全文获取类型
收费全文 | 50870篇 |
免费 | 3018篇 |
国内免费 | 246篇 |
专业分类
耳鼻咽喉 | 630篇 |
儿科学 | 1171篇 |
妇产科学 | 1221篇 |
基础医学 | 7060篇 |
口腔科学 | 1499篇 |
临床医学 | 5573篇 |
内科学 | 10976篇 |
皮肤病学 | 807篇 |
神经病学 | 5011篇 |
特种医学 | 1761篇 |
外科学 | 6301篇 |
综合类 | 325篇 |
一般理论 | 44篇 |
预防医学 | 3618篇 |
眼科学 | 805篇 |
药学 | 3441篇 |
1篇 | |
中国医学 | 59篇 |
肿瘤学 | 3831篇 |
出版年
2023年 | 321篇 |
2022年 | 632篇 |
2021年 | 1147篇 |
2020年 | 749篇 |
2019年 | 981篇 |
2018年 | 1194篇 |
2017年 | 1070篇 |
2016年 | 1255篇 |
2015年 | 1311篇 |
2014年 | 1740篇 |
2013年 | 2505篇 |
2012年 | 3790篇 |
2011年 | 3979篇 |
2010年 | 2365篇 |
2009年 | 2157篇 |
2008年 | 3292篇 |
2007年 | 3589篇 |
2006年 | 3204篇 |
2005年 | 3260篇 |
2004年 | 3001篇 |
2003年 | 2797篇 |
2002年 | 2567篇 |
2001年 | 425篇 |
2000年 | 348篇 |
1999年 | 479篇 |
1998年 | 561篇 |
1997年 | 459篇 |
1996年 | 407篇 |
1995年 | 346篇 |
1994年 | 304篇 |
1993年 | 308篇 |
1992年 | 234篇 |
1991年 | 229篇 |
1990年 | 208篇 |
1989年 | 221篇 |
1988年 | 195篇 |
1987年 | 172篇 |
1986年 | 177篇 |
1985年 | 210篇 |
1984年 | 181篇 |
1983年 | 166篇 |
1982年 | 192篇 |
1981年 | 159篇 |
1980年 | 139篇 |
1979年 | 112篇 |
1978年 | 122篇 |
1977年 | 131篇 |
1976年 | 94篇 |
1975年 | 107篇 |
1974年 | 81篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
961.
Jan-Frederik Güth Jan Wallbach Michael Stimmelmayr Wolfgang Gernet Florian Beuer Daniel Edelhoff 《Clinical oral investigations》2013,17(5):1389-1395
Objective
The aim of this study was the evaluation of preparations from general dental practitioners for zirconia crowns and their correlation with clinical recommendations using a digital approach.Material and method
Seventy-five datasets of left first upper molars (FDI 16) prepared for single zirconia crowns by general dental practitioners were analyzed using a computer-aided design software (LAVATM Design; 3M ESPE, Seefeld, Germany) and a 3D-inspection software (COMETinspect®plus version 4.5; Steinbichler Optotechnik, Neubeuern, Germany). Evaluated parameters were convergence angle, undercuts, interocclusal reduction, abutment height, and design of preparation margin.Results
The mean convergence angle was determined to be 26.7°. The convergence angle in the mesiobuccal to distopalatal dimension was significantly the highest (31.7°), and the abutment height showed a mean value of 4.1 mm. Convergence angle and abutment height showed a negative correlation. Seventy-three percent of the evaluated locations revealed a margin design conforming to ceramic restorations. In over 30 % of the cases, the interocclusal reduction was insufficient. Generally, no preparation fulfilled all recommendations. Five (6.66 %) of the preparations fulfilled four criteria, 16 (21.33 %) preparations fulfilled three criteria, 31 (41.33 %) fulfilled two criteria, 17 (22.66 %) preparations fulfilled one criterion, and 6 (8 %) fulfilled no criterion.Conclusions
Within the limitations of this study, most general dental practitioners seem to have difficulties fulfilling all clinical recommendations given for the preparation of zirconia crowns. The presented digital approach seems to be a useful method to evaluate the preparation geometry.Clinical relevance
The correct preparation geometry represents an important prerequisite for the success of all-ceramic full crowns. As preparations clearly need to be improved, the approach presented could be the basis of a future tool to increase preparation quality in practice and education by direct objective feedback. 相似文献962.
