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41.
Ioannou E Quesada A Rahman MM Gibbons S Vagias C Roussis V 《Journal of natural products》2011,74(2):213-222
Seventeen diterpenes featuring the dolabellane skeleton (1-17) were isolated from the organic extracts of the brown alga Dilophus spiralis. Seven compounds are new natural products (1, 3, 5, 6, 11, 14, 15) and eight are structurally revised (2, 4, 7-10, 12, 13), among which three are reported for the first time from a natural source (4, 9, 10). The structure elucidation and the assignment of the relative configurations of the isolated natural products were based on detailed analyses of their spectroscopic data. The structure of metabolite 10 was confirmed by single-crystal X-ray diffraction analysis, whereas the absolute configurations of compounds 2, 4-10, 12, and 13 were determined using the modified Mosher's method on the semisynthetic product 18 and chemical interconversions. The antibacterial activities of compounds 1-18 were evaluated against six strains of Staphylococcus aureus, including multidrug- and methicillin-resistant variants. 相似文献
42.
Marco E. Favretto Showan Marouf Panagiotis Ioannou Sophia G. Antimisiaris Terence L. Parker Paraskevi Kallinteri 《Pharmaceutical research》2009,26(10):2237-2246
Purpose
To investigate the arsonoliposome effect on medulloblastoma cells (VC312Rs) related to uptake, endocytotic mechanism and cell viability. 相似文献43.
Noncardiogenic pulmonary edema is a recognized but uncommon manifestation of type 2 decompression sickness. It typically occurs within 6 hours of a dive. Because the adult respiratory distress syndrome in this setting is believed to be due to microbubbles in the pulmonary vasculature, recompression in a hyperbaric chamber has been recommended as a form of therapy. A patient developed noncardiogenic pulmonary edema following a seawater dive to 75 feet. There was complete radiologic and clinical resolution within 5 hours of hyperbaric therapy. 相似文献
44.
Candidemia at selected Canadian sites: results from the Fungal Disease Registry, 1992-1994 总被引:3,自引:0,他引:3 下载免费PDF全文
D L Yamamura C Rotstein L E Nicolle S Ioannou 《Canadian Medical Association journal》1999,160(4):493-499
BACKGROUND: Candida species are important bloodstream pathogens that are being isolated with increasing frequency. Despite the availability of effective antifungal therapy, the mortality rate associated with Candida infection remains high. With the objective of describing the epidemiology of candidemia, the Canadian Infectious Disease Society conducted a study of candidemia in Canada. METHODS: Fourteen medical centres across Canada identified all patients with candidemia from March 1992 to February 1994 through blood culture surveillance for Candida spp. Patient-related data for invasive fungal infection were compiled retrospectively by chart review using a standardized data-recording form developed for the Fungal Disease Registry of the Canadian Infectious Disease Society. Cases of Candidemia were studied in relation to underlying medical conditions, predisposing factors, concurrent infection, antimicrobial agents, antifungal treatment and deaths. RESULTS: In total, 415 cases of candidemia were identified, 48 (11.6%) in children and 367 (88.4%) in adults. The causative pathogens were C. albicans in 286 cases (68.9%), C. parapsilosis in 43 (10.4%), C. glabrata in 34 (8.2%), C. tropicalis in 27 (6.5%) and other Candida species in 18 (4.3%); polymicrobial candidemia occurred in 7 cases (1.7%). The overall mortality rate was 46%, and the rate of deaths clinically related to candidemia was 19%. However, only 13 (27%) of the children died. A univariate analysis indicated that significant risk factors for death were age greater than 60 years, therapy for concomitant bacterial infection, stay in an intensive care unit, concurrent malignant disease, cytotoxic chemotherapy and granulocytopenia, although only age and stay in an intensive care unit emerged as significant risk factors in the multivariate analysis. After adjustment for other predictors of death, only infection with C. parapsilosis was associated with a lower mortality rate than infection with C. albicans. Treatment was given in 352 (84.8%) of cases. Amphotericin B was the preferred agent in 244 cases (69.3% of those treated); fluconazole was used in 101 cases (28.7%) and ketoconazole in 5 cases (1.4%). INTERPRETATION: Candidemia in Canada is caused predominantly by C. albicans. The mortality rate associated with candidemia is high, but it varies with the species of Candida and is lower in children than in adults. Age greater than 60 years and stay in an intensive care unit were the most significant risk factors for overall mortality. 相似文献
45.
