全文获取类型
收费全文 | 2230篇 |
免费 | 123篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 36篇 |
儿科学 | 81篇 |
妇产科学 | 34篇 |
基础医学 | 215篇 |
口腔科学 | 55篇 |
临床医学 | 179篇 |
内科学 | 797篇 |
皮肤病学 | 18篇 |
神经病学 | 127篇 |
特种医学 | 63篇 |
外科学 | 205篇 |
综合类 | 52篇 |
一般理论 | 1篇 |
预防医学 | 92篇 |
眼科学 | 69篇 |
药学 | 197篇 |
中国医学 | 5篇 |
肿瘤学 | 131篇 |
出版年
2023年 | 25篇 |
2022年 | 35篇 |
2021年 | 103篇 |
2020年 | 62篇 |
2019年 | 118篇 |
2018年 | 109篇 |
2017年 | 63篇 |
2016年 | 86篇 |
2015年 | 63篇 |
2014年 | 94篇 |
2013年 | 93篇 |
2012年 | 149篇 |
2011年 | 153篇 |
2010年 | 80篇 |
2009年 | 75篇 |
2008年 | 130篇 |
2007年 | 110篇 |
2006年 | 103篇 |
2005年 | 81篇 |
2004年 | 83篇 |
2003年 | 58篇 |
2002年 | 41篇 |
2001年 | 39篇 |
2000年 | 31篇 |
1999年 | 21篇 |
1998年 | 18篇 |
1997年 | 9篇 |
1996年 | 8篇 |
1995年 | 8篇 |
1994年 | 11篇 |
1993年 | 7篇 |
1992年 | 23篇 |
1991年 | 23篇 |
1990年 | 22篇 |
1989年 | 23篇 |
1988年 | 20篇 |
1987年 | 12篇 |
1986年 | 11篇 |
1985年 | 11篇 |
1984年 | 13篇 |
1983年 | 14篇 |
1981年 | 14篇 |
1979年 | 13篇 |
1978年 | 6篇 |
1975年 | 6篇 |
1974年 | 8篇 |
1973年 | 11篇 |
1972年 | 7篇 |
1969年 | 10篇 |
1966年 | 8篇 |
排序方式: 共有2357条查询结果,搜索用时 15 毫秒
41.
Manan Pareek Philip R. Schauer Lee M. Kaplan Lawrence A. Leiter Francesco Rubino Deepak L. Bhatt 《Journal of the American College of Cardiology》2018,71(6):670-687
The alarming rise in the worldwide prevalence of obesity is paralleled by an increasing burden of type 2 diabetes mellitus. Metabolic surgery is the most effective means of obtaining substantial and durable weight loss in individuals with obesity. Randomized trials have recently shown the superiority of surgery over medical treatment alone in achieving improved glycemic control, as well as a reduction in cardiovascular risk factors. The mechanisms seem to extend beyond the magnitude of weight loss alone and include improvements in incretin profiles, insulin secretion, and insulin sensitivity. Moreover, observational data suggest that the reduction in cardiovascular risk factors translates to better patient outcomes. This review describes commonly used metabolic surgical procedures and their current indications and summarizes the evidence related to weight loss and glycemic outcomes. It further examines their potential effects on cardiovascular outcomes and mortality and discusses future perspectives. 相似文献
42.
Alok A. Bhatt 《Emergency radiology》2018,25(5):547-551
There are multiple reasons for imaging the soft tissues of the neck in the emergency setting, in particular when symptoms are vague or if there is worry for complications from a certain clinical diagnosis. When fluid is seen in the retropharyngeal space, it is important to pay attention to history and look at key structures in the neck. This article will discuss anatomy of the retropharyngeal space, followed by four causes of fluid within the space that the radiologist is likely to encounter in the emergency setting: tonsillitis/pharyngitis, acute calcific tendinitis of the longus colli muscles, internal jugular vein thrombosis, and post-radiation changes. It is important to recognize these entities because each has different clinical implications and management. 相似文献
43.
44.
45.
Vijaya Raj Bhatt Hagop Kantarjian Jorge E. Cortes Farhad Ravandi Gautam Borthakur 《Clinical Lymphoma, Myeloma & Leukemia》2013,13(2):153-158
BackgroundDespite being considered as good prognostic acute myelogenous leukemia (AML), the long-term survival rate in core binding factor (CBF) AML leaves room for substantial improvement.Materials and MethodsWe reviewed relevant English language literature related to treatment of CBF AML available in PubMed. Review also included meeting abstracts.ResultsMulticycle high dose cytarabine in consolidation improves remission duration but larger groups report overall survival in the range of 40% to 50% at 5 years or longer.ConclusionsConcerted effort is needed toward improving outcomes in CBF AML through clinical trials and risk-adapted approach. 相似文献
46.
47.
