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61.
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Bukharin OV Cherkasov SV Sgibnev AV Zabirova TM Ivanov YB 《Bulletin of experimental biology and medicine》2000,130(7):679-681
The effects of cell extracts and supernatants ofLactobacillus spp. andCorynebacterium spp. on catalase activity and growth ofStaphylococcus aureus 6538 P were studied. Intra- and extracellular metabolites of lactobacilli and corynebacteria inhibited catalase activity
ofS. aureus 6538 P. The growth ofS. aureus 6538 P decreased after incubation with lactobacillus metabolites. The inhibitory effect of intra- and extracellular metabolites
of lactobacilli and corynebacteria on catalase activity ofS. aureus is a possible pathway of microbial interrelations responsible for the formation and/or development of microbial biocenoses.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 7, pp. 80–82, July, 2000 相似文献
64.
Bhattacharya S; MacLennan F; Hamilton MP; Templeton A 《Human reproduction (Oxford, England)》1997,12(7):1440-1442
Although the conventional method of pain relief during outpatient oocyte
recovery involves physician-administered drugs, patient- controlled
analgesia (PCA) offers an alternative technique with the potential to give
women more control over peroperative analgesia. We conducted a prospective
randomized study to compare the effect of fentanyl administered either
through a PCA delivery system or by a physician. Thirty-nine women were
randomized to PCA during egg collection while 42 were allocated to receive
intermittent doses administered by a physician. Pain was evaluated by means
of a 100 mm linear analogue scale. The mean (SD) pain score in the PCA
group was 38.5 (19.8) while in the other group it was 46.1 (21.3) (P =
0.1). In the PCA group, 64% of women felt very satisfied with their
analgesia as compared with 57% in the non-PCA group (P = 0.6). Among the
PCA users, 39% of demands were successful. Significantly more fentanyl
(97.5 microg) was used in the PCA group than in the other group (84.6
microg) (P = 0.03). Though intraoperative PCA with fentanyl is an effective
alternative to physician-administered techniques, many women still feel the
need for more analgesia during the procedure.
相似文献
65.
Gladskikh OP Danilova TI Kuznetsova AV Andreeva IuIu Vinarov AZ Ivanov AA Pal'tsev MA 《Arkhiv patologii》2002,64(6):40-43
Primary culture of prostatic adenocarcinoma is obtained from surgical material after radical prostatectomy. Typing of the obtained culture with antibodies to vimentin and cytokeratins has shown that the proportion of basic cell components--stromal and epithelial--in vitro correlates with such in the initial tumor tissue. In cultivation in different media active migration and proliferation of all cell types in the presence of embryonal serum and suppression of the stromal component in the medium where the serum was replaced for bovine hypophysis extract were observed. A comparative immunohistochemical analysis registered a release into culture of alpha SMA-positive myofibroblasts and active expression of TGF beta-1 in the medium containing serum. Design of dynamic mixed cell systems may serve a convenient model for investigation of stromal-epithelial interactions and their changes in cancer progression. 相似文献
66.
Morphological studies have shown that macrophages and microglia undergo
apoptosis in the central nervous system (CNS) in acute experimental
autoimmune encephalomyelitis (EAE) in the Lewis rat. To assess the relative
levels of macrophage and microglial apoptosis, and the molecular mechanisms
involved in this process, we used three-colour flow cytometry to identify
CD45lowCD11b/c+ microglial cells and CD45highCD11b/c+ macrophages in the
inflammatory cells isolated from the spinal cords of Lewis rats 13 days
after immunization with myelin basic protein (MBP) and complete Freund's
adjuvant. Simultaneously, we analyzed the DNA content of these cell
populations to assess the proportions of cells undergoing apoptosis and in
different stages of the cell cycle or examined their expression of three
apoptosis- regulating proteins, i.e. Fas (CD95), Fas ligand (FasL) and
Bcl-2. Microglia were highly vulnerable to apoptosis and were
over-represented in the apoptotic population. Macrophages were less
susceptible to apoptosis than microglia and underwent mitosis more
frequently than microglia. The different susceptibilities of microglia and
macrophages to apoptosis did not appear to be due to variations in Fas,
FasL or Bcl- 2 expression, as the proportions of microglia and macrophages
expressing these proteins were similar, and were relatively high.
Furthermore, in contrast to T cell apoptosis, apoptosis of
microglia/macrophages did not occur more frequently in cells expressing Fas
or FasL, or less frequently in cells expressing Bcl-2. These results
indicate that the apoptosis of microglia and CNS macrophages in EAE is not
mediated through the Fas pathway, and that Bcl-2 expression does not
protect them from apoptosis. Expression of FasL by macrophages and
microglia may contribute to the pathogenesis and immunoregulation of EAE
through interactions with Fas+ oligodendrocytes and Fas+ T cells. The high
level of microglial apoptosis in EAE indicates that microglial apoptosis
may be an important homeostatic mechanism for controlling the number of
microglia in the CNS following microglial activation and proliferation.
相似文献
67.
L. V. Ivanov N. A. Lyapunov I. N. Orlova K. E. Mayat 《Pharmaceutical Chemistry Journal》1993,27(12):846-849
1. | Comparative study of the pharmacokinetics of HCA from a suspension and foam during rectal and intramuscular administration to rabbits showed that only the foam preparation introduced rectally ensures continuous and prolonged absorption of HCA from the foam for 5–6 h into the systemic blood flow and a considerable accumulation of HCA in the rectal tissue for the same period of time, and also the maximal degree of absorption of HCA (AUC0–8) in comparison with other forms due to prolonged action. |
2. | For prolonged accumulation of HCA in the rectal tissue, the content of PG in the foam emulsions should not exceed 15–20%. The PG may serve as a modulator of the bioavailability of foam preparations in aerosol packings containing corticosteroids. |
68.
Y G Zorbas A L Ivanov Y N Fuziyama 《Materia medica Polona. Polish journal of medicine and pharmacy》1990,22(4):286-288
It has been suggested that the electrolyte composition of rat skeletal muscles may change after the exposure to hypokinesia (diminished muscular activity). Thus, the aim of this study was to determine the concentration levels of ions of Na, K, Ca and Mg in muscle tissue and the endogenous media of 135 rats weighing 140-160 g during the readaptation period (RP) of 30 days and after a 96 days exposure to hypokinesia (HK). The animals were divided into two groups. The 1st group (70 rats) was subjected to "pure" HK, that is, without the use of any preventive measures, and the 2nd group (65 rats) was placed under usual conditions and served as control. For the simulation of the hypokinetic effect, the 1st group of rats were kept in small individual cages made of plexiglass. The concentration levels of ions of Na, K, Ca and Mg were determined in muscle tissue and the endogenous media of rats by the method of atom-absorption spectrophotometry. Blood plasma ion composition changed significantly. Tissular fluid content and the tissular concentrations of Na, K, Ca and Mg in muscles also changed significantly during the readaptation period. It was concluded that the concentration levels of ions of Na, K, Ca and Mg in connective tissues, as well as endogenous medium of rats evidently changed significantly during the readaptation period and after the exposure to hypokinesia. 相似文献
69.
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