全文获取类型
收费全文 | 703篇 |
免费 | 27篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 10篇 |
妇产科学 | 11篇 |
基础医学 | 137篇 |
口腔科学 | 16篇 |
临床医学 | 61篇 |
内科学 | 118篇 |
皮肤病学 | 6篇 |
神经病学 | 119篇 |
特种医学 | 43篇 |
外科学 | 96篇 |
综合类 | 6篇 |
预防医学 | 31篇 |
眼科学 | 4篇 |
药学 | 56篇 |
中国医学 | 4篇 |
肿瘤学 | 8篇 |
出版年
2023年 | 5篇 |
2022年 | 14篇 |
2021年 | 13篇 |
2020年 | 8篇 |
2019年 | 12篇 |
2018年 | 12篇 |
2017年 | 17篇 |
2016年 | 10篇 |
2015年 | 21篇 |
2014年 | 32篇 |
2013年 | 29篇 |
2012年 | 62篇 |
2011年 | 75篇 |
2010年 | 51篇 |
2009年 | 35篇 |
2008年 | 54篇 |
2007年 | 50篇 |
2006年 | 50篇 |
2005年 | 48篇 |
2004年 | 30篇 |
2003年 | 33篇 |
2002年 | 23篇 |
2001年 | 5篇 |
2000年 | 5篇 |
1999年 | 6篇 |
1998年 | 6篇 |
1997年 | 8篇 |
1996年 | 1篇 |
1995年 | 2篇 |
1993年 | 2篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1984年 | 1篇 |
1982年 | 1篇 |
1980年 | 3篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1975年 | 2篇 |
1938年 | 1篇 |
排序方式: 共有733条查询结果,搜索用时 15 毫秒
51.
52.
We report the case of a previously healthy 47-year-old woman suffering an acute embolic stroke in the left middle cerebral artery distribution. A filiform structure along the line of the aortic valve was first identified by transesophageal echocardiography, leading to the diagnosis of a valvular strand. These masses are thought to represent giant Lambl's excrescences, although differential diagnoses include several benign cardiac tumors, e.g. papillary fibroelastoma. Valvular strands have previously been associated with embolic events including stroke, although exact pathogenetic mechanisms and further patient management have not yet been fully established. This case report additionally provides a short overview of the currently existing literature. As a conclusion, standard recommendations for patient management and treatment cannot be derived from currently available evidence. 相似文献
53.
Studies on working memory (WM) dysfunction in schizophrenia have reported several functionally aberrant brain areas including prefrontal and temporal cortex. Longitudinal studies have shown changes in prefrontal activation during treatment. We used event-related functional magnetic resonance imaging and a parametric verbal WM task to investigate cerebral function during WM performance in healthy subjects and medicated patients with schizophrenia with an acute symptom exacerbation. Patients were scanned twice: within the first week after admission to the hospital and after 7-8 weeks of a multimodal treatment including atypical antipsychotic agents. There were no differences in activation of lateral prefrontal regions in patients relative to healthy controls neither at baseline nor after 7-8 weeks. Controls showed relatively more activation in parietal, striatal and cerebellar regions. In patients with schizophrenia, frontotemporal function was bilaterally enhanced after 7-8 weeks. This activation change was associated with improved accuracy in a verbal WM task, improved verbal WM-span and symptom reduction as measured by the BPRS global score and the BPRS factor for thought disturbance. Although we could not replicate findings of functional hypofrontality in the patients with schizophrenia, frontotemporal activation changed with treatment and was associated with verbal WM performance and significant reduction of psychopathology. 相似文献
54.
55.
56.
Irina Alafuzoff Dietmar R. Thal Thomas Arzberger Nenad Bogdanovic Safa Al-Sarraj Istvan Bodi Susan Boluda Orso Bugiani Charles Duyckaerts Ellen Gelpi Stephen Gentleman Giorgio Giaccone Manuel Graeber Tibor Hortobagyi Romana Höftberger Paul Ince James W. Ironside Nikolaos Kavantzas Andrew King Penelope Korkolopoulou Gábor G. Kovács David Meyronet Camelia Monoranu Tatjana Nilsson Piero Parchi Efstratios Patsouris Maria Pikkarainen Tamas Revesz Annemieke Rozemuller Danielle Seilhean Walter Schulz-Schaeffer Nathalie Streichenberger Stephen B. Wharton Hans Kretzschmar 《Acta neuropathologica》2009,117(3):309-320
β-Amyloid (Aβ) related pathology shows a range of lesions which differ both qualitatively and quantitatively. Pathologists,
to date, mainly focused on the assessment of both of these aspects but attempts to correlate the findings with clinical phenotypes
are not convincing. It has been recently proposed in the same way as ι and α synuclein related lesions, also Aβ related pathology
may follow a temporal evolution, i.e. distinct phases, characterized by a step-wise involvement of different brain-regions.
