Perceptual and acoustic analysis of lexical stress in Greek speakers with dysarthria

The study reported in this paper investigated the abilities of Greek speakers with dysarthria to signal lexical stress at the single word level. Three speakers with dysarthria and two unimpaired control participants were recorded completing a repetition task of a list of words consisting of minimal pairs of Greek disyllabic words contrasted by lexical stress location only. Fourteen listeners were asked to determine the attempted stress location for each word pair. Acoustic analyses of duration and intensity ratios, both within and across words, were undertaken to identify possible acoustic correlates of the listeners’ judgments concerning stress location. Acoustic and perceptual data indicate that while each participant with dysarthria in this study had some difficulty in signaling stress unambiguously, the pattern of difficulty was different for each speaker. Further, it was found that the relationship between the listeners’ judgments of stress location and the acoustic data was not conclusive.     

Concomitant versus sequential therapy for the treatment of Helicobacter pylori infection: a Greek randomized prospective study

Objective: The objective of this study is to compare, in Greece, a region with >20% local resistance to clarithromycin, the efficacy rates of the concomitant versus the sequential H. pylori eradication therapy. Materials and methods: Our prospective randomized study included 364 patients with newly diagnosed H. pylori infection, randomized to receive a 10-day concomitant or 10-day sequential therapy. Treatment outcome was assessed by C¹³-urea breath test at least 4 weeks after therapy. Intention to treat (ITT) and per protocol (PP) analysis of the eradication rates were performed. Secondary end points included patient compliance and safety. Results: The concomitant therapy group achieved statistically significant higher eradication rates when compared with the sequential treatment group, both in the ITT and in the PP analysis (84.6% versus 70.9%, p?=?0.002, and 90.6% versus 78.1%, p?=?0.001, respectively), after adjusting for age, gender, smoking status, and the presence or not of ulcer and/or non-ulcer dyspepsia. Both groups displayed excellent compliance rates (99.5% for the concomitant therapy group and 96.2% for the sequential therapy group, p?=?0.067). Regarding treatment safety, major adverse events that led to the discontinuation of both regimens were few, with no statistical difference between the two groups (7.0% for the concomitant therapy group and 2.9% for the sequential therapy group). Conclusions: Concomitant therapy led to statistically significant higher eradication rates over sequential therapy. Both therapies showed excellent compliance and an acceptable safety profile. The 10-day quadruple concomitant scheme should be the adopted for first-line H. pylori eradication in Greece.     

Which are the most important discriminatory items for subclassifying non‐specific low back pain? A Delphi study among Greek health professionals

Rationale, aims and objectives Developing homogenous low back pain (LBP) classification groups is recommended for enhancing clinical outcomes. However, an important step towards the development of specific subgroups is the selection and consensus agreement among health professionals on the discriminatory clinical items (sings and symptoms) that should be included in the classification process. Thus, this study's objective was to develop a list of clinical features for the assessment of LBP by health care providers within Greece, which are believed to be discriminatory in identifying LBP subgroups. Methods A random sample stratified by geographical region and work status of 150 Greek physiotherapists (PTs) participated in a two‐round Delphi study. PTs were asked to obtain consensus and hierarchy, the most important items out of a list of evaluating/diagnostic features believed to be discriminatory for LBP patients. These items included 80 clinical features and were generated in by PTs and doctors previous work. Results Second‐round questionnaires were returned by 112 PTs (74.6% response rate). A total of 66 clinical features were rated as important discriminatory items in LBP assessment. Clinical items included characteristics of present symptoms and the history's condition, general medical history, information regarding patient function, patients' attitudes regarding movement, diagnosis, expectations, fear‐avoidance beliefs as well as aspects of a physical examination including observation, active and passive movements, neurological and muscular examination. Conclusions This is the first study identifying important clinical items for LBP patients in Greece. It may be that these features are ‘discriminatory’ for different LBP subsets; however, further research is needed.