Rania M. Nada Bram van Loon Thomas J.J. Maal Stefaan J. Bergé Yehya A. Mostafa Anne Marie Kuijpers-Jagtman Jan GJH Schols 《Clinical oral investigations》2013,17(9):2017-2024
Objectives
This study seeks to three-dimensionally assess soft tissue changes in the orofacial region following tooth-borne and bone-borne surgically assisted rapid maxillary expansion (SARME).Materials and methods
This prospective cohort study included 40 skeletally mature patients with transverse maxillary hypoplasia. A tooth-borne distractor (Hyrax) was used for expansion in 25 patients. In the remaining 15, a bone-borne distractor (transpalatal distractor, TPD) was used. Cone beam computed tomography (CBCT) scans were acquired before treatment (T0) and 22 months later (T1). 3D models were constructed from CBCT data and superimposed using voxel-based matching. Distance maps between the superimposed 3D models were computed to evaluate the degree of skeletal and soft tissue changes in the maxillary region.Results
Distance maps showed negative distances (mean ?1.25 (±1.5) mm) in the middle of the upper lip, indicating posterior repositioning of this area. The cheek region showed positive changes (mean 1.66 (±1.1) mm), reflecting the underlying increase in maxillary width. There was no significant difference between the two groups in all measured distances (p?>?0.05). Retro-positioning of the upper lip accompanied skeletal remodeling in the anterior alveolar region at a mean ratio of 88 %, while the cheek region followed 32 % of the alveolar expansion.Conclusion
Soft tissue changes following SARME include posterior repositioning of the upper lip and increased projection of the cheek area. These changes were comparable between bone-borne and tooth-borne appliances.Clinical relevance
This study provides clinicians with more information over the expected orofacial soft tissue changes following SARME 相似文献963.
Hugo De Bruyn DDS MSc PhD Peter Bouvry MD Bruno Collaert DDS MSc PhD Calix De Clercq MD DDS G. Rutger Persson DDS MSc PhD Jan Cosyn DDS MSc PhD 《Clinical implant dentistry and related research》2013,15(1):73-82
Purpose: The purpose of this study was to document the long‐term outcome of Brånemark implants installed in augmented maxillary bone and to identify parameters that are associated with peri‐implant bone level. Material and Methods: Patients of a periodontal practice who had been referred to a maxillofacial surgeon for iliac crest bone grafting in the atrophic maxilla were retrospectively recruited. Five months following grafting, they received 7–8 turned Brånemark implants. Following submerged healing of another 5 months, implants were uncovered and restorative procedures for fixed rehabilitation were initiated 2–3 months thereafter. The primary outcome variable was bone level defined as the distance from the implant‐abutment interface to the first visible bone‐to‐implant contact. Secondary outcome variables included plaque index, bleeding index, probing depth, and levels of 40 species in subgingival plaque samples as identified by means of checkerboard DNA–DNA hybridization. Results: Nine out of 16 patients (eight females, one male; mean age 59) with 71 implants agreed to come in for evaluation after on average 9 years (SD 4; range 3–13) of function. One implant was deemed mobile at the time of inspection. Clinical conditions were acceptable with 11% of the implants showing pockets ≥ 5 mm. Periodontopathogens were encountered frequently and in high numbers. Clinical parameters and bacterial levels were highly patient dependent. The mean bone level was 2.30 mm (SD 1.53; range 0.00–6.95), with 23% of the implants demonstrating advanced resorption (bone level > 3 mm). Regression analysis showed a significant association of the patient (p < .001) and plaque index (p = .007) with bone level. Conclusions: The long‐term outcome of Brånemark implants installed in iliac crest‐augmented maxillary bone is acceptable; however, advanced peri‐implant bone loss is rather common and indicative of graft resorption. This phenomenon is patient dependent and seems also associated with oral hygiene. 相似文献
964.