BACKGROUND: Repeat hospitalizations of patients with atherosclerosis represent a considerable burden on the health care system. We sought to determine whether clopidogrel compared with aspirin decreases the need for rehospitalization for ischemia and bleeding. METHODS AND RESULTS: The Clopidogrel Versus Aspirin in Patients at Risk of Ischemic Events (CAPRIE) trial was a randomized, blinded, multicenter, trial of 19,185 patients with atherosclerotic disease manifested as recent ischemic stroke or myocardial infarction or symptomatic peripheral arterial disease. Without any double-counting of events, the number of rehospitalizations for ischemic events (defined as angina, transient ischemic attack, or limb ischemia) or bleeding events was determined for the entire cohort. There was a significant reduction in the total number of rehospitalizations for ischemic events or bleeding with clopidogrel use compared with aspirin (1502 vs 1673; P =.010) over an average of 1.6 years of treatment. This reduction in rehospitalization was consistent across individual outcomes of angina, transient ischemic attack, limb ischemia, and bleeding. Compared with aspirin, clopidogrel also resulted in a 7.9% relative risk reduction in a combined end point of vascular death, stroke, myocardial infarction, or rehospitalization for ischemic events or bleeding (15.1% to 13.7% at 1 year; P =.011). Adjusting for baseline prognostic variables, clopidogrel therapy was an independent predictor for reduction of vascular death, stroke, myocardial infarction, or rehospitalization for ischemic events or bleeding (P =.009). CONCLUSIONS: Treatment with clopidogrel results in a significant decrease in the need for rehospitalization for ischemic events or bleeding compared with aspirin. This meaningful end point tracks well with other, more traditional measures of outcome and has incremental value beyond such end points. 相似文献
48.
Hasan K. Siddiqi Brittany Weber Guohai Zhou James Regan Jesse Fajnzylber Kendyll Coxen Heather Corry Xu G. Yu Marcelo DiCarli Jonathan Z. Li Deepak L. Bhatt 《The American journal of medicine》2021,134(4):542-546
BackgroundPatients with coronavirus disease 2019 (COVID-19) have a high prevalence of detectable troponin and myocardial injury. In addition, a subset of patients with COVID-19 has detectable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral loads. The objective of this study was to understand the relationship among SARS-CoV-2 viremia, detectable troponin, and myocardial injury in hospitalized patients with COVID-19.MethodsSARS-CoV-2 plasma viral load was measured in plasma samples drawn from patients hospitalized for COVID-19 at 2 academic medical centers. Baseline characteristics and clinically obtained high-sensitivity cardiac troponin T (hs-cTnT) values were abstracted from the medical record. The main outcome was detectable hs-cTnT (≥6 ng/mL) and myocardial injury (hs-cTnT ≥14 ng/mL; >99th percentile for assay).ResultsA total of 70 hospitalized patients with COVID-19 were included in this study, with 39% females and median age 58 ± 17 years; 21 patients (30%) were found to have detectable SARS-CoV-2 viral load and were classified in the viremia group. Patients with viremia were significantly older than those without viremia. All of the patients with viremia (100%) had detectable troponin during hospitalization compared with 59% of patients without viremia (P = 0.0003). Myocardial injury was seen in 76% of patients with viremia and 38% of those patients without viremia (P = 0.004).ConclusionsHospitalized patients with COVID-19 with SARS-CoV-2 viremia have a significantly higher prevalence of detectable troponin and myocardial injury during their hospitalization compared with patients who did not. This first report of the relationship among SARS-CoV-2 viremia, detectable troponin, and myocardial injury in patients with COVID-19 points to additional mechanistic pathways that require deeper study to understand the complex interplay among these unique findings, cardiovascular outcomes, and mortality in COVID-19. 相似文献
49.
Sarvepalli Shashank Garber Ari Burke Carol A. Gupta Niyati Ibrahim Mounir McMichael John Morris-Stiff Gareth Bhatt Amit Vargo John Rizk Maged Rothberg Michael B. 《Digestive diseases and sciences》2021,66(6):2059-2068
Digestive Diseases and Sciences - Inadequate bowel preparation (IBP) is associated with reduced adenoma detection. However, limited research has examined the impact of different commercial bowel... 相似文献
50.
Recurrent Massive Upper Gastrointestinal Hemorrhage Due to Strongyloides stercoralis Infection 总被引:3,自引:0,他引:3
Bankim D. Bhatt M.D. Mitchell S. Cappell M.D. Ph.D. Paul C. Smilow M.D. Kiron M. Das M.D. Ph.D. 《The American journal of gastroenterology》1990,85(8):1034-1036
A 29-yr-old black male immigrant from Africa presented with recurrent life-threatening upper gastrointestinal bleeding due to massive duodenal infection by Strongyloides stercoralis. The diagnosis was missed by repeated examinations of fresh stool specimens for ova and parasites and by an initial esophagogastroduodenoscopy. The diagnosis was made by pathologic examination of a duodenal biopsy and of a duodenal aspirate obtained at a second esophagogastroduodenoscopy. This has been previously reported as a cause of massive upper gastrointestinal hemorrhage in four cases. Patients with obscure gastrointestinal bleeding who have travelled or lived in an endemic area should have a duodenal aspiration performed at esophagogastroduodenoscopy. 相似文献