全文获取类型
收费全文 | 8053篇 |
免费 | 312篇 |
国内免费 | 47篇 |
专业分类
耳鼻咽喉 | 203篇 |
儿科学 | 210篇 |
妇产科学 | 441篇 |
基础医学 | 1253篇 |
口腔科学 | 102篇 |
临床医学 | 450篇 |
内科学 | 1899篇 |
皮肤病学 | 188篇 |
神经病学 | 609篇 |
特种医学 | 206篇 |
外国民族医学 | 1篇 |
外科学 | 785篇 |
综合类 | 51篇 |
一般理论 | 1篇 |
预防医学 | 466篇 |
眼科学 | 195篇 |
药学 | 846篇 |
中国医学 | 42篇 |
肿瘤学 | 464篇 |
出版年
2023年 | 29篇 |
2022年 | 109篇 |
2021年 | 195篇 |
2020年 | 72篇 |
2019年 | 102篇 |
2018年 | 183篇 |
2017年 | 161篇 |
2016年 | 176篇 |
2015年 | 212篇 |
2014年 | 313篇 |
2013年 | 389篇 |
2012年 | 604篇 |
2011年 | 625篇 |
2010年 | 321篇 |
2009年 | 240篇 |
2008年 | 464篇 |
2007年 | 493篇 |
2006年 | 535篇 |
2005年 | 495篇 |
2004年 | 521篇 |
2003年 | 472篇 |
2002年 | 442篇 |
2001年 | 187篇 |
2000年 | 194篇 |
1999年 | 119篇 |
1998年 | 45篇 |
1997年 | 31篇 |
1996年 | 22篇 |
1995年 | 23篇 |
1994年 | 21篇 |
1993年 | 16篇 |
1992年 | 24篇 |
1991年 | 31篇 |
1990年 | 28篇 |
1989年 | 20篇 |
1988年 | 34篇 |
1987年 | 30篇 |
1986年 | 29篇 |
1985年 | 33篇 |
1984年 | 24篇 |
1983年 | 23篇 |
1982年 | 24篇 |
1981年 | 16篇 |
1979年 | 29篇 |
1978年 | 19篇 |
1977年 | 24篇 |
1975年 | 38篇 |
1974年 | 19篇 |
1973年 | 19篇 |
1971年 | 22篇 |
排序方式: 共有8412条查询结果,搜索用时 15 毫秒
21.
目的:探讨抗青光眼餐引流术后的白内障患眼进行超声乳化吸除术的手术入路,操作方式及临床效果。方法:避开功能性滤过泡,选择角巩膜隧道切口或透明角膜切口,瞳孔麻痹性散大时,做一个完美的直径约5mm的连续环形撕囊以补偿之;恰当处理虹膜后粘连后,在病理性小瞳孔下完成超声乳化手术;眼压失控者行青光眼白内障人工晶体植入三联术。结果:无后囊破裂,人工晶体全部囊袋内植入,术后1周视力≥0.5者20只眼(64.5%),0.1-0.4者8只眼(25.8%),<0.1者3只眼(9.7%)。随访1-16个月,眼压均在20.55mmHg以下。结论:体外流术后的白内障患眼,超声乳化手术因其切口小,并发症少,不破坏功能性滤过泡,不损伤瞳孔,是目前各种手术方法中的最佳选择。 相似文献
22.
Tomasz Trojanowski Jerzy P ceszyński Krzysztof Turowski Stanisław Kamiński Igor Gościński Marian Reinfus Tadeusz Krzyszkowski Marek Pyrich Adam Bielawski Czesława Leszczyk Barbara Bendarzewska Andrzej Staszczak Halina Koźniewska 《Journal of neuro-oncology》1988,6(3):285-291
A prospective, randomized trial evaluates the effects of two postoperative treatment regimens on survival in 198 adult patients with supratentorial gliomas. All patients were irradiated with 6 000 rads after possibly radical removal of tumors. CCNU administration in the dosis of 100 mg/sq m of body surface every 6–8 weeks following surgery proved to have no significant effect on the survival of patients. The median survival time in patients receiving radiation therapy alone was 61±7 weeks, while in those receiving additional chemotherapy was 56±4 weeks. Tumor histological malignancy and patients age were found to be the only important prognostic factors, irrespective of the treatment modality.
