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21.
Aleksandar P. Simić Ognjan M. Skrobić Richard R. Gurski Vladimir M. Šljukić Nenad R. Ivanović Predrag M. Peško 《Journal of gastrointestinal surgery》2014,18(10):1723-1729
Background
Ineffective esophageal motility (IEM) in patients with gastroesophageal reflux disease includes three different subsets that may affect symptom profiles. Our aim was to assess symptoms and functional outcome in patients with erosive esophagitis according to different subsets of IEM, before and after Nissen fundoplication (NF).Methodology
A retrospective study with prospective follow-up of 72 patients with reflux esophagitis and IEM in whom open NF was performed. Based on principal manometric esophageal body motility disorder, patients were divided in three groups: predominantly low-amplitude (LAC, N?=?38), non-propulsive (NPC, N?=?18), and simultaneous low-amplitude esophageal contractions (SC, N?=?16). Patients underwent symptomatic questionnaire and stationary esophageal manometry before and 6 months, 1 year, and 3 years after surgery.Results
Preoperatively, patients in NPC and SC groups had higher mean scores of dysphagia, without statistical significance as opposed to the LAC group (p?=?0.239). Postoperative dysphagia occurred in 36 patients, without statistical significance between groups regarding dysphagia grades (p?=?0.390). A longer duration of postoperative dysphagia was noted in the SC group (p?0.05). Improvement of nadir values of contraction amplitudes in distal esophagus occurred postoperatively in all groups, significantly higher in LAC (p?0.001).Conclusion
Three years after NF, successful symptomatic and functional outcome was achieved in analyzed groups of patients with erosive esophagitis regardless of IEM subtype. 相似文献22.
In this paper, the influence of the variation in transformer oil temperature on the accuracy of the all-acoustic non-iterative method for partial discharge location in a power transformer is researched. The research can improve power transformers’ testing and monitoring, particularly given the large transformer oil temperature variations during real-time monitoring. The research is based on quantifying the contribution of oil temperature to the standard combined measurement uncertainty of the non-iterative algorithm by using analytical, statistical, and Monte Carlo methods. The contribution can be quantified and controlled. The contribution varied significantly with different mutual placements of partial discharge and acoustic sensors. The correlation between the contribution and the mean distance between partial discharge and acoustic sensors was observed. Based on these findings, the procedure to quantify and control the contribution in practice was proposed. The procedure considers the specificity of the method’s mathematical model (the assumption that the oil temperature is constant), the non-iterative algorithm’s nonlinearity, and the large variations in transformer oil temperature. Existing studies did not consider the significant effect of the oil temperature on the combined measurement uncertainty of partial discharge location influenced by those phenomena. The research is limited to partial discharge located in the transformer oil. 相似文献
23.
Stojan Peric Vuk Milosevic Ivana Berisavac Olivera Stojiljkovic Ljiljana Beslac‐Bumbasirevic Ivan Marjanovic Vanja Djuric Gordana Djordjevic Sonja Rajic Milan Cvijanovic Milica Babic Aleksandra Dominovic Balsa Vujovic Mirjana Cukic Milutin Petrovic Gordana Toncev Nenad Komatina Vesna Martic Dragana Lavrnic 《Journal of the peripheral nervous system : JPNS》2014,19(4):317-321
The aim of this study was to define features of Guillain‐Barré syndrome in a large cohort of patients from three Western Balkans countries. Data from adult Guillain‐Barré syndrome (GBS) cases from 2009 to 2013 were retrospectively obtained from all tertiary health care centers. During the 5‐year period, 327 new cases of GBS were identified with a male to female ratio of 1.7 : 1. The most common GBS variants were demyelinating (65%) and axonal (12%). At nadir 45% of patients were chair‐bound, confined to bed, or required assisted ventilation, while 5% died. The crude incidence of GBS in Serbia and Montenegro was 0.93 per 100,000 population, and age‐adjusted incidence according to the world standard population was 0.86 per 100,000. Incidence was particularly high in 50‐ to 80‐year‐old men. Statistically significant seasonal variations of GBS were not observed. This study of patients with GBS in the Western Balkans allows us to prepare the health system better and to improve the management of patients. This study also opens opportunities for international collaboration and for taking part in the multinational studies on GBS. 相似文献
24.
