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Kozłowska I Kosiński K Rózański J Kurowski M Nikodemska I Ciechanowski K 《Polskie Archiwum Medycyny Wewn?trznej》2005,113(4):359-363
Changes of lymphatic system, vascular disease during pulmonary hypertension or aneurysms are very often considered to be a cause of wide pulmonary hilus. However, we should remember developmental anomaly of pulmonary artery, too. We present a case of a patient hospitalized very often due to necessity of diagnostic wide, polycyclic pulmonary hilus. Only digital subtraction angiography allowed us to know the reason of wide pulmonary hilus as the developmental anomaly of pulmonary artery. 相似文献
23.
Giebel S Locatelli F Wojnar J Velardi A Mina T Giorgiani G Krawczyk-Kulis M Markiewicz M Wylezol I Holowiecki J 《British journal of haematology》2005,131(4):483-486
Human leucocyte antigen (HLA)-C molecules regulate the function of natural killer cells and may be subdivided into two groups, C(1) and C(2), based on their specificity for inhibitory killer immunoglobulin-like receptors. We analysed the impact of the HLA-C genotype on outcome of HLA-C-matched unrelated donor haematopoietic stem cell transplantation (URD-HSCT) recipients. HLA-C(2) homozygous patients (n = 18) had lower probability of overall survival (P = 0.01) and disease-free survival (P = 0.02), resulting from increased relapse rate (P = 0.02) when compared with both HLA-C(1) homozygous (n = 43) and HLA-C(1),C(2) heterozygous (n = 50) subgroups. Patients lacking HLA-C(1) should, therefore, be considered at increased risk of relapse following HLA-C-matched URD-HSCT. 相似文献
24.
A female patient suffering from dermatomyositis in whom symptoms of heart failure without angina is described. An impairment of left ventricular function and significant coronary lesions were diagnosed using noninvasive and invasive procedures. Coronary angioplasty with stent implantation was successfully applied to improve the quality of life and clinical symptoms. 相似文献
25.
Kozłowska I Krzystolik A Rózański J Nikodemska I Kurowski M Ciechanowski K 《Kardiologia polska》2005,62(2):151-152
A case of a 49-year-old female with a history of two myocardial infarctions (MI) and ischaemic stroke is presented. The patient was admitted to the hospital due to a third acute MI. Laboratory investigations revealed resistance to activated protein C due to factor V Leiden mutation. Diagnosis and treatment of patients with this condition are discussed. 相似文献
26.
The coincidence of viral hepatitis and acute pancreatitis is well described. Most of the cases are related to acute hepatitis A or B. Hepatitis E virus (HEV) infections are rare in Europe, and very few reports describe HEV as a causative agent of acute pancreatitis in areas of endemic hepatitis E prevalence. We report a case of acute pancreatitis in the course of acute hepatitis E in a 28-year-old male patient. The majority of reported cases, including our case, show several common epidemiological and clinical features: young age, male predominance, onset of acute pancreatitis at the early stage of acute hepatitis, and favorable outcome. Acute pancreatitis should be considered in acute hepatitis E, especially in young, male patients presenting with severe epigastric pain early in the course of disease. The pancreatitis in these patients usually runs a benign course. The patients should be closely monitored because life-threatening complications have been reported. 相似文献
27.
The relevance of tyrosine kinase inhibitors (TKIs) in the treatment of malignancies has
been already defined. Aberrant activation of tyrosine kinase signaling pathways has been causally
linked not only to cancers but also to other non-oncological diseases. This review concentrates on the
novel plausible usage of this group of drugs in neurological disorders, such as ischemic brain stroke,
subarachnoid hemorrhage, Alzheimer’s disease, multiple sclerosis. The drugs considered here are
representatives of both receptor and non-receptor TKIs. Among them imatinib and masitinib have the
broadest spectrum of therapeutic usage. Both drugs are effective in ischemic brain stroke and multiple
sclerosis, but only imatinib produces a therapeutic effect in subarachnoid hemorrhage. Masitinib and
dasatinib reduce the symptoms of Alzheimer’s disease. In the case of multiple sclerosis several TKIs are useful, including
apart from imatinib and masitinib, also sunitinib, sorafenib, lestaurtinib. Furthermore, the possible molecular targets for
the drugs are described in connection with the underlying pathophysiological mechanisms in the diseases in question. The
most frequent target for the TKIs is PDGFR which plays a pivotal role particularly in ischemic brain stroke and
subarachnoid hemorrhage. The collected data indicates that TKIs are very promising candidates for new therapeutic
interventions in neurological diseases. 相似文献
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29.
Deliberately controlled interfacial interactions between incorporated nanofiller particles and host polymer backbone chains constitute a critical element in the realm of polymer nanocomposites with tailorable multifunctional properties. We demonstrate the physicochemical effects induced by graphene nanoplatelets (GNP) of different sizes on the condensation polymerization reaction of aromatic thermosetting copolyester (ATSP) through the formation of electrically conductive percolating networks as enabled by interfacial interactions. Carboxylic acid and acetoxy-capped precursor oligomers of ATSP are solid-state mixed with chemically pristine GNP particles at various loading levels. Upon in situ endothermic condensation polymerization reaction, crosslinked backbone of the ATSP foam matrix is formed while the carbonaceous nanofillers are incorporated into the polymer network via covalent conjugation with functional end-groups of the oligomers. The controlled GNP size promotes different electrical percolation thresholds and ultimate electrical conductivities. Microstructural analysis demonstrates GNP distributions in the matrix as well as morphological modifications induced by the formation of conductive percolating GNP networks. Cure characteristics reveal the thermochemical changes prompted in the polymerization processes for GNP content above the requirement for percolation formation. Chemical spectroscopy of the ATSP nanocomposite morphology exhibits the formation of a robust interfacial coupling mechanism between the GNPs and ATSP backbone. The findings here may guide the developmental efforts of nanocomposites through better identifying roles of the morphology and content of nanofillers in polymerization processes.Physicochemical effects induced by graphene nanoplatelets on the in situ polycondensation reaction of aromatic thermosetting copolyester through the formation of conductive percolating network assembled via interfacial interactions. 相似文献
30.
FDG‐based quantitative comparison of glucose metabolism in vitro,exemplified by a head‐to‐head comparison between a triple‐negative breast cancer cell line and a non‐malignant foetal cell line 下载免费PDF全文