Address for offprints: T Trojanowski, Department of Neurosurgery, Medical School, Jaczewskiego 8, 20-950 Lublin, Poland 相似文献
23.
Rats with impaired active avoidance induced by chronic (9 weeks) administration of ethanol were studied. Angiotensin II (ANG II) administered (ICV, 2.0 g) 12 h after the withdrawal of the alcohol not only neutralized the toxic effect of ethanol but also improved learning. When administered on the 5th day after ethanol withdrawal, the effect of ANG II was weaker. Tests of stereotypy and catalepsy were used to study the possible role of the dopaminergic system in this action of ANG II. It was shown that both chronic alcohol treatment and ANG II alone increased apomorphine (1 mg/kg) and amphetamine (7.5 mg/kg) stereotypy but the effects of ANG II were greater. ANG II did not change the stereotypy induced by amphetamine but increased the stereotypy induced by apomorphine in the group of animals chronically treated with alcohol. Haloperidol — induced catalepsy was reduced in these rats. ANG II alone intensified catalepsy and eliminated the effect of ethanol. Both ANG II and alcohol increased striatal dopamine (DA) concentration. This effect of ANG II was significantly greater in the animals chronically treated with alcohol. The above changes were not observed after the DA level had been reduced by alpha-methyl-p-tyrosine (250 mg/kg), nor were changes observed in the striatal DOPAC. The results suggest involvement of the central dopaminergic system in the effect of ANG II on the ethanol — induced impairment of acquisition of active avoidance but, however, the results of the biochemical determinations of DA turnover do not provide an explanation of these changes. 相似文献
24.
25.
Anna Okulewicz Jerzy Okulewicz Joanna Hildebrand Grzegorz Zaleśny 《Acta parasitologica / Witold Stefański Institute of Parasitology, Warszawa, Poland》2007,52(3):292-294
Three male specimens of the eyeworm, Oxyspirura chabaudi, were found during the post mortem examination of one individual of Turdus merula L. (Passeriformes). This is the first record of Turdus merula as a host for O. chabaudi. 相似文献
26.
The relationship between malignancy and histamine metabolism in the liver and the small intestine has been examined in sarcoma-bearing Wistar rats two weeks after subcutaneous implantation of a transplantable methylcholanthrene sarcoma Sa1828 and on the 3, 7 and 14th days after tumour extirpation. Two weeks after tumour implantation, the histamine level was increased by 100% and 50% in the liver and the small intestine, respectively. On the 3rd day after extirpation of the tumour the level of histamine had returned to the control values and remained unchanged during the next 10 days. Neither of the histamine catabolizing enzymes, diamine oxidase with a putrescine as a substrate or histamine methyltransferase were influenced by the existing tumour or by its extirpation except on the 14th day where a high increase in diamine oxidase activity was found. Some changes in the distribution of histamine metabolites suggest an involvement of an oxidative pathway of histamine catabolism as well as the aldehyde catabolizing enzymes in tumour development. 相似文献
27.
Zielonka TM Marchel A Pogorzelski R Górska K Safianowska A Byśkiniewicz K Chazan R 《Pneumonologia i alergologia polska》2004,72(9-10):429-432
The authors describe the case of survival for the period of 10 years after brain metastasis surgery and removal of the left lung upper lobe due to adeno-squamous cells carcinoma. Surgery did not generate any complications. Within 8 years after the surgery the radiological examination showed infiltrations resembling changes typical for tuberculosis. Microbiological analysis showed a culture of Mycobacterium kansasi leading to diagnosis of mycobacteriosis. Hence the antituberculous treatment was extended to 12 months to be interrupted due to liver damage. Two years later the patient experienced incident of haemoptysis. Detailed examination and assessment of the respiratory tract condition revealed COPD without features of renewal of the neoplastic process or infection by Mycobacterium tuberculosis or mycobacterium other than tuberculosis. This case demonstrates that aggressive surgical approaches to lung cancer with solitary cerebral metastasis significantly improve patient survival and justifies its widespread use. 相似文献
28.