Carole A. Tucker Alarcos Cieza Anne W. Riley Gerold Stucki Jin Shei Lai T. Bedirhan Ustun Nenad Kostanjsek William Riley David Cella Christopher B. Forrest 《Quality of life research》2014,23(6):1677-1686
Purpose
The Patient Reported Outcomes Measurement Information System (PROMIS ® ) is a US National Institutes of Health initiative that has produced self-report outcome measures, using a framework of physical, mental, and social health defined by the World Health Organization in 1948 (WHO, in Preamble to the Constitution of the World Health Organization as adopted by the International Health Conference, New York, 1948). The World Health Organization’s International Classification of Functioning, Disability and Health (ICF) is a comprehensive classification system of health and health-related domains that was put forward in 2001. The purpose of this report is to compare and contrast PROMIS and ICF conceptual frameworks to support mapping of PROMIS instruments to the ICF classification system .Methods
We assessed the objectives and the classification schema of the PROMIS and ICF frameworks, followed by content analysis to determine whether PROMIS domain and sub-domain level health concepts can be linked to the ICF classification.Results
Both PROMIS and ICF are relevant to all individuals, irrespective of the presence of health conditions, person characteristics, or environmental factors in which persons live. PROMIS measures are intended to assess a person’s experiences of his or her health, functional status, and well-being in multiple domains across physical, mental, and social dimensions. The ICF comprehensively describes human functioning from a biological, individual, and social perspective. The ICF supports classification of health and health-related states such as functioning, but is not a specific measure or assessment of health, per se. PROMIS domains and sub-domain concepts can be meaningfully mapped to ICF concepts.Conclusions
Theoretical and conceptual similarities support the use of PROMIS instruments to operationalize self-reported measurement for many body function, activity and participation ICF concepts, as well as several environmental factor concepts. Differences observed in PROMIS and ICF conceptual frameworks provide a stimulus for future research and development. 相似文献25.
Nenad Filipović Sonja Grubišić Maja Jovanović Marija Dulović Ivanka Marković Olivera Klisurić Aleksandar Marinković Dragana Mitić Katarina Anđelković Tamara Todorović 《Chemical biology & drug design》2014,84(3):333-341
Novel Pd(II) complex with N‐heteroaromatic Schiff base ligand, derived from 8‐quinolinecarboxaldehyde (q8a) and ethyl hydrazinoacetate (haOEt), was synthesized and characterized by analytical and spectroscopy methods. The structure of novel complex, as well as structures of its quinoline and pyridine analogues, was optimized by density functional theory calculations, and theoretical data show good agreement with experimental results. A cytotoxic action of the complexes was evaluated on cultures of human promyelocytic leukemia (HL‐60), human glioma (U251), rat glioma (C6), and mouse fibrosarcoma (L929) cell lines. Among investigated compounds, only complexes with quinoline‐based ligands reduce the cell numbers in a dose‐dependent manner in investigated cell lines. The observed cytotoxic effect of two isomeric quinoline‐based complexes is predominantly mediated through the induction of apoptotic cell death in HL‐60 cell line. The cytotoxicity of most efficient novel Pd(II) complex is comparable to the activity of cisplatin, in all cell lines investigated. 相似文献
26.
Zrinka Stritof Majetic Renee Galloway Eva Ruzic Sabljic Zoran Milas Vesna Mojcec Perko Josipa Habus Josip Margaletic Renata Pernar Nenad Turk 《Acta tropica》2014
In this survey we investigated a population of small mammals in Eastern Croatia in order to determine Leptospira carriage rates and identify circulating serovars. Out of 67 trapped animals, 20 (29.9%) isolates were obtained. Identification of isolates using microscopic agglutination test, pulsed field gel electrophoresis and multi locus sequence typing revealed that 10 (50.0%) isolates belong to serogroup Pomona, serovar Mozdok, 6 (30.0%) isolates to serogroup Australis, serovar Jalna, 2 (10.0%) isolates to serogroup Sejroe, serovar Saxkoebing, and 1 (5.0%) isolate to serogroup Grippotyphosa, serovar Grippotyphosa. One isolate from serogroup Bataviae was unable to be identified to the serovar level. Amplification of a 331-bp region of the locus LA0322 using real-time polymerase chain reaction determined that 12 (60.0%) isolates belong to L. kirschneri, 6 (30.0%) isolates to L. interrogans, and 2 (10.0%) isolates to L. borgpetersenii. Leptospira carriage rate was high (29.9%), which corresponds to a high incidence of human and domestic animal leptospirosis in Eastern Croatia. Furthermore, 90.0% of the isolates belong to serogroups Pomona, Australis and Sejroe which are also the most prevalent serogroups in humans in this area. These findings suggest that small mammals might be an important source of Leptospira spp. infection in Eastern Croatia. 相似文献
27.
