全文获取类型
收费全文 | 44937篇 |
免费 | 5028篇 |
国内免费 | 56篇 |
专业分类
耳鼻咽喉 | 632篇 |
儿科学 | 1265篇 |
妇产科学 | 1258篇 |
基础医学 | 6993篇 |
口腔科学 | 1050篇 |
临床医学 | 6082篇 |
内科学 | 8372篇 |
皮肤病学 | 593篇 |
神经病学 | 3624篇 |
特种医学 | 1461篇 |
外国民族医学 | 1篇 |
外科学 | 6028篇 |
综合类 | 907篇 |
一般理论 | 29篇 |
预防医学 | 4679篇 |
眼科学 | 676篇 |
药学 | 3629篇 |
中国医学 | 61篇 |
肿瘤学 | 2681篇 |
出版年
2021年 | 618篇 |
2020年 | 407篇 |
2019年 | 698篇 |
2018年 | 803篇 |
2017年 | 577篇 |
2016年 | 721篇 |
2015年 | 753篇 |
2014年 | 1032篇 |
2013年 | 1576篇 |
2012年 | 2103篇 |
2011年 | 2164篇 |
2010年 | 1215篇 |
2009年 | 1084篇 |
2008年 | 1885篇 |
2007年 | 1956篇 |
2006年 | 1919篇 |
2005年 | 1873篇 |
2004年 | 1796篇 |
2003年 | 1745篇 |
2002年 | 1774篇 |
2001年 | 1559篇 |
2000年 | 1592篇 |
1999年 | 1376篇 |
1998年 | 610篇 |
1997年 | 506篇 |
1996年 | 428篇 |
1995年 | 467篇 |
1994年 | 436篇 |
1993年 | 405篇 |
1992年 | 1117篇 |
1991年 | 1051篇 |
1990年 | 1030篇 |
1989年 | 948篇 |
1988年 | 872篇 |
1987年 | 899篇 |
1986年 | 866篇 |
1985年 | 885篇 |
1984年 | 704篇 |
1983年 | 601篇 |
1982年 | 427篇 |
1981年 | 348篇 |
1980年 | 361篇 |
1979年 | 578篇 |
1978年 | 440篇 |
1977年 | 361篇 |
1976年 | 368篇 |
1974年 | 379篇 |
1973年 | 333篇 |
1972年 | 338篇 |
1971年 | 304篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
12.
13.
ABSTRACTBoth international tourism and migration of people with low English proficiency (LEP) to Australia are increasing. Thus, health-care practitioners (HPs) increasingly use interpreters to communicate with patients with LEP. Although qualified interpreters are the most suggested and policy-endorsed mechanism for communicating with patients with LEP, family members (FMIs) are also used as interpreters. This study investigated (a) when do health professionals consider it appropriate to use FMIs and (b) what characteristics of family members health professionals believe make them suitable to act as FMIs. As part of a larger project examining the decision-making processes of HPs regarding interpreter use, 69 HPs from neonatal and pediatric departments in one hospital in Queensland Australia were interviewed. Results indicated HPs thought the appropriateness of using FMIs depended on the type of information, such that it was either completely acceptable (e.g., explaining some basic or non-medical information) or completely unacceptable (e.g., confidential information or consent). However, in an emergency, when no other options were available, FMIs were used. The characteristics of suitable FMIs included age, level of English proficiency and medical understanding, and the relationship between patient and FMI. Results were to some extent consistent with Queensland government policies but there were notable differences, including using children and regarding FMIs as first preference. Improving HP’s knowledge of policies may increase their confidence in their practice and appropriate use of FMIs, thereby improving their care delivery to patients and families with LEP. 相似文献
14.
15.
Nasal masks for domiciliary positive pressure ventilation: patient usage and complications. 总被引:2,自引:1,他引:1
下载免费PDF全文
![点击此处可从《Thorax》网站下载免费的PDF全文](/ch/ext_images/free.gif)
BACKGROUND--Nasal mask discomfort is a major factor in compliance with treatment by nasal intermittent positive pressure ventilation (NIPPV) and nasal continuous positive airway pressure (CPAP). METHODS--A study of skin complications resulting from mask usage, with particular reference to predisposing factors, was carried out in 66 patients by means of a postal questionnaire. An effective means of managing ulceration at the nasal bridge while continuing therapy is described. RESULTS--Some disruption of treatment due solely to mask discomfort was experienced by 35 patients (53%), consisting of broken skin or open sores in 11 cases (17%). CONCLUSIONS-Although complications resulting from nasal mask usage are common, early identification of patients at risk of developing such complications and appropriate intervention will result in improved patient compliance. 相似文献
16.
