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951.
Otte Valentin Lewy Oberniedermayr Blumenfeldt Mendel Loewenberg Siefart Böhm Schuler Stilling Girndt Hubert Stockinger Husler Dressler W. Pappenheim M. Bauer J. 《Journal of molecular medicine (Berlin, Germany)》1932,11(17):743-751
Ohne Zusammenfassung 相似文献
952.
Michael Bartl MD Mohammed Dakna PhD Sebastian Schade MD Birgit Otte Tamara Wicke MSc Elisabeth Lang BSc Maritta Starke Jens Ebentheuer MD Sandrina Weber MD Karl Toischer MD Moritz Schnelle MD PhD Friederike Sixel-Döring MD Claudia Trenkwalder MD Brit Mollenhauer MD 《Movement disorders》2023,38(1):68-81
Background
Recent studies point toward a significant impact of cardiovascular processes and inflammation on Parkinson's disease (PD) progression.Objective
The aim of this study was to assess established markers of neuronal function, inflammation, and cardiovascular risk by high-throughput sandwich immune multiplex panels in deeply phenotyped PD.Methods
Proximity Extension Assay technology on 273 markers was applied in plasma of 109 drug-naive at baseline (BL) patients with PD (BL, 2-, 4-, and 6-year follow-up [FU]) and 96 healthy control patients (HCs; 2- and 4-year FU) from the de novo Parkinson's cohort. BL plasma from 74 individuals (37 patients with PD, 37 healthy control patients) on the same platform from the Parkinson Progression Marker Initiative was used for independent validation. Correlation analysis of the identified markers and 6 years of clinical FU, including motor and cognitive progression, was evaluated.Results
At BL, 35 plasma markers were differentially expressed in PD, showing downregulation of atherosclerotic risk markers, eg, E-selectin and ß2-integrin. In contrast, we found a reduction of markers of the plasminogen activation system, eg, urokinase plasminogen activator. Neurospecific markers indicated increased levels of peripheral proteins of neurodegeneration and inflammation, such as fibroblast growth factor 21 and peptidase inhibitor 3. Several markers, including interleukin-6 and cystatin B, correlated with cognitive decline and progression of motor symptoms during FU. These findings were independently validated in the Parkinson Progression Marker Initiative.Conclusions
We identified and validated possible PD plasma biomarker candidates for state, fate, and disease progression, elucidating new molecular processes with reduced endothelial/atherosclerotic processes, increased thromboembolic risk, and neuroinflammation. Further investigations and validation in independent and larger longitudinal cohorts are needed. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. 相似文献953.
Verbeek Luzie Rabold Denise Hartig Arne Stephan Sophia Deus Elisabeth Otte Insa Beutling Anne Schollmeyer Karoline de Coninck Pieter Höppner Karin Saal Kristina Vogler Timo Hach Lukas Steinmetz Elke Benner Thomas Derksen Leonie Militzer Nina Probst Carolina Teichert Ute 《Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz》2023,66(6):593-598
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz - Aus Sicht der Bundesregierung ist der One-Health-Ansatz ein wegweisender Kompass für ein inter- und transdisziplinäres... 相似文献
954.
Despite improved ancillary investigations in epilepsy care, patients' narratives remain indispensable for diagnosing and treatment monitoring. This wealth of information is typically stored in electronic health records and accumulated in medical journals in an unstructured manner, thereby restricting complete utilization in clinical decision-making. To this end, clinical researchers increasing apply natural language processing (NLP)—a branch of artificial intelligence—as it removes ambiguity, derives context, and imbues standardized meaning from free-narrative clinical texts. This systematic review presents an overview of the current NLP applications in epilepsy and discusses the opportunities and drawbacks of NLP alongside its future implications. We searched the PubMed and Embase databases with a “natural language processing” and “epilepsy” query (March 4, 2022) and included original research articles describing the application of NLP techniques for textual analysis in epilepsy. Twenty-six studies were included. Fifty-eight percent of these studies used NLP to classify clinical records into predefined categories, improving patient identification and treatment decisions. Other applications of NLP had structured clinical information retrieval from electronic health records, scientific papers, and online posts of patients. Challenges and opportunities of NLP applications for enhancing epilepsy care and research are discussed. The field could further benefit from NLP by replicating successes in other health care domains, such as NLP-aided quality evaluation for clinical decision-making, outcome prediction, and clinical record summarization. 相似文献
955.
Megan Lynn Otte Raju Lama Tamang Julia Papapanagiotou Rizwan Ahmad Punita Dhawan Amar B Singh 《World journal of gastroenterology : WJG》2023,29(7):1157-1172
Mucosal healing (MH) is vital in maintaining homeostasis within the gut and protecting against injury and infections. Multiple factors and signaling pathways contribute in a dynamic and coordinated manner to maintain intestinal home ostasis and mucosal regeneration/repair. However, when intestinal homeostasis becomes chronically disturbed and an inflammatory immune response is constitutively active due to impairment of the intestinal epithelial barrier auto immune disease results, particularly inflammatory bowel disease (IBD). Many proteins and signaling pathways become dysregulated or impaired during these pathological conditions, with the mechanisms of regulation just beginning to be understood. Consequently, there remains a relative lack of broadly effective thera peutics that can restore MH due to the complexity of both the disease and healing processes, so tissue damage in the gastrointestinal tract of patients, even those in clinical remission, persists. With increased understanding of the molecular mecha nisms of IBD and MH, tissue damage from autoimmune disease may in the future be ameliorated by developing therapeutics that enhance the body’s own healing response. In this review, we introduce the concept of mucosal healing and its re levance in IBD as well as discuss the mechanisms of IBD and potential strategies for altering these processes and inducing MH. 相似文献