Twenty-six independent observers reached an 81% absolute agreement while assessing the phase of Aβ, i.e. phase 1 = deposition
of Aβ exclusively in neocortex, phase 2 = additionally in allocortex, phase 3 = additionally in diencephalon, phase 4 = additionally
in brainstem, and phase 5 = additionally in cerebellum. These high agreement rates were reached when at least six brain regions
were evaluated. Likewise, a high agreement (93%) was reached while assessing the absence/presence of cerebral amyloid angiopathy
(CAA) and the type of CAA (74%) while examining the six brain regions. Of note, most of observers failed to detect capillary
CAA when it was only mild and focal and thus instead of type 1, type 2 CAA was diagnosed. In conclusion, a reliable assessment
of Aβ phase and presence/absence of CAA was achieved by a total of 26 observers who examined a standardized set of blocks
taken from only six anatomical regions, applying commercially available reagents and by assessing them as instructed. Thus,
one may consider rating of Aβ-phases as a diagnostic tool while analyzing subjects with suspected Alzheimer’s disease (AD).
Because most of these blocks are currently routinely sampled by the majority of laboratories, assessment of the Aβ phase in
AD is feasible even in large scale retrospective studies. 相似文献
57.
Staging/typing of Lewy body related α-synuclein pathology: a study of the BrainNet Europe Consortium
Irina Alafuzoff Paul G. Ince Thomas Arzberger Safa Al-Sarraj Jeanne Bell Istvan Bodi Nenad Bogdanovic Orso Bugiani Isidro Ferrer Ellen Gelpi Stephen Gentleman Giorgio Giaccone James W. Ironside Nikolaos Kavantzas Andrew King Penelope Korkolopoulou Gábor G. Kovács David Meyronet Camelia Monoranu Piero Parchi Laura Parkkinen Efstratios Patsouris Wolfgang Roggendorf Annemieke Rozemuller Christine Stadelmann-Nessler Nathalie Streichenberger Dietmar R. Thal Hans Kretzschmar 《Acta neuropathologica》2009,117(6):635-652
58.
Kesselring J Coenen M Cieza A Thompson A Kostanjsek N Stucki G 《Multiple sclerosis (Houndmills, Basingstoke, England)》2008,14(2):252-254
Functioning is increasingly being taken into account for evaluating the impact of multiple sclerosis (MS) on the individual and the effectiveness of treatment and rehabilitation. With the International Classification of Functioning, Disability and Health (ICF), we can now rely on a globally-agreed-upon framework and system for classifying the typical spectrum of problems in functioning of persons given the environmental context in which they live. ICF Core Sets are lists of ICF categories selected to capture those aspects of functioning that are most likely to be affected by specific diseases. The objective of this document is to outline the development process for the ICF Core Sets for MS. The ICF Core Sets for MS will be defined at an ICF Core Set Consensus Conference, which will integrate evidence from preparatory studies, namely: a) a systematic review on parameters reported in MS studies; b) a qualitative study using focus groups and individual interviews with individuals with MS; c) an expert survey with international health professionals participating and d) an empirical cross-sectional study. The ICF Core Sets for MS are being designed with the goal of providing useful standards for research and clinical practice. 相似文献
59.
Myocardial dysfunction is the leading cause of death in single-ventricle patients. Heart transplantation has traditionally been reserved for Fontan patients with end-stage myocardial dysfunction. Cardiac resynchronization therapy with multisite pacing was found to improve the myocardial performance in Fontan patients in acute postoperative settings; however, its role is unclear in chronic Fontan patients with progressive myocardial dysfunction. We present a case in which cardiac resynchronization therapy improved both hemodynamics and clinical condition in a Fontan patient with advanced myocardial dysfunction. 相似文献
60.
Gnjidić Z Sajko T Malenica M Kudelić N Talan-Hranilović J Rumboldt Z 《Neurologia medico-chirurgica》2008,48(10):433-8; discussion 438-9
Pituitary adenomas frequently invade the cavernous sinus. The standard transsphenoidal approach does not provide satisfactory visualization of the cavernous sinus structures. The transcranial approach has no advantages, and increases the operative trauma and complications. The oblique transsphenoethmoidal approach, a modified standard transsphenoidal approach, was used to treat 19 patients with pituitary adenomas invading the cavernous sinus. Complete tumor removal was achieved in 15 patients and subtotal removal in 4 patients. The patients tolerated this modified transsphenoethmoidal approach well and the postoperative results were satisfactory. Although the number of patients was too small to allow any statistical analysis, the results, compared with other series, are encouraging. 相似文献