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131.
Eduardo Suárez-Castaneda Lorenzo Pezzoli Miguel Elas Rafael Baltrons Elner Osmin Crespin-Elías Oscar A. Rivera Pleitez María Isabel Quintanilla de Campos M. Carolina Danovaro-Holliday 《Vaccine》2014
While assessing immunization programmes, not only vaccination coverage is important, but also timely receipt of vaccines. We estimated both vaccination coverage and timeliness, as well as reasons for non-vaccination, and identified predictors of delayed or missed vaccination, for vaccines of the first two years of age, in El Salvador. 相似文献
132.
Maria Isabel Fernández-San-Martín Luis Miguel Martín-López Roser Masa-Font Noemí Olona-Tabueña Yuani Roman Jaume Martin-Royo Silvia Oller-Canet Susana González-Tejón Luisa San-Emeterio Albert Barroso-Garcia Lidia Viñas-Cabrera Gemma Flores-Mateo 《Community mental health journal》2014,50(1):81-95
Patients with severe mental illness have higher prevalences of cardiovascular risk factors (CRF). The objective is to determine whether interventions to modify lifestyles in these patients reduce anthropometric and analytical parameters related to CRF in comparison to routine clinical practice. Systematic review of controlled clinical trials with lifestyle intervention in Medline, Cochrane Library, Embase, PsycINFO and CINALH. Change in body mass index, waist circumference, cholesterol, triglycerides and blood sugar. Meta-analyses were performed using random effects models to estimate the weighted mean difference. Heterogeneity was determined using i2 statistical and subgroups analyses. 26 studies were selected. Lifestyle interventions decrease anthropometric and analytical parameters at 3 months follow up. At 6 and 12 months, the differences between the intervention and control groups were maintained, although with less precision. More studies with larger samples and long-term follow-up are needed. 相似文献
133.
Viviana Marin-Torres Justo Valverde Aliaga Ignacio Sánchez Miró María Isabel Sáenz del Castillo Vicente Elena Polentinos-Castro Araceli Garrido Barral 《Atencion primaria / Sociedad Espa?ola de Medicina de Familia y Comunitaria》2013,45(1):46-53
ObjectiveTo describe the use of the Internet by primary care patients to seek health related information, understand how they are influenced by this information, and evaluate its impact on the doctor-patient relationship.DesignCross sectional study, through self-administered survey.SettingOne urban health center in Madrid.ParticipantsA total of 323 questionnaires were collected from patients between 14 and 75 years old who attended a physician's office for any reason, excluding illiterate patients and those with neurological or psychiatric problems preventing them from completing the survey.MeasurementsInternet usage, ability of the internet to clarify doubts regarding health issues, patient lifestyle changes, socio-demographic variables, and physician's receptivity to the use of internet by patients.Results61% (CI 95%: 56%-67%) of patients used the Internet as a source of health information: Internet queries were able to address health doubts in 92.4% of users, 53.5% reported that the Internet changed their thinking about their health in at least one instance, 30% made behavioral changes (of which 60.1% discussed these changes with their physician), 44.3% had more questions at the physician's office, and 80.8% believe that the doctor would be willing to talk about the information found on the internet.ConclusionsUsing the Internet to find information about health is very common, with positive influence on physician-patient relationship. This may be useful for achieving behavioral changes in patients and can be used as a tool in medical practice. 相似文献
134.
