling the analysis of the tissue metabolic content. It may offer a more accurate diagnosis of the intracranial tumors than conventional MRI sequences. MRS of normal brain parenchyma displays 4 main metabolites: N-acetyl aspartate (neuronal marker), creatine (cellular density marker), choline (membrane activity marker) and myoinositol (glial marker); pathological processes lead to variations of the level of these metabolites and/or the appearance of abnormal metabolites (lactate), following different patterns according to pathological process involved: glioma, meningioma, metastasis, bacterial or toxoplasmic abscess, radionecrosis. The potential clinical use of this method includes positive, differential and etiological diagnosis of tumors, determination of the level of malignancy of gliomas, screening for tumor recurrence following treatment. Our laboratory has been performing MR spectroscopic explorations of brain tumors for many years. Based on this experience, we show how MRS can be routinely performed in the clinical setting, what are its limitations and potential, and what kind of information can be supplied to the clinician. 相似文献
78.
79.
80.
Discrepancy between simultaneous digital skin microvascular and brachial artery macrovascular post-occlusive hyperemia in systemic sclerosis 总被引:1,自引:0,他引:1
Roustit M Simmons GH Baguet JP Carpentier P Cracowski JL 《The Journal of rheumatology》2008,35(8):1576-1583
OBJECTIVE: Vascular impairment, a main feature of the pathogenesis of systemic sclerosis (SSc), involves both the macro- and the microvasculature. We compared and correlated simultaneously measured skin microvascular and brachial artery macrovascular post-occlusive hyperemia in 3 groups: patients with SSc, patients with primary Raynaud's phenomenon (RP), and healthy volunteers. METHODS: Thirty-three healthy volunteers, 36 patients with primary RP, and 42 patients with SSc were enrolled. For each subject, brachial artery flow-mediated dilation (FMD) and cutaneous post-occlusive reactive hyperemia (PORH) were simultaneously recorded after 5-minute occlusion of the brachial artery. Local thermal hyperemia, nitroglycerin-mediated dilation (NMD), intima-media thickness (IMT), and pulse wave velocity (PWV) were also assessed. RESULTS: Digital cutaneous peak PORH was altered in patients with primary RP and SSc compared to healthy controls, whereas FMD was not significantly different among all groups. We observed a correlation between digital peak cutaneous vascular conductance and brachial FMD in healthy controls (r = 0.49; p = 0.004), but not in patients with primary RP or SSc. Thermal hyperemia was altered only in patients with SSc. Brachial NMD, IMT, and PWV were not different among all groups. CONCLUSION: We observed a loss of the correlation between brachial FMD and digital cutaneous PORH in patients with SSc and primary RP. Microvascular function is impaired in SSc, whereas brachial artery endothelial function is normal. 相似文献