965.
Tomasz Lyson Andrzej Sieskiewicz Andrzej Sobolewski Robert Rutkowski Jan Kochanowicz Grzegorz Turek Anna Baclawska Jacek Krajewski Marek Rogowski Zenon Mariak 《Acta neurochirurgica》2013,155(5):903-908
Background
Data regarding the safety of endoscopic skull base exploration are very scarce. With this method, fragile vital structures (cranial nerves, the optic complex, brainstem, hypothalamus or cerebral ventricles) are exposed to direct illumination within a closed space. Also, high-speed drills, cauterization and ultrasonic aspiration deliver a significant load of thermal energy. The aim of this study was to record the temperature close to the structures of the skull base and in the intradural space during the procedures performed using extended endoscopic transnasal approaches.Methods
The temperature of the skull base was continuously recorded during six transnasal endoscopic procedures. Implantable copper-constantan thermocouples were inserted: one into the esophagus and another through the nostril to reach the operative field at the skull base.Results
At the beginning of the procedure, the temperature of the operative field was on average 36.8 °C?±?0.80 °C, i.e. only 1 °C higher than the esophageal temperature. Then it grew continuously during the whole procedure, to eventually reach a level of 42–43 °C at the final stage, whereas the esophageal temperature remained stable. Occasionally, the temperature increased up to 45 °C during cauterization and ultrasonic aspiration, and even up to 62 °C during high-speed drilling.Conclusion
Endoscopic skull base surgery is associated with an incessant increase of the temperature of the intraoperative field. The temperature can peak suddenly to levels which can potentially harm neural structures and influence the rate of postoperative complications. 相似文献966.
Background
Traumatic brain injury is common. Guidelines from the Brain Trauma Foundation and the Scottish Intercollegiate Guidelines Network recommend that patients with suspected severe traumatic brain injury should be treated in centres with neurosurgical expertise. Scotland does not have a framework for the delivery of trauma care. The aim of this study was to examine the demographic characteristics of incidents involving patients who have suffered a suspected traumatic brain injury, and to evaluate the level of the destination healthcare facility which patients are currently taken to.Methods
Retrospective analysis of prospectively collected Scottish Ambulance Service data on incidents involving traumatic injury, between Nov 2008 and Oct 2010. Two groups of casualties were analysed: those who had a Glasgow coma scale of less than 14 (GCS < 14), and those who had a Glasgow coma scale of less than 9 (GCS < 9).Results
126,934 incidents were identified and analysed. 3890 (3.1%) patients had a GCS of less than 14, and 657 (0.5% of total) had a GCS of less than 9. Almost one-third of incidents involving patients with either a GCS < 14 or GCS < 9 occurred in the greater Glasgow health board area. The Lothian health board region had the second-highest number of patients with either a GCS < 14 or GCS < 9. Only 13.8% of patients with a GCS < 14, and 16.7% of those with a GCS < 9, were taken to a hospital with a neurosurgical service.Conclusions
Many patients who may harbour a traumatic brain injury are taken to a facility which may not be equipped or staffed to deal with such injuries. This mismatch needs to be addressed. However, the care of patients with head injuries is only one aspect of trauma care. The UK has long lagged behind North America in terms of the quality of trauma care provided, although the provision of trauma care in England is currently undergoing major changes. Scotland should consider the development of a similar service delivery framework. 相似文献967.
968.
