全文获取类型
收费全文 | 3915篇 |
免费 | 254篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 31篇 |
儿科学 | 94篇 |
妇产科学 | 59篇 |
基础医学 | 372篇 |
口腔科学 | 89篇 |
临床医学 | 346篇 |
内科学 | 850篇 |
皮肤病学 | 51篇 |
神经病学 | 227篇 |
特种医学 | 68篇 |
外科学 | 716篇 |
综合类 | 110篇 |
一般理论 | 2篇 |
预防医学 | 291篇 |
眼科学 | 107篇 |
药学 | 433篇 |
1篇 | |
中国医学 | 67篇 |
肿瘤学 | 279篇 |
出版年
2023年 | 32篇 |
2022年 | 140篇 |
2021年 | 169篇 |
2020年 | 91篇 |
2019年 | 111篇 |
2018年 | 136篇 |
2017年 | 80篇 |
2016年 | 99篇 |
2015年 | 112篇 |
2014年 | 153篇 |
2013年 | 192篇 |
2012年 | 302篇 |
2011年 | 299篇 |
2010年 | 147篇 |
2009年 | 130篇 |
2008年 | 238篇 |
2007年 | 210篇 |
2006年 | 186篇 |
2005年 | 205篇 |
2004年 | 174篇 |
2003年 | 153篇 |
2002年 | 132篇 |
2001年 | 68篇 |
2000年 | 72篇 |
1999年 | 63篇 |
1998年 | 42篇 |
1997年 | 22篇 |
1996年 | 18篇 |
1995年 | 15篇 |
1994年 | 16篇 |
1993年 | 12篇 |
1992年 | 26篇 |
1991年 | 26篇 |
1990年 | 25篇 |
1989年 | 25篇 |
1988年 | 22篇 |
1987年 | 15篇 |
1986年 | 19篇 |
1985年 | 26篇 |
1984年 | 13篇 |
1983年 | 16篇 |
1980年 | 11篇 |
1979年 | 12篇 |
1978年 | 12篇 |
1977年 | 11篇 |
1974年 | 14篇 |
1973年 | 13篇 |
1971年 | 9篇 |
1969年 | 10篇 |
1966年 | 11篇 |
排序方式: 共有4193条查询结果,搜索用时 15 毫秒
81.
82.
Khan BA Sodhi JS Zargar SA Javid G Yattoo GN Shah A Gulzar GM Khan MA 《Journal of gastroenterology and hepatology》2012,27(6):1078-1082
Background and Aim: Nocturnal gastro‐esophageal reflux causes heartburn and sleep disturbances impairing quality of life. Lifestyle modifications, like bed head elevation during sleep, are thought to alleviate the symptoms of gastroesophageal reflux. We tested the hypothesis that bed head elevation might decrease recumbent acid exposure compared to sleeping in a flat bed. Methods: Patients of symptomatic nocturnal reflux and documented recumbent (supine) reflux verified by esophageal pH test entered the trial. On day 1, baseline pH was measured while the patient slept on a flat bed. Then patients slept on a bed with the head end elevated by a 20‐cm block for the next 6 consecutive days from day 2 to day 7. The pH test was repeated on day 2 and day 7. Each patient acted as his own control. Results: Twenty of 24 (83.3%) patients with mean age of 36 ± 5.5 years completed the trial. The mean (± SD) supine reflux time %, acid clearance time, number of refluxes 5 min longer and symptom score on day 1 and day 7 were 15.0 ± 8.4 and 13.7 ± 7.2; P = 0.001, 3.8 ± 2.0 and 3.0 ± 1.6; P = 0.001, 3.3 ± 2.2 and 1.0 ± 1.2; P = 0.001, and 2.3 ± 0.6 and 1.5 ± 0.6; P = 0.04, respectively. The sleep disturbances improved in 13 (65%) patients. Conclusions: Bed head elevation reduced esophageal acid exposure and acid clearance time in nocturnal (supine) refluxers and led to some relief from heartburn and sleep disturbance. 相似文献
83.
84.
85.
A 31-year-old male presented with chest pain started after eating chicken about 2 weeks earlier. Upper endoscopy and Computed tomography scan of the chest revealed a sharp chicken bone penetrating the esophageal wall into the right lung. The foreign body was removed endoscopically using a rat-tooth forceps, followed by prophylactic placement of a metal stent across the esophageal perforation site. Foreign body-induced perforation is one of the common etiologies of benign esophageal perforations. Although the primary treatment is surgery, endoscopic therapy may be appropriate in individualized cases like our patient. 相似文献
86.