Howard M Sellors JW Jang D Robinson NJ Fearon M Kaczorowski J Chernesky M 《Journal of clinical microbiology》2003,41(1):84-89
This study estimated the regional and age- and gender-specific seroprevalences of herpes simplex virus type 1 (HSV-1) and HSV-2 in Ontario, Canada. Stored serum specimens from subjects aged 15 to 44 years, including men (n = 979), women not under prenatal care (n = 638), and women under prenatal care (n = 701) submitted for routine viral serology were randomly selected according to regional population size from public health laboratories. HSV-1 and HSV-2 testing was done with the MRL enzyme immunoassay (EIA) (Focus Technologies), and HSV-2 was also tested by the Gull/Meridian EIA. Specimens discordant for HSV-2 antibodies between the two EIAs were resolved by a recombinant immunoblot assay (Focus Technologies). The overall age- and gender-standardized seroprevalences of HSV-1 and HSV-2 were 51.1% (95% confidence interval [CI], 50.1 to 52.1) and 9.1% (95% CI, 8.6 to 9.7), respectively. The seroprevalence of HSV-1 antibodies increased from 26.9 to 54.7% in men between 15 to 16 and 40 to 44 years of age, from 32.0 to 88.7% in women not under prenatal care, and from 55.2 to 69.2% in women under prenatal care. The seroprevalence of HSV-2 increased from 3.8 to 21.3% in men between 15 to 16 and 40 to 44 years of age, from 0 to 18.9% in women not under prenatal care, and from 3.4 to 23.1% in women under prenatal care. HSV-2 results were discordant for 3.3% (76 of 2,318) of specimens. Both types of HSV antibodies appeared to be acquired earlier among women under prenatal care than among men and women not under prenatal care. Antibodies were more prevalent among people in northern Ontario (72.9% of subjects [range, 68.4 to 77.4%] for HSV-1 and 13.7% of subjects [95% CI, 10.2 to 17.2%] for HSV-2) than elsewhere. 相似文献
29.
An inhibition enzyme-linked immunosorbent assay for the detection of antibody to Rift Valley fever virus in humans, domestic and wild ruminants 总被引:2,自引:0,他引:2
This paper describes the development and validation of an inhibition ELISA based on gamma-irradiated tissue culture-derived antigen for the detection of antibody to Rift Valley fever virus (RVFV) in humans, domestic and wild ruminants. Validation data sets derived from field-collected sera in Africa (humans=1367, cattle=649, goats=806, sheep=493, buffalo=258, camels=156) were categorized according to the results of a virus neutralisation test. In addition, individual sera from 93 laboratory workers immunized with inactivated RVF vaccine, 136 serial bleeds from eight sheep experimentally infected with wild-type of RVFV, and 200 serial bleeds from 10 sheep vaccinated with the live-attenuated strain of the virus, were used to study the kinetics of RVFV antibody production under controlled conditions. At cut-off values selected at 95% accuracy level by the two-graph receiver operating characteristic analysis the ELISA sensitivity ranged from 99.47% (humans) to 100% (sheep, buffalo, camels). The specificity ranged from 99.29% (sheep) to 100% (camels). Compared to virus neutralisation and haemagglutination-inhibition tests, the ELISA was more sensitive in detection of the earliest immunological responses in experimentally infected and vaccinated sheep. Our results demonstrate that the ELISA format reported here can be used as a safe, robust and highly accurate diagnostic tool in disease-surveillance and control programmes, import/export veterinary certification, and for monitoring of the immune response in vaccinees. 相似文献
30.
Maciej Bero Janusz Kasperczyk Zbigniew J. Jedlinski 《Macromolecular chemistry and physics.》1990,191(10):2287-2296
Racemic lactide was polymerized with various initiators containing Zn and Al, and the structures of the obtained polymers were determined by means of 13C NMR spectroscopy. The extent of transesterification reactions was calculated on the basis of the analysis of the methine carbon signal in the polymer 13C NMR spectra. Three groups of initiators can be distinguished in view of their influence on transesterification: ZnCl2 exhibits the strongest transesterification activity, ZnEt2 and ZnEt2/Al(OiPr)3 are among those of medium activity, and Al(acac)3 does not show transesterification activity at all. 相似文献