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Lorenzo Kiferle Sonia Mazzucchi Elisa Unti Ilaria Pesaresi Serena Fabbri Valentina Nicoletti Duccio Volterrani Mirco Cosottini Ubaldo Bonuccelli Roberto Ceravolo 《Parkinsonism & related disorders》2013,19(9):800-805
BackgroundHuntington disease (HD) is pathologically characterized by a selective neurodegeneration of vulnerable populations of neurons, with an early marked neuronal loss and atrophy in the neostriatum. Dopaminergic innervations of neostriatal neurons originate in the substantia nigra pars compacta. Few studies investigated the neuronal loss and the functional role of the substantia nigra in modulating clinical features in HD.Methods12 patients and 12 age-matched controls underwent SPECT scans with 123I-FP-CIT and a 1.5 T MRI scan with inversion recovery technique. The association between both clinical and neuropsychological features and striatal uptake and volume of substantia nigra was explored.ResultsStriatal (p < 0.05), caudate (p < 0.05), and putaminal (p < 0.01) uptake was significantly lower in patients with respect to controls. Further, the volume of substantia nigra was reduced in HD when compared to controls (p < 0.01). No relationship between the volume of SN and tracer striatal uptake was found as well as between clinical and neuropsychological features with the SPECT and MRI results.ConclusionsOur results confirm that the degeneration of nigrostriatal pathway may occur in symptomatic HD patients. If confirmed by larger studies, the lack of any kind of correlation between clinical and neuropsychological features with striatal uptake and volume of substantia nigra suggests that motor and cognitive aspects in HD are not directly related to nigrostriatal degeneration. 相似文献
63.
Edoardo Picetti Marta Velia Antonini Maria Chiara Lucchetti Serena Pucciarelli Adriana Valente Ilaria Rossi Paolo Schiavi Franco Servadei Maria Luisa Caspani Mario Mergoni 《Neurocritical care》2013,18(3):298-304
Introduction
Discrepant data exist regarding the incidence and severity of clinical problems related to intra-hospital transport of brain-injured patients and no consensus exists whether modern-day intra-hospital transport represents a safe or potentially problematic environment for neurointensive care unit (NICU) patients.Methods
We examined the incidence of clinical complications and physiological derangements that occurred in 160 neurologically injured patients (90 males, 70 females, mean age 57 ± 17 years) who underwent intra-hospital transport (288 cases, 237 scheduled, 51 unscheduled) for computed tomography scans.Results
Our findings indicate that (1) at least one significant complication (predominantly hemodynamic) occurred in over one-third (36 %) of all transports (p = n.s scheduled vs. unscheduled) necessitating the deployment of interventions designed to treat changes in arterial pressure (2) despite the presence of trained medical personnel and availability of specialized equipment, intra-cranial pressure was not adequately monitored during transports (especially in patients with intra-cranial hypertension prior to transport) (3) intra-hospital transfer was associated with minor but statistically significant clinical changes, including a reduction in arterial partial pressure of oxygen ( $ {\text{Pa}}_{{{\text{O}}_{ 2} }} $ )/inspired oxygen fraction ( $ {\text{Fi}}_{{{\text{O}}_{ 2} }} $ ) (only in the scheduled transport population), decreased arterial lactate levels (scheduled transport population), lowered body temperature (scheduled transport population), and increased arterial partial pressure of carbon dioxide ( $ {\text{Pa}}_{{{\text{CO}}_{ 2} }} $ ) (scheduled transport population).Conclusions
Intra-hospital transport of brain-injured NICU patients may present some hazards even if performed by skilled personnel with specialized equipment. In Trauma Centers such as ours, an improvement in the frequency of neuromonitoring [intra-cranial pressure (ICP) and end-tidal CO2 ( $ {\text{ET}}_{{{\text{CO}}_{ 2} }} $ )] during transport is recommended. 相似文献64.
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Lotta LA Mancini I Tuana G Musallam KM Peyvandi F 《Journal of thrombosis and thrombolysis》2012,34(3):416-418
Thienopyridines are commonly used anti-platelet drugs that may be associated with the development of secondary, drug-induced thrombotic thrombocytopenic purpura (TTP), a rare but potentially life threatening condition. We report the case of a 70?year-old man with a history of recurrent idiopathic TTP episodes who was treated with clopidogrel and then ticlopidine for thromboprophylaxis after percutaneous coronary intervention. Treatment was successful with no signs of TTP recurrence. Platelet counts and ADAMTS13 activity levels remained normal for months after the initiation of anti-platelet therapy, with no reappearance of anti-ADAMTS13 autoantibodies. This report demonstrates that thienopyridines do not necessarily induce TTP in patients with a history of TTP who are in disease remission. 相似文献
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Cimaz R Moretti D Pagnini I Marino A Cantarini L Simonini G 《Current rheumatology reports》2012,14(2):150-154
Classification of juvenile idiopathic arthritis is an ongoing process and up to now has been predominantly based on clinical
manifestations—mainly number of joints at onset of disease. In the meantime, basic studies have advanced our knowledge regarding
the disease pathogenesis. Unfortunately, studies of cytokines and cytokine polymorphisms have not followed the predominantly
clinical International League of Associations for Rheumatology classification in that no significant biological differences
among the different disease categories have been demonstrated with robust associations. Only systemic-onset disease seems
to be quite different from other disease categories with regard to biologic mechanisms; indeed, it now seems closer to autoinflammatory
than to classic autoimmune diseases. New players in the immunologic basis of juvenile idiopathic arthritis (eg, interleukin-17
and regulatory T cells) are also discussed in this review. 相似文献
70.
Rebecca L. Mather Abhijit Parolia Sandra E. Carson Erik Venalainen David RoigCarles Mustapha Jaber ShihChun Chu Ilaria Alborelli Rebecca Wu Dong Lin Noushin Nabavi Elena Jachetti Mario P. Colombo Hui Xue Perla Pucci Xinpei Ci Cheryl Hawkes Yinglei Li Hardev Pandha Igor Ulitsky Crystal Marconett Luca Quagliata Wei Jiang Ignacio Romero Yuzhuo Wang Francesco Crea 《Molecular oncology》2021,15(7):1921