Vergoulas Georgios; Eleftheriadis Theodoros; Avdelidou Aphroditi; Ioannou Konstantinos; Miserlis Gregorios; Solonaki Fillio; Papagiannis Andreas; Takoudas Dimitrios 《Nephrology, dialysis, transplantation》2005,20(2):473
Sir, Currently administered immunosuppression schemes usually includecyclosporin. Cyclosporin has brought about a revolution in patientprognosis and in renal graft survival, but, unfortunately, ithas many side effects [1,2]. While physicians are attentiveto the more serious and life threatening of these side effects, 相似文献
46.
Petros Ioannou Aggeliki Andrianaki Tonia Akoumianaki Irene Kyrmizi Nathaniel Albert David Perlin George Samonis Dimitrios P. Kontoyiannis Georgios Chamilos 《Antimicrobial agents and chemotherapy》2016,60(3):1226-1233
The modest in vitro activity of echinocandins against Aspergillus implies that host-related factors augment the action of these antifungal agents in vivo. We found that, in contrast to the other antifungal agents (voriconazole, amphotericin B) tested, caspofungin exhibited a profound increase in activity against various Aspergillus species under conditions of cell culture growth, as evidenced by a ≥4-fold decrease in minimum effective concentrations (MECs) (P = 0. 0005). Importantly, the enhanced activity of caspofungin against Aspergillus spp. under cell culture conditions was strictly dependent on serum albumin and was not observed with the other two echinocandins, micafungin and anidulafungin. Of interest, fluorescently labeled albumin bound preferentially on the surface of germinating Aspergillus hyphae, and this interaction was further enhanced upon treatment with caspofungin. In addition, supplementation of cell culture medium with albumin resulted in a significant, 5-fold increase in association of fluorescently labeled caspofungin with Aspergillus hyphae (P < 0.0001). Collectively, we found a novel synergistic interaction between albumin and caspofungin, with albumin acting as a potential carrier molecule to facilitate antifungal drug delivery to Aspergillus hyphae. 相似文献
47.
48.
Zarogiannis S Hatzoglou C Stefanidis I Ioannou M Paraskeva E Gourgoulianis K Molyvdas PA 《Clinical and experimental pharmacology & physiology》2007,34(1-2):129-131
1. Pleural permeability may contribute to pleural fluid turnover. The transmesothelial resistance (R(TM)), is an established surrogate of mesothelial permeability. The aim of the present study was to compare the electrophysiological properties of costal and diaphragmatic parietal pleura. 2. Specimens of the parietal pleura were isolated from 12 adult sheep from the chest wall and the diaphragm. Electrophysiological measurements were conducted with the Ussing system. Specimens of the parietal pleura of both types (diaphragmatic and costal) were compared histologically and total protein content measurements were also made. 3. The R(TM) of the diaphragmatic parietal pleura was significantly higher than that of the costal parietal pleura throughout the experiment. The diaphragmatic parietal pleura contains more cuboidal cells than the costal parietal pleura and its protein content was higher, however this difference was not statistically significant. 4. The costal parietal pleura consists of a more 'leaky' mesothelium than the diaphragmatic pleura. The morphological differences between the two types of parietal pleura may underline the electrophysiological findings. 相似文献
49.
C. Fiorella Murillo Perez Stephanie Ioannou Iman Hassanally Palak J. Trivedi Christophe Corpechot Adriaan J. van der Meer Willem J. Lammers Pier Maria Battezzati Keith D. Lindor Frederik Nevens Kris V. Kowdley Tony Bruns Nora Cazzagon Annarosa Floreani Andrew L. Mason Aliya Gulamhusein Cyriel Y. Ponsioen Marco Carbone Ana Lleo Marlyn J. Mayo George N. Dalekos Nikolaos K. Gatselis Douglas Thorburn Xavier Verhelst Albert Parés Maria-Carlota Londoño Harry L. A. Janssen Pietro Invernizzi Raj Vuppalanchi Gideon M. Hirschfield Bettina E. Hansen Cynthia Levy the Global PBC Study Group 《Liver international》2023,43(7):1497-1506