全文获取类型
收费全文 | 709876篇 |
免费 | 49059篇 |
国内免费 | 1326篇 |
专业分类
耳鼻咽喉 | 9184篇 |
儿科学 | 23309篇 |
妇产科学 | 17677篇 |
基础医学 | 110995篇 |
口腔科学 | 20080篇 |
临床医学 | 64011篇 |
内科学 | 135516篇 |
皮肤病学 | 16226篇 |
神经病学 | 49752篇 |
特种医学 | 25837篇 |
外国民族医学 | 76篇 |
外科学 | 105171篇 |
综合类 | 14829篇 |
现状与发展 | 2篇 |
一般理论 | 161篇 |
预防医学 | 51521篇 |
眼科学 | 16351篇 |
药学 | 54222篇 |
3篇 | |
中国医学 | 2367篇 |
肿瘤学 | 42971篇 |
出版年
2021年 | 5503篇 |
2018年 | 7943篇 |
2017年 | 6174篇 |
2016年 | 6884篇 |
2015年 | 7623篇 |
2014年 | 10344篇 |
2013年 | 15482篇 |
2012年 | 20636篇 |
2011年 | 21689篇 |
2010年 | 12820篇 |
2009年 | 12036篇 |
2008年 | 20158篇 |
2007年 | 21678篇 |
2006年 | 22115篇 |
2005年 | 20618篇 |
2004年 | 20180篇 |
2003年 | 19096篇 |
2002年 | 18640篇 |
2001年 | 36464篇 |
2000年 | 37018篇 |
1999年 | 30505篇 |
1998年 | 7919篇 |
1997年 | 6694篇 |
1996年 | 7010篇 |
1995年 | 6667篇 |
1994年 | 6118篇 |
1993年 | 5613篇 |
1992年 | 23066篇 |
1991年 | 23020篇 |
1990年 | 22392篇 |
1989年 | 22174篇 |
1988年 | 20111篇 |
1987年 | 19490篇 |
1986年 | 18531篇 |
1985年 | 17376篇 |
1984年 | 12743篇 |
1983年 | 10782篇 |
1982年 | 5944篇 |
1979年 | 11569篇 |
1978年 | 8152篇 |
1977年 | 6862篇 |
1976年 | 6617篇 |
1975年 | 7291篇 |
1974年 | 8519篇 |
1973年 | 8162篇 |
1972年 | 7680篇 |
1971年 | 7139篇 |
1970年 | 6903篇 |
1969年 | 6322篇 |
1968年 | 5805篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
31.
N. N. Polygalova A. G. Mikhailovskii E. S. Limanskii B. Ya. Syropyatov M. I. Vakhrin 《Pharmaceutical Chemistry Journal》2006,40(3):132-134
A series of 1-alkyl-3,4-dihydroisoquinolines and the related 4-alkyl-1,2-dihydro-benzo[f]isoquinolines was synthesized using
reactions of dialkylbenzylcarbinols and their naphthyl analogs with alkylcyanides. Experiments showed that 1-alkyl-6,7-dimethoxy-3,4-dihydroisoquinolines
typically produce a hypotensive action, while the benzo-annelated structures usually exhibit a hypertensive effects. The most
active compound decreases the arterial pressure in cats by 52 Torr and the effect lasts for about 4 hours.
__________
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 3, pp. 15–17, March, 2006. 相似文献
32.
33.
34.
35.
Nobuyuki Inoue Kouji Nagaike Shinichi Ishihara Mitsuhiko Nakamura Toshio Kuroshima 《Digestive endoscopy》2006,18(2):134-137
Background: For management of bowel obstruction due to colorectal cancer, endoscopic trans‐anal decompression technique has been first reported by Lelcuk et al. in 1986 using balloon dilatation technique. Since then, various types of trans‐anal decompression tubes have been clinically used for patients suffering from left side obstructing colorectal cancer as an emergent decompressing device. At present, two types of trans‐anal ileus tube (trans‐anal decompression tube) have been available for clinical use, but they have two main problems that are late colon perforations caused by the tip of the tube and tube obstruction by stool. Methods: Analysis on three late colon perforations experienced with the use of conventional devices drew possible improvements to make a trans‐anal ileus tube less harmful. To overcome the pitfalls inherent to conventional tubes, the author has developed an improved trans‐anal ileus tube with a balloon installed at the very end of the tube (‘balloon‐tipped type’) made of silicone, measuring 1200 or 1700 mm in total length and 22 Fr in outer diameter. It has been used for 12 cases with obstructing colorectal cancer etc. and its outcomes were compared with those obtained by the use of conventional trans‐anal ileus tube. Results: No late perforations have been encountered, but tube obstruction did occur in one of 12 cases. Conclusion: The new trans‐anal ileus tube with a balloon installed at the tip of ileus tube is considered to be safer and especially effective in preventing late colon perforation and tube obstruction. 相似文献
36.