Matina Kouvari Nathan M. DCunha Nikolaj Travica Domenico Sergi Manja Zec Wolfgang Marx Nenad Naumovski 《Nutrients》2022,14(2)
Background: This narrative review presents the association between metabolic syndrome (MetS), along with its components, and cognition-related disorders, as well as the potential reversal role of diet against cognitive impairment by modulating MetS. Methods: An electronic research in Medline (Pubmed) and Scopus was conducted. Results: MetS and cognitive decline share common cardiometabolic pathways as MetS components can trigger cognitive impairment. On the other side, the risk factors for both MetS and cognitive impairment can be reduced by optimizing the nutritional intake. Clinical manifestations such as dyslipidemia, hypertension, diabetes and increased central body adiposity are nutrition-related risk factors present during the prodromal period before cognitive impairment. The Mediterranean dietary pattern stands among the most discussed predominantly plant-based diets in relation to cardiometabolic disorders that may prevent dementia, Alzheimer’s disease and other cognition-related disorders. In addition, accumulating evidence suggests that the consumption of specific dietary food groups as a part of the overall diet can improve cognitive outcomes, maybe due to their involvement in cardiometabolic paths. Conclusions: Early MetS detection may be helpful to prevent or delay cognitive decline. Moreover, this review highlights the importance of healthy nutritional habits to reverse such conditions and the urgency of early lifestyle interventions. 相似文献
28.
Tasic V Korneti P Gucev Z Hoppe B Blau N Cheong HI 《Pediatric nephrology (Berlin, Germany)》2008,23(7):1177-1181
Primary distal renal tubular acidosis (dRTA) is an inherited disease characterized by the inability of the distal tubule to lower urine pH <5.50 during systemic acidosis. We report two male siblings who presented with severe hyperchloremic metabolic acidosis, high urinary pH, nephrocalcinosis, growth retardation, sensorineural hearing loss, and hypokalemic paralysis. Laboratory investigations revealed proximal tubular dysfunction (low molecular weight proteinuria, generalized hyperaminoaciduria, hypophosphatemia with hyperphosphaturia, and hypouricemia with hyperuricosuria). There was significant hyperoxaluria and laboratory evidence for mild rhabdomyolysis. Under potassium and alkali therapy, proximal tubular abnormalities, muscular enzymes, and oxaluria normalized. A homozygous mutation in the ATP6V1B1 gene, which is responsible for dRTA with early hearing loss, was detected in both siblings. In conclusion, proximal tubular dysfunction and hyperoxaluria may be found in children with dRTA and are reversible under appropriate therapy. 相似文献
29.
Nenad Baletic Hidajet Malicevic Zeljko Petrovic Jelena Marinkovic-Eric Aleksandar Peric 《European archives of oto-rhino-laryngology》2010,267(6):925-931
Any endoscopic diagnostic procedure that is capable of giving exact information on laryngeal lesions without damaging the
tissue has essential advantages over standard biopsy. Tissue autofluorescence is defined as a natural ability of tissue to
fluoresce when exposed to a certain light wavelength. This feature is a consequence of the presence of fluorophores in the
tissues, which are activated by a narrow wavelength range. However, due to their biochemical and biophysical characteristics,
laryngeal precancerosis and cancer do not fluoresce when exposed to blue light. In the present study, we used Pentax’s System
of Autofluorescent Endoscopy (SAFE 1000) to detect autofluorescence disturbances from laryngeal mucosa. Diagnostic parameters
(sensitivity and specificity) of the microlaryngoscopy (MLS) and SAFE 1000 in the diagnosis of laryngeal precancerosis and
carcinoma were compared and discussed. We have found that SAFE had a better sensitivity with regard to mentioned laryngeal
pathology, but MLS had better specificity than SAFE. The overall diagnostic sensitivity in the diagnostics of laryngeal atypical
hyperplasia and cancer with SAFE was 89%, as opposed to 73% with MLS. Diagnostic specificity of SAFE for all cases of laryngeal
carcinomas and atypical hyperplasia was 78%. The specificity of MLS in diagnostics of laryngeal carcinomas cases was 98%,
while that for cases of atypical hyperplasia was 100%. Many other conditions that have impact on autofluorescent features
of laryngeal mucosa were also discussed. 相似文献
30.
We apply wide-field interferometric microscopy techniques to acquire quantitative phase profiles of ventricular cardiomyocytes in vitro during their rapid contraction with high temporal and spatial resolution. The whole-cell phase profiles are analyzed to yield valuable quantitative parameters characterizing the cell dynamics, without the need to decouple thickness from refractive index differences. Our experimental results verify that these new parameters can be used with wide field interferometric microscopy to discriminate the modulation of cardiomyocyte contraction dynamics due to temperature variation. To demonstrate the necessity of the proposed numerical analysis for cardiomyocytes, we present confocal dual-fluorescence-channel microscopy results which show that the rapid motion of the cell organelles during contraction preclude assuming a homogenous refractive index over the entire cell contents, or using multiple-exposure or scanning microscopy. 相似文献