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排序方式: 共有2511条查询结果,搜索用时 23 毫秒
21.
Jamal M. Arif Mohammed Kunhi Yunus M. Siddiqui Khalid A. El Sayed Khaled Y. Orabi Amal Al-Hazzani Mohammed N. Al-Ahdal Fahad M. Al-Khodairy 《Medicinal chemistry research》2004,13(6-7):553-562
In the present study, two of the probable an umor marine compounds, manzamine A and sarcophine, were screened using benzo[a]pyrene (BP)-derived DNA adduct formation in MCF-7 cells as intermediary biomarker. Briefly, MCF-7 cells were treated with
the compounds for 24 h followed by treatment with BP (0.5 μM). After 24h incubation, cellular DNA was isolated and analyzed
for BP-derived DNA adducts by 32P-postlabeling technique. Manzamine A and sarcophine increased the BP-DNA adducts by 2 to 4-folds. Further, manzamine A (50
μM) substantially down regulated the expression of p53 while sarcophine (50 μM) slightly induced the level of p21. The residual
DNA repair ability was almost completely abolished by manzamine A while sarcophine was ineffective. Based on our preliminary
results, these compounds may be classified as potential genotoxic. 相似文献
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Ibrahim bin Jantan Mira Febrina Yalvema Nazni Wasi Ahmad Jamia Azdina Jamal 《Pharmaceutical biology》2013,51(6):526-532
AbstractThe leaf oils of eight Cinnamomum. species (C. rhyncophyllum. Miq., C. microphyllum. Ridl., C. pubescens. Kochummen, C. mollissimum. Hook. f., C. impressicostatum. Kosterm, C. scortechinii. Gamb., C. sintoc. Bl., and C. cordatum. Kosterm) were investigated for their larvicidal and adulticidal activities against Aedes aegypti. (Aedes aegypti Lynn) and Aedes albopictus. (Aedes albopictus Skuse). Acute mortalities of the fourth instar larvae and the adult mosquitoes were determined according to the standard WHO methods. Among the essential oils studied, the leaf oils of C. rhyncophyllum., C. microphyllum., C. pubescens., C. mollissimum., and C. impressicostatum. showed significant effects against the larvae of Ae. aegypti. and Ae. albopictus. with concentrations that caused 50% mortality (LC50) values of less than 12.8 and 11.8 µg ml?1, respectively. The essential oils that showed strong larvicidal effects also demonstrated relatively strong adulticidal effects on the mosquitoes after 3 h exposure with LC50 values ranging from 133.0 to 243.0 µg ml?1 against Ae. aegypti. and from 118.0 to 194.0 µg ml?1 against Ae. albopictus.. The efficacy of the oils toward the larvae and adult mosquitoes of both species was nonselective as the LC50 values showed little variation. The chemical composition of the oils was investigated by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). This study suggested that the essential oils containing high levels of benzyl benzoate and benzyl salicylate exhibited strong insecticidal activities against the larvae and adult mosquitoes. 相似文献
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Jamal A. Ahmed Edna Moturi Paul Spiegel Marian Schilperoord Wagacha Burton Nailah H. Kassim Abdinoor Mohamed Melvin Ochieng Leonard Nderitu Carlos Navarro-Colorado Heather Burke Susan Cookson Thomas Handzel Lilian W. Waiboci Joel M. Montgomery Eyasu Teshale Nina Marano 《Emerging infectious diseases》2013,19(6):1010-1011
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Muhammad Jamal PhD 《Behavioral medicine (Washington, D.C.)》2013,39(2):60-68
Abstract This study examined Type A and Type B differences in job performance, psychosomatic complaints, and career progression among white-collar employees (N = 218) in a field setting. Significant differences were found between Type A's and Type B's in quality of performance, effort exerted at the job, and psychosomatic complaints. Employees' cultural background and sex moderated some of the relationships observed in the study. Implications of the findings for future research on the topic are discussed. 相似文献
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Ali Zohair Nomani Humayun Rashid Jamal Janjua Hanna Nomani Azer Majeed 《Renal failure》2014,36(7):1169-1176
Mannitol is commonly used to lower intracranial and intraocular pressures. Large doses/massive infusions of mannitol have been found to be associated with acute renal failure (MI-ARF), that is, osmotic nephrosis. While many researchers have reported individual experiences with this pathology, we felt that there is need of an updated comprehensive review of all reported cases with elaboration of etiology, pathogenesis, diagnosis and management plan for MI-ARF. The purpose of the present communication is to share our own experience with MI-ARF, to review the effect of mannitol on kidney function and to highlight the dynamics of MI-ARF with considerations for the cautious use of mannitol in patients with risk factors for kidney diseases. 相似文献
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Seyed Mostafa Nachvak Shima Moradi Javad Anjom-shoae Jamal Rahmani Morteza Nasiri Vahid Maleki Omid Sadeghi 《Journal of the Academy of Nutrition and Dietetics》2019,119(9):1483-1500.e17
ObjectiveWe conducted a systematic review and dose–response meta-analysis of prospective studies to summarize findings on the associations between intakes of soy, soy isoflavones, and soy protein and risk of mortality from all causes, cancers, and cardiovascular diseases.MethodsOnline databases were systematically searched to identify relevant articles published earlier than May 2018. We applied restricted cubic splines using random-effects analysis to assess dose–response associations. Between-study heterogeneity was assessed by I2 value and Cochrane Q test. Potential publication bias was assessed by visual inspection of funnel plots and Begg regression test.ResultsIn total, 23 prospective studies with an overall sample size of 330,826 participants were included in the current systematic review and the meta-analysis. Soy/soy products consumption was inversely associated with deaths from cancers (pooled relative risk 0.88, 95% CI 0.79 to 0.99; P=0.03; I2=47.1%, 95% CI 0.0% to 75.4%) and cardiovascular diseases (pooled effect size: 0.85, 95% CI 0.72 to 0.99; P=0.04; I2=50.0%, 95% CI 0.0% to 77.6%). Such significant associations were also observed for all-cause mortality in some subgroups of the included studies, particularly those with higher quality. In addition, higher intake of soy was associated with decreased risk of mortality from gastric, colorectal, and lung cancers as well as ischemic cardiovascular diseases. Participants in the highest category of dietary soy isoflavones intake had a 10% lower risk of all-cause mortality compared with those in the lowest category. We also found that a 10-mg/day increase in intake of soy isoflavones was associated with 7% and 9% decreased risk of mortality from all cancers and also breast cancer respectively. Furthermore, a 12% reduction in breast cancer death was indicated for each 5-g/day increase in consumption of soy protein. However, intake of soy protein was not significantly associated with all-cause and cardiovascular diseases mortality.ConclusionsSoy and its isoflavones may favorably influence risk of mortality. In addition, soy protein intake was associated with a decreased risk in the mortality of breast cancer. Our findings may support the current recommendations to increase intake of soy for greater longevity. 相似文献