Nick Wlazlo Marleen M.J. van Greevenbroek Isabel Ferreira Eugene J.H.M. Jansen Edith J.M. Feskens Carla J.H. van der Kallen Casper G. Schalkwijk Bert Bravenboer Coen D.A. Stehouwer 《Metabolism: clinical and experimental》2012,61(12):1787-1796
ObjectiveTo investigate the role of low-grade inflammation and insulin resistance (HOMA2-IR) in adiposity-related increases in serum complement factor 3 (C3). Although C3 has been linked to type 2 diabetes and cardiovascular diseases, and C3 levels are closely related to body fat, the underlying mechanisms explaining this association are still unknown.MethodsAdiposity measures (including BMI, waist circumference (WC), sagittal diameter and several skinfolds), HOMA2-IR and markers of inflammation (hs-CRP, IL-6, SAA, haptoglobin, ceruloplasmin, sICAM-1) were determined in 532 individuals (62% men, mean age 59 ± 6.9 yrs) from the Cohort on Diabetes and Atherosclerosis Maastricht study. Markers of inflammation were standardized and compiled into an averaged inflammation score. Cross-sectional associations between adiposity measures and C3 and the mediating role of low-grade inflammation and/or HOMA2-IR herein were analysed with multiple linear regression models.ResultsAdiposity measurements were significantly associated with C3 levels, with the strongest (adjusted) associations found for WC (β = 0.383; 95%CI 0.302–0.464) and sagittal diameter (β = 0.412; 95%CI 0.333-0.490). Further adjustment for inflammation and HOMA2-IR attenuated these associations to β = 0.115 (95%CI 0.030-0.200) and β = 0.163 (95%CI 0.082-0.244) respectively. Multiple mediation analyses showed that inflammation [β = 0.090 (95%CI 0.060–0.126)] and HOMA2-IR [β = 0.179 (95%CI 0.128–0.236)] each explained, independently of one another, a significant portion of the association between WC and C3 (23% and 47%, respectively). Similar mediation by inflammation (19-27%) and HOMA2-IR (37-56%) was found for other adiposity measures.ConclusionSystemic low-grade inflammation and insulin resistance may represent two independent pathways by which body fat leads to elevated C3 levels. 相似文献
135.
Rodrigo Jiménez-Garcia Maria Angeles Martinez-Huedo Valentin Hernandez-Barrera Ana Lopez De Andres Isabel Jimenez-Trujillo Pilar Carrasco-Garrido 《Primary Care Diabetes》2012,6(4):269-276
ObjectivesTo describe and compare sexuality between subjects with diabetes with matched non-diabetic controls.MethodsPopulation based case control study using individual data from the Spanish National Sexual Health Survey. Diabetes status was self reported, we selected type 2 patients. We identified 461 diabetes sufferers. Two controls were matched by age, sex and sexual partner for each diabetic case.Sexuality measures included: sexual activity, importance of sex, satisfaction with partner, bothersome with one's sexual life and self-rated sexual health. Independent variables included: socio-demographics, physical health, chronic diseases and medications use.ResultsNo differences were found in “Sexually activity”, “Importance of sex” or “Bothersome” between those with and without diabetes. Dissatisfaction with partner was 25% in women with diabetes and 12.9% in non-diabetic controls (Adjusted-OR 1.82 95%CI 1.02–4.85).Diabetes sufferers reported sexual health as “fair/poor/very poor” more than their non-diabetic control, 58.1% vs. 45.1% for women (Adjusted-OR 1.74 95%CI 1.15–2.63) and 54.3% vs. 38% for men (Adjusted-OR 1.88 95%CI 1.29–2.75).Among diabetes sufferers “fair/poor/very poor” sexual health was associated with poorer physical health, not having a sexual partner and among men taking heart medications.ConclusionsWomen and men with diabetes have significantly worse sexuality measures than non diabetic controls. 相似文献
136.
Fernando De Ory María Eulalia Guisasola Juan Carlos Sanz Isabel García-Bermejo 《Enfermedades infecciosas y microbiología clínica》2012
Enzyme linked fluorescent assays (VIDAS EBV VCA IgM, VIDAS EBV VCA/EA IgG and VIDAS EBV EBNA IgG (Biomérieux, France) were evaluated to determine markers for infection of Epstein Barr virus, as well as to establish antibody profiles, compared with immunofluorescence assays as reference. The assays evaluated showed good values for sensitivity, specificity and agreement, making them useful for their application in clinical laboratories. 相似文献
137.