Amina Asghar Muhammad Yousuf Ghulam Fareed Rabia Nazir Abida Hassan Aneela Maalik Tayyaba Noor Naseem Iqbal Lubna Rasheed 《RSC advances》2020,10(33):19346
Synthesis of a compound with balanced bioactivities against a specific target is always a challenging task. In this study, a novel compound (1) has been synthesized by combination of flurbiprofen and isoniazide and shows ∼2.5 times enhanced acetylcholinesterase (AChE) inhibition activity and ∼1.7 times improved butyrylcholinesterase (BuChE) inhibition activity compared to flurbiprofen and a standard drug (i.e. physostigmine). A comparative AutoDock study has been performed, based on the optimized structure, by the DFT/B3LYP method, which confirmed that compound (1) is more active against AChE and BuChE, with calculated binding energies of −12.9 kcal mol−1 and −9.8 kcal mol−1 respectively as compared to flurbiprofen and an eserine (physostigmine) standard for which the binding energy was calculated to be −10.1 kcal mol−1 and −8.9 kcal mol−1, respectively. A mixed mode of inhibition of AChE and BuChE with compound 1 was confirmed by Lineweaver–Burk plots. AChE and BuChE inhibition activity alongside docking results suggests that compound (1) could be used for treatment of Alzheimer''s disease. Moreover, compound (1) also exhibit better α-chymotrypsin activity compared to flurbiprofen. Furthermore, in vitro and in vivo analysis confirmed that compound (1) exhibit more activity and less toxicity than the parent compounds.A novel compound (1) shows ∼2.5 and ∼1.7 times enhanced AChE inhibition activity and BuChE inhibition activity respectively compared to flurbiprofen and standard drug (i.e. physostigmine). It has also been confirmed by comparative AutoDock studies. 相似文献
87.
Lileswar Kaman Javid Iqbal Rakesh Kochhar Saroj Sinha 《The Indian journal of surgery》2013,75(5):391-394
Laparoscopic Heller cardiomyotomy and Dor fundoplication is the surgical procedure of choice for esophageal achalasia. The aim of our study was to investigate the clinical outcome and safety of laparoscopic Heller–Dor procedure performed by using Hook electrocautery and as a teaching module for advanced laparoscopic surgery. Between January 2005 and December 2010, 25 consecutive patients with achalasia underwent laparoscopic Heller–Dor operation by a single surgeon. All the patients received upper gastrointestinal series (barium swallow), esophagogastroscopy, and esophageal manometry to exclude esophageal carcinoma and to confirm the diagnosis. All the patients were operated by laparoscopic modified Heller myotomy with Dor fundoplication by using hook electrocautery. Among 25 operated patients, 14 were male and 11 were female with a median age of 43 years (range 18–72 years). The mean operative time was 93.3 min (range 50–50 min), the mean operative blood loss was 90 ml (range 40–200 ml), the median time to oral feeding was 2 days (2–4 days), and the median hospital stay was 4 days (4–7 days). There was no conversion to open surgery. Intraoperative mucosal perforation was encountered in three patients and was repaired in all of them by laparoscopic suture. All the patients had an uneventful recovery without postoperative complication and had excellent clinical response (96 %) during follow-up. Laparoscopic Heller–Dor operation using hook electrocautery is safe, inexpensive, and effective treatment for achalasia which is useful for teaching and training surgical residents in advanced laparoscopic surgery. 相似文献
88.
Kristian Bartnes Trude Sildnes Amjid Iqbal Øystein Dahl-Eriksen Thor Trovik Terje Kristian Steigen 《Scandinavian cardiovascular journal : SCJ》2013,47(2):83-86
Objectives. Angiography by selective catheterization is the reference standard for coronary bypass graft patency assessment but carries a risk of serious complications. We have investigated whether 16-slice multidetector spiral computed tomography (MDCT) can substitute for selective angiography. Design. Two to three years after coronary artery bypass grafting, 45 patients with a total of 156 bypasses (100 single and 28 sequential grafts) were examined with both MDCT and conventional selective angiography on the same day. The bypasses were classified as patent, stenotic or occluded. Results. The likelihood ratio for MDCT-detected occlusion was 40, reflecting a fairly high combined sensitivity and specificity. However, 24% of the distal anastomoses could not be evaluated by MDCT, mainly because of respiratory movements, artifacts due to metal clips, and small vessel dimensions. Moreover, seven out of 117 bypasses (6%) deemed evaluable by MDCT were wrongly classified by this method. Conclusions. At present, 16-slice MDCT cannot replace selective angiography for assessment of coronary bypass graft patency since 24% of bypasses could not be evaluated by this method, and an error rate of 6% is unacceptable. 相似文献
89.
Complete dislocation of the ulnar 4 carpometacarpal joints of the hand (excluding the thumb) is an uncommon injury. Anatomic reduction of the carpometacarpal joint (CMCJ) is essential to maintain function of the hand, and this can often be accomplished by prompt closed reduction and percutaneous Kirschner-wire fixation. The diagnosis is sometimes delayed or missed in the emergency department (ED), and a true lateral radiograph is mandatory in suspected cases. We present a case of dorsal unilateral dislocation of the ulnar 4 CMCJs without associated fracture. The injury was difficult to diagnose because of gross swelling of the hand. We describe a simple clinical test (Indian salutation test) that we found to be very helpful in raising the index of suspicion and hence increasing the likelihood of avoiding any clinical and medicolegal difficulties in such cases. A true lateral radiograph of the wrist confirmed the diagnosis, and prompt closed reduction and percutaneous Kirschner-wire fixation resulted in a good outcome in the case described here. 相似文献
90.
Piyush Gupta Pooja Dewan Dheeraj Shah Nisha Sharma Nidhi Bedi Iqbal R. Kaur Ajay Kumar Bansal S.V. Madhu 《Indian pediatrics》2016,53(11):967-976