37.
H Ishihara M Bjeljac D Straumann Y Kaku P Roth Y Yonekawa 《Minimally invasive neurosurgery》2006,49(3):168-172
OBJECTIVE: A safe entry zone to tegmental lesions was identified based on intraoperative electrophysiological findings, the compound muscle action potentials (CMAP) from the extraocular muscles, and anatomic considerations. This entry zone is bordered caudally by the intramesencephalic path of the trochlear, laterally by the spinothalamic tract, and rostrally by the caudal margin of the brachium of the superior colliculus. METHODS: Four intrinsic midbrain lesions were operated upon via the safe entry zone using the infratentorial paramedian supracerebellar approach. All lesions involved the tegmentum and included an anaplastic astrocytoma, a metastatic brain tumor, a radiation necrosis, and a cavernous angioma. CMAP were bilaterally monitored from the inferior recti (for oculomotor function) and superior oblique (for trochlear nerve function) muscles. RESULTS: In three of four cases, CMAP related to the oculomotor nerve were obtained upon stimulation at the cavity wall after removal of the tumor. Stimulation at the surface of the quadrigeminal plate, however, did not cause any CMAP response. Using this monitoring as an indicator, the lesions were totally removed. CONCLUSIONS: In the surgery of tegmental lesions, CMAP monitoring from extraocular muscles is particularly helpful to prevent damage to crucial neural structures during removal of intrinsic lesions, but less so to select the site of the medullary incision. The approach via the lateral part of the colliculi is considered to be a safe route to approach the tegmental lesions. 相似文献
38.
39.
N Jastrow E Antonelli R Robyr O Irion M Boulvain 《Ultrasound in obstetrics & gynecology》2006,27(4):420-424
OBJECTIVE: To evaluate the reproducibility of sonographic measurement of the lower uterine segment in pregnant women at term. METHODS: Two independent observers performed transabdominal sonography on 129 women between 36 and 38 weeks of gestation who had had a previous Cesarean section. Sonography was performed when the patients had a full and a half-full bladder; in 100 patients, the measurements were also performed transvaginally, with the patients having an empty bladder. Agreement was quantified by the intraclass correlation coefficient and, using a cut-off of 3.5 mm, by the kappa coefficient. RESULTS: The intraobserver agreement was generally high (intraclass correlation coefficient > 0.90). The interobserver agreement was higher on transvaginal (intraclass correlation coefficient, 0.94) compared with transabdominal (0.70 and 0.84, with full and half-full bladder, respectively) ultrasound. The kappa coefficient was 0.75 transvaginally, compared with 0.34 and 0.54 using the transabdominal approach, with full and half-full bladder, respectively. CONCLUSION: The agreement between two observers for sonographic transvaginal measurement of the lower uterine segment can be considered good, compared with poor to moderate agreement using the transabdominal approach. 相似文献
40.
A Sharma H L Goh N Asokananthan A Bakker G A Stewart H W Mitchell 《The European respiratory journal》2006,27(1):20-28
Mucosal trypsin, a protease-activated receptor (PAR) stimulant, may have an endogenous bronchoprotective role on airway smooth muscle. To test this possibility the effects of lumenal trypsin on airway tone in segments of pig bronchus were tested. Bronchial segments from pigs were mounted in an organ chamber containing Kreb's solution. Contractions were assessed from isovolumetric lumen pressure induced by acetylcholine (ACh) or carbachol added to the adventitia. Trypsin, added to the airway lumen (300 microg x mL(-1)), had no immediate effect on smooth muscle tone but suppressed ACh-induced contractions after 60 min, for at least 3 h. Synthetic activating peptides (AP) for PAR1, PAR2 or PAR3 were without effect, but PAR4 AP caused rapid, weak suppression of contractions. Lumenal thrombin was without effect and did not prevent the effects of trypsin. Effects of trypsin were reduced by N(omega)-nitro-L-arginine methyl ester but not indomethacin. Trypsin, thrombin and PAR4 AP released prostaglandin E2. Adventitially, trypsin, thrombin and PAR4 AP (but not PAR2 AP) relaxed carbachol-toned airways after <3 min. The findings of this study show that trypsin causes delayed and persistent bronchoprotection by interacting with airway cells accessible from the lumen. The signalling mechanism may involve nitric oxide synthase but not prostanoids or protease-activated receptors. 相似文献