R G Jones J W Bass M E Weisse J M Vincent 《The Pediatric infectious disease journal》1991,10(8):557-559
We tested the urine of 30 infants 6 weeks to 7 months of age after they received standard 10-micrograms (0.5-ml) doses of HbOC (HibTITER) Haemophilus influenzae b (Hib) conjugate vaccine for the presence of Hib antigenuria using a commercially available latex particle agglutination assay (Directigen). Urines were collected within 1 hour, from 1 to 3 hours, at 24 hours and at 3, 6 and 9 days after vaccine administration and reactions were quantitated from 0 to 3+. In contrast to previous studies in older children which showed little or no antigenuria following HbOC vaccination, our study shows that in infants intense Hib antigenuria is evident within 2 to 3 hours and persists 3 days after vaccine administration and that less intense antigenuria may be detected in some infants for several days. With efficacious vaccines now being used in 2- to 6-month-old infants, invasive Hib disease may soon be limited to infants of this age just before their seroconversion. It should be recognized that antigenuria occurs for several days after vaccination with Hib conjugate vaccines and that it could be erroneously interpreted as evidence of invasive Hib infection. 相似文献
17.
Veronique Braud E. Yvonne Jones Andrew McMichael 《European journal of immunology》1997,27(5):1164-1169
Human histocompatibility leukocyte antigen E (HLA-E) and mouse major histocompatibility complex (MHC) class Ib antigen, Qa-1, share the same substitutions at two normally conserved positions 143 and 147, which are likely to affect binding of the C terminus of peptides. Qa-1 is able to bind a peptide derived from the leader sequence of H-2 D and H-2 L molecules. We developed a peptide binding assay in vitro to compare the binding specificity of HLA-E with the mouse MHC class Ib molecule Qa-1. We demonstrate that HLA-E binds, although poorly, the peptide which binds to Qa-1 and that it also binds nonamer signal sequence-derived peptides from human MHC class I molecules. Using alanine and glycine substitutions, we could define primary anchor residues at positions 2 and 9 and secondary anchor residues at position 7 and possibly 3. 相似文献
18.
19.
It is well established that painful distension of hollow viscera such as the oesophagus can evoke a reflex tachycardia and pressor response; however, the nature of the oesophageal afferent pathway(s) remains controversial. This study investigated the afferent arc which mediates these reflex cardiovascular changes in the decerebrate rat. In addition, the effect of oesophageal distension on the respiratory activity of the costal diaphragm was studied. Focal distension of the oesophagus (volume of 0.3 ml applied for 10 s) just above the diaphragmatic hiatus evoked a reproducible pressor response and tachycardia in the decerebrate rat. Respiration was transiently inhibited at the beginning of oesophageal distension and prior to the rise in blood pressure. Neuromuscular blockade with the nicotinic acetylcholine receptor blocker alpha-bungarotoxin (140 microg bolus) had no effect on the magnitude of the cardiovascular response. Therefore the efferent supply to the striated muscle of the rat oesophagus was not essential in mediating this reflex. Signal averaging of the mean blood pressure response showed that neither selective ablation of oesophageal spinal afferents nor bilateral vagotomy altered the early trajectory of the pressure response. Bilateral vagotomy reduced the peak magnitude of the response to sustained oesophageal distension. In contrast, selective removal of spinal afferents had no effect on the response. Ablation of both neural pathways was essential to abolish the reflex cardiovascular and respiratory responses. It can be concluded that both vagal and spinal afferent pathways are utilised in the reflex cardiorespiratory response to painful oesophageal distension. Although ablation of one neural pathway had no effect on the response it was still implicated in the reflex, since ablation of both pathways was necessary to prevent the cardiorespiratory changes. This study emphasises the need for caution when inferences are made concerning single selective ablations of multiply innervated organs. 相似文献
20.
The administration of prophylactic antibiotics in surgery is appropriate for many patients. Data have shown extending the duration of prophylaxis beyond 48 hours does not lower the rate of postoperative-infection. The purpose of this project was to concurrently assess the duration of prophylactic antibiotic use. A total of 95 patients were monitored over 3 weeks. Eighty patients (84.2%) received antimicrobial therapy. In 23 of these patients (28.75%) the duration of antibiotic administration was longer than 2 days without clinical or microbiological evidence of infection. In 5 other patients only postoperative antibiotics were prescribed. The cost difference between the actual duration of antibiotic administration and 2 days of the same regimen was +1,364.58. Extrapolating for one year, it can be estimated that antibiotic costs could be reduced about +23,600. Pharmacists can focus on the duration of antibiotic prophylaxis as a cost containment measure. 相似文献