Volker Ott Graham Finlayson Hendrik Lehnert Birte Heitmann Markus Heinrichs Jan Born Manfred Hallschmid 《Diabetes》2013,62(10):3418-3425
Experiments in animals suggest that the neuropeptide oxytocin acts as an anorexigenic signal in the central nervous control of food intake. In humans, however, research has almost exclusively focused on the involvement of oxytocin in the regulation of social behavior. We investigated the effect of intranasal oxytocin on ingestion and metabolic function in healthy men. Food intake in the fasted state was examined 45 min after neuropeptide administration, followed by the assessment of olfaction and reward-driven snack intake in the absence of hunger. Energy expenditure was registered by indirect calorimetry, and blood was repeatedly sampled to determine concentrations of blood glucose and hormones. Oxytocin markedly reduced snack consumption, restraining, in particular, the intake of chocolate cookies by 25%. Oxytocin, moreover, attenuated basal and postprandial levels of adrenocorticotropic hormone and cortisol and curbed the meal-related rise in plasma glucose. Energy expenditure and hunger-driven food intake as well as olfactory function were not affected. Our results indicate that oxytocin, beyond its role in social bonding, regulates nonhomeostatic, reward-related energy intake, hypothalamic-pituitary-adrenal axis activity, and the glucoregulatory response to food intake in humans. These effects can be assumed to converge with the psychosocial function of oxytocin and imply possible applications in the treatment of metabolic disorders.The hypothalamic nonapeptide oxytocin is released into the circulation by axonal terminals in the posterior pituitary and, moreover, acts directly on central nervous receptors. Oxytocin, which has been highly preserved during mammalian evolution, regulates physiological functions related to reproduction and mother-infant interaction, such as lactation, and in recent years, has been shown to modulate affiliative behavior (1). Research in humans has almost exclusively focused on the role of oxytocin in the regulation of prosocial behavior, including trust, attachment, and sexual behavior (2–5), largely ignoring potential effects of the neuropeptide on ingestive behavior and metabolism. In fact, evidence from rodent studies indicates that the neuropeptide acts as a strong inhibitor of food intake and affects energy expenditure and glucose homeostasis (6–9). Oxytocinergic neurons in the hypothalamic paraventricular nucleus are assumed to mediate the food intake–limiting effect of leptin, an adipokine that provides the brain with negative feedback on body fat stores and sensitizes caudal brainstem nuclei to satiety factors such as cholecystokinin (10). Hypothalamic oxytocin signaling, moreover, mediates anorexigenic effects of the satiety factor nesfatin-1 in a leptin-independent manner (11). Importantly, oxytocin reduces food intake not only in normal-weight rodents but also in animals with diet-induced obesity (8,12,13), so oxytocinergic pathways might be a promising target of clinical interventions in obese patients.The direct manipulation of neuropeptidergic central nervous signaling pathways can be achieved via the intranasal administration of peptides, which is known to bypass the blood–brain barrier and result in significant cerebrospinal fluid elevations in substance levels within 40 min, without the need for systemic infusion (14,15). This approach has been validated, among others, for vasopressin, a close homolog of oxytocin (14), and intranasal oxytocin administration has been shown to reliably modulate neuropsychological functions in a series of studies (2–5) in the absence of relevant side effects (16). Surprisingly, however, the effect of intranasal oxytocin on energy metabolism, including ingestive behavior, has not been investigated in humans so far. The assessment of respective effects of intravenous oxytocin (17) is hampered because peripheral oxytocin is not readily transported across the blood–brain barrier (18).In the present experiments, we studied the contribution of oxytocin signaling to the control of ingestive behavior and energy expenditure in normal-weight, healthy men, with a particular view to endocrine regulators of metabolism, such as ghrelin and insulin, as well as hypothalamic-pituitary-adrenal (HPA) axis secretory activity. Ingestive behavior is not only regulated homeostatically (i.e., by central nervous pathways that respond to energy depletion) but also by nonhomeostatic brain circuits that process the reward-related, “hedonic” qualities of food intake (19). Therefore, we applied a twofold assessment of food intake that relied, on the one hand, on a large breakfast buffet after an overnight fast to investigate homeostatic, primarily hunger-driven energy intake (20–22), and on the other hand, on a collection of snacks of varying palatability offered after breakfast intake for the measurement of reward-driven food intake (22–24). 相似文献
969.
970.