Marta Martínez-Gil José Miguel Quesada María Isabel Ramos-González María Isabel Soriano Ricardo E. de Cristóbal Manuel Espinosa-Urgel 《Research in microbiology》2013,164(5):382-389
The extracellular matrix of bacterial biofilms has at least two key functions: to serve as a structural scaffold for the multicellular community, and to play a protective role against external stress. In this work, we report a compensatory effect whereby Pseudomonas putida reacts to the lack of either of the two main surface proteins involved in biofilm formation, LapA and LapF, by increasing expression and production of a species-specific EPS. Elevated levels of the second messenger molecule cyclic di-GMP alter the balance of extracellular matrix components, and the phenotypes of lapA and lapF mutants under these conditions are indicative of direct interactions taking place between large secreted proteins and exopolysaccharides. Our data suggest the existence of a mechanism by which bacteria would sense alterations in the composition of the extracellular matrix, leading to changes in expression of the different elements. 相似文献
138.
Histopathological evaluation of duodenal biopsy in the PreventCD project. An observational interobserver agreement study
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Vincenzo Villanacci Luisa Lorenzi Francesco Donato Renata Auricchio Piotr Dziechciarz Judit Gyimesi Sibylle Koletzko Zrinjka Mišak Vanesa Morente Laguna Isabel Polanco David Ramos Raanan Shamir Riccardo Troncone Sabine L. Vriezinga M. Luisa Mearin 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2018,126(3):208-214
Aim of the current study was to evaluate the inter‐observer agreement between pathologists in the diagnosis of celiac disease (CD), in the qualified context of a multicenter study. Biopsies from the “PreventCD” study, a multinational‐ prospective‐ randomized study in children with at least one‐first‐degree relative with CD and positive for HLA‐DQ2/HLA‐DQ8. Ninety‐eight biopsies were evaluated. Considering diagnostic samples with villous atrophy (VA), the agreement was satisfactory (κ = 0.84), but much less when assessing the severity of these lesions. The use of the recently proposed Corazza‐Villanacci classification showed a moderately higher level of agreement (κ = 0.39) than using the Marsh‐Oberhuber system (κ = 0.31). 57.1% of cases were considered correctly oriented. A number of >4 samples per patient was statistically associated to a better agreement; orientation did not impact on κ values. Agreement results in this study appear more satisfactory than in previous papers and this is justified by the involvement of centers with experience in CD diagnosis and by the well‐controlled setting. Despite this, the reproducibility was far from optimal with a poor agreement in grading the severity of VA. Our results stress the need of a minimum of four samples to be assessed by the pathologist. 相似文献
139.
Microevolution due to pollution can occur mainly through genetic drift bottlenecks, especially of small sized populations facing intense lethal pulses of contaminants, through mutations, increasing allelic diversity, and through natural selection, with the disappearance of the most sensitive genotypes. This loss of genotypes can lead to serious effects if coupled to specific hypothetical scenarios. These may be categorized as leading, first, to the loss of alleles—the recessive tolerance inheritance hypothesis. Second, leading to a reduction of the population growth rate—the mutational load and fitness costs hypotheses. Third, leading to an increased susceptibility of further genetic erosion both at future inputs of the same contaminant—differential physiological recovery, endpoints (dis)association, and differential phenotypic plasticity hypotheses—and at sequential or simultaneous inputs of other contaminants—the multiple stressors differential tolerance hypothesis. Species in narrowly fluctuating environments (tropics and deep sea) may have a particularly high susceptibility to genetic erosion—the Plus ça change (plus c’est la meme chose) hypothesis. A discussion on the consequences of these hypotheses is what this essay aimed at. 相似文献
140.
Midline anterior neck inclusion cyst: A novel superficial congenital developmental anomaly of the neck
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Rabina Walsh MD Jeffrey North MD Kelly M. Cordoro MD Ana Isabel Rodríguez Bandera MD Leonard Kristal MD Ilona J. Frieden MD 《Pediatric dermatology》